Structural basis of protein kinase C isoform function

Physiological Reviews

Volumn 88, Issue 4, 2008, Pages 1341-1378

  Steinberg, Susan F ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C IOTA; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C THETA; PROTEIN KINASE C ZETA; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RECEPTOR FOR ACTIVATED C KINASE 1; RECEPTOR FOR ACTIVATED C KINASE 2; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; ISOENZYME;

CELL CULTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENETIC ENGINEERING; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ENZYME ACTIVATION; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN KINASE C;

EID: 55949109631     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00034.2007     Document Type: Review

References (239)

1. Acs P, Beheshti M, Szallasi Z, Li L, Yuspa SH, Blumberg PM. Effect of a tyrosine 155 to phenylalanine mutation of protein kinase C-δ on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis 21: 887-891, 2000.
2. Alessi DR. The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70 S6 kinase. FEBS Lett 402: 121-123, 1997.
3. Ananthanarayanan B, Stahelin RV, Digman MA, Cho W. Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains. J Biol Chem 278: 46886-46894, 2003.
4. Anilkumar N, Parsons M, Monk R, Ng T, Adams JC. Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility. EMBO J 22: 5390-5402, 2003.
5. q protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Circulation 113: 60-66, 2006.
6. Babwah AV, Dale LB, Ferguson SS. Protein kinase C isoformspecific differences in the spatial-temporal regulation and decoding of metabotropic glutamate receptor1a-stimulated second messenger responses. J Biol Chem 278: 5419-5426, 2003.
7. Balafanova Z, Bolli R, Zhang J, Zheng Y, Pass JM, Bhatnagar A, Tang XL, Wang O, Cardwell E, Ping P. Nitric oxide induces nitration of PKCε, facilitating PKCε translocation via enhanced PKCε-RACK2 interactions: a novel mechanism of NO-triggered activation of PKC. J Biol Chem 277: 15021-15027, 2002.
8. Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D. Molecular dynamics characterization of the C2 domain of protein kinase Cβ. J Biol Chem 277: 12988-12997, 2002.
9. Basu A, Lu D, Sun B, Moor AN, Akkaraju GR, Huang J. Proteolytic activation of protein kinase C-ε by caspase-mediated processing and transduction of antiapoptotic signals. J Biol Chem 277: 41850-41856, 2002.
10. Becker KP, Hannun YA. cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem 278: 52747-52754, 2003.
11. Becker KP, Hannun YA. Isoenzyme-specific translocation of PKC-βII and not PKCβI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem 279: 28251-28256, 2004.
12. Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCδ is a phosphotyrosine binding domain. Cell 121: 271-280, 2005.
13. Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D, Kharbanda S. Inactivation of DNA-dependent protein kinase by protein kinase Cδ: implications for apoptosis. Mol Cell Biol 18: 6719-6728, 1998.
14. Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, Brodie C. Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide. Mol Cell Biol 22: 182-195, 2002.
15. Blobe GC, Stribling DS, Fabbro D, Stabel S, Hannun YA. Protein kinase C βII specifically binds to and is activated by F-actin. J Biol Chem 271: 15823-15830, 1996.
16. Bornancin F, Parker PJ. Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Cα. Curr Biol 6: 1114-1123, 1996.
17. Bornancin F, Parker PJ. Phosphorylation of protein kinase C-α on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. J Biol Chem 272: 3544-3549, 1997.
18. Bourbon NA, Yun J, Kester M. Ceramide directly activates protein kinase C-ζ to regulate a stress-activated protein kinase signaling complex. J Biol Chem 275: 35617-35623, 2000.
19. Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. Peptides derived from the C2 domain of protein kinase Cε modulate εPKC activity and identify potential protein-protein interaction surfaces. J Biol Chem 282: 4113-4123, 2007.
20. Braun DC, Garfield SH, Blumberg PM. Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cδ in the intact cell. J Biol Chem 280: 8164-8171, 2005.
21. Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke 36: 2781-2790, 2005.
22. Burkart EM, Sumandea MP, Kobayashi T, Nili M, Martin AF, Homsher E, Solaro RJ. Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem 278: 11265-11272, 2003.
23. Cauthron RD, Carter KB, Liauw S, Steinberg RA. Physiological phosphorylation of protein kinase A at Thr-197 is by a protein kinase A kinase. Mol Cell Biol 18: 1416-1423, 1998.
24. Cenni V, Doppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A. Regulation of novel protein kinase Cε by phosphorylation. Biochem J 363: 537-545, 2002.
25. 2 in pulmonary endothelium: involvement of a pertussis toxin sensitive protein. Biochemistry 44: 5246-5257, 2005.
26. Chalfant CE, Mischak H, Watson JE, Winkler BC, Goodnight J, Farese RV, Cooper DR. Regulation of alternative splicing of protein kinase C-β by insulin. J Biol Chem 270: 13326-13332, 1995.
27. Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VC. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem 278: 20453-20456, 2003.
28. Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC. Centrosomal anchoring of protein kinase CβII by pericentrin controls microtubule organization, spindle function, cytokinesis. J Biol Chem 279: 4829-4839, 2004.
29. Chen DH, Brkanac Z, Verlinde CL, Tan XJ, Bylenok L, Nochlin D, Matsushita M, Lipe H, Wolff J, Fernandez M, Cimino PJ, Bird TD, Raskind WH. Missense mutations in the regulatory domain of PKCγ: a new mechanism for dominant nonepisodic cerebellar ataxia. Am J Hum Genet 72: 839-849, 2003.
30. Cheng N, He R, Tian J, Dinauer MC, Ye RD. A critical role of protein kinase Cδ activation loop phosphorylation in formyl-methionyl- leucyl-phenylalanine-induced phosphorylation of p47phox and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol 179: 7720-7728, 2007.
31. Cho W. Membrane targeting by C1 and C2 domains. J Biol Chem 276: 32407-32410, 2001.
32. Clarke CJ, Ohanian V, Ohanian J. Noradrenaline and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries. Am J Physiol Heart Circ Physiol 292: H2248-H2256, 2007.
33. Clerk A. Death by protein kinase C inhibitor. J Mol Cell Cardiol 33: 1773-1776, 2001.
34. Corbalán-García S, Garcia-García J, Rodríguez-Alfaro JA, Gómez-Fernández JC. A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Cα. J Biol Chem 278: 4972-4980, 2003.
35. Cross T, Griffiths G, Deacon E, Sallis R, Gough M, Watters D, Lord JM. PKC-δ is an apoptotic lamin kinase. Oncogene 19: 2331-2337, 2000.
36. Crotty T, Cai J, Sakane F, Taketomi A, Prescott SM, Topham MK. Diacylglycerol kinase δ regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci USA 103: 15485-15490, 2006.
37. Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D. The coatomer protein β′-COP, a selective binding protein (RACK) for protein kinase C. J Biol Chem 272: 29200-29206, 1997.
38. Datta R, Kojima H, Yoshida K, Kufe D. Caspase-3-mediated cleavage of protein kinase Cθ in induction of apoptosis. J Biol Chem 272: 20317-20320, 1997.
39. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105, 2000.
40. Dekker LV, Parker PJ. Regulated binding of the protein kinase C substrate GAP-43 to the V0/C2 region of protein kinase C-δ. J Biol Chem 272: 12747-12753, 1997.
41. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 279: L429-L438, 2000.
42. Denzel A, Hare KJ, Zhang C, Shokat K, Jenkinson EJ, Anderson G, Hayday A. Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development. J Immunol 171: 519-523, 2003.
43. DeVries TA, Neville MC, Reyland ME. Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21: 6050-6060, 2002.
44. Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res 210: 287-297, 1994.
45. Doble BW, Dang X, Ping P, Fandrich RR, Nickel BE, Jin Y, Cattini PA, Kardami E. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. J Cell Sci 117: 507-514, 2004.
46. Doble BW, Ping P, Kardami E. The ε subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res 86: 293-301, 2000.
47. Dries DR, Gallegos LL, Newton AC. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem 282: 826-830, 2007.
48. Dutil EM, Toker A, Newton AC. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1. Curr Biol 8: 1366-1375, 1998.
49. Edwards AS, Faux MC, Scott JD, Newton AC. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C-βII. J Biol Chem 274: 6461-6468, 1999.
50. Edwards AS, Newton AC. Phosphorylation at conserved carboxylterminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. J Biol Chem 272: 18382-18390, 1997.
51. Edwards AS, Newton AC. Regulation of protein kinase C βII by its C2 domain. Biochemistry 36: 15615-15623, 1997.
52. Emoto Y, Manome Y, Meinhardt G, Kisaki H, Kharbanda S, Robertson M, Ghayur T, Wong WW, Kamen R, Weichselbaum R, Kufe D. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J 14: 6148-6156, 1995.
53. Emrick MA, Lee T, Starkey PJ, Mumby MC, Resing KA, Ahn NG. The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity. Proc Natl Acad Sci USA 103: 18101-18106, 2006.
54. 2 recognition by its C2 domain. Mol Biol Cell 17: 56-66, 2006.
55. Feng X, Becker KP, Stribling SD, Peters KG, Hannun YA. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. J Biol Chem 275: 17024-17034, 2000.
56. Feng X, Hannun YA. An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem 273: 26870-26874, 1998.
57. Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, Unal O, Yun JK, Naides SJ, Kester M. Ceramide recruits and activates protein kinase C-ζ within structured membrane microdomains. J Biol Chem 282: 12450-12457, 2007.
58. Frutos S, Moscat J, Diaz-Meco MT. Cleavage of ζPKC but not λιPKC by caspase-3 during UV-induced apoptos. J Biol Chem 274: 10765-10770, 1999.
59. Gallegos LL, Kunkel MT, Newton AC. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem 281: 30947-30956, 2006.
60. Gao T, Newton AC. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem 277: 31585-31592, 2002.
61. Gao T, Newton AC. Invariant leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with hsp70. J Biol Chem 281: 32461-32468, 2006.
62. Gao T, Toker A, Newton AC. The carboxyl terminus of protein kinase C provides a switch to regulate its interaction with the phosphoinositide- dependent kinase, PDK-1. J Biol Chem 276: 19588-19596, 2001.
63. Garcia-Paramio P, Cabrerizo Y, Bornancin F, Parker PJ. The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation. Biochem J 333: 631-636, 1998.
64. Giorgione JR, Lin JH, McCammon JA, Newton AC. Increased membrane affinity of the C1 domain of protein kinase Cδ compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem 281: 1660-1669, 2006.
65. Gökmen-Polar Y, Fields AP. Mapping of a molecular determinant for protein kinase C-βII isozyme function. J Biol Chem 273: 20261-20266, 1998.
66. Gonfloni S, Williams JC, Hattula K, Weijland A, Wierenga RK, Superti-Furga G. The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src. EMBO J 16: 7261-7271, 1997.
67. Goode NT, Hajibagheri N, Parker PJ. Protein kinase C (PKC)-induced PKC down-regulation: association with up-regulation of vesicle traffic. J Biol Chem 270: 2669-2673, 1995.
68. Goodnight JA, Mischak H, Kolch W, Mushinski JF. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, nuclear and cell membranes. J Biol Chem 270: 9991-10001, 1995.
69. Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med 28: 1349-1361, 2000.
70. Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO. Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C-ε. J Biol Chem 279: 3596-3604, 2004.
71. Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7: 281-294, 2007.
72. Grodsky N, Li Y, Bouzida D, Love R, Jensen J, Nodes B, Nonomiya J, Grant S. Structure of the catalytic domain of human protein kinase C βII complexed with a bisindolylmaleimide inhibitor. Biochemistry 45: 13970-13981, 2006.
73. Hamaguchi A, Suzuki E, Murayama K, Fujimura T, Hikita T, Iwabuchi K, Handa K, Withers DA, Masters SC, Fu H, Hakomori S. Sphingosine-dependent protein kinase-1 (SDK1), directed to 14-3-3, is identified as the kinase domain of PKCδ. J Biol Chem 278: 41557-41565, 2003.
74. Herberg FW, Zimmermann B, McGlone M, Taylor SS. Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Sci 6: 569-579, 1997.
75. Hommel U, Zurini M, Luyten M. Solution structure of a cysteine rich domain of rat protein kinase C. Nat Struct Biol 1: 383-387, 1994.
76. Hu T, Exton JH. Mechanisms of regulation of phospholipase D1 by protein kinase Cα. J Biol Chem 278: 2348-2355, 2003.
77. Hu T, Exton JH. Protein kinase Cα translocates to the perinuclear region to activate phospholipase D1. J Biol Chem 279: 35702-35708, 2004.
78. Hurley JH, Misra S. Signaling and subcellular targeting by membrane-binding domains. Annu Rev Biophys Biomol Struct 29: 49-79, 2000.
79. Huwiler A, Fabbro D, Pfeilschifter J. Selective ceramide binding to protein kinase C-α and -δ isoenzymes in renal mesangial cells. Biochemistry 37: 14556-14562, 1998.
80. Idkowiak-Baldys J, Becker KP, Kitatani K, Hannun YA. Dynamic sequestration of the recycling compartment by classical protein kinase C. J Biol Chem 281: 22321-22331, 2006.
81. Imai S, Kai M, Yamada K, Kanoh H, Sakane F. The plasma membrane translocation of diacylglycerol kinase δ1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. Biochem J 382: 957-966, 2004.
82. Ivaska J, Vuoriluoto K, Huovinen T, Izawa I, Inagaki M, Parker PJ. PKCε-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J 24: 3834-3845, 2005.
83. Ivaska J, Whelan RD, Watson R, Parker PJ. PKC-ε controls the traffic of β1-integrins in motile cells. EMBO J 21: 3608-3619, 2002.
84. Iyer GH, Garrod S, Woods VL Jr, Taylor SS. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol 351: 1110-1122, 2005.
85. Iyer GH, Moore MJ, Taylor SS. Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J Biol Chem 280: 8800-8807, 2005.
86. Jiang K, Apostolatos AH, Ghansah T, Watson JE, Vickers T, Cooper DR, Epling-Burnette PK, Patel NA. Identification of a novel antiapoptotic human protein kinase c delta isoform, PKC-deltaVIII in NT2 cells. Biochemistry 47: 787-797, 2008.
87. Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem 271: 24962-24966, 1996.
88. Jose Lopez-Andreo M, Gomez-Fernandez JC, Corbalan-Garcia S. The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cε to the plasma membrane in RBL-2H3 cells. Mol Biol Cell 14: 4885-4895, 2003.
89. Joseloff E, Cataisson C, Aamodt H, Ocheni H, Blumberg P, Kraker AJ, Yuspa SH. Src family kinases phosphorylate protein kinase C-δ on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. J Biol Chem 277: 12318-12323, 2002.
90. Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, Saito N. Ceramide-induced apoptosis by translocation, phosphorylation, activation of protein kinase Cδ in the Golgi complex. J Biol Chem 279: 12668-12676, 2004.
91. Kashiwagi K, Shirai Y, Kuriyama M, Sakai N, Saito N. Importance of C1B domain for lipid messenger-induced targeting of protein kinase C. J Biol Chem 277: 18037-18045, 2002.
92. Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci USA 100: 9470-9475, 2003.
93. Kazanietz MG. Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Mol Pharmacol 61: 759-767, 2002.
94. Keranen LM, Dutil EM, Newton AC. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5: 1394-1403, 1995.
95. 2+ differentially regulates conventional protein kinase Cs′ membrane interaction and activation. J Biol Chem 272: 25959-25967, 1997.
96. Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. Protein kinase Cδ-annexin V interaction: a required step in δPKC translocation and function. J Biol Chem 281: 23218-23226, 2006.
97. Kitatani K, Idkowiak-Baldys J, Hannun YA. Mechanism of inhibition of sequestration of protein kinase C-α/βII by ceramide: roles of ceramide-activated protein phosphatases and phosphorylation/ dephosphorylation of protein kinase C-α/β II on threonine 638/641. J Biol Chem 282: 20647-20656, 2007.
98. Klein G, Schaefer A, Hilfiker-Kleiner D, Oppermann D, Shukla P, Quint A, Podewski E, Hilfiker A, Schroder F, Leitges M, Drexler H. Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCε. Circ Res 96: 748-755, 2005.
99. Knapp LT, Kanterewicz BI, Hayes EL, Klann E. Peroxynitrite-induced tyrosine nitration and inhibition of protein kinase C. Biochem Biophys Res Commun 286: 764-770, 2001.
100. Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253: 407-414, 1991.
101. Knighton DR, Zheng JH, Ten Eyck LF, Xuong NH, Taylor SS, Sowadski JM. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253: 414-420, 1991.
102. 2. Proc Natl Acad Sci USA 94: 11233-11237, 1997.
103. 2-treated cells and its activation by tyrosine kinase in vitro. Proc Natl Acad Sci USA 98: 6587-6592, 2001.
104. Kronfeld I, Kazimirsky G, Lorenzo PS, Garfield SH, Blumberg PM, Brodie C. Phosphorylation of protein kinase Cδ on distinct tyrosine residues regulates specific cellular functions. J Biol Chem 275: 35491-35498, 2000.
105. Kumar S, Bharti A, Mishra NC, Raina D, Kharbanda S, Saxena S, Kufe D. Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress. J Biol Chem 276: 17281-17285, 2001.
106. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281: 2042-2045, 1998.
107. Lee SJ, Kim DC, Choi BH, Ha H, Kim KT. Regulation of p53 by activated protein kinase C-δ during nitric oxide-induced dopaminergic cell death. J Biol Chem 281: 2215-2224, 2006.
108. Lehel C, Olah Z, Jakab G, Anderson WB. Protein kinase C-ε is localized to the Golgi via its zinc-finger domain and modulates Golgi function. Proc Natl Acad Sci USA 92: 1406-1410, 1995.
109. Leitges M, Elis W, Gimborn K, Huber M. Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-δ in hemopoietic cells. Lab Invest 81: 1087-1095, 2001.
110. Leitges M, Gimborn K, Elis W, Kalesnikoff J, Hughes MR, Krystal G, Huber M. Protein kinase C-δ is a negative regulator of antigen-induced mast cell degranulation. Mol Cell Biol 22: 3970-3980, 2002.
111. Li W, Chen XH, Kelley CA, Alimandi M, Zhang J, Chen Q, Bottaro DP, Pierce JH. Identification of tyrosine 187 as a protein kinase C-δ phosphorylation site. J Biol Chem 271: 26404-26409, 1996.
112. Li W, Zhang J, Bottaro DP, Pierce JH. Identification of serine 643 of protein kinase C-δ as an important autophosphorylation site for its enzymatic activity. J Biol Chem 272: 24550-24555, 1997.
113. Lin D, Barnett M, Lobell S, Madgwick D, Shanks D, Willard L, Zampighi GA, Takemoto DJ. PKCγ knockout mouse lenses are more susceptible to oxidative stress damage. J Exp Biol 209: 4371-4378, 2006.
114. Lin D, Shanks D, Prakash O, Takemoto DJ. Protein kinase C-γ mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. Exp Eye Res 85: 113-122, 2007.
115. Lin D, Takemoto DJ. Oxidative activation of protein kinase Cγ through the C1 domain. Effects on gap junctions. J Biol Chem 280: 13682-13693, 2005.
116. Lin D, Zhou J, Zelenka PS, Takemoto DJ. Protein kinase Cγ regulation of gap junction activity through caveolin-1-containing lipid rafts. Invest Ophthalmol Vis Sci 44: 5259-5268, 2003.
117. Ling M, Sunesson L, Larsson C. Comparison of the PKCα and the PKCε C1b domains: identification of residues critical for PKCε-mediated neurite induction. J Mol Biol 368: 951-965, 2007.
118. Ling M, Troller U, Zeidman R, Stensman H, Schultz A, Larsson C. Identification of conserved amino acids N-terminal of the PKC-ε C1b domain crucial for protein kinase C-ε-mediated induction of neurite outgrowth. J Biol Chem 280: 17910-17919, 2005.
119. Liu XJ, He AB, Chang YS, Fang FD. Atypical protein kinase C in glucose metabolism. Cell Signal 18: 2071-2076, 2006.
120. Liu Y, Belkina NV, Graham C, Shaw S. Independence of protein kinase C-δ activity from activation loop phosphorylation: structural basis and altered functions in cells. J Biol Chem 281: 12102-12111, 2006.
121. Liu Y, Graham C, Li A, Fisher RJ, Shaw S. Phosphorylation of the protein kinase C-θ activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-B induction. Biochem J 361: 255-265, 2002.
122. Liu Y, Witte S, Liu YC, Doyle M, Elly C, Altman A. Regulation of protein kinase Cθ function during T cell activation by Lck-mediated tyrosine phosphorylation. J Biol Chem 275: 3603-3609, 2000.
123. Lopez-Lluch G, Bird MM, Canas B, Godovac-Zimmerman J, Ridley A, Segal AW, Dekker LV. Protein kinase C-δ C2-like domain is a binding site for actin and enables actin redistribution in neutrophils. Biochem J 357: 39-47, 2001.
124. Lu W, Finnis S, Xiang C, Lee HK, Markowitz Y, Okhrimenko H, Brodie C. Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCδ in glioma cells. Biochem Biophys Res Commun 352: 431-436, 2007.
125. Lu W, Lee HK, Xiang C, Finniss S, Brodie C. The phosphorylation of tyrosine 332 is necessary for the caspase 3-dependent cleavage of PKCδ and the regulation of cell apoptosis. Cell Signal 19: 2165-2173, 2007.
126. Luo B, Prescott SM, Topham MK. Association of diacylglycerol kinase-ζ with protein kinase C-α: spatial regulation of diacylglycerol signaling. J Cell Biol 160: 929-937, 2003.
127. Luo B, Prescott SM, Topham MK. Protein kinase C-α phosphorylates and negatively regulates diacylglycerol kinase-ζ. J Biol Chem 278: 39542-39547, 2003.
128. Mackay K, Mochly-Rosen D. Localization, anchoring, functions of protein kinase C isozymes in the heart. J Mol Cell Cardiol 33: 1301-1307, 2001.
129. Maeda Y, Beznoussenko GV, Van Lint J, Mironov AA, Malhotra V. Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain. EMBO J 20: 5982-5990, 2001.
130. McCahill A, Warwicker J, Bolger GB, Houslay MD, Yarwood SJ. The RACK1 scaffold protein: a dynamic cog in cell response mechanisms. Mol Pharmacol 62: 1261-1273, 2002.
131. 2+ ligands and membrane binding residues. J Biol Chem 273: 17544-17552, 1998.
132. Melowic HR, Stahelin RV, Blatner NR, Tian W, Hayashi K, Altman A, Cho W. Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cθ. J Biol Chem 282: 21467-21476, 2007.
133. Messerschmidt A, Macieira S, Velarde M, Badeker M, Benda C, Jestel A, Brandstetter H, Neuefeind T, Blaesse M. Crystal structure of the catalytic domain of human atypical protein kinase Cι reveals interaction mode of phosphorylation site in turn motif. J Mol Biol 352: 918-931, 2005.
134. Mineo C, Ying YS, Chapline C, Jaken S, Anderson RG. Targeting of protein kinase Cα to caveolae. J Cell Biol 141: 601-610, 1998.
135. Mizuno K, Noda K, Araki T, Imaoka T, Kobayashi Y, Akita Y, Shimonaka M, Kishi S, Ohno S. The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis. Eur J Biochem 250: 7-18, 1997.
136. Moore MJ, Kanter JR, Jones KC, Taylor SS. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem 277: 47878-47884, 2002.
137. Morgan A, Burgoyne RD, Barclay JW, Craig TJ, Prescott GR, Ciufo LF, Evans GJ, Graham ME. Regulation of exocytosis by protein kinase C. Biochem Soc Trans 33: 1341-1344, 2005.
138. Moscat J, Diaz-Meco MT, Albert A, Campuzano S. Cell signaling and function organized by PB1 domain interactions. Mol Cell 23: 631-640, 2006.
139. Moscat J, Rennert P, Diaz-Meco MT. PKCζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways. Cell Death Differ 13: 702-711, 2006.
140. Muller G, Ayoub M, Storz P, Rennecke J, Fabbro D, Pfizenmaier K. PKC-ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J 14: 1961-1969, 1995.
141. Newton AC, Johnson JE. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta 1376: 155-172, 1998.
142. Ng T, Squire A, Hansra G, Bornancin F, Prevostel C, Hanby A, Harris W, Barnes D, Schmidt S, Mellor H, Bastiaens PI, Parker PJ. Imaging protein kinase Cα activation in cells. Science 283: 2085-2089, 1999.
143. Nguyen TA, Takemoto LJ, Takemoto DJ. Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cγ from 14-3-3: identification of PKCγ-binding sites. J Biol Chem 279: 52714-52725, 2004.
144. Oancea E, Teruel MN, Quest AF, Meyer T. Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells. J Cell Biol 140: 485-498, 1998.
145. 2+-independent C2 domains. J Mol Biol 311: 837-849, 2001.
146. O'Connell MJ, Raleigh JM, Verkade HM, Nurse P. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J 16: 545-554, 1997.
147. Odawara M, Kadowaki T, Yamamoto R, Shibasaki Y, Tobe K, Accili D, Bevins C, Mikami Y, Matsuura N, Akanuma Y. Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. Science 245: 66-68, 1989.
148. Oka N, Yamamoto M, Schwencke C, Kawabe JI, Ebina T, Ohno S, Couet J, Lisanti MP, Ishikawa Y. Caveolin interaction with protein kinase C: isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. J Biol Chem 272: 33416-33421, 1997.
149. Okhrimenko H, Lu W, Jiang C, Ju D, Blumberg PM, Gomel R, Kazimirsky G, Brodie C. Roles of tyrosine phosphorylation and cleavage of PKCδ in its protective effect against trail-induced apoptosis. J Biol Chem 280: 23643-23652, 2005.
150. Okhrimenko H, Lu W, Xiang C, Hamburger N, Kazimirsky G, Brodie C. Protein kinase C-ε regulates the apoptosis and survival of glioma cells. Cancer Res 65: 7301-7309, 2005.
151. Pappa H, Murray-Rust J, Dekker LV, Parker PJ, McDonald NQ. Crystal structure of the C2 domain from protein kinase C-δ. Structure 6: 885-894, 1998.
152. Parekh D, Ziegler W, Yonezawa K, Hara K, Parker PJ. Mammalian TOR controls one of two kinase pathways acting upon nPKCδ and nPKCε. J Biol Chem 274: 34758-34764, 1999.
153. Parekh DB, Ziegler W, Parker PJ. Multiple pathways control protein kinase C phosphorylation. EMBO J 19: 496-503, 2000
154. Parton RG, Simons K. The multiple faces of caveolae. Nat Rev Mol Cell Biol 8: 185-194, 2007.
155. Perander M, Bjorkoy G, Johansen T. Nuclear import and export signals enable rapid nucleocytoplasmic shuttling of the atypical protein kinase C-λ. J Biol Chem 276: 13015-13024, 2001.
156. Porter MJ, Heidkamp MC, Scully BT, Patel N, Martin JL, Samarel AM. Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes. Am J Physiol Cell Physiol 285: C39-C47, 2003.
157. Prekeris R, Hernandez RM, Mayhew MW, White MK, Terrian DM. Molecular analysis of the interactions between protein kinase C- and filamentous actin. J Biol Chem 273: 26790-26798, 1998.
158. Prekeris R, Mayhew MW, Cooper JB, Terrian DM. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J Cell Biol 132: 77-90, 1996.
159. Prevostel C, Alice V, Joubert D, Parker PJ. Protein kinase Cα actively downregulates through caveolae-dependent traffic to an endosomal compartment. J Cell Sci 113: 2575-2584, 2000.
160. Pu Y, Peach ML, Garfield SH, Wincovitch S, Marquez VE, Blumberg PM. Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms. J Biol Chem 281: 33773-33788, 2006.
161. Quittau-Prevostel C, Delaunay N, Collazos A, Vallentin A, Joubert D. Targeting of PKCα and ε in the pituitary: a highly regulated mechanism involving a GD(E)E motif of the V3 region. J Cell Sci 117: 63-72, 2004.
162. Ranganathan S, Wang Y, Kern FG, Qu Z, Li R. Activation loop phosphorylation-independent kinase activity of human protein kinase C-ζ. Proteins 67: 709-719, 2007.
163. Ren J, Datta R, Shioya H, Li Y, Oki E, Biedermann V, Bharti A, Kufe D. p73β is regulated by protein kinase Cδ catalytic fragment generated in the apoptotic response to DNA damage. J Biol Chem 277: 33758-33765, 2002.
164. Roberts NA, Haworth RS, Avkiran M. Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes. Br J Pharmacol 145: 477-489, 2005.
165. Roberts NA, Marber MS, Avkiran M. Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes? Biochem Pharmacol 68: 1923-1928, 2004.
166. Robles-Flores M, Rendon-Huerta E, Gonzalez-Aguilar H, Mendoza-Hernandez G, Islas S, Mendoza V, Ponce-Castaneda MV, Gonzalez-Mariscal L, Lopez-Casillas F. p32 (gC1qBP) is a general protein kinase C (PKC)-binding protein. J Biol Chem 277: 5247-5255, 2002.
167. Ron D, Luo J, Mochly-Rosen D. C2 region-derived peptides inhibit translocation and function of β-protein kinase C in vivo. J Biol Chem 270: 24180-24187, 1995.
168. Ron D, Mochly-Rosen D. An autoregulatory region in protein kinase C: The pseudoanchoring site. Proc Natl Acad Sci USA 92: 492-496, 1995.
169. Roumiantsev S, Shah NP, Gorre ME, Nicoll J, Brasher BB, Sawyers CL, Van Etten RA. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc Natl Acad Sci USA 99: 10700-10705, 2002.
170. Rybin VO, Guo J, Gertsberg Z, Elouardighi H, Steinberg SF. Protein kinase C and Src control PKCδ activation loop phosphorylation in cardiomyocytes. J Biol Chem 282: 23631-23638, 2007.
171. 311 phosphorylation in cardiomyocyte caveolae. J Biol Chem. 283: 17777-17788, 2008.
172. Rybin VO, Guo J, Sabri A, Elouardighi H, Schaefer E, Steinberg SF. Stimulus-specific differences in protein kinase C-δ localization and activation mechanisms in cardiomyocytes. J Biol Chem 279: 19350-19361, 2004.
173. Rybin VO, Sabri A, Short J, Braz JC, Molkentin JD, Steinberg SF. Cross regulation of nPKC isoform function in cardiomyocytes: role of PKCε in activation loop phosphorylations and PKCδ in hydrophobic motif phosphorylations. J Biol Chem 278: 14555-14564, 2003.
174. Rybin VO, Steinberg SF. Immunoblotting PKCδ: a cautionary note from the bench. Am J Physiol Cell Physiol 290: C750-C756, 2006.
175. Rybin VO, Xu X, Steinberg SF. Activated protein kinase C isoforms target to cardiomyocyte caveolae. Circ Res 84: 980-988, 1999.
176. Sabri A, Steinberg SF. Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure. Mol Cell Biochem 251: 97-101, 2003.
177. Sakurai Y, Onishi Y, Tanimoto Y, Kizaki H. Novel protein kinase C delta isoform insensitive to caspase-3. Biol Pharm Bull 24: 973-977, 2001.
178. Sawai H, Okazaki T, Takeda Y, Tashima M, Sawada H, Okuma M, Kishi S, Umehara H, Domae N. Ceramide-induced translocation of protein kinase C-δ and -ε to the cytosol: implications in apoptosis. J Biol Chem 272: 2452-2458, 1997.
179. Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem 282: 14952-14959, 2007.
180. Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D. A critical intramolecular interaction for protein kinase Cε translocation. J Biol Chem 279: 17617-17624, 2004.
181. Schechtman D, Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20: 6339-6347, 2001.
182. Schultz A, Jonsson JI, Larsson C. The regulatory domain of protein kinase Cθ localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells. Cell Death Differ 10: 662-675, 2003.
183. Schultz A, Ling M, Larsson C. Identification of an amino acid residue in the protein kinase C C1b domain crucial for its localization to the Golgi network. J Biol Chem 279: 31750-31760, 2004.
184. Shah K, Shokat KM. A chemical genetic approach for the identification of direct substrates of protein kinases. Methods Mol Biol 233: 253-271, 2003.
185. Singer WD, Brown HA, Jiang X, Sternweis PC. Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity. J Biol Chem 271: 4504-4510, 1996.
186. Skaggs BJ, Gorre ME, Ryvkin A, Burgess MR, Xie Y, Han Y, Komisopoulou E, Brown LM, Loo JA, Landaw EM, Sawyers CL, Graeber TG. Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci USA 103: 19466-19471, 2006.
187. Slater SJ, Seiz JL, Cook AC, Buzas CJ, Malinowski SA, Kershner JL, Stagliano BA, Stubbs CD. Regulation of PKC-α activity by C1-C2 domain interactions. J Biol Chem 277: 15277-15285, 2002.
188. Smith L, Smith JB. Lack of constitutive activity of the free kinase domain of protein kinase C-ζ. Dependence on transphosphorylation of the activation loop. J Biol Chem 277: 45866-45873, 2002.
189. Soltoff SP. Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks PKCδ tyrosine phosphorylation. J Biol Chem 276: 37986-37992, 2001.
190. Soltoff SP. Rottlerin: an inappropriate and ineffective inhibitor of PKCδ. Trends Pharmacol Sci 28: 453-458, 2007.
191. Song JS, Swann PG, Szallasi Z, Blank U, Blumberg PM, Rivera J. Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-δ with Src family kinases in the RBL-2H3 mast cell line. Oncogene 16: 3357-3368, 1998.
192. Sonnenburg ED, Gao T, Newton AC. The phosphoinositidedependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J Biol Chem 276: 45289-45297, 2001.
193. Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D. State-specific monoclonal antibodies identify an intermediate state in -protein kinase C activation. J Biol Chem 279: 17617-17624, 2004.
194. Spitaler M, Villunger A, Grunicke H, Uberall F. Unique structural and functional properties of the ATP-binding domain of atypical protein kinase C-ι. J Biol Chem 275: 33289-33296, 2000.
195. Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Melowic HR, Rafter JD, Cho W. Diacylglycerol-induced membrane targeting and activation of protein kinase Cε: mechanistic differences between protein kinases Cδ and Cε. J Biol Chem 280: 19784-19793, 2005.
196. Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Rafter JD, Melowic HR, Cho W. Mechanism of diacylglycerolinduced membrane targeting and activation of protein kinase Cδ. J Biol Chem 279: 29501-29512, 2004.
197. 2. J Biol Chem 278: 12452-12460, 2003.
198. Stahelin RV, Wang J, Blatner NR, Rafter JD, Murray D, Cho W. The origin of C1A-C2 interdomain interactions in protein kinase Cα. J Biol Chem 280: 36452-36463, 2005.
199. Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN. PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol 128: 263-271, 1995.
200. Stebbins EG, Mochly-Rosen D. Binding specificity for RACK1 resides in the V5 region of βII protein kinase C. J Biol Chem 276: 29644-29650, 2001.
201. Steinberg SF. Distinctive activation mechanisms and functions for protein kinase C-δ. Biochem J 384: 449-459, 2004.
202. Steinberg SF, Sussman MA. Cardiac hypertrophy served with protein kinase C-ε: δ isoform substitution available at additional cost. Circ Res 96: 711-713, 2005.
203. Stempka L, Girod A, Muller HJ, Rincke G, Marks F, Gschwendt M, Bossemeyer D. Phosphorylation of protein kinase Cδ at threonine 505 is not a prerequisite for enzymatic activity. J Biol Chem 272: 6805-6811, 1997.
204. Stempka L, Schnolzer M, Radke S, Rincke G, Marks F, Gschwendt M. Requirements of protein kinase C δ for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J Biol Chem 274: 8886-8892, 1999.
205. Stensman H, Raghunath A, Larsson C. Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Cα in response to diacylglycerol. J Biol Chem 279: 40576-40583, 2004.
206. Sumandea M, Rybin VO, Wang C, Hinken A, Kobayashi T, Harleton E, Sievert G, Feinmark SJ, Balke CW, Solaro RJ, Steinberg SF. Tyrosine phosphorylation modifies PKCδ phosphorylation of cardiac troponin I. Mol Cell. In press.
207. Sun X, Wu F, Datta R, Kharbanda S, Kufe D. Interaction between protein kinase Cδ and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem 275: 7470-7473, 2000.
208. 2+. Structure 6: 1395-1405, 1998.
209. Szallasi Z, Denning MF, Chang EY, Rivera J, Yuspa SH, Lehel C, Olah Z, Anderson WB, Blumberg PM. Development of a rapid approach to identification of tyrosine phosphorylation sites. Biochem Biophys Res Commun 214: 888-894, 1995.
210. Takahashi H, Takeishi Y, Seidler T, Arimoto T, Akiyama H, Hozumi Y, Koyama Y, Shishido T, Tsunoda Y, Niizeki T, Nozaki N, Abe J, Hasenfuss G, Goto K, Kubota I. Adenovirus-mediated overexpression of diacylglycerol kinase-ζ inhibits endothelin-1-induced cardiomyocyte hypertrophy. Circulation 111: 1510-1516, 2005.
211. Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature 300: 762-765, 1982.
212. Thuille N, Heit I, Fresser F, Krumbock N, Bauer B, Leuthaeusser S, Dammeier S, Graham C, Copeland TD, Shaw S, Baier G. Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes. EMBO J 24: 3869-3880, 2005.
213. Vallentin A, Lo TC, Joubert D. A single point mutation in the V3 region affects protein kinase Cα targeting and accumulation at cell-cell contacts. Mol Cell Biol 21: 3351-3363, 2001.
214. Verbeek DS, Warrenburg BP, Hennekam FA, Dooijes D, Ippel PF, Verschuuren-Bemelmans CC, Kremer HP, Sinke RJ. Gly118Asp is a SCA14 founder mutation in the Dutch ataxia population. Hum Genet 117: 88-91, 2005.
215. 2+ bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine. EMBO J 18: 6329-6338, 1999.
216. Veron M, Radzio-Andzelm E, Tsigelny I, Ten Eyck LF, Taylor SS. A conserved helix motif complements the protein kinase core. Proc Natl Acad Sci USA 90: 10618-10622, 1993.
217. Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol 161: 899-909, 2003.
218. Wang QJ, Fang TW, Fenick D, Garfield S, Bienfait B, Marquez VE, Blumberg PM. The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. J Biol Chem 275: 12136-12146, 2000.
219. Watanabe T, Ono Y, Taniyama Y, Hazama K, Igarashi K, Ogita K, Kikkawa U, Nishizuka Y. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-δ subspecies. Proc Natl Acad Sci USA 89: 10159-10163, 1992.
220. Way KJ, Katai N, King GL. Protein kinase C and the development of diabetic vascular complications. Diabetes Med 18: 945-959, 2001.
221. White WO, Seibenhener ML, Wooten MW. Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C. J Cell Biochem 85: 42-53, 2002.
222. Williams MR, Arthur JS, Balendran A, van der KJ, Poli V, Cohen P, Alessi DR. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 10: 439-448, 2000.
223. Wolfman A, Macara IG. Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts. Nature 325: 359-361, 1987.
224. Wooten MW, Vandenplas ML, Seibenhener ML, Geetha T, Diaz-Meco MT. Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway. Mol Cell Biol 21: 8414-8427, 2001.
225. Xu RX, Pawelczyk T, Xia TH, Brown SC. NMR structure of a protein kinase C-γ phorbol-binding domain and study of protein-lipid micelle interactions. Biochemistry 36: 10709-10717, 1997.
226. Xu ZB, Chaudhary D, Olland S, Wolfrom S, Czerwinski R, Malakian K, Lin L, Stahl ML, Joseph-McCarthy D, Benander C, Fitz L, Greco R, Somers WS, Mosyak L. Catalytic domain crystal structure of protein kinase Cθ. J Biol Chem 279: 50401-50409, 2004.
227. Yamaguchi Y, Shirai Y, Matsubara T, Sanse K, Kuriyama M, Oshiro N, Yoshino K, Yonezawa K, Ono Y, Saito N. Phosphorylation and up-regulation of diacylglycerol kinase-γ via its interaction with protein kinase C-γ. J Biol Chem 281: 31627-31637, 2006.
228. Yamamoto M, Acevedo-Duncan M, Chalfant CE, Patel NA, Watson JE, Cooper DR. The roles of protein kinase C-βI and -βII in vascular smooth muscle cell proliferation. Exp Cell Res 240: 349-358, 1998.
229. Yamamoto S, Seta K, Morisco C, Vatner SF, Sadoshima J. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol 33: 1829-1848, 2001.
230. Yan SF, Harja E, Andrassy M, Fujita T, Schmidt AM. Protein kinase C-β/early growth response-1 pathway: a key player in ischemia, atherosclerosis, restenosis. J Am Coll Cardiol 48: A47-A55, 2006.
231. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 9: 1227-1240, 2002.
232. Yang J, Garrod SM, Deal MS, Anand GS, Woods VL Jr, Taylor S. Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol 346: 191-201, 2005.
233. Yeong SS, Zhu Y, Smith D, Verma C, Lim WG, Tan BJ, Li QT, Cheung NS, Cai M, Zhu YZ, Zhou SF, Tan SL, Duan W. The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Cα. J Biol Chem 281: 30768-30781, 2006.
234. Yoshida K, Wang HG, Miki Y, Kufe D. Protein kinase Cδ is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J 22: 1431-1441, 2003.
235. Zeidan YH, Hannun YA. Activation of acid sphingomyelinase by protein kinase Cδ-mediated phosphorylation. J Biol Chem 282: 11549-11561, 2007.
236. Zeidman R, Lofgren B, Pahlman S, Larsson C. PKCε, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells. J Cell Biol 145: 713-726, 1999.
237. Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C-δ in complex with phorbol ester. Cell 81: 917-924, 1995.
238. Zhu Y, Smith D, Verma C, Lim WG, Tan BJ, Armstrong JS, Zhou S, Chan E, Tan SL, Zhu YZ, Cheung NS, Duan W. The very C-terminus of protein kinase Cε is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1. Cell Signal 18: 807-818, 2006.
239. Ziegler WH, Parekh DB, Le Good JA, Whelan RD, Kelly JJ, Frech M, Hemmings BA, Parker PJ. Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. Curr Biol 9: 522-529, 1999.