Paroxysmal extreme pain disorder M1627K mutation in human Nav 1.7 renders DRG neurons hyperexcitable

Molecular Pain

Volumn 4, Issue , 2008, Pages

  Dib Hajj, Sulayman D ^a,b   Estacion, Mark ^a,b   Jarecki, Brian W ^c   Tyrrell, Lynda ^a,b   Fischer, Tanya Z ^a,b   Lawden, Mark ^d   Cummins, Theodore R ^c   Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; LYSINE; METHIONINE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL NAV1.7; SCN9A PROTEIN, HUMAN; SODIUM CHANNEL;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CASE REPORT; CHANNEL GATING; DRUG DOSE REDUCTION; DRUG EFFICACY; EXON; FEMALE; GENE ACTIVATION; GENE INACTIVATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; INFANT; MALE; MUTANT; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE EXCITABILITY; NERVE POTENTIAL; PAIN; PAROXYSMAL EXTREME PAIN DISORDER; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SODIUM CURRENT; SPINAL GANGLION; STIMULUS RESPONSE; UNITED KINGDOM; VOLTAGE CLAMP; WILD TYPE; ACTION POTENTIAL; ANIMAL; GENETICS; HYPERALGESIA; METABOLISM; MISSENSE MUTATION; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PEDIGREE; PHYSIOLOGY; RAT; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; ADULT; AMINO ACID SUBSTITUTION; ANIMALS; FEMALE; GANGLIA, SPINAL; HUMANS; HYPERALGESIA; LYSINE; MALE; METHIONINE; MUTATION, MISSENSE; NEURONS; PAIN; PEDIGREE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; SPINAL CORD INJURIES;

EID: 53349171632     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-4-37     Document Type: Article

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