Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats

Molecular Pharmacology

Volumn 69, Issue 3, 2006, Pages 823-832

  Brochu, Richard M ^a   Dick, Ivy E ^a   Tarpley, Jason W ^a   McGowan, Erin ^a   Gunner, David ^b   Herrington, James ^a   Shao, Pengcheng P ^a   Ok, Dong ^a   Li, Chunshi ^a   Parsons, William H ^a   Stump, Gary L ^a   Regan, Christopher P ^a   Lynch Jr , Joseph J ^a   Lyons, Kathryn A ^a   McManus, Owen B ^a   Clark, Samantha ^b   Ali, Zahid ^b   Kaczorowski, Gregory J ^a   Martin, William J ^a   Priest, Birgit T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CDA 54; N {[2' (AMINOSULFONYL)BIPHENYL 4 YL]METHYL} N METHYL N' [4 (TRIFLUOROMETHOXY)BENZYL]CYCLOPENTANE 1, 2 DICARBOXAMIDE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ACTION POTENTIAL; AFFERENT NERVE GROUP 1; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG MECHANISM; HEART ELECTROPHYSIOLOGY; MALE; MOTOR COORDINATION; NERVE BLOCK; NERVE CONDUCTION; NERVE FIBER C; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PERIPHERAL NERVE INJURY; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ADMINISTRATION, ORAL; ANIMALS; BENZYL COMPOUNDS; CYCLOPENTANES; DOGS; ELECTROPHYSIOLOGY; HEART; HUMANS; MICE; MOTOR ACTIVITY; NEURALGIA; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPINAL NERVES;

EID: 33644836275     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.018127     Document Type: Article

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