Camptothecins and topoisomerase I: A foot in the door. Targeting the genome beyond topoisomerase I with camptothecins and novel anticancer drugs: Importance of DNA replication, repair and cell cycle checkpoints

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 4, Issue 5, 2004, Pages 429-434

  Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Camptothecins; Checkpoints; DNA repair; Indenoisoquinolines; Indolocarbazoles

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; BMS 250749; CAMPTOTHECIN DERIVATIVE; DIFLOMOTECAN; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; INDENOISOQUINOLINE; INDOLOCARBAZOLE; IRINOTECAN; MJ III 65; PACLITAXEL; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; COLORECTAL CARCINOMA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA TRANSCRIPTION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TARGETING; HUMAN; LUNG SMALL CELL CANCER; MOLECULAR MECHANICS; NONHUMAN; OVARY CANCER; PROTEIN DEGRADATION; REVIEW; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CARBAZOLES; CATALYSIS; CELL CYCLE; DNA; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; MODELS, CHEMICAL;

EID: 4444358344     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011043352777     Document Type: Review

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