Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms

Journal of Biological Chemistry

Volumn 281, Issue 44, 2006, Pages 33773-33788

  Pu, Yongmei ^a   Peach, Megan L ^b   Garfield, Susan H ^a   Wincovitch, Stephen ^a   Marquez, Victor E ^c   Blumberg, Peter M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROSTATICS; ENZYMES; ESTERS; GLYCEROL;

ISOFORMS; LIGANDS; PROTEIN KINASE C (PKC); ZINC FINGER STRUCTURE;

AMINO ACIDS;

ARGININE; DIACYLGLYCEROL; ISOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C GAMMA; TRITIUM;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL MEMBRANE; CONTROLLED STUDY; ELECTRICITY; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; CELL LINE, TUMOR; CELL MEMBRANE; COMPUTATIONAL BIOLOGY; CRICETINAE; ELECTROSTATICS; HUMANS; IONS; ISOENZYMES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SEQUENCE ALIGNMENT;

EID: 33845946450     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606560200     Document Type: Article

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