Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays

Experimental Parasitology

Volumn 112, Issue 1, 2006, Pages 21-30

  Jean Moreno, Valerie ^a   Rojas, Ricardo ^a   Goyeneche, Diego ^a   Coombs, Graham H ^b   Walker, John ^a  

^a CENTRO INTERNACIONAL DE ENTRENAMIENTO E INVESTIGACIONES MÉDICAS CIDEIM   (Colombia)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Antileishmanials; Bis benzimidazole; Camptothecin; Cytotoxicity; DNA topoisomerase I; Enzyme inhibition; Flavonoid; Leishmania donovani; Protoberberine

Indexed keywords

ANTILEISHMANIAL AGENT; BENZIMIDAZOLE DERIVATIVE; CAMPTOTHECIN; DIAMIDINE DERIVATIVE; DIMINAZENE ACETURATE; DNA TOPOISOMERASE INHIBITOR; FLAVONOID; PENTAMIDINE; PROTOBERBERINE CORALYNE; PROTOBERBERINE DERIVATIVE; QUERCETIN; STIBOGLUCONATE SODIUM; UNCLASSIFIED DRUG;

AMASTIGOTE; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; FEASIBILITY STUDY; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; LEISHMANIA DONOVANI; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ACID PHOSPHATASE; ANIMALS; ANTIMONY SODIUM GLUCONATE; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; BERBERINE ALKALOIDS; BISBENZIMIDE; CAMPTOTHECIN; CELL LINE; DIMINAZENE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; LUCIFERASES, FIREFLY; LUMINESCENT AGENTS; MACROPHAGES; MONOCYTES; PENTAMIDINE; QUERCETIN;

LEISHMANIA DONOVANI;

EID: 29144509689     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2005.08.014     Document Type: Article

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