Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells

Endocrinology

Volumn 140, Issue 9, 1999, Pages 4367-4370

  Hofbauer, Lorenz C ^a   Khosla, Sundeep ^a   Dunstan, Colin R ^b   Lacey, David L ^b   Spelsberg, Thomas C ^a   Riggs, B Lawrence ^a  

^a MAYO CLINIC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; MESSENGER RNA; OSTEOPROTEGERIN;

ARTICLE; BONE ATROPHY; CONTROLLED STUDY; GENE EXPRESSION; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; OSTEOBLAST; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS;

EID: 0033304632     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.9.7131     Document Type: Article

References (20)

1. Skeletal effects of estrogen
2. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
3. Bone marrow, cytokines, and bone remodeling: Emerging insights into the pathophysiology of osteoporosis
4. Cytokines, bone remodeling, and estrogen deficiency: A 1998 update
5. Osteoprotegerin: A novel secreted protein involved in the regulation of bone-density
6. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
7. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
8. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
9. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
10. Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein, and cytokines
11. Human bone cells in vitro
12. Development and characterization of a conditionally immortalized human fetal osteoblastic cell line
13. Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene
14. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency
15. Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors
16. Osteoprotegerin (OPG) ligand is a cytokine that regulates osteoclast differentiation and activation
17. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
18. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
19. Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: Increased serum concentrations in postmenopausal women with osteoporosis
20. Osteoprotegerin serum levels in healthy volunteers