Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop

Journal of Molecular Biology

Volumn 346, Issue 1, 2005, Pages 191-201

  Yang, Jie ^a   Garrod, Siv M ^a   Deal, Michael S ^a   Anand, Ganesh S ^a   Woods Jr , Virgil L ^b   Taylor, Susan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

cAMP dependent protein kinase; catalytic mechanism; hydrogen deuterium exchange; long range interaction; protein dynamics

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DEUTERIUM; GLUTAMIC ACID; HYDROGEN; PROTEIN SUBUNIT; TYROSINE;

ALLOSTERISM; ANALYTIC METHOD; ARTICLE; CATALYSIS; DEUTERIUM HYDROGEN EXCHANGE; ELECTRICITY; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBUNIT; HYPOTHESIS; KINETICS; MASS SPECTROMETRY; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULE; MUTANT; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; STRUCTURE ANALYSIS; SURFACE PROPERTY;

EID: 12344334691     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.11.030     Document Type: Article

References (26)

1. D.R. Knighton, J.H. Zheng, L.F. ten Eyck, V.A. Ashford, N.H. Xuong, S.S. Taylor, and J.M. Sowadski Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase Science 253 1991 407 414
2. D.A. Johnson, P. Akamine, E. Radzio-Andzelm, M. Madhusudan, and S.S. Taylor Dynamics of cAMP-dependent protein kinase Chem. Rev. 101 2001 2243 2270
3. P. Akamine, M. Madhusudan, J. Wu, N.H. Xuong, L.F. ten Eyck, and S.S. Taylor Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure J. Mol. Biol. 327 2003 159 171
4. N. Narayana, S. Cox, X. Nguyen-huu, L.F. ten Eyck, and S.S. Taylor A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility Structure 5 1997 921 935
5. J. Zheng, D.R. Knighton, L.F. ten Eyck, R. Karlsson, N.-h. Xuong, S.S. Taylor, and J.M. Sowadski Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor Biochemistry 32 1993 2154 2161
6. Madhusudan, M. Akamine, N.H. Xuong, and T. SS Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase Nature Struct. Biol. 9 2002 273 277
7. J. Yang, L.F. ten Eyck, N.H. Xuong, and S.S. Taylor Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism J. Mol. Biol. 336 2004 473 487
8. S.S. Taylor, J. Yang, J. Wu, N.M. Haste, E. Radzio-Andzelm, and G. Anand PKA: a portrait of protein kinase dynamics Biochim. Biophys. Acta 1697 2004 259 269
9. Z. Zhang, and D.L. Smith Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation Protein Sci. 2 1993 522 531
10. A.N. Hoofnagle, K.A. Resing, and N.G. Ahn Protein analysis by hydrogen exchange mass spectrometry Annu. Rev. Biophys. Biomol. Struct. 32 2003 1 25
11. A. Baerga-Ortiz, C.A. Hughes, J.G. Mandell, and E.A. Komives Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved protein Protein Sci. 11 2002 1300 1308
12. V.L. Woods Jr, and Y. Hamuro High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: utility in pharmaceutical design J. Cell. Biochem. Suppl. 37 2001 89 98
13. G.S. Anand, D. Law, J.G. Mandell, A.N. Snead, I. Tsigelny, and S.S. Taylor Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking Proc. Natl Acad. Sci. USA 100 2003 13264 13269
14. Y. Hamuro, G.S. Anand, J.S. Kim, C. Juliano, D.D. Stranz, S.S. Taylor, and V.L. Woods Jr Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase a by amide hydrogen/deuterium exchange mass spectrometry (DXMS) J. Mol. Biol. 340 2004 1185 1196
15. G.S. Anand, C.A. Hughes, J.M. Jones, S.S. Taylor, and E.A. Komives Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A J. Mol. Biol. 323 2002 377 386
16. Y. Hamuro, K.M. Zawadzki, J.S. Kim, D.D. Stranz, S.S. Taylor, and V.L. Woods Jr Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS) J. Mol. Biol. 327 2003 1065 1076
17. Y. Hamuro, L. Burns, J. Canaves, R. Hoffman, S. Taylor, and V. Woods Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS) J. Mol. Biol. 321 2002 703 714
18. B.D. Grant, I. Tsigelny, J.A. Adams, and S.S. Taylor Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit Protein Sci. 5 1996 1316 1324
19. M.J. Moore, J.A. Adams, and S.S. Taylor Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop J. Biol. Chem. 278 2003 10613 10618
20. I. Tsigelny, B.D. Grant, S.S. Taylor, and L.F. ten Eyck Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition Biopolymers 39 1996 353 365
21. F.W. Herberg, M.L. Doyle, S. Cox, and S.S. Taylor Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase Biochemistry 38 1999 6352 6360
22. M.D. Andersen, J. Shaffer, P.A. Jennings, and J.A. Adams Structural characterization of protein kinase A as a function of nucleotide binding. Hydrogen-deuterium exchange studies using matrix-assisted laser desorption ionization-time of flight mass spectrometry detection J. Biol. Chem. 276 2001 14204 14211
23. C. Kim, N.-H. Xuong, and S.S. Taylor Crystal structure of a complex between the catalytic and regulatory (RI alpha) subunits of PKA Science 2004 In the press
24. S.W. Lockless, and R. Ranganathan Evolutionarily conserved pathways of energetic connectivity in protein families Science 286 1999 295 299
25. F. Li, M. Gangal, C. Juliano, E. Gorfain, S.S. Taylor, and D.A. Johnson Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase J. Mol. Biol. 315 2002 459 469
26. T. Lee, A.N. Hoofnagle, Y. Kabuyama, J. Stroud, X. Min, and E.J. Goldsmith Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry Mol. Cell. 14 2004 43 55