Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

Current Biology

Volumn 9, Issue 10, 1999, Pages 522-529

  Ziegler, W H ^a,c   Parekh, D B ^a   Le Good, J A ^a   Whelan, R D H ^a   Kelly, J J ^a   Frech, M ^b   Hemmings, B A ^b   Parker, P J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0033587133     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80236-X     Document Type: Article

References (32)

1. Nishizuka Y: Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992, 258:607-614.
2. Hug H, Sarre TF: Protein kinase C isoenzymes - Divergence in signal transduction. Biochem J 1993, 291:329-343.
3. Dekker LV, Parker PJ: Protein kinase C - A question of specificity. Trends Biochem Sci 1994, 19:73-77.
4. Keranen LM, Dutil EM, Newton AC: Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 1995, 5:1394-1403.
5. Tsutakawa SE, Medzihradszky KF, Flint AJ, Burlingame AL, Koshland Jr De: Determination of in vivo phosphorylation sites in protein kinase C. J Biol Chem 1995, 270:26807-26812.
6. Bornancin F, Parker PJ: Phosphorylation of protein kinase C-α on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. J Biol Chem 1997, 272:3544-3549.
7. Hanks SK, Hunter T: Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification. FASEB J 1995, 9:576-596.
8. Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y: Protein kinase C ζ subspecies from rat brain: Its structure, expression and properties. Proc Natl Acad Sci USA 1989, 86:3099-3103.
9. Selbie LA, Schmitzpeiffer C, Sheng YH, Biden TJ: Molecular-cloning and characterization of PKC(iota), an atypical isoform of protein-kinase-C derived from insulin-secreting cells. J Biol Chem 1993, 268:24296-24302.
10. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, et al.: 3-phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 1997, 7:776-789.
11. Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, et al.: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998, 279:710-714.
12. Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, et al.: Phosphorylation and activation of p70s6k by PDK1. Science 1998, 279:707-710.
13. Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J: 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol 1998, 8:69-81.
14. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998, 281:2042-2045.
15. Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, et al.: Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol 1998, 8:1069-1077.
16. s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J 1995, 14:5279-5287.
17. Li WQ, Zhang JC, Bottaro DP, Li W, Pierce JH: Identification of serine-643 of protein-kinase C-delta as an important autophosphorylation site for its enzymatic-activity. J Biol Chem 1997, 272:24550-24555.
18. Pullen N, Thomas G: The modular phosphorylation and activation of P70S6K. FEBS Lett 1997, 410:78-82.
19. Garcia-Paramio P, Cabrerizo Y, Bornancin F, Parker PJ: The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation. Biochem J 1998, 333:631-636.
20. + transport in A6 cells. J Biol Chem 1996, 271:32468-32473.
21. Thomas G, Hall MN: TOR signalling and control of cell growth. Curr Opin Cell Biol 1997, 9:782-787.
22. Ferrari S, Pearson RB, Siegmann M, Kozma SC, Thomas G: The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites. J Biol Chem 1993, 268:16091-16094.
23. Bornancin F, Parker P: Phosphorylation of threonine-638 critically controls the dephosphorylation and inactivation of protein-kinase C-alpha. Curr Biol 1996, 6:1114-1123.
24. Heitman J, Movva NR, Hall MN: Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast Science 1991, 253:905-909.
25. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC, Abraham RT: Direct inhibition of the signaling functions of the mammalian target of rapamycin. EMBO J 1996, 15:5256-5267.
26. Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA 1998, 95:1432-1437.
27. Dennis PB, Pullen N, Kozma SC, Thomas G: The principal rapamycin-sensitive p70s6k phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol Cell Biol 1996, 16:6242-6251.
28. Mahalingam M, Templeton DJ: Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains. Mol Cell Biol 1996, 16:405-413.
29. Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J: Amino acid sufficiency and mTor regulate p70 S6 kinase and elf-4e BP1 through a common effector mechanism. J Biol Chem 1998, 273:14484-14494.
30. Olivier AR, Parker PJ: Identification of multiple PKC isoforms in Swiss 3T3 cells - Differential down-regulation by phorbol ester. J Cell Physiol 1992, 152:240-244.
31. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, et al.: Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 1993, 268:9194-9197.
32. Olivier AR, Parker PJ: Expression and characterization of PKC-δ. Eur J Biochem 1991, 200:805-810.