Anti-trypanosomal activities of DNA topoisomerase inhibitors

Acta Tropica

Volumn 93, Issue 3, 2005, Pages 311-316

  Deterding, Alexander ^a   Dungey, Fiona A ^a   Thompson, Katy Anne ^a   Steverding, Dietmar ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Chemotherapy; DNA topoisomerase inhibitors; Drug screening; Sleeping sickness; Trypanosoma brucei

Indexed keywords

10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ACLARUBICIN; ANTHRACYCLINE DERIVATIVE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTITRYPANOSOMAL AGENT; AURINTRICARBOXYLIC ACID; BETA LAPACHONE; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ELLAGIC ACID; ELLIPTICINE; ERIOCHROME BLACK T; ETOPOSIDE; IRINOTECAN; MITOXANTRONE; PENTAMIDINE ISETHIONATE; REBECCAMYCIN; SURAMIN; TOPOSAR; TOPOTECAN; UNCLASSIFIED DRUG;

DNA; TRYPANOSOMIASIS;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TRYPANOSOMA BRUCEI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 14844336328     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2005.01.005     Document Type: Article

References (41)

1. C. Bailly, J.F. Riou, P. Colson, C. Houssier, E. Rodrigues-Pereira, and M. Prudhomme DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin Biochemistry 36 1997 3917 3929
2. T. Baltz, D. Baltz, C. Giroud, and J. Crockett Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense EMBO J. 4 1985 1273 1277
3. S.V. Barrett, and M.P. Barrett Anti-sleeping sickness drugs and cancer chemotherapy Parasitol. Today 16 2000 7 9
4. Y. Benchokroun, J. Couprie, and A.K. Larsen Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells Biochem. Pharmacol. 49 1995 305 313
5. J.M. Berger, S.J. Gamblin, S.C. Harrison, and J.C. Wang Structure and mechanism of DNA topoisomerase II Nature 379 1996 225 232
6. BNF, 2002. British National Formulary (44th ed.). British Medical Association and Royal Pharmaceutical Society of Great Britain, 416-417.
7. A.L. Bodley, M.C. Wani, M.E. Wall, and T.A. Shapiro Antitrypanosomal activity of camptothecin analogs. Structure-activity correlations Biochem. Pharmacol. 50 1995 937 942
8. D.J. Bridewell, G.J. Finlay, and B.C. Baguley Differential actions of aclarubicin and doxorubicin: the role of topoisomerase I Oncol. Res. 9 1997 535 542
9. A. Constantinou, G.D. Stoner, R. Mehta, K. Rao, C. Runyan, and R. Moon The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro Nutr. Cancer 23 1995 121 130
10. M.D. Crespi, S.E. Ivanier, J. Genovese, and A. Baldi Mitoxantrone affects topoisomerase activities in human breast cancer cells Biochem. Biophys. Res. Commun. 136 1986 521 528
11. A.H. Fairlamb Chemotherapy of human African trypanosomiasis: current and future prospects Trends Parasitol. 19 2003 488 494
12. M.E. Figueiredo-Pereira, W.E. Chen, J. Li, and O. Johdo The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome J. Biol. Chem. 271 1996 16455 16459
13. S.J. Froelich-Ammon, M.W. Patchan, N. Osheroff, and R.B. Thompson Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy J. Biol. Chem. 270 1995 14998 15004
14. M. Gálvez, C. Martín-Cordero, M. López- Lázaro, F. Cortés, and M.J. Ayuso Cytotoxic effect of Plantago spp. on cancer cell lines J. Ethnopharmacol. 88 2003 125 130
15. K.R. Hande Etoposide: four decades of development of a topoisomerase II inhibitor Eur. J. Cancer 34 1998 1514 1521
16. H. Hirumi, K. Hirumi, J.J. Doyle, and G.A.M. Cross In vitro cloning of animal-infective bloodstream forms of Trypanosoma brucei Parasitology 80 1980 371 382
17. Y.-H. Hsiang, R. Hertzberg, S. Hecht, and L.F. Liu Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I J. Biol. Chem. 260 1985 14873 14878
18. 50 in studies of drug resistance of malaria parasites Acta Trop. 55 1993 257 261
19. C.J. Li, L. Averboukh, and A.B. Pardee β-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin J. Biol. Chem. 268 1993 22463 22468
20. Y.H. Ling, B.S. Andersson, and J.A. Nelson DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells Cancer Biochem. Biophys. 11 1990 23 30
21. B.H. Long, W.C. Rose, D.M. Vyas, J.A. Matson, and S. Forenza Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649 and fluoroindolocarbazoles Curr. Med. Chem. Anti-Canc. Agents 2 2002 255 266
22. E. Matovu, T. Seebeck, J.C.K. Enyaru, and R. Kaminsky Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle Microbes Infect. 3 2001 763 770
23. K. Merschjohann, F. Sporer, D. Steverding, and M. Wink In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense Planta Med. 67 2001 623 627
24. A.D. Morris, S. Leonce, N. Guilbaud, G.C. Tucker, V. Perez, M. Jan, A.A. Cordi, A. Pierre, and G. Atassi Eriochrome Black T, structurally related to suramin, inhibits angiogenesis and tumor growth in vivo Anticancer Drugs 8 1997 746 755
25. J.L. Nitiss Investigating the biological functions of DNA topoisomerases in eukaryotic cells Biochim. Biophys. Acta 1400 1998 63 81
26. J.L. Nitiss, P. Pourquier, and Y. Pommier Aclacinomycin A stabilizes topoisomerase I covalent complexes Cancer Res. 57 1997 4564 4569
27. J. Nkemgu-Njinkeng, V. Rosenkranz, M. Wink, and D. Steverding Antitrypanosomal activities of proteasome inhibitors Antimicrob. Agents Chemother. 46 2002 2038 2040
28. N.J. Nkemngu, R. Grande, E. Hansell, J.H. McKerrow, C.R. Caffrey, and D. Steverding Improved trypanocidal activities of cathepsin L inhibitors Int. J. Antimicrob. Agents 22 2002 155 159
29. M.L. Rothenberg Topoisomerase I inhibitors: review and update Ann. Oncol. 8 1997 837 855
30. T. Rowe, G. Kupfer, and W. Ross Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage Biochem. Pharmacol. 34 1985 2483 2487
31. B.K. Sinha Topoisomerase inhibitors. A review of their therapeutic potential in cancer Drugs 49 1995 11 19
32. J.G. Slatter, P. Su, J.P. Sams, L.J. Schaaf, and L.C. Wienkers Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions Drug Metab. Dispos. 25 1997 1157 1164
33. L. Stewart, M.R. Redinbo, X. Qui, W.G.J. Hol, and J.J. Champoux A model for the mechanism of human topoisomerase I Science 279 1998 1534 1541
34. C.H. Takimoto, J. Wright, and S.G. Arbuck Clinical applications of the camptothecins Biochim. Biophys. Acta 1400 1998 107 119
35. M.W. Timms, F.J. van Deursen, E.F. Hendriks, and K.R. Matthews Mitochondrial development during life cycle differentiation of African trypanosomes: evidence for a kinetoplast-dependent differentiation control point Mol. Biol. Cell 13 2002 3747 3759
36. Z. Topcu DNA topoisomerases as targets for anticancer drugs J. Clin. Pharm. Ther. 26 2001 405 416
37. P. Trouiller, P. Olliaro, E. Torreele, J. Orbinski, R. Laing, and N. Ford Drug development for neglected diseases: a deficient market and a public-health policy failure Lancet 359 2002 2188 2194
38. K. Wassermann, J. Markovits, C. Jaxel, G. Capranico, K.W. Kohn, and Y. Pommier Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II Mol. Pharmacol. 38 1990 38 45
39. P. Wickware Resurrecting the resurrection drug Nat. Med. 8 2002 908 909
40. J. Williamson, and T.J. Scott-Finnigan Trypanocidal activity of antitumor antibiotics and other metabolic inhibitors Antimicrob. Agents Chemother. 13 1978 735 744
41. WHO, 2001. African trypanosomiasis or sleeping sickness. World Health Org. Fact Sheet 259. (http://www.who.int/mediacentre/factsheets/fs259/en/).