Catalytic domain crystal structure of protein kinase C-θ (PKCθ)

Journal of Biological Chemistry

Volumn 279, Issue 48, 2004, Pages 50401-50409

  Xu, Zhang Bao ^a   Chaudhary, Divya ^a   Olland, Stephane ^a   Wolfrom, Scott ^a   Czerwinski, Robert ^a   Malakian, Karl ^a   Lin, Laura ^a   Stahl, Mark L ^a   Joseph McCarthy, Diane ^a   Benander, Christina ^a   Fitz, Lori ^a   Greco, Rita ^a   Somers, William S ^a,b   Mosyak, Lidia ^a,b  

^a PFIZER INC   (United States)

^b Wyeth ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; HYDROPHOBICITY; PROTEINS;

CELL ACTIVATION; CELL SYNAPSE; KINASE DOMAIN; PHOSPHORYLATION;

ENZYMES;

ADENOSINE TRIPHOSPHATE; GLYCINE; PHOSPHATE; PROTEIN KINASE C THETA; RECOMBINANT ENZYME; STAUROSPORINE;

ARTICLE; BACTERIUM; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; EXPRESSION VECTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STAUROSPORINE; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 9644264028     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409216200     Document Type: Article

References (41)

1. Cohen, P. (2002) Nat. Rev. Drug Discov. 1, 309-315
2. Jiang, T., and Qiu, Y. (2003) J. Biol. Chem. 278, 15789-15793
3. Tan, S. L., and Parker, P. J. (2003) Biochem. J. 376, 545-552
4. Arendt, C. W., Albrecht, B., Soos, T. J., and Littman, D. R. (2002) Curr. Opin. Immunol. 14, 323-330
5. Bauer, B., Krumbock, N., Fresser, F., Hochholdinger, F., Spitaler, M., Simm, A., Uberall, F., Schraven, B., and Baier, G. (2001) J. Biol. Chem. 276, 31627-31634
6. Bauer, B., Krumbock, N., Ghaffari-Tabrizi, N., Kampfer, S., Villunger, A., Wilda, M., Hameister, H., Utermann, G., Leitges, M., Uberall, F., and Baier, G. (2000) Eur. J. Immunol. 30, 3645-3654
7. Altman, A., and Villalba, M. (2003) Immunol. Rev. 192, 53-63
8. Pfeifhofer, C., Kofler, K., Gruber, T., Tabrizi, N. G., Lutz, C., Maly, K., Leitges, M., and Baier, G. (2003) J. Exp. Med. 197, 1525-1535
9. Sun, Z., Arendt, C. W., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P. L., and Littman, D. R. (2000) Nature 404, 402-407
10. Diaz-Flores, E., Siliceo, M., Martinez, A. C., and Merida, I. (2003) J. Biol. Chem. 278, 29208-29215
11. Villalba, M., and Altman, A. (2002) Curr. Cancer Drug Targets 2, 125-137
12. Huse, M., and Kuriyan, J. (2002) Cell 109, 275-282
13. Knighton, D. R., Zheng, J. H., Ten Eyck, L. F., Ashford, V. A., Xuong, N. H., Taylor, S. S., and Sowadski, J. M. (1991) Science 253, 407-414
14. Hidaka, H., Inagaki, M., Kawamoto, S., and Sasaki, Y. (1984) Biochemistry 23, 5036-5041
15. Breitenlechner, C., Gassel, M., Hidaka, H., Kinzel, V., Huber, R., Engh, R. A., and Bossemeyer, D. (2003) Structure (Lond.) 11, 1595-1607
16. Yang, J., Cron, P., Good, V. M., Thompson, V., Hemmings, B. A., and Barford, D. (2002) Nat. Struct. Biol. 9, 940-944
17. Gassel, M., Breitenlechner, C. B., Ruger, P., Jucknischke, U., Schneider, T., Huber, R., Bossemeyer, D., and Engh, R. A. (2003) J. Mol. Biol. 329, 1021-1034
18. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
19. CCP4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
20. Prade, L., Engh, R. A., Girod, A., Kinzel, V., Huber, R., and Bossemeyer, D. (1997) Structure (Lond.) 5, 1627-1637
21. Bricogne, G. (1993) Acta Crystallogr. Sect. D Biol. Crystallogr. 49, 37-60
22. Tronrud, D. E. (1997) Methods Enzymol. 277, 306-319
23. Brunger, A. T., Adams, P. D., Clore, G. M., De Lano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuzewski, J., Nigles, M., Pannu, N. S., Read, R. J., Rice, L. M., Somonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
24. De Lano, W. L. (2002) The PyMOL Molecular Graphics System, DeLano Scientific, San Carlos, CA
25. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S., and Karplus, M. (1983) J. Comput. Chem. 4, 187-217
26. MacKerell, A. D., Bashford, D., Bellott, M., Dunbrack, R. L., Evanseck, J. D., Field, M. J., Fischer, S., Gao, J., Guo, H., Ha, S., Joseph-McCarthy, D., Kuchnir, L., Kuczera, K., Lau, F. T. K., Mattos, C., Michnick, S., Ngo, T., Nguyen, D. T., Prodhom, B., Reiher, W. E., Roux, B., Schlenkrich, M., Smith, J. C., Stote, R., Straub, J., Watanabe, M., Wiorkiewicz-Kuczera, J., Yin, D., and Karplus, M. (1998) J. Phys. Chem. B 102, 3586-3616
27. Halgren, T. A. (1996) J. Comput. Chem. 17, 490-519
28. Johnson, L. N., Noble, E. M., and Owen, D. J. (1996) Cell 85, 149-158
29. Liu, Y., Graham, C., Li, A., Fisher, R. J., and Shaw, S. (2002) Biochem. J. 361, 255-265
30. Meggio, F., Donella-Deana, A., Ruzzene, M., Brunati, A. M., Cesaro, L., Guerra, B., Meyer, T., Mett, H., Fabbro, D., Furet, P., Dobrowska, G., and Pinna, L. A. (1995) Eur. J. Biochem. 234, 317-322
31. Johnson, D. A., Akamine, P., Radzio-Andzelm, E., Madhusudan, and Taylor, S. S. (2001) Chem. Rev. 101, 2243-2270
32. Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., and van Aalten, D. M. F. (2002) EMBO J. 21, 4219-4228
33. Yang, J., Cron, P., Thompson, V., Good, V. M., Hess, D., Hemmings, B. A., and Barford, D. (2002) Mol. Cell 9, 1227-1240
34. Alessi, D. R., Caudwell, F. B., Adndjelkovic, M., Hemmings, B. A., and Cohen, P. (1996) FEBS Lett. 399, 333-338
35. Newton, A. C. (2001) Chem. Rev. 101, 2353-2364
36. Nishikawa, K., Toker, A., Johannes, F.-J., Songyang, Z., and Cantley, C. L. (1997) J. Biol. Chem. 272, 952-960
37. Yonemoto, W., McGlone, M. L., Grant, B., and Taylor, S. S. (1997) Protein Eng. 10, 915-925
38. Newton, A. C. (2003) Biochem. J. 370, 361-371
39. Zheng, J., Knighton, D. R., Ten Eyck, L. F., Karlsson, R., Xuong, N. H., Taylor, S. S., and Sowadski, J. M. (1993) Biochemistry 32, 2154-2161
40. Karlsson, R., Zheng, J., Xuong, N. H., Taylor, S. S., and Sowadski, J. M. (1993) Acta Crystallogr. Sect. D Biol. Crystallogr. 49, 381-388
41. Balendran, A., Hare, G. R., Kieloeh, A., Williams, M. R., and Alessi, D. R. (2000) FEBS Lett. 484, 217-223