Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes

EMBO Journal

Volumn 24, Issue 22, 2005, Pages 3869-3880

  Thuille, Nikolaus ^a   Heit, Isabelle ^b   Fresser, Friedrich ^a   Krumböck, Nina ^a   Bauer, Birgit ^a   Leuthaeusser, Sabine ^b   Dammeier, Sascha ^b   Graham, Caroline ^c   Copeland, Terry D ^c   Shaw, Steve ^c   Baier, Gottfried ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b ALTANA PHARMA AG   (Germany)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Autophosphorylation; Cellular function; IL 2 activation; PKC ; T cells

Indexed keywords

CD3 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; PHORBOL ESTER; PROTEIN KINASE B; PROTEIN KINASE C THETA; THREONINE; TRANSCRIPTION FACTOR NFAT; VANADIC ACID;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MUTATION; MYRISTYLATION; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

CELL MEMBRANE; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-2; ISOENZYMES; JURKAT CELLS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THREONINE; TRANS-ACTIVATION (GENETICS);

EID: 27844439874     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600856     Document Type: Article

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