Antinociceptive effects of tetrodotoxin (TTX) in rodents

British Journal of Anaesthesia

Volumn 96, Issue 6, 2006, Pages 761-768

  Marcil, J ^a   Walczak, J S ^a   Guindon, J ^a   Ngoc, A H ^b   Lu, S ^c   Beaulieu, Pierre ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Wex Pharmaceuticals Inc   (Canada)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Pain, inflammatory; Pain, neuropathic; Pain, visceral; Sodium channel blocker, tetrodotoxin

Indexed keywords

ACETIC ACID; FORMALDEHYDE; MORPHINE SULFATE; SODIUM CHLORIDE; TETRODOTOXIN;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; HYPERALGESIA; MALE; MOTOR DYSFUNCTION; MOUSE; MOUSE STRAIN; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RESPIRATORY DISTRESS; SCIATIC NERVE; SEDATION; SYSTEMIC THERAPY; VISCERAL PAIN; WRITHING TEST;

EID: 33646874779     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/ael096     Document Type: Article

References (23)

1. Kao CY. Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmacol Rev 1966; 18: 997-1049
2. Kao CY. Pharmacology of tetrodotoxin and saxitoxin. Fed Proc 1972; 31: 1117-23
3. Lyu YS, Park SK, Kyungsoon C, Chung JM. Low dose of tetrodotoxin reduces neuropathic pain behaviours in an animal model. Brain Res 2000; 871: 98-103
4. Tetrodotoxin is safe and effective for severe, refractory cancer pain. J Support Oncol 2004; 2: 18
5. Lai J, Porreca F, Hunter JC, Gold MS. Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 2004; 44: 371-97
6. Waxman SG, Cummins TR, Dib-Hajj SD, Bkack JA. Voltage-gated sodium channels and the molecular pathogenesis of pain: A review. J Rehabil Res Dev 2000; 37: 517-528
7. Yoshimura N, Seki S, Novakovic SD, et al. The involvement of the tetrodotoxin-resistant sodium channel Nav1.8 (PN3/SNS) in a rat model of visceral pain. J Neurosci 2001; 21: 8690-6
8. Dubuisson D, Dennis SG. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977; 4: 161-74
9. Tjølsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test an evaluation of the method. Pain 1992; 51: 5-17
10. Watson GS, Sufka KJ, Coderre TJ. Optimal scoring strategies and weights for the formalin test in rats. Pain 1997; 70: 53-58
11. Tjølsen A, Hole K. Animal models of analgesia. In: Dickenson AH, Besson J-MR, eds. The Pharmacology of Pain. Berlin: Springer-Verlag, 1997, pp. 1-20
12. Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 1990; 43: 205-18
13. Tal M, Bennett GJ. Extra-territorial pain in rats with a peripheral mononeuropathy: Mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain 1994; 57: 375-82
14. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88
15. Winer BJ. Statistical Principles in Experimental Design. New York: McGraw-Hill, 1971
16. De Léan A, Munson PJ, Rodbard D. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 1978; 235: E97-102
17. Boucher TJ, Okuse K, Bennett DL, Munson JB, Wood JN, McMahon SB. Potent analgesic effects of GDNF in neuropathic pain states. Science 2000; 290: 124-7
18. v1.8. Pain 2002; 95: 143-52
19. Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, Lai J. Redistribution of Na (V)1.8 in uninjured axons enables neuropathic pain. J Neurosci 2003; 23: 158-66
20. Gould HJ, England JD, Liu ZP, Levinson SR. Rapid sodium channel augmentation in response to inflammation induced by complete Freund's adjuvant. Brain Res 1998; 802: 69-74
21. + channel expression increases in dorsal root ganglion neurones in the carrageenan inflammatory pain model. Neuroreport 1998; 9: 967-72
22. Chernov HI, Wilson DE, Fowler F, Plummer AJ. Non-specificity of the mouse writhing test. Arch Int Pharmacodyn Ther 1967; 167: 171-8
23. Hagen NA, Fisher K, du Sourich P. et al. Safety of intramuscular tetrodotoxin for inadequately controlled, severe cancer pain. 11th World Congress on Pain (IASP), Sydney, August 24 2005, 1082-P324.