Characterisation of the gene encoding type II DNA topoisomerase from Leishmania donovani: A key molecular target in antileishmanial therapy

Nucleic Acids Research

Volumn 29, Issue 9, 2001, Pages 1844-1851

  Das, Aditi ^a   Dasgupta, Arindam ^a   Sharma, Shalini ^a   Ghosh, Monidipa ^a   Sengupta, Tanushri ^a   Bandopadhyay, Santu ^a   Majumder, Hemanta K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; ANTIGEN; ANTILEISHMANIAL AGENT; CELL EXTRACT; DNA TOPOISOMERASE (ATP HYDROLYSING); GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MAGNESIUM ION; PROTOZOAL DNA; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY; TOP2 PROTEIN, LEISHMANIA DONOVANI;

AMINO ACID SEQUENCE; ARTICLE; BIOCHEMISTRY; CATALYSIS; CHROMOSOME; CONTROLLED STUDY; CRITHIDIA; DNA LIBRARY; ESCHERICHIA COLI; EXON; FLAGELLATE; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; INTRON; LEISHMANIA DONOVANI; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PARASITE; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; PROTOZOON; RABBIT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TRYPANOSOMA; WESTERN BLOTTING; 5' UNTRANSLATED REGION; ANIMAL; DNA SEQUENCE; DRUG DELIVERY SYSTEM; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; SEQUENCE ALIGNMENT; VISCERAL LEISHMANIASIS;

CRITHIDIA; ESCHERICHIA COLI; KINETOPLASTIDA; LEISHMANIA DONOVANI; MASTIGOPHORA (FLAGELLATES); NEGIBACTERIA; ORYCTOLAGUS CUNICULUS; PROTOZOA; TRYPANOSOMA;

5' UNTRANSLATED REGIONS; ANIMAL; ANTIBODIES, PROTOZOAN; BASE SEQUENCE; CONSERVED SEQUENCE; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, PROTOZOAN; DRUG DELIVERY SYSTEMS; FLUORESCENT ANTIBODY TECHNIQUE; GENES, PROTOZOAN; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SUPPORT, NON-U.S. GOV'T;

EID: 0035339610     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.9.1844     Document Type: Article

References (32)

1. Wang, J.C. (1996) DNA topoisomerases. Annu. Rev. Biochem., 65, 635-692.
2. Nitiss, J.L. (1998) Investigating the biological functions of DNA topoisomerases in eukaryotic cells. Biophys. Biochem. Acta, 1400, 63-81.
3. Dinardo, S., Voelkel, K. and Sternglanz, R. (1984) DNA topoisomerase II mutant of S.cerevisiae: topoisomerase II is required for the segregation of daughter molecules of the termination of DNA replication. Proc. Natl Acad. Sci. USA, 81, 2616-2620.
4. Nitiss, J.L. (1994) Roles of DNA topoisomerases in chromosomal replication and segregation. Adv. Pharmacol., 29, 103-134.
5. Earnshaw, W.C., Halligan, B., Cooke, C.A., Heck, M.M.S. and Liu, L.F. (1985) Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol., 100, 1706-1715.
6. Adachi, Y., Luke, M. and Laemmli, U.K. (1991) Chromosome assembly 'in vitro': topoisomerase II is required for condensation. Cell, 64, 137-148.
7. Schneider, E., Hsiang, Y.H. and Liu, L.F. (1991) DNA topoisomerases as anticancer drug targets. Adv. Pharmacol., 21, 149-183.
8. Shapiro, T.A. (1993) Inhibition of topoisomerases in African trypanosomes. Acta Trop., 54, 251-260.
9. Strauss, P.R. and Wang, J.C. (1990) The TOP2 gene of Trypanosoma brucei: a single copy gene that shares extensive homology with other TOP2 genes encoding eukaryotic DNA topoisomerase II. Mol. Biochem. Parasitol., 38, 141-150.
10. Fragoso, S.P. and Goldenberg, S. (1992) Cloning and characterization of the gene encoding Trypanosoma cruzi DNA topoisomerase II. Mol. Biochem. Parasitol., 55, 127-134.
11. Pasion, S.G., Hines, J.C., Aebersold, R. and Ray, D.S. (1992) Molecular cloning and expression of the gene encoding the kinetoplast-associated type II DNA topoisomerase of Crithidia fasciculata. Mol. Biochem Parasitol., 50, 57-68.
12. Chakraborty, A.K. and Majumder, H.K. (1987) Decatenation of kinetoplast DNA by an ATP-dependent DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani. Mol. Biochem. Parasitol., 26, 215-224.
13. Chakraborty, A.K. and Majumder, H.K. (1991) An ATP-independent catenating enzyme from the kinetoplast hemoflagellate Leishmania donovani. Biochem. Biophys. Res. Commun., 180, 279-285.
14. Jaffe, C.L., Grimaldi, G. and McMahon-Pratt, D. (1984) The cultivation and cloning of Leishmania. In Morel,C.M. (ed.), Genes and Antigens of Parasites, A Laboratory Manual. UNDP/World Bank/WHO, 2nd edition, pp. 47-91.
15. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
16. Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J. (1990) Basic local alignment search tool. J. Mol. Biol., 215, 403-410.
17. Brendel, V., Bucher, P., Nourbaksh, I., Blaisdell, B.E. and Karlin, S. (1992) Methods and algorithms for statistical analysis of protein sequences. Proc. Natl Acad. Sci. USA, 89, 2002-2006.
18. Geourjon, C. and Deleage, G. (1994) SOPM: a self-optimized method for protein secondary structure prediction. Protein Eng., 7, 157-164.
19. Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
20. Page, R.D.M. (1996) TREEVIEW: an application to display phylogenetic trees on personal computers. Comput. Appl. Biosci., 12, 357-358.
21. Wilson, K., Hanson, S., Landfear, S. and Ullman, B. (1991) Nucleotide sequence of the Leishmania donovani medRNA gene. Nucleic Acids Res., 19, 5787.
22. Harlow, E. and Lane, D. (1988) Antibodies Manual: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. Reece, R.J. and Maxwell, A. (1991) DNA gyrase: structure and function. Crit. Rev. Biochem. Mol. Biol., 26, 335-375.
24. Van der Ploeg, L.H.T., Liu, A.Y.C, Michels, P.A.M., De Lange, T., Borst, P., Majumder, H.K., Weber, H., Weeneman, G.H. and Van Boom, J. (1982) RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. Nucleic Acids Res., 10, 3591-3604.
25. Michels, P.A.M. (1986) Evolutionary aspects of trypanosomes: analysis of genes. J. Mol. Biol., 24, 45-52.
26. Engel, M.L. and Ray, D.S. (1999) The kinetoplast structure-specific endonuclease I is related to the 5′ exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase β during replication. Proc. Natl Acad. Sci. USA, 96, 8455-8460.
27. Torri, A.F. and Englund, P.T. (1995) A DNA polymerase β in the mitochondrion of the trypanosomatid Crithidia fasciculata. J. Biol. Chem., 270, 3495-3497.
28. Folsch, H., Guiard, B., Neupert, W. and Stuart, R.A. (1996) Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria. EMBO J., 15, 479-487.
29. Fragoso, S.P., Mattei, D., Hines, J.C., Ray, D.S. and Goldenberg, S. (1998) Expression and cellular localization of Trypanosoma cruzi type II DNA topoisomerase. Mol. Biochem. Parasitol., 94, 197-204.
30. Douc-Rasy, S., Kayser, A., Riou, J.F. and Riou, G. (1986) ATP independent type II topoisomerase from trypanosomes. Proc. Natl Acad. Sci. USA, 83, 7152-7156.
31. Shlomai, J. and Zadok, A. (1983) Reversible decatenation of kinetoplast DNA by a DNA topoisomerase from trypanosomatids. Nucleic Acids Res., 11, 4019-4034.
32. Pasion, S.G., Hines, J.C., Ou, X., Mahmood, R. and Ray, D.S. (1996) Sequences within the 5′ untranslated region regulate the levels of a kinetoplast DNA topoisomerase mRNA during the cell cycle. Mol. Cell Biol., 16, 6724-6735.