TRAF5 functions in both RANKL- and TNFα-induced osteoclastogenesis

Journal of Bone and Mineral Research

Volumn 18, Issue 3, 2003, Pages 443-450

  Kanazawa, Kiyoshi ^a   Azuma, Yoshiaki ^a,b   Nakano, Hiroyasu ^c,d   Kudo, Akira ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b TEIJIN LTD   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Osteoclast differentiation; RANK ligand; TNF ; TRAF5

Indexed keywords

CALCIUM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CALCIUM HOMEOSTASIS; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FEMALE; GEL MOBILITY SHIFT ASSAY; HYPERCALCEMIA; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PATHOGENESIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE GLYCOPROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OSTEOCLASTS; PROTEINS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 5; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037370779     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.3.443     Document Type: Article

References (37)

1. Scheven BA, Visser JW, Nijweide PJ 1986 In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietetic stem cell population. Nature 321:79-81.
2. Ibbotson KJ, Roodman GD, McManus LM, Mundy GR 1984 Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells. J Cell Biol 99:471-480.
3. Burger EH, Van der Meer JW, van de Gevel JS, Gribnau JC, Thesingh GW, van Furth R 1982 In vitro formation of osteoclasts from long term cultures of bone marrow mononuclear phagocytes. J Exp Med 156:1604-1614.
4. Kahn AJ, Partridge NC 1991 Bone resorption in vivo. In: Hall BK (ed.) Bone, vol. 2. CRC Press, Boca Raton, FL, USA, pp. 119.
5. Mills BG 1991 Bone resorbing cells and human clinical conditions. In: Hall BK (ed.) Bone, vol. 2. CRC Press, Boca Raton, FL, USA, pp. 175.
6. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S 1999 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323.
7. Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J 1999 RANK is essential for osteoclast and lymph node development. Genes Dev 13:2412-2424.
8. Old LJ 1990 Tumor necrosis factor: Structure, mechanism of action, role in disease and therapy. In: Bonavida B, Granger G (eds.) Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. Karger, Basel, Switzerland, pp. 1-30.
9. Ashkenazi A, Dixit VM 1999 Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11:255-260.
10. Saxne T, Palladino MA Jr, Heinegard D, Talal N, Wollheim FA 1988 Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum 31:1041-1045.
11. Xu JW, Konttinen YT, Lassus J, Natah S, Ceponis A, Solovieva S, Aspenberg P, Santavirta S 1996 Tumor necrosis factor-alpha in loosening of total hip replacement. Clin Exp Rheumatol 14:643-648.
12. Merkel KD, Erdmann JM, McHugh KP, Abu-Amer Y, Ross FP, Teitelbaum SL 1999 Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol 154:203-210.
13. Nair SP, Meghji S, Wilson M, Reddi K, White P, Henderson B 1996 Bacterially induced bone destruction: Mechanisms and misconceptions. Infect Immun 64:2371-2380.
14. Azuma Y, Kaji K, Katogi R, Takeshita S, Kudo A 2000 Tumor necrosis factor-α induces differentiation of and bone resorption by osteoclasts. J Biol Chem 275:4858-4864.
15. Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Morinaga T, Higashio K, Martin TJ, Suda T 2000 Tumor necrosis factor-α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 19:275-285.
16. Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL 2000 TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 106:1481-1488.
17. Song HY, Regnier CH, Kirschning CJ, Goeddel DV, Rothe M 1997 Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 94:9792-9796.
18. Naito A, Azuma S, Tanaka S, Miyazaki T, Takai S, Takatsu K, Nakao K, Nakamura K, Katsuki M, Yamamoto T, Inoue J 1999 Severe osteopetrosis, defective interleukin-1 signaling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4:353-362.
19. Lomaga MA, Yeh W-C, Sarosi I, Gordon DS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van den Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW 1999 TRAF6 deficiency results in osteopetrosis and defective interleukin-1 CD40, and LPS signaling. Gene Dev 13:1015-1024.
20. Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC 1998 The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem 273:34120-34127.
21. Hsu H, Xiong J, Goeddel DV 1995 The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81:495-504.
22. Rothe M, Wong SC, Henzel WJ, Goeddel DV 1994 A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kD tumor necrosis factor receptor. Cell 78:681-692.
23. Cao Z, Xiong J, Takeuchi T, Kurame T, Goeddel DV 1996 TRAF6 is a signal transducer for inteleukin-1. Nature 383:443-446.
24. Kaji K, Katogi R, Azuma Y, Naito A, Inoue JI, Kudo A 2001 Tumor necrosis factor alpha-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6. J Bone Miner Res 16:1593-1599.
25. Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T 2000 Tumor necrosis factor receptor-associated factor (TRAF) family: Adapter proteins that mediate cytokine signaling. Exp Cell Res 254:14-24.
26. Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, Munechika E, Sakai T, Shirasawa T, Akiba H, Kobata T, Santee SM, Ware CF, Rennert PD, Taniguchi M, Yagita H, Okumura K 1999 Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci USA 96:9803-9808.
27. Takeshita S, Kaji K, Kudo A 2000 Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res 15:1477-1488.
28. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T 1988 Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122:1373-1382.
29. Byung-Chul K, Mi-Na L, Ja-Young K, Sang-Soo L, Jun-Dong S-SK, Soo-Young L, Jae-Hong K 1999 Roles of Phosphatidylinositol 3-kinase and rac in the nuclear signaling by tumor necrosis factor-α in Rat-2 fibroblasts. J Biol Chem 274:24372-24377.
30. Dignam JD, Lebovitz RM, Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
31. Morony S, Capparelli C, Lee R, Shimamoto G, Boone T, Lacey DL, Dunstan CR 1999 A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3. J Bone Miner Res 14: 1478-1485.
32. Rothe M, Sarma V, Dixit VM, Goeddel DV 1995 TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424-1427.
33. Liu Z-G, Hu H, Goeddel DV, Karin M 1996 Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis, while NF-κB activation prevents cell death. Cell 87: 565-576.
34. Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh W-C, Nakano H 2001 Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J Biol Chem 276:36530-36534.
35. Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K 1996 TRAF-5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor. J Biol Chem 271:14661-14664.
36. Ishida T, Mizushima Si, Azuma S, Kobayashi N, Tojo T, Suzuki K, Aizawa S, Watanabe T, Mosialos G, Kieff E, Yamamoto T, Inoue J 1996 Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem 271:28745-28748.
37. Zhang Y-H, Heulsmann A, Tondravi MM, Mukherjee A, Abu-Amer Y 2001 Tumor necrosis factor-α (TNF) stimulates RANKL-induced osteoclasogenesis via coupling of TNF type I receptor and RANK signaling pathways. J Biol Chem 276:563-568.