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Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 112:2003;293-301 This elegant study established an unexpected and unambigious link between a TRP channel (TRPM5) and a taste sensation. Convincing evidence was also provided that PLCβ2 transduced the signals from distinct taste receptors to TRPM5.
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This work shed light on the controversial activation mechanism of TRPM5. Increases in intracellular calcium concentration directly stimulate channel activity in heterologous systems. PIP2 reverses desensitization, thus increasing channel activity.
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This exciting study described striking phenotypes for male mice lacking TRPC2, establishing a connection between pheromone sensation and TRP channels, and highlighting the role of the vomeronasal system in gender recognition.
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Aarts M., Iihara K., Wei W.L., Xiong Z.G., Arundine M., Cerwinski W., MacDonald J.F., Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell. 115:2003;863-877 The authors found a novel, NMDA- independent pathway that mediates excitotoxicity in central neurons. They identified TRPM7 as an essential player during anoxic injury, and a potential therapeutic target.
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