PKCε controls the traffic of β1 integrins in motile cells

EMBO Journal

Volumn 21, Issue 14, 2002, Pages 3608-3619

  Ivaska, Johanna ^a   Whelan, Richard D H ^a   Watson, Rose ^a   Parker, Peter J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Integrin; Migration; Protein kinase C; Trafficking

Indexed keywords

BETA1 INTEGRIN; CYTOSKELETON PROTEIN; ISOENZYME; PAXILLIN; PHOSPHOPROTEIN; PRIMER DNA; PRKCE PROTEIN, MOUSE; PROTEIN KINASE C; PROTEIN KINASE C EPSILON; PXN PROTEIN, MOUSE;

ANIMAL; ARTICLE; CELL LINE; CELL MOTION; CONFOCAL MICROSCOPY; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PROTEIN TRANSPORT; ANIMAL CELL; CATALYSIS; CELL MIGRATION; CELL MOTILITY; CYTOSOL; ELECTRON MICROSCOPY; ENERGY; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; ANTIGENS, CD29; BASE SEQUENCE; CELL LINE; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DNA PRIMERS; ISOENZYMES; MICE; MICROSCOPY, CONFOCAL; PAXILLIN; PHOSPHOPROTEINS; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; PROTEIN TRANSPORT;

ANIMALIA;

EID: 0037099313     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf371     Document Type: Article

References (33)

1. Complexes of tetraspanins with integrins: More than meets the eye
2. Circulating integrins: α5β1, α6β4 and Mac-1, α3β1, α4β1 or LFA-1
3. Moving membrane up to the front of migrating cells
4. Distribution of ferritin receptors and coated pits on giant HeLa
5. Protein kinase Cε is required for macrophage activation and against bacterial infection
6. Differential translocation of protein kinase Cε during HeLa cell adhesion to a gelatin substratum
7. Cell migration: GAPs between membrane traffic and the cytoskeleton
8. The AP-1 adaptor complex binds to immature secretory granules from cells and is regulated by ADP-ribosylation factor
9. Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cε upon cell passage
10. Integrin signaling
11. G proteins and small GTPases: Distant relatives keep in touch
12. Cell migration - Movin' on
13. Protein kinase Cδ involvement in mammary tumor cell metastasis
14. Receptor tyrosine kinase signaling required for integrin αVβ5-directed cell motility but not adhesion on vitronectin
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Differential dynamics of α5 integrin, paxillin and α-actinin during formation and disassembly of adhesions in migrating cells
17. PKCα regulates β1 integrin-dependent cell motility through association and control of integrin traffic
18. Integrin dynamics on the tail region of migrating fibroblasts
19. Cis-polyunsaturated fatty acids stimulate β1 integrin-mediated of human breast carcinoma cells to type IV collagen by activating protein kinases C-ε and -μ
20. Multiple pathways control protein kinase C phosphorylation
21. Breast cancer cell invasiveness: Correlation with protein kinase C activity and differential regulation by phorbol ester in estrogen receptor-positive and -negative cells
22. Dynamics of β1 integrin-mediated adhesive contacts in motile fibroblasts
23. Integrin ligation and PKC activation are required for migration of colon carcinoma cells
24. PDGF-regulated rab4-dependent recycling of αvβ3 integrin endosomes is necessary for cell adhesion and spreading
25. CD9, but not other tetraspans, associates with the β1 integrin precursor
26. Expression, purification and characterization of protein kinase C-ε
27. Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes
28. Overexpression of protein kinase Cα in MCF-10A human breast cells engenders dramatic alterations in morphology, proliferation and motility
29. Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor
30. Requirement for protein kinase Cθ for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells
31. A novel 115-kD peripheral membrane protein is required for intercisternal transport in the Golgi stack
32. Protein kinase C involvement in focal adhesion formation
33. A monoclonal antibody recognising the site of limited proteolysis of protein kinase C