Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA

Biochemistry

Volumn 39, Issue 23, 2000, Pages 6832-6840

  Redinbo, Matthew R ^a,b,c   Champoux, James J ^c   Hol, Wim G J ^a,b,c  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DNA; DNA TOPOISOMERASE; GLYCINE; LYSINE; PHOSPHATE; THYMINE; TRYPTOPHAN; WATER;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; DNA TOPOISOMERASES, TYPE I; DNA-BINDING PROTEINS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEOPROTEINS; PROTEIN CONFORMATION;

EID: 0034643810     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992690t     Document Type: Article

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