Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 51, 2006, Pages 19466-19471

  Skaggs, Brian J ^a   Gorre, Mercedes E ^a   Ryvkin, Ann ^a,b   Burgess, Michael R ^a   Xie, Yongming ^a   Han, Yun ^c   Komisopoulou, Evangelia ^a,b   Brown, Lauren M ^a,b   Loo, Joseph A ^a,c   Landaw, Elliot M ^a   Sawyers, Charles L ^a,b,d   Graeber, Thomas G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Chronic myelogenous leukemia; Dasatinib; Imatinib; Kinase inhibitor resistance; Phosphoproteomics

Indexed keywords

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; ALANINE; BCR ABL PROTEIN; ISOLEUCINE; PROTEIN P21; PROTEOME; THREONINE; TYROSINE;

ARTICLE; CANCER RESISTANCE; CARCINOGENICITY; CHRONIC MYELOID LEUKEMIA; DISEASE COURSE; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RELAPSE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, NEOPLASM; FUSION PROTEINS, BCR-ABL; MASS SPECTROMETRY; MICE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEOMICS;

PYRONIA TITHONUS;

EID: 33845893074     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609239103     Document Type: Article

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