Characterizing the Bi-Subunit Type IB DNA Topoisomerase of Leishmania Parasites; a Novel Scenario for Drug Intervention in Trypanosomatids

Current Drug Targets

Volumn 9, Issue 11, 2008, Pages 966-978

  Reguera, Rosa M ^a   Díaz González, Rosario ^a   Pérez Pertejo, Yolanda ^a   Balaña Fouce, Rafael ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

Camptothecin; DNA topoisomerase IB; Leishmania; Parasitic protozoa; Tropical diseases; Trypanosomatids

Indexed keywords

DNA TOPOISOMERASE; ENZYME INHIBITOR; PROTEIN SUBUNIT; PROTOZOAL PROTEIN;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; FLAGELLATE INFECTION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LEISHMANIA; METABOLISM; PARASITOLOGY; REVIEW;

ANIMALS; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEISHMANIA; MASTIGOPHORA INFECTIONS; MOLECULAR STRUCTURE; PROTEIN SUBUNITS; PROTOZOAN PROTEINS;

EID: 59049098263     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945008786786118     Document Type: Review

References (123)

1. Molyneux, D.H. (2003) Trans. R. Soc. Trop. Med. Hyg., 97, 129-132.
2. Curry A. (2004) J. Submicrosc. Cytol. Pathol., 36,105-119.
3. Schwartz, E.; Hatz, C. and Blum, J. (2006) Lancet Infect. Dis., 6, 342-349.
4. Kioy, D.; Jannin, J. and Mattock, N. (2004) Nat. Rev. Microbiol., 2, 186-187.
5. Teixeira, A.R.; Nitz, N.; Guimaro, M.C.; Gomes, C. and Santos-Buch, C.A. (2006) Postgrad. Med. J., 82, 788-798.
6. Desjeux, P. (2004) Comp. Immunol. Microbiol. Infect. Dis., 27, 305-318.
7. Berman, J. (2006) Indian J. Med. Res., 123, 289-294.
8. Cruz, I.; Nieto, J.; Moreno, J.; Canavate, C.; Desjeux, P. and Alvar, J. (2006) Indian J. Med. Res., 123, 357-388.
9. Legros, D.; Ollivier, G.; Gastellu-Etchegorry, M.; Paquet, C.; Burri, C.; Jannin, J. and Büscher, P. (2002) Lancet Infect. Dis., 2, 437-440.
10. Kennedy, P.G. (2004) J. Clin. Invest., 113, 496-504.
11. Bacchi, C.J.; Nathan, H.C.; Hutner, S.H.; McCann, P. P and Sjoerdsma, A. (1980) Science, 210, 332-334.
12. Burri, C. and Brun, R. (2003) Parasitol. Res., 90 Suppl. 1, S49-52.
13. Urbina, J.A. and Docampo, R. (2003) Trends Parasitol., 19, 495-501.
14. Balaña-Fouce, R.; Reguera, R.M.; Cubría, J.C. and Ordóñez, D. (1998) Gen. Pharmacol., 30, 435-443.
15. Alvar, J.; Croft, S. and Olliaro, P. (2006) Adv. Parasitol., 61, 223-274.
16. Bhattacharya, S.K.; Sinha, P.K.; Sundar, S.; Thakur, C.P.; Jha, T.K.; Pandey, K.; Das, V.R.; Kumar, N.; Lal, C.; Verma, N.; Singh, V.P.; Ranjan, A.; Verma, R.B.; Anders, G.; Sindermann, H. and Ganguly, N.K. (2007) J. Infect. Dis., 196, 591-598.
17. Berman, J. (2005) Expert Opin. Pharmacother., 6, 1381-1388.
18. Bakshi, R.P. and Shapiro, T.A. (2003) Mini Rev. Med. Chem., 3, 597-608.
19. Bailly, C. (2000) Curr. Med. Chem., 7, 39-58.
20. Villa, H.; Otero Marcos, A.R.; Reguera, R.M.; Balaña-Fouce, R.; García-Estrada, C.; Pérez-Pertejo, Y.; Tekwani, B.L.; Myler, P.J.; Stuart, K.D.; Bjornsti, M.A. and Ordóñez, D. (2003) J. Biol. Chem., 278, 3521-3526.
21. Reguera, R.M.; Redondo, C.M.; Gutiérrez de Prado, R.; Pérez-Pertejo, Y. and Balaña-Fouce, R. (2006) Biochim. Biophys. Acta, 1759, 117-131.
22. Balaña-Fouce, R.; Redondo, C.M.; Pérez-Pertejo, Y.; Díaz-González, R. and Reguera, R.M. (2006) Drug Discov. Today, 11, 733-740.
23. Das, B.B.; Sem, N.; Dasgupta, S.B.; Ganguly, A.; Das, R. and Majumder, H.K. (2006) Indian J. Med. Res., 123, 221-232.
24. Vinograd, J.; Lebowitz, J.; Radloff, R.; Watson, R. and Laipis, P. (1965) Proc. Natl. Acad. Sci. U.S. A, 53, 1104-1111.
25. De Witt, S. (1995) Notices AMS, 42, 528-537.
26. Champoux, J.J. (2001) Annu. Rev. Biochem., 70, 369-413.
27. Wang, J.C. (1996) Annu. Rev. Biochem., 65, 635-692.
28. Wang, J.C. (2002) Nat. Rev. Mol. Cell Biol., 3, 430-440.
29. Corbett, K.D. and Berger, J.M. (2004) Annu. Rev. Biophys. Biomol. Struct., 33, 95-118.
30. Wang, J.C. (1971) J. Mol. Biol., 55, 523-533.
31. Chen, S.J. and Wang, J.C. (1998) J. Biol. Chem., 273, 6050-6056.
32. Champoux, J.J., and Dulbecco, R. (1972) Proc. Natl. Acad. Sci. USA, 69,143-146.
33. Sharma, A.; Hanai, R. and Mondragón, A. (1994) Structure, 2, 767-777.
34. Brown, P.O. and Cozzarelli, N.R. (1979) Science, 206, 1081-1083.
35. Berger, J.M.; Gamblin, S.J.; Harrison, S.C. and Wang JC. (1996) Nature, 379, 225-232.
36. Bergerat, A.; Gadelle, D. and Forterre P. (1994) J. Biol. Chem., 269, 27663-27669.
37. Strauss, P.R. and Wang, J.C. (1990) Mol. Biochem. Parasitol., 38,141-150.
38. Fragoso, S.P. and Goldenberg, S. (1992) Mol. Biochem. Parasitol., 55, 127-134.
39. Das A.; Dasgupta A.; Sharma S.; Ghosh M.; Sengupta T.; Bandopadhyay S. and Majumder, H.K. (2001) Nucleic Acids Res., 29, 1844-1851.
40. Hanke, T.; Ramiro, M.J.; Trigueros, S.; Roca, J. and Larraga, V. (2003) Nucleic Acids Res., 31, 4917-4928.
41. Shapiro, T.A. (1994) Mol. Cell Biol., 14, 3660-3667.
42. Wang Z. and Englund P.T. (2001) EMBO J., 20, 4674-4683.
43. Lee, M.P.; Brown, S.D.; Chen, A. and Hsieh, T.S. (1993) Proc. Natl. Acad. Sci. USA, 90, 6656-6660.
44. Morham, S.G.; Kluckman, K.D.; Voulomanos, N. and Smithies, O. (1996) Mol. Cell Biol., 16, 6804-6809.
45. Bakshi, R.P. and Shapiro, T.A. (2004) Mol. Biochem. Parasitol., 136, 249-255.
46. Balaña-Fouce, R.; Garcia-Estrada, C.; Perez-Pertejo, Y. and Reguera, R.M. (2008) BMC Microbiol., 8, 113.
47. Stewart, L.; Redinbo, M.R.; Qiu, X.; Hol, W.G. and Champoux, J.J. (1998) Science, 279, 1534-1541.
48. Champoux, J.J. (1998) Prog. Nucleic Acids Res. Mol. Biol., 60, 111-132.
49. Stewart, L.; Ireton, G.C. and Champoux, J.J. (1996) J. Biol. Chem., 271, 7602-7608.
50. Redinbo, M.R.; Stewart, L.; Kuhn, P.; Champoux, J.J. and Hol, W.G. (1998) Science, 279, 1504-1513.
51. Redinbo, M.R.; Champoux, J.J. and Hol, W.G. (1999) Curr. Opin. Struct. Biol., 9, 29-36.
52. Redinbo, M.R.; Champoux, J.J. and Hol, W.G. (2000) Biochemistry, 39, 6832-6840.
53. Lisby, M.; Olesen, J.R.; Skouboe, C.; Krogh, B.O.; Straub, T.; Boege, F.; Velmurugan, S.; Martensen, P.M.; Andersen, A.H.; Jayaram, M.; Westergaard, O. and Knudsen, B.R. (2001) J. Biol. Chem., 276, 20220-20227.
54. Stewart, L.; Ireton, G.C. and Champoux, J.J. (1999) J. Biol. Chem., 274, 32950-32960.
55. Zhang, H.; Barcelo, J.M.; Lee, B.; Kohlhagen, G.; Zimonjic, D.B.; Popescu, N.C. and Pommier, Y. (2001) Proc. Natl. Acad. Sci. USA, 98,10608-10613.
56. Zhang, H.; Meng, L.H. and Pommier, Y. (2007) Biochimie, 89, 474-481.
57. Broccoli, S.; Marquis, J.F.; Papadopoulou, B.; Olivier, M. and Drolet, M. (1999) Nucleic Acids Res., 27, 2745-2752.
58. Das, A.; Mandal, C.; Dasgupta, A.; Sengupta, T. and Majumder, H.K. (2002) Nucleic Acids Res., 30, 794-802.
59. Das, B.B.; Sengupta, T.; Ganguly A. and Majumder H.K. (2006) Mol. Microbiol., 62, 917-927.
60. Bodley, A.L.; Chakraborty, A.K.; Xie, S.; Burri, C. and Shapiro, T.A. (2003) Proc. Natl. Acad. Sci. USA, 100, 7539-7544.
61. Das, B.B.; Sen, N.; Ganguly, A. and Majumder, H.K. (2004) FEBS Lett., 565, 81-88.
62. Bosedasgupta, S.; Das, B.B.; Sengupta, S.; Ganguly, A.; Roy, A.; Tripathi, G. and Majumder, H.K. (2008) Biochem. J., 409, 481-489.
63. Davies, D.R.; Mushtaq, A.; Interthal, H.; Champoux, J.J. and Hol, W.G. (2006) J. Mol. Biol., 357, 1202-1210.
64. Das, B.B.; Sen, N.; Dasgupta, S.B.; Ganguly, A. and Majumder, H.K. (2005) J. Biol. Chem., 280, 16335-16344.
65. Diaz-González, R.; Pérez-Pertejo, Y.; Pommier, Y.; Balaña-Fouce, R. and Reguera, R.M. (2008) Biochem. Pharmacol., (in press).
66. Marquis, J.F.; Hardy, I. and Olivier, M. (2005) Antimicrob Agents Chemother., 49, 1441-1446.
67. Díaz González, R.; Pérez Pertejo, Y.; Ordóñez, D.; Balaña-Fouce, R. and Reguera, R.M. (2007) PLoS ONE, 2, e1177
68. Das, B.B.; Bose Dasgupta, S.; Ganguly, A.; Mazumder, S.; Roy, A. and Majumder, H.K. (2007) FEBS J., 274, 150-163.
69. Díaz-González, R.; Pérez-Pertejo, Y.; Redondo, C.M.; Pommier, Y.; Balaña-Fouce, R. and Reguera, R.M. (2007) Biochimie, 89, 1517-1527.
70. Stewart, L.; Ireton, G.C. and Champoux, J.J. (1997) J. Mol. Biol., 269, 355-372.
71. Ireton, G.C.; Stewart, L.; Parker, L.H. and Champoux, J.J. (2000) J. Biol. Chem., 275, 25820-25830.
72. Vanhamme, L. and Pays, E. (1995) Microbiol. Rev., 59, 223-240.
73. Stiles, J.K.; Hicock, P.I.; Shah, P.H. and Meade, J.C. (1999) Ann. Trop. Med. Parasitol., 93, 781-807.
74. Teixeira, S.M. (1998) Braz. J. Med. Biol. Res., 31, 1503-1516.
75. Sordet, O.; Khan, Q.A.; Kohn, K.W. and Pommier, Y. (2003) Curr. Med. Chem. Anticancer Agents, 3, 271-290.
76. Kohn, K.W.; Shao, R.G. and Pommier, Y. (2000) Cell Biochem. Biophys. 33,175-180.
77. Larsen, A.K. and Gobert, C. (1999) Pathol. Oncol. Res., 5, 171-178.
78. St-Amant, C.; Lussier, S.; Lehoux, J.; Laberge, R.M. and Boissonneault, G. (2006) Biochem. Cell Biol., 84, 55-66.
79. Samuels, D.S.; Shimizu, Y. and Shimizu, N. (1989) FEBS Lett., 259, 57-60.
80. Pommier, Y.; Kerrigan, D.; Hartman, K.D. and Glazer, R.I. (1990) J. Biol. Chem., 265, 9418-9422.
81. D'Arpa, P. and Liu, L.F. (1995) Exp. Cell. Res., 217, 125-131.
82. Pommier, Y.; Redon, C.; Rao, V.A.; Seiler, J.A.; Sordet, O.; Takemura, H.; Antony, S.; Meng, L.; Liao, Z.; Kohlhagen, G.; Zhang, H. and Kohn, K.W. (2003) Mutat. Res., 532, 173-203.
83. Boothman, D.A.; Fukunaga, N. and Wang, M. (1994) Cancer Res., 54, 4618-4626.
84. Podesta, D.; García-Herreros, M.I.; Cannata, J.J.; Stoppani, A.O.; Fernández, Villamil, S.H. (2004) Mol. Biochem. Parasitol., 135, 211-219.
85. Desai, S.D.; Liu, L.F.; Vazquez-Abad, D. and D'Arpa, P. (1997) J. Biol. Chem., 272, 24159-24164.
86. Desai, S.D.; Li, T.K.; Rodríguez-Bauman, A.; Rubin, E.H. and Liu, L.F. (2001) Cancer Res., 61, 5926-5932.
87. Cusack Jr., J.C.; Liu, R.; Houston, M.; Abendroth, K.; Elliott, P.J.; Adams, J. and Baldwin Jr., A.S. (2001) Cancer Res., 61, 3535-3540.
88. Yao Y.; Toth C.R.; Huang L.; Wong M.L.; Dias P.; Burlingame A.L.; Coffino P. and Wang C.C. (1999) Biochem. J., 344, 349-358.
89. Diego, J.L.; Katz, J.M.; Marshall, P.; Gutierrez, B.; Manning, J.E.; Nussenzweig, V. and Gonzalez, J. (2001) Biochemistry, 40, 1053-1062.
90. Robertson, C.D. (1999) Mol. Biochem. Parasitol., 103, 49-60.
91. Paugam, A.; Bulteau, A.-L.; Dupouy-Camet, J.; Creuzet, C. and Friguet, B. (2003) Trends Parasitol., 19, 55-59.
92. Mao, Y.; Sun, M.; Desai, S.D. and Liu, L.F. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 4046-4051.
93. Horie, K.; Tomida, A.; Sugimoto, Y.; Yasugi, T.; Yoshikawa, H.; Taketani, Y. and Tsuruo, T. (2002) Oncogene, 21, 7913-7922.
94. Desai, S.D.; Mao, Y.; Sun, M.; Li, T.K.; Wu, J. and Liu, L.F. (2000) Ann. N. Y. Acad. Sci., 922, 306-308.
95. Mo, Y.Y.; Yu, Y.; Shen, Z. and Beck, W.T. (2002) J. Biol. Chem., 277, 2958-2964.
96. Pommier, Y. (2004) Curr. Med. Chem. Anticancer Agents, 4, 429-434.
97. D'Arpa, P. and Liu, L.F. (1989) Biochim. Biophys. Acta, 989,163-177.
98. Pommier, Y.; Pourquier, Ph.; Fan, Y. and Strumberg, D. (1998) Biochim. Biophys. Acta, 1400, 83-106.
99. Das, A.; Dasgupta, A.; Sengupta, T. and Majumder, H. K. (2004) Trends Parasitol., 20, 381-387.
100. Wall, M.E.; Wani, M.C.; Cook, C.E.; Palmer, K.H.; McPhail, A.I. and Sim, G. A. (1966). J. Am. Chem. Soc., 88, 3888-3890.
101. Champoux, J.J. (2000) Ann. N. Y. Acad. Sci., 922, 56-64.
102. Pommier, Y. (2006) Nat. Rev. Cancer, 6, 789-802.
103. Liu, L.F.; Desai, S.D.; Li, T.K.; Mao, Y.; Sun, M. and Sim, S.P. (2000) Ann. N. Y. Acad. Sci., 922, 1-10.
104. Bodley, A.L.; Cumming, J.N. and Shapiro, T.A. (1998) Biochem. Pharmacol., 55, 709-711.
105. Bodley, A.L. and Shapiro, T.A. (1995) Proc. Natl. Acad. Sci. USA, 92, 3726-3730.
106. Bodley, A.L.; Wani, M.C.; Wall, M.E. and Shapiro, T.A. (1995) Biochem. Pharmacol., 50, 937-942.
107. Deterding, A.; Dungey, F.A.; Thompson, K.A. and Steverding, D. (2005) Acta Trop., 93, 311-316.
108. Staker, B.L.; Hjerrild, K.; Feese, M.D.; Behnke, C.A.; Burgin, A.B. Jr and Stewart, L. (2002) Proc. Natl. Acad. Sci. U.S.A., 99, 15387-15392.
109. Proulx, M.E.; Desormeaux, A.; Marquis, J.F.; Olivier, M. and Bergeron, M.G. (2001) Antimicrob. Agents Chemother., 45, 2623-2627.
110. Yamashita, Y.; Fujii, N.; Murakata, C.; Ashizawa, T.; Okabe, M. and Nakano, H. (1992) Biochemistry, 31, 12069-12075.
111. Prudhomme, M. (2003) Eur. J. Med. Chem., 38, 123-140.
112. Hazra, B.; Saha, A.K.; Ray, R.; Roy, D.K.; Sur, P. and Banerjee, A. (1987) Trans. R. Soc. Trop. Med. Hyg., 81, 738-741.
113. Ray S.; Hazra B.; Mittra B.; Das A. and Majumder H.K. (1998) Mol. Pharmacol., 54, 994-999.
114. Syrovets, T.; Buchele, B.; Gedig, E.; Slupsky, J.R. and Simmet T. (2000) Mol. Pharmacol., 58, 71-81.
115. Chowdhury, A.R.; Mandal, S.; Goswami, A.; Ghosh, M.; Mandal, L.; Chakraborty, D.; Ganguly, A.; Tripathi, G.; Mukhopadhyay, S.; Bandyopadhyay, S. and Majumder H.K. (2003) Mol. Med., 9, 26-36.
116. Vennerstrom, J.; Lovelace, J.K.; Waits, V.B.; Hanson, W.L. and Klayman D.L. (1990) Antimicrob. Agents Chemother., 34, 918-921.
117. Merschjohann, K.; Sporer, F.; Steverding, D. and Wink, M. (2001) Planta Med., 67, 623-627.
118. Marquis, J.F.; Makhey, D.; LaVoie, E.J. and Olivier, M. (2003) J. Parasitol., 89, 1048-1052.
119. Das, B.B.; Sen, N.; Roy, A.; Dasgupta, S.B.; Ganguly, A.; Mohanta, B.C.; Dinda, B. and Majumder, H.K. (2006) Nucleic Acids Res., 34,1121-1132.
120. Chakraborty, A.K. and Majumder, H.K. (1988) Biochem. Biophys. Res. Commun., 152, 605-611.
121. Walker, J. and Saravia, N.G. (2004) J. Parasitol., 90, 1155-1162.
122. Chen, A.Y.; Yu, C.; Gatto, B. and Liu, L.F. (1993) Proc. Natl. Acad. Sci. U.S.A., 90, 8131-8135.
123. Jean-Moreno, V.; Rojas, R.; Goyeneche, D.; Coombs, G.H. and Walker, J. (2006) Exp. Parasitol., 112, 21-30.