Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 4, 2005, Pages 1441-1446

  Marquis, Jean François ^a,b   Hardy, Isabelle ^a,b   Olivier, Martin ^a,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; GLYCINE;

AMINO ACID SUBSTITUTION; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE; GENE EXPRESSION; GENE MUTATION; LDTOP1A GENE; LEISHMANIA; LEISHMANIA DONOVANI; LEISHMANIASIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTOZOAL INFECTION;

AMINO ACID SUBSTITUTION; ANIMALS; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE; ENZYME INHIBITORS; LEISHMANIA DONOVANI; PARASITIC SENSITIVITY TESTS; SEQUENCE ANALYSIS, DNA;

EID: 16244400448     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.4.1441-1446.2005     Document Type: Article

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