The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1

Journal of Biological Chemistry

Volumn 276, Issue 22, 2001, Pages 19588-19596

  Gao, Tianyan ^a   Toker, Alex ^b   Newton, Alexandra C ^a  

^a San Diego   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBICITY; IMMUNOLOGY; PRECIPITATION (CHEMICAL);

AUTOPHOSPHORYLATION;

ENZYMES;

ENZYME; PHOSPHOINOSITIDE DEPENDENT KINASE; PROTEIN KINASE C; UNCLASSIFIED DRUG; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE; COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; ISOENZYME; PROTEIN KINASE C BETA; PROTEIN SERINE THREONINE KINASE;

ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOPRECIPITATION; IN VIVO STUDY; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; GENETIC TRANSFECTION; METABOLISM; MUTATION; PHOSPHORYLATION; PLASMID; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RAT; SERODIAGNOSIS;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CELL LINE; DNA, COMPLEMENTARY; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0035380478     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101357200     Document Type: Article

References (36)

1. Toker, A., and Newton, A. (2000) Cell 103, 185-188
2. Johnson, L. N., and O'Reilly, M. (1996) Curr. Opin. Struct. Biol. 6, 762-769
3. Yonemoto, W., McGlone, M. L., and Taylor, S. S. (1993) J. Biol. Chem. 268, 2348-2352
4. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
5. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
6. Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., and Avruch, J. (1998) Curr. Biol. 8, 69-81
7. Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C. S., Newton, A. C., Schaffhausen, B. S., and Toker, A. (1998) Curr. Biol. 8, 1069-1077
8. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science 281, 2042-2045
9. Dutil, E. M., Toker, A., and Newton, A. C. (1998) Curr. Biol. 8, 1366-1375
10. Vanhaesebroeck, B., and Alessi, D. R. (2000) Biochem. J. 346, 561-576
11. Toker, A. (2000) Mol. Pharmacol. 57, 652-658
12. Bornancin, F., and Parker, P. J. (1996) Curr. Biol. 6, 1114-1123
13. Bornancin, F., and Parker, P. J. (1997) J. Biol. Chem. 272, 3544-3549
14. Edwards, A. S., and Newton, A. C. (1997) J. Biol. Chem. 272, 18382-18390
15. Edwards, A. S., Faux, M. C., Scott, J. D., and Newton, A. C. (1999) J. Biol. Chem. 274, 6461-6488
16. Nishizuka, Y. (1995) FASEB J. 9, 484-496
17. Newton, A. C. (1997) Curr. Opin. Cell Biol. 9, 161-167
18. Johnson, J. E., Giorgione, J., and Newton, A. C. (2000) Biochemistry 39, 11360-11369
19. Keranen, L. M., Dutil, E. M., and Newton, A. C. (1995) Curr. Biol. 5, 1394-1403
20. Behn-Krappa, A., and Newton, A. C. (1999) Curr. Biol. 9, 728-737
21. Sweatt, J. D., Atkins, C. M., Johnson, J., English, J. D., Roberson, E. D., Chen, S. J., Newton, A., and Klann, E. (1998) J. Neurochem. 71, 1075-1085
22. Orr, J. W., and Newton, A. C. (1994) J. Biol. Chem. 269, 27715-27718
23. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., and Alessi, D. R. (1999) Curr. Biol. 9, 393-404
24. Orr, J. W., Keranen, L. M., and Newton, A. C. (1992) J. Biol. Chem. 267, 15263-15266
25. Keranen, L. M., and Newton, A. C. (1997) J. Biol. Chem. 272, 25959-25967
26. Dutil, E. M., and Newton, A. C. (2000) J. Biol. Chem. 275, 10697-10701
27. Orr, J. W., and Newton, A. C. (1994) J. Biol. Chem. 269, 8383-8387
28. Dutil, E. M., Keranen, L. M., DePaoli-Roach, A. A., and Newton, A. C. (1994) J. Biol. Chem. 269, 29359-29362
29. Toker, A., and Newton, A. C. (2000) J. Biol. Chem. 275, 8271-8274
30. Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., and Alessi, D. R. (2000) EMBO J. 19, 979-988
31. Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., and Alessi, D. R. (2000) Curr. Biol. 10, 439-448
32. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Science 277, 567-570
33. Knighton, D. R., Zheng, J., Ten Eyck, L. F., Ashford, V. A., Xuong, N.-H., Taylor, S. S., and Sowadski, J. M. (1991) Science 253, 407-414
34. Frodin, M., Jensen, C. J., Merienne, K., and Gammeltoft, S. (2000) EMBO J. 19, 2924-2934
35. Ziegler, W. H., Parekh, D. B., Le Good, J. A., Whelan, R. D., Kelly, J. J., Frech, M., Hemmings, B. A., and Parker, P. J. (1999) Curr. Biol. 9, 522-529
36. Andjelkovic, M., Maira, S.-M., Cron, P., Parker, P. J., and Hemmings, B. A. (1999) Mol. Cell. Biol. 19, 5061-5072