Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

Journal of Biological Chemistry

Volumn 277, Issue 49, 2002, Pages 47564-47571

  Peng, Kuan ^a   Shu, Qin ^a   Liu, Zhonghua ^a   Liang, Songping ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEALING; NUCLEAR MAGNETIC RESONANCE; SODIUM;

TETRODOTOXINS;

BIOCHEMISTRY;

HUWENTOXIN IV; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CHANNEL GATING; COMPARATIVE STUDY; DISULFIDE BOND; FEMALE; INHIBITION KINETICS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; SODIUM CURRENT; SPIDER; STRUCTURE ANALYSIS; TOXIN ANALYSIS; TOXIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FEMALE; GANGLIA, SPINAL; INHIBITORY CONCENTRATION 50; IODOACETAMIDE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURONS; NEUROTOXINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM; SODIUM CHANNELS; SOFTWARE; SPIDER VENOMS; SPIDERS; TETRODOTOXIN; TIME FACTORS;

ARANEAE; AVES; INVERTEBRATA; ORNITHOCTONUS HUWENA; THERAPHOSIDAE;

EID: 0037033085     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204063200     Document Type: Article

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