Specificity of action of bisindolylmaleimide protein kinase C inhibitors: Do they inhibit the 70 kDa ribosomal S6 kinase in cardiac myocytes?

Biochemical Pharmacology

Volumn 68, Issue 10, 2004, Pages 1923-1928

  Roberts, Neil A ^a   Marber, Michael S ^a   Avkiran, Metin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Bisindolylmaleimides; Cardiac myocytes; Drug selectivity; Protein kinase C; Ribosomal S6 kinases

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C INHIBITOR; PROTEIN S6; RAPAMYCIN; S6 KINASE; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE CELL; HEART VENTRICLE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ENZYME INHIBITORS; INDOLES; INSULIN-LIKE GROWTH FACTOR I; MALE; MALEIMIDES; MYOCYTES, CARDIAC; PROTEIN KINASE C; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

EID: 5144230416     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.07.040     Document Type: Article

References (35)

1. D. Toullec, P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, and M. Ajakane The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C J. Biol. Chem. 266 24 1991 15771 15781
2. P.D. Davis, C.H. Hill, E. Keech, G. Lawton, J.S. Nixon, and A.D. Sedgwick Potent selective inhibitors of protein kinase C FEBS Lett. 259 1 1989 61 63
3. Y. Pi, and J.W. Walker Diacylglycerol and fatty acids synergistically increase cardiomyocyte contraction via activation of PKC Am. J. Physiol. 279 1 2000 H26 H34
4. i-proteins and protein kinase C-isozymes Naunyn Schmiedebergs Arch. Pharmacol. 360 3 1999 301 308
5. M. Kitakaze, K. Node, T. Minamino, K. Komamura, H. Funaya, and Y. Shinozaki Role of activation of protein kinase C in the infarct size-limiting effect of ischemic preconditioning through activation of ecto-5'-nucleotidase Circulation 93 4 1996 781 791
6. + current in human and rabbit ventricular myocytes Circ. Res. 78 3 1996 492 498
7. 2+ signaling in guinea-pig ventricular myocytes: role of protein kinase C J. Mol. Cell. Cardiol. 31 3 1999 631 643
8. - channel function in guinea pig ventricular myocytes Am. J. Physiol. 275 1 part 1 1998 C293 C302
9. i in guinea pig ventricular myocytes Am. J. Physiol. 279 4 2000 661 668
10. M. Pucéat, O. Clement-Chomienne, A. Terzic, and G. Vassort α1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells Am. J. Physiol. 264 2 part 2 1993 H310 H319
11. + exchanger Circ. Res. 86 2000 214 220
12. + exchanger. Evidence for a receptor-mediated mechanism involving protein kinase C Circ. Res. 79 4 1996 705 715
13. 2 receptors Circ. Res. 85 1999 919 930
14. +exchange pathway J. Mol. Cell. Cardiol. 32 8 2000 1415 1427
15. + exchange in rat ventricular myocytes Anesthesiology 94 6 2001 1096 1104
16. + exchange by hydrogen peroxide in adult rat ventricular myocytes Cardiovasc. Res. 53 2 2002 470 480
17. D.R. Alessi The protein kinase C inhibitors Ro 318220 and GF109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70 S6 kinase FEBS Lett. 402 2-3 1997 121 123
18. S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351 part 1 2000 95 105
19. H. Takano, I. Komuro, Y. Zou, S. Kudoh, T. Yamazaki, and Y. Yazaki Activation of p70 S6 protein kinase is necessary for angiotensin II-induced hypertrophy in neonatal rat cardiac myocytes FEBS Lett. 379 3 1996 255 259
20. S6K Am. J. Physiol. 276 4 part 2 1999 H1393 H1398
21. L. Pesce, A. Comellas, and J.I. Sznajder Beta-adrenergic agonists regulate Na-K-ATPase via p70S6k Am. J. Physiol. 285 4 2003 L802 L807
22. H.R. Bandi, S. Ferrari, J. Krieg, H.E. Meyer, and G. Thomas Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum J. Biol. Chem. 268 6 1993 4530 4533
23. R.S. Haworth, and M. Avkiran Inhibition of protein kinase D by resveratrol Biochem. Pharmacol. 62 12 2001 1647 1651
24. -/- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway Mol. Cell. Biol. 24 8 2004 3112 3124
25. R.L. Erikson Structure, expression and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6 J. Biol. Chem. 266 10 1991 1600 6007
26. J. Chung, C.J. Kuo, G.R. Crabtree, and J. Blenis Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kDa S6 protein kinases Cell 69 7 1992 1227 1236
27. M.A. Mamas, and D.A. Terrar Actions of arachidonic acid on contractions and associated electrical activity in guinea-pig isolated ventricular myocytes Exp. Physiol. 86 4 2001 437 449
28. M.G. Kazanietz, M.J. Caloca, P. Eroles, T. Fujii, M.L. Garcia-Bermejo, and M. Reilly Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties Biochem. Pharmacol. 60 10 2000 1417 1424
29. O. Aharonovitz, S. Aboulafia-Etzion, J. Leor, A. Battler, and Y. Granot Stimulation of 42/44 kDa mitogen-activated protein kinases by arginine vasopressin in rat cardiomyocytes Biochim. Biophys. Acta 1401 1 1998 105 111
30. Vijayan K, Szotek EL, Martin JL, Samarel AM. Protein Kinase Cα-induced hypertrophy of neonatal rat ventricular myocytes. Am J Physiol 2004; in press.
31. I. Allue, O. Gandelman, E. Dementieva, N. Ugarova, and P. Cobbold Evidence for rapid consumption of millimolar concentrations of cytoplasmic ATP during rigor-contracture of metabolically compromised single cardiomyocytes Biochem. J. 319 part 2 1996 463 469
32. K.M. Hannan, G. Thomas, and R.B. Pearson Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex Biochem. J. 370 part 2 2003 469 477
33. J. Beltman, F. McCormick, and S.J. Cook The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and activates Jun N-terminal kinase J. Biol. Chem. 271 43 1996 27018 27024
34. S. Yamamoto, K. Seta, C. Morisco, S.F. Vatner, and J. Sadoshima Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes J. Mol. Cell. Cardiol. 33 10 2001 1829 1848
35. A. Clerk Death by protein kinase C inhibitor: a stressful event J. Mol. Cell. Cardiol. 33 10 2001 1773 1776