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Volumn 198, Issue 5, 2003, Pages 771-781

The IκB function of NF-κB2 p100 controls stimulated osteoclastogenesis

Author keywords

Bone remodeling physiology; Cultured cells physiology; MAP kinase kinase kinases; Mice knockout; Murine RANKL

Indexed keywords

CYTOKINE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN P52; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR P100; UNCLASSIFIED DRUG; CARRIER PROTEIN; I KAPPA B; MEMBRANE PROTEIN; NF KAPPA B KINASE; NF-KAPPA B KINASE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TNFRSF11A PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE;

EID: 0042386014     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030116     Document Type: Article
Times cited : (247)

References (43)
  • 1
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science. 289:1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 2
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and REL proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., M.J. May, and E.B. Kopp. 1998. NF-κB and REL proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225-260.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 3
    • 0033607313 scopus 로고    scopus 로고
    • The NF-κB activation pathway: A paradigm in information transfer from membrane to nucleus
    • Rothwarf, D.M., and M. Karin. 1999. The NF-κB activation pathway: a paradigm in information transfer from membrane to nucleus. Sci. STKE. 1999:RE1.
    • (1999) Sci. STKE , vol.1999
    • Rothwarf, D.M.1    Karin, M.2
  • 4
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing of the NF-κB1 precursor protein and the activation of NF-κB
    • Palombella, V.J., O.J. Rando, A.L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing of the NF-κB1 precursor protein and the activation of NF-κB. Cell. 78:773-785.
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 5
    • 0033523947 scopus 로고    scopus 로고
    • The generation of nfkb2 p52: Mechanism and efficiency
    • Heusch, M., L. Lin, R., Geleziunas, and W.C. Greene. 1999. The generation of nfkb2 p52: mechanism and efficiency. Oncogene. 16:6201-6208.
    • (1999) Oncogene , vol.16 , pp. 6201-6208
    • Heusch, M.1    Lin, L.2    Geleziunas, R.3    Greene, W.C.4
  • 6
    • 0026742527 scopus 로고
    • The precursor of NF-κ p50 has IκB-like functions
    • Rice, N.R., M.L. MacKichan, and A. Israel. 1992. The precursor of NF-κ p50 has IκB-like functions. Cell. 71:243-253.
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice, N.R.1    MacKichan, M.L.2    Israel, A.3
  • 7
    • 0027439305 scopus 로고
    • NF-κB p100 (Lyt-10) is a component of H2TF1 and can function as an IκB-like molecule
    • Scheinman, R.I., A.A. Beg, and J. Baldwin, A.S. 1993. NF-κB p100 (Lyt-10) is a component of H2TF1 and can function as an IκB-like molecule. Mol. Cell. Biol. 13:6089-6101.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6089-6101
    • Scheinman, R.I.1    Beg, A.A.2    Baldwin, J.3
  • 8
    • 0032813948 scopus 로고    scopus 로고
    • Genomic organization and chromosomal mapping of mouse nuclear factor kappa B2 (NFKB2)
    • Paxian, S., S. Liptay, A. Alder, H. Hameister, and R.M. Schmid. 1999. Genomic organization and chromosomal mapping of mouse nuclear factor kappa B2 (NFKB2). Immunogenetics. 49:743-750.
    • (1999) Immunogenetics , vol.49 , pp. 743-750
    • Paxian, S.1    Liptay, S.2    Alder, A.3    Hameister, H.4    Schmid, R.M.5
  • 9
    • 0034745420 scopus 로고    scopus 로고
    • NF-κB-inducing kinase regulates the processing of NF-κB2 p100
    • Xiao, G., E.W. Harhaj, and S.-C. Sun. 2001. NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol. Cell. 7:401-409.
    • (2001) Mol. Cell. , vol.7 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.-C.3
  • 11
    • 0031985287 scopus 로고    scopus 로고
    • Nuclear factor (NF)-κB (p100/p52) is required for nomial splenic microarchitecture and B cell-mediated immune responses
    • Caamano, J.H., C. Rizzo, S.K. Durham, D.S. Barton, C. Kaventos-Suarez, C.M. Snapper, and R. Bravo. 1998. Nuclear factor (NF)-κB (p100/p52) is required for nomial splenic microarchitecture and B cell-mediated immune responses. J. Exp. Med. 187:185-196.
    • (1998) J. Exp. Med. , vol.187 , pp. 185-196
    • Caamano, J.H.1    Rizzo, C.2    Durham, S.K.3    Barton, D.S.4    Kaventos-Suarez, C.5    Snapper, C.M.6    Bravo, R.7
  • 13
    • 0028107190 scopus 로고
    • A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice
    • Miyawaki, S., Y. Nakamura, H. Suzuka, M. Koba, R. Yasumizu, S. Ikehara, and Y. Shibata. 1994. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24:429-434.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 429-434
    • Miyawaki, S.1    Nakamura, Y.2    Suzuka, H.3    Koba, M.4    Yasumizu, R.5    Ikehara, S.6    Shibata, Y.7
  • 14
    • 0035809310 scopus 로고    scopus 로고
    • Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I
    • Matsushima, A., T. Kaisho, P.D. Rennert, H. Nakano, K. Kurosawa, D. Uchida, K. Takeda, S. Akira, and M. Matsumoto. 2001. Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I. J. Exp. Med. 193:631-636.
    • (2001) J. Exp. Med. , vol.193 , pp. 631-636
    • Matsushima, A.1    Kaisho, T.2    Rennert, P.D.3    Nakano, H.4    Kurosawa, K.5    Uchida, D.6    Takeda, K.7    Akira, S.8    Matsumoto, M.9
  • 16
    • 0034662002 scopus 로고    scopus 로고
    • Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase
    • Yamada, T., T. Mitani, K. Yorita, D. Uchida, A. Matsushima, K. Iwamasa, S. Fujita, and M. Matsumoto. 2000. Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase. J. Immunol. 165:804-812.
    • (2000) J. Immunol. , vol.165 , pp. 804-812
    • Yamada, T.1    Mitani, T.2    Yorita, K.3    Uchida, D.4    Matsushima, A.5    Iwamasa, K.6    Fujita, S.7    Matsumoto, M.8
  • 17
    • 0030763645 scopus 로고    scopus 로고
    • Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2
    • Ishikawa, H., D. Carrasco, E. Claudio, R.-P. Ryseck, and R. Bravo. 1997. Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2. J. Exp. Med. 186:999-1014.
    • (1997) J. Exp. Med. , vol.186 , pp. 999-1014
    • Ishikawa, H.1    Carrasco, D.2    Claudio, E.3    Ryseck, R.-P.4    Bravo, R.5
  • 18
    • 0035896422 scopus 로고    scopus 로고
    • Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice
    • Yin, L., L. Wu, H. Wesche, C.D. Arthur, J.M. White, D.V. Goeddel, and R.D. Schreiber. 2001. Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice. Science. 291:2162-2165.
    • (2001) Science , vol.291 , pp. 2162-2165
    • Yin, L.1    Wu, L.2    Wesche, H.3    Arthur, C.D.4    White, J.M.5    Goeddel, D.V.6    Schreiber, R.D.7
  • 19
  • 20
    • 0028151432 scopus 로고
    • Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice
    • Kitazawa, R., R.B. Kimble, J.L. Vannice, V.T. Kung, and R. Pacifici. 1994. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J. Clin. Invest. 94:2397-2406.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2397-2406
    • Kitazawa, R.1    Kimble, R.B.2    Vannice, J.L.3    Kung, V.T.4    Pacifici, R.5
  • 21
    • 0033940801 scopus 로고    scopus 로고
    • Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts
    • Takeshita, S., K. Kaji, and A. Kudo. 2000. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J. Bone Miner. Res. 15:1477-1488.
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1477-1488
    • Takeshita, S.1    Kaji, K.2    Kudo, A.3
  • 24
    • 0028171036 scopus 로고
    • Transcriptional regulation of NF-κB2: Evidence for κB-mediated positive and negative autoregulation
    • Liptay, S., R.M. Schmid, E.G. Nabel, and G.J. Nabel. 1994. Transcriptional regulation of NF-κB2: evidence for κB-mediated positive and negative autoregulation. Mol. Cell. Biol. 14:7695-7703.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7695-7703
    • Liptay, S.1    Schmid, R.M.2    Nabel, E.G.3    Nabel, G.J.4
  • 25
    • 0030039250 scopus 로고    scopus 로고
    • A new model for the regulation of bone resorption, with particular reference to the effects of bisphonates
    • Parfitt, A.M., G.R. Mundy, G.D. Roodman, D.E. Hughes, and B. Boyce. 1996. A new model for the regulation of bone resorption, with particular reference to the effects of bisphonates. J. Bone Miner. Res. 11:150-159.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 150-159
    • Parfitt, A.M.1    Mundy, G.R.2    Roodman, G.D.3    Hughes, D.E.4    Boyce, B.5
  • 28
    • 12644272789 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
    • Song, H.Y., C.H. Regnier, C.J. Kirschning, D.V. Goeddel, and M. Rothe. 1997. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl. Acad. Sci. USA. 94:9792-9796.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9792-9796
    • Song, H.Y.1    Regnier, C.H.2    Kirschning, C.J.3    Goeddel, D.V.4    Rothe, M.5
  • 29
    • 0031017618 scopus 로고    scopus 로고
    • MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
    • Malinin, N.L., M.P. Boldin, A.V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 385:540-544.
    • (1997) Nature , vol.385 , pp. 540-544
    • Malinin, N.L.1    Boldin, M.P.2    Kovalenko, A.V.3    Wallach, D.4
  • 30
    • 0034677019 scopus 로고    scopus 로고
    • Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40
    • Garceau, N., Y. Kosaka, S. Masters, J. Hambor, R. Shinkura, T. Honjo, and R.J. Noelle. 2000. Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40. J. Exp. Med. 191:381-386.
    • (2000) J. Exp. Med. , vol.191 , pp. 381-386
    • Garceau, N.1    Kosaka, Y.2    Masters, S.3    Hambor, J.4    Shinkura, R.5    Honjo, T.6    Noelle, R.J.7
  • 31
    • 0036794398 scopus 로고    scopus 로고
    • BAFF-induced NEMO-independent processing of NF-KB2 in maturing B cells
    • Claudio, E., K. Brown, S. Park, H. Wang, and U. Siebenlist. 2002. BAFF-induced NEMO-independent processing of NF-KB2 in maturing B cells. Nat. Immunol. 3:958-965.
    • (2002) Nat. Immunol. , vol.3 , pp. 958-965
    • Claudio, E.1    Brown, K.2    Park, S.3    Wang, H.4    Siebenlist, U.5
  • 32
    • 0037155165 scopus 로고    scopus 로고
    • Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and MAP kinase signaling
    • Wei, S., M.W. Wang, S.L. Teitelbaum, and F.P. Ross. 2001. Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and MAP kinase signaling. J. Biol. Chem. 21:6622-6630.
    • (2001) J. Biol. Chem. , vol.21 , pp. 6622-6630
    • Wei, S.1    Wang, M.W.2    Teitelbaum, S.L.3    Ross, F.P.4
  • 34
    • 0347927258 scopus 로고    scopus 로고
    • Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism
    • Mordmuller, B., D. Krappmann, M. Esen, E. Wegener, and C. Scheidereit. 2003. Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism. EMBO Rep. 4:82-87.
    • (2003) EMBO Rep. , vol.4 , pp. 82-87
    • Mordmuller, B.1    Krappmann, D.2    Esen, M.3    Wegener, E.4    Scheidereit, C.5
  • 35
    • 0034523328 scopus 로고    scopus 로고
    • TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam, J., S. Takeshita, B.J.E., O. Kanagawa, F.P. Ross, and S.L. Teitelbaum. 2000. TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J. Clin. Invest. 106:1481-1488.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1481-1488
    • Lam, J.1    Takeshita, S.2    Kanagawa, O.3    Ross, F.P.4    Teitelbaum, S.L.5
  • 36
    • 0027406040 scopus 로고
    • Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappaBalpha (MAD3)
    • Duckett, C.S., N.D. Perkins, T.F. Kowalik, R.M. Schmid, E.S. Huang, A.S. Baldwin, Jr., and G.J. Nabel. 1993. Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappaBalpha (MAD3). Mol. Cell. Biol. 13:1315-1322.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1315-1322
    • Duckett, C.S.1    Perkins, N.D.2    Kowalik, T.F.3    Schmid, R.M.4    Huang, E.S.5    Baldwin A.S., Jr.6    Nabel, G.J.7
  • 37
    • 0027512187 scopus 로고
    • Both Nand C-terminal domains of RelB are required for full transactivation: Role of the N-terminal leucine zipper-like motif
    • Dobrzanski, P., R.P. Ryseck, and R. Bravo. 1993. Both Nand C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. Mol. Cell. Biol. 13:1572-1582.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1572-1582
    • Dobrzanski, P.1    Ryseck, R.P.2    Bravo, R.3
  • 39
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer, J., L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, and G. Kollias. 1991. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10:4025-4031.
    • (1991) EMBO J. , vol.10 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3    Georgopoulos, S.4    Kaslaris, E.5    Kioussis, D.6    Kollias, G.7
  • 40
    • 0027692326 scopus 로고
    • Role of cytokines and inflammatory mediators in tissue destruction
    • Birkedal-Hansen, H. 1993. Role of cytokines and inflammatory mediators in tissue destruction. J. Periodontal Res. 28:500-510.
    • (1993) J. Periodontal Res. , vol.28 , pp. 500-510
    • Birkedal-Hansen, H.1
  • 41
    • 0030801832 scopus 로고    scopus 로고
    • Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its p55 receptor
    • Abu-Amer, Y., F.P. Ross, J. Edwards, and S.L. Teitelbaum. 1997. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its p55 receptor. J. Clin. Invest. 100:1557-1565.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1557-1565
    • Abu-Amer, Y.1    Ross, F.P.2    Edwards, J.3    Teitelbaum, S.L.4
  • 42
  • 43
    • 0034667934 scopus 로고    scopus 로고
    • Endogenous production of TGF-β is essential for osteoclastogenesis induced by a combination of receptor activator of NF-κB ligand and macrophage-colony-stimulating factor
    • Kaneda, T., T. Nojima, M. Nakagawa, A. Ogasawara, H. Kaneko, T. Sato, H. Mano, M. Kumegawa, and Y. Hakeda. 2000. Endogenous production of TGF-β is essential for osteoclastogenesis induced by a combination of receptor activator of NF-κB ligand and macrophage-colony-stimulating factor. J. Immunol. 165:4254-4263.
    • (2000) J. Immunol. , vol.165 , pp. 4254-4263
    • Kaneda, T.1    Nojima, T.2    Nakagawa, M.3    Ogasawara, A.4    Kaneko, H.5    Sato, T.6    Mano, H.7    Kumegawa, M.8    Hakeda, Y.9


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