Amino acids 39-456 of the large subunit and 210-262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania

Biochemical Journal

Volumn 409, Issue 2, 2008, Pages 481-489

  Bosedasgupta, Somdeb ^a   Das, Benu Brata ^b   Sengupta, Souvik ^a   Ganguly, Agneyo ^a   Roy, Amit ^a   Tripathi, Gayatri ^a   Majumder, Hemanta K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Co immobilization; DNA topoisomerase; Far Western analysis; Fragment complementation; Leishmania; Substrate competition

Indexed keywords

CO-IMMOBILIZATION; DNA TOPOISOMERASE; FAR-WESTERN ANALYSIS; HETERODIMERIC ENZYMES; LEISHMANIA;

CATALYST ACTIVITY; DNA; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; SUBSTRATES;

AMINO ACIDS;

AMINO ACID; ASPARTIC ACID; DNA; ENZYME; LYSINE; TOPOISOMERASE 1B; UNCLASSIFIED DRUG;

ARTICLE; DNA BINDING; ENZYME STRUCTURE; LEISHMANIA; MUTAGENESIS; NONHUMAN; PARASITE; PRIORITY JOURNAL;

ANIMALS; ASPARTIC ACID; BASE SEQUENCE; CATALYTIC DOMAIN; DIMERIZATION; DNA; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; LEISHMANIA; LYSINE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN SUBUNITS; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS;

EID: 38749101000     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071358     Document Type: Article

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