The ε subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation

Circulation Research

Volumn 86, Issue 3, 2000, Pages 293-301

  Doble, Bradley W ^a   Ping, Peipei ^b   Kardami, Elissavet ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Cardiomyocyte gap junction; Fibroblast growth factor 2; Phosphorylation; Protein kinase C

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CHELERYTHRINE; CONNEXIN 43; FIBROBLAST GROWTH FACTOR 2; GAP JUNCTION PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; ALKALOID; BENZOPHENANTHRIDINE DERIVATIVE; ENZYME INHIBITOR; ISOENZYME; PHENANTHRIDINE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PRKCE PROTEIN, HUMAN; PRKCE PROTEIN, RAT; PROTEIN KINASE C EPSILON; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME BINDING; ENZYME SUBUNIT; GAP JUNCTION; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL JUNCTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HEART MUSCLE; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TISSUE DISTRIBUTION;

ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; CELLS, CULTURED; CONNEXIN 43; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; GAP JUNCTIONS; HUMANS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; PHENANTHRIDINES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; RATS; RECOMBINANT PROTEINS; TETRADECANOYLPHORBOL ACETATE; TISSUE DISTRIBUTION;

EID: 0033621884     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.86.3.293     Document Type: Article

References (42)

1. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochern. 1996;65:475-502.
2. Darrow BJ, Laing JG, Lampe PD, Saffitz JE, Beyer EC. Expression of multiple connexins in cultured neonatal rat ventricular myocytes. Circ Res. 1995;76:381-387.
3. Beyer EC, Paul DL, Goodenough DA. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987;105: 2621-2629.
4. Crow DS, Kurata WE, Lau AF. Phosphorylation of connexin43 in cells containing mutant src oncogenes. Oncogene. 1992;7:999-1003.
5. Laird DW, Castillo M, Kasprzak L. Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells. J Cell Biol. 1995;131:1193-1203.
6. Musil LS, Goodenough DA. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J Cell Biol. 1991;115:1357-1374.
7. Moreno AP, Saez JC, Fishman GI, Spray DC. Human connexin43 gap junction channels: regulation of unitary conductances by phosphorylation. Circ Res. 1994;74:1050-1057.
8. Darrow BJ, Fast VG, Kleber AG, Beyer EC, Saffitz JE. Functional and structural assessment of intercellular communication: increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996;79:174-183.
9. Chanson M, White MM, Garber SS. cAMP promotes gap junctional coupling in T84 cells. Am J Physiol. 1996;271:C533-C539.
10. Atkinson MM, Lampe PD, Lin HH, Kollander R, Li XR, Kiang DT. Cyclic AMP modifies the cellular distribution of connexin43 and induces a persistent increase in the junctional permeability of mouse mammary tumor cells. J Cell Sci. 1995;108:3079-3090.
11. Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem. 1998;273:9188-9196.
12. Kwak BR, Saez JC, Wilders R, Chanson M, Fishman GI, Hertzberg EL, Spray DC, Jongsma HJ. Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels. Pflugers Arch. 1995;430: 770-778.
13. Saez JC, Nairn AC, Czernik AJ, Fishman GI, Spray DC, Hertzberg EL. Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. J Mol Cell Cardiol. 1997;29:2131-2145.
14. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J. 1995;9: 726-735.
15. Newton AC. Regulation of protein kinase C. Curr Opin Cell Biol. 1997;9: 161-167.
16. Mochly-Rosen D, Gordon AS. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J. 1998;12:35-42.
17. Doble BW, Chen Y, Bosc DG, Litchfield DW, Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ Res. 1996;79: 647-658.
18. Bogoyevitch MA, Glennon PE, Andersson MB, Clerk A, Lazou A, Marshall CJ, Parker PJ, Sugden PH. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes: the potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. J Biol Chem. 1994;269: 1110-1119.
19. Padua RR, Merle PL, Doble BW, Yu CH, Zahradka P, Pierce GN, Panagia V, Kardami E. FGF-2-induced negative inotropism and cardioprotection are inhibited by chelerythrine: involvement of sarcolemmal calcium-independent protein kinase C. J Mol Cell Cardiol. 1998;30:2695-2709.
20. Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco MT, Moscat J, Rapp U, Cooper GM. Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol. 1997;17:732-741.
21. Jordan M, Schallhorn A, Wurm FM. Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 1996;24:596-601.
22. Ping P, Zhang J, Cao X, Li RC, Kong D, Tang XL, Qiu Y, Manchikalapudi S, Auchampach JA, Black RG, Bolli R. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits. Am J Physiol. 1999;276:H1468-H1481.
23. Kobayashi E, Nakano H, Morimoto M, Tamaoki T. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1989;159:548-553.
24. Kaufmann U, Martin B, Link D, Witt K, Zeitler R, Reinhard S, Starzinski-Powitz A. M-Cadherin and its sisters in development of striated muscle. Cell Tissue Res. 1999;296:191-198.
25. Kardami E, Doble BW. Cardiomyocyte gap junctions: a target for growth factor signaling. Trends Cardiovasc Med. 1998;8:180-187.
26. Peters NS, Green CR, Poole-Wilson PA, Severs NJ. Cardiac arrhythmogenesis and the gap junction. J Mol Cell Cardiol. 1995;27:37-44.
27. Yamasaki H, Naus CC. Role of connexin genes in growth control. Carcinogenesis. 1996;17:1199-1213.
28. Hossain MZ, Ao P, Boynton AL. Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor. J Cell Physiol. 1998;174:66-77.
29. Kanemitsu MY, Lau AF. Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-O-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase. Mol Biol Cell. 1993;4:837-848.
30. Lampe PD. Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly. J Cell Biol. 1994;127:1895-1905.
31. Matesic DF, Rupp HL, Bonney WJ, Ruch RJ, Trosko JE. Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells. Mol Carcinog. 1994;10:226-236.
32. Kwak BR, Jongsma HJ. Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions. Mol Cell Biochem. 1996;157:93-99.
33. Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res. 1994;210:287-297.
34. Disatnik MH, Jones SN, Mochly-Rosen D. Stimulus-dependent subcellular localization of activated protein kinase C: a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes. J Mol Cell Cardiol. 1995;27:2473-2481.
35. Doble BW, Merle P-L, Kardami E. Involvement of protein kinase C-∈ in mediating growth factor induced phosphorylation of connexin43 at gap junctions of the intact cardiomyocyte. Circulation. 1998;98(suppl I):I-677. Abstract.
36. Calero G, Kanemitsu M, Taffet SM, Lau AF, Delmar M. A 17-mer peptide interferes with acidification-induced uncoupling of connexin43. Circ Res. 1998;82:929-935.
37. Homma N, Alvarado JL, Coombs W, Stergiopoulos K, Taffet SM, Lau AF, Delmar M. A particle-receptor model for the insulin-induced closure of connexin43 channels. Circ Res. 1998;83:27-32.
38. Stergiopoulos K, Alvarado JL, Mastroianni M, Ek-Vitorin JF, Taffet SM, Delmar M. Hetero-domain interactions as a mechanism for the regulation of connexin channels. Circ Res. 1999;84:1144-1155.
39. Acs P, Bogi K, Lorenzo PS, Marquez AM, Biro T, Szallasi Z, Blumberg PM. The catalytic domain of protein kinase C chimeras modulates the affinity and targeting of phorbol ester-induced translocation. J Biol Chem. 1997;272: 22148-22153.
40. Cope DK, Impastato WK, Cohen MV, Downey JM. Volatile anesthetics protect the ischemic rabbit myocardium from infarction. Anesthesiology. 1997;86:699-709.
41. Cacace AM, Guadagno SN, Krauss RS, Fabbro D, Weinstein IB. The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene. 1993;8:2095-2104.
42. Yamasaki H, Mesnil M, Omori Y, Mironov N, Krutovskikh V. Intercellular communication and carcinogenesis. Mutat Res. 1995;333:181-188.