Osteoprotegerin mRNA is expressed in primary human osteoblast-like cells: Down-regulation by glucocorticoids

Journal of Endocrinology

Volumn 159, Issue 1, 1998, Pages 191-195

  Vidal, N O A ^b   Brandstrom H ^a   Jonsson, K B ^a   Ohlsson, C ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; MESSENGER RNA; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BONE METABOLISM; CELL DIFFERENTIATION; DOSE TIME EFFECT RELATION; DOWN REGULATION; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DENSITOMETRY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; GENE EXPRESSION REGULATION; GENETIC TECHNIQUES; GLYCOPROTEINS; HUMANS; HYDROCORTISONE; OSTEOBLASTS; OSTEOPROTEGERIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; STIMULATION, CHEMICAL; TESTOSTERONE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0031721590     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1590191     Document Type: Article

References (27)

1. Advani S, LaFrancis D, Bogdanovic E, Taxel P, Raisz LG & Kream BE 1997 Dexamethasone suppresses in vivo levels of bone collagen synthesis in neonatal mice. Bone 20 41-46.
2. Bockman RS & Weinerman SA 1990 Steroid-induced osteoporosis. Orthopedic Clinics of North America 21 97-107.
3. Canalis E 1996 Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. Journal of Endocrinology and Metabolism 81 3441-3447.
4. Canalis E & Avioli L 1992 Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast-enriched cells. Journal of Bone and Mineral Research 7 1085-1092.
5. Chomczynski P & Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162 156-159.
6. Conaway HH, Grigorie D & Lerner UH 1996 Stimulation of neonatal mouse calvarial bone resorption by the glucocorticoids hydrocortisone and dexamethasone. Journal of Bone and Mineral Research 11 1419-1429.
7. Delaney AM, Dong Y & Canalis E 1994 Mechanisms of glucocorticoid action in bone cells. Journal of Biochemistry 56 295-302.
8. Dempster DW, Moonga BS, Stem LS, Horbert WR & Antakly T 1997 Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis. Journal of Endocrinology 154 397-406.
9. Hofbauer LC & Heufelder AE 1996 Intercellular chatter: osteoblasts, osteoclasts and interleukin 6. European Journal of Endocrinology 134 425-426.
10. Jilka RL 1986 Are osteoblastic cells required for the control of osteoclast activity by parathyroid hormone? Journal of Bone and Mineral Research 1 261-266.
11. Jimi E, Nakamura I, Amano H, Taguchi Y, Tsurukai T, Tamura M, Takahashi N & Suda T 1996 Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology 137 2187-2190.
12. Kaji H, Sugimoto T, Kanatani M, Fukase M, Kumegawa M & Chihara K 1996 Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoblasts: role of cAMP-dependent protein kinase. Journal of Bone and Mineral Research 11 62-71.
13. 2. Journal of Bone and Mineral Research 12 734-741.
14. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Caparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J & Boyle WJ 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 165-176.
15. Lerner UH 1996 Transforming growth factor-β stimulates bone resorption in neonatal calvariae by a prostaglandin-unrelated but cell proliferation-dependent pathway. Journal of Bone and Mineral Research 11 1628-1639.
16. Lerner UH & Ohlin A 1993 Tumor necrosis factors alpha and beta can stimulate bone resorption in cultured mouse calvariae by a prostaglandin-independent mechanism. Journal of Bone and Mineral Research 8 147-155.
17. Lowe C, Gray DH & Reid IR 1992 Serum blocks the osteolytic effect of cortisol in neonatal mouse calvaria. Calcified Tissue International 50 189-192.
18. Martin TJ & Ng KW 1994 Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. Journal of Cellular Biochemistry 56 357-366.
19. Nilsson A, Swolin D, Enerbäck S & Ohlsson C 1995 Expression of functional growth hormone receptors in cultured human osteoblast-like cells. Journal of Clinical Endocrinology and Metabolism 80 3483-3488.
20. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Amgen EST Program & Boyle WJ 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 309-319.
21. Suda T, Takahashi N & Abe E 1992 Role of vitamin D in bone resorption. Journal of Biochemistry 49 53-58.
22. Suda T, Udagawa N, Nakamura I, Miyaura C & Takahashi N 1995 Modulation of osteoclast differentiation by local factors. Bone 17 87S-91S.
23. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM & Suda T 1988 Osteoblastic cells are involved in osteoclast formation. Endocrinology 123 2600-2602.
24. Tobias J & Chambers TJ 1989 Glucocorticoids impair bone resorptive activity and viability of osteoclasts disaggregated from neonatal rat long bones. Endocrinology 125 1290-1295.
25. Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T & Higashio K 1997 Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochemical and Biophysical Research Communications. 234 137-142.
26. Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S & Findlay DM 1995 Interleukm-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. Journal of Experimental Medicine 182 1461-1468.
27. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N & Suda T 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proceedings of the National Academy of Sciences of the USA 95 3597-3602.