Transcriptional control of energy homeostasis by the estrogen-related receptors

Endocrine Reviews

Volumn 29, Issue 6, 2008, Pages 677-696

  Giguère, Vincent ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN RECEPTOR; CELL NUCLEUS RECEPTOR; ESTROGEN RELATED RECEPTOR ALPHA; ESTROGEN RELATED RECEPTOR BETA; ESTROGEN RELATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; AMINO TERMINAL SEQUENCE; B LYMPHOCYTE; BIOGENESIS; CANCER CELL; CELL FUNCTION; CELL SURVIVAL; DIABETES MELLITUS; DNA BINDING; ENERGY BALANCE; ENERGY METABOLISM; FATTY ACID OXIDATION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HEART FAILURE; HEART FUNCTION; HOMEOSTASIS; HUMAN; INTESTINE; KNOCKOUT MOUSE; LIPID METABOLISM; LIPOGENESIS; MITOCHONDRION; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; ENDOCRINE SYSTEM; ENERGY METABOLISM; HOMEOSTASIS; HUMANS; RECEPTORS, ESTROGEN; TRANS-ACTIVATION (GENETICS);

EID: 53849088227     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/er.2008-0017     Document Type: Review

References (170)

1. Desvergne B, Michalik L, Wahli W 2006 Transcriptional regulation of metabolism. Physiol Rev 86:465-514
2. Evans RM 1988 The steroid and thyroid hormone receptor super-family. Science 240:889-895
3. Kronenberg HM, Melmed S, Polonsky KS, Larsen PR 2007 Williams textbook of endocrinology. 11th ed. Philadelphia: Saunders
4. Kliewer SA, Lehmann JM, Willson TM 1999 Orphan nuclear receptors: shifting endocrinology into reverse. Science 284:757-760
5. Giguère V 1999 Orphan nuclear receptors: from gene to function. Endocr Rev 20:689-725
6. Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E 2007 The nuclear receptor LXR is a glucose sensor. Nature 445:219-223
7. Sladek R, Giguère V 2000 Orphan nuclear receptors: an emerging family of metabolic regulators. Adv Pharmacol 47:23-87
8. Hummasti S, Tontonoz P 2008 Adopting new orphans into the family of metabolic regulators. Mol Endocrinol 22:1743-1753
9. Stafford JM, Waltner-Law M, Granner DK 2000 Role of accessory factors and SRC1 in the regulation of PEPCK gene transcription by glucocorticoids. J Biol Chem 276:3811-3819
10. Louet JF, Hayhurst G, Gonzalez FJ, Girard J, Decaux JF 2002 The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 α and cAMP-response element-binding protein (CREB). J Biol Chem 277:37991-38000
11. Giguère V 2002 To ERR in the estrogen pathway. Trends Endocrinol Metab 13:220-225
12. Tremblay AM, Giguère V 2007 The NR3B subgroup: an ovERR-view. Nucl Recept Signal 5:e009
13. Bardet PL, Laudet V, Vanacker JM 2006 Studying non-mammalian models? Not a fool's ERRand! Trends Endocrinol Metab 17:166-171
14. Bonnelye E, Aubin JE 2005 Estrogen receptor-related receptor α: a mediator of estrogen response in bone. J Clin Endocrinol Metab 90:3115-3121
15. Ariazi EA, Jordan VC 2006 Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem 6:203-215
16. Stein RA, McDonnell DP 2006 Estrogen-related receptor α as a therapeutic target in cancer. Endocr Relat Cancer 13(Suppl 1):S25-S32
17. Giguère V, Yang N, Segui P, Evans RM 1988 Identification of a new class of steroid hormone receptors. Nature 331:91-94
18. Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmage CB, Cheng JJ, Kimberling WJ, Sumegi J 1998 Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41. Genomics 50:382-384
19. Heard DJ, Norby PL, Holloway J, Vissing H 2000 Human ERRγ, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol Endocrinol 14:382-392
20. Hong H, Yang L, Stallcup MR 1999 Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem 274:22618-22626
21. Tremblay AM, Wilson BJ, Yang XJ, Giguère V 2008 Phosphorylation-dependent sumoylation regulates ERRα and γ transcriptional activity through a synergy control motif. Mol Endocrinol 22:570-584
22. Vu EH, Kraus RJ, Mertz JE 2007 Phosphorylation-dependent sumoylation of estrogen-related receptor α1. Biochemistry (Mosc) 46:9795-9804
23. Yang XJ, Gregoire S 2006 A recurrent phospho-sumoyl switch in transcriptional repression and beyond. Mol Cell 23:779-786
24. Iniguez-Lluhi JA, Pearce D 2000 A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol 20:6040-6050
25. Sladek R, Bader J-A, Giguère V 1997 The orphan nuclear receptor estrogen-related receptor α is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol 17:5400-5409
26. Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguère V 2007 Genomewide orchestration of cardiac functions by orphan nuclear receptors ERRα and γ. Cell Metab 5:345-356
27. Barry JB, Laganière J, Giguère V 2006 A single nucleotide in an estrogen related receptor α site can dictate mode of binding and PGC-1α activation of target promoters. Mol Endocrinol 20:302-310
28. Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE 2003 Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol 327:819-832
29. Huppunen J, Aarnisalo P 2004 Dimerization modulates the activity of the orphan nuclear receptor ERRγ. Biochem Biophys Res Commun 314:964-970
30. Johnston SD, Liu X, Zuo F, Eisenbraun TL, Wiley SR, Kraus RJ, Mertz JE 1997 Estrogen-related receptor α1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol 11:342-352
31. Vanacker J-M, Bonnelye E, Chopin-Delannoy S, Delmarre C, Cavailles V, Laudet V 1999 Transcriptional activities of the orphan nuclear receptor ERR α (estrogen receptor-related receptor-α). Mol Endocrinol 13:764-773
32. Vanacker JM, Pettersson K, Gustafsson J, Laudet V 1999 Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ. EMBO J 18:4270-4279
33. Yang N, Shigeta H, Shi HP, Teng CT 1996 Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J Biol Chem 271:5795-5804
34. Zhang Z, Teng CT 2000 Estrogen receptor-related receptor α 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene. J Biol Chem 275:20837-20846
35. Nettles KW, Greene GL 2005 Ligand control of coregulator recruitment to nuclear receptors. Annu Rev Physiol 67:309-333
36. Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dirsselaer A, Moras D, Renaud JP 2002 Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Mol Cell 9:303-313
37. Kallen J, Lattmann R, Beerli R, Blechschmidt A, Blommers MJ, Geiser M, Ottl J, Schlaeppi JM, Strauss A, Fournier B 2007 Crystal structure of human estrogen-related receptor α in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem 282:23231-23239
38. Kallen J, Schlaeppi JM, Bitsch F, Filipuzzi I, Schilb A, Riou V, Graham A, Strauss A, Geiser M, Fournier B 2004 Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor α (ERRα): crystal structure of ERRα ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1α. J Biol Chem 279:49330-49337
39. Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT 2006 X-ray crystal structures of the estrogen-related receptor-γ ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J Biol Chem 281:37773-37781
40. Coward P, Lee D, Hull MV, Lehmann JM 2001 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ. Proc Natl Acad Sci USA 98:8880-8884
41. Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader J-A, Rossant J, Giguère V 2001 Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERRβ. Genes Dev 15:833-838
42. Tremblay GB, Bergeron D, Giguère V 2001 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors β and γ. Endocrinology 142:4572-4575
43. Busch BB, Stevens Jr WC, Martin R, Ordentlich P, Zhou S, Sapp DW, Horlick RA, Mohan R 2004 Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor α. J Med Chem 47:5593-5596
44. Willy PJ, Murray IR, Qian J, Busch BB, Stevens Jr WC, Martin R, Mohan R, Zhou S, Ordentlich P, Wei P, Sapp DW, Horlick RA, Heyman RA, Schulman IG 2004 Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand. Proc Natl Acad Sci USA 101:8912-8917
45. Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ 2006 Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ. Bioorg Med Chem Lett 16:821-824
46. Yu DD, Forman BM 2005 Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg Med Chem Lett 15: 1311-1313
47. Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM 2005 Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J Med Chem 48:3107-3109
48. Lonard DM, Lanz RB, O'Malley BW 2007 Nuclear receptor coregulators and human disease. Endocr Rev 28:575-587
49. Lonard DM, O'Malley BW 2007 Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell 27:691-700
50. Feige JN, Auwerx J 2007 Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol 17:292-301
51. Lin J, Handschin C, Spiegelman BM 2005 Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361-370
52. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM 2005 Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metab 1:259-271
53. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP 2005 PGC-1α deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 3:e101
54. Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM 2006 Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab 3:333-341
55. Knutti D, Kralli A 2001 PGC-1, a versatile coactivator. Trends Endocrinol Metab 12:360-365
56. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC 2003 PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273
57. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM 2004 Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice. Cell 119:121-135
58. Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler IE, Mock DC, Bataille AR, Robert F, Lee C-H, Giguère V, Evans RM 2007 Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ induced host defense. Genes Dev 21:1909-1920
59. Rohas LM, St-Pierre J, Uldry M, Jager S, Handschin C, Spiegelman BM 2007 A fundamental system of cellular energy homeostasis regulated by PGC-1α. Proc Natl Acad Sci USA 104: 7933-7938
60. Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM 2007 PGC-1β controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci USA 104:5223-5228
61. Rodriguez-Calvo R, Jove M, Coll T, Camins A, Sanchez RM, Alegret M, Merlos M, Pallas M, Laguna JC, Vazquez-Carrera M 2006 PGC-1β down-regulation is associated with reduced ERRα activity and MCAD expression in skeletal muscle of senescence-accelerated mice. J Gerontol A Biol Sci Med Sci 61:773-780
62. Jeong JW, Kwak I, Lee KY, White LD, Wang XP, Brunicardi FC, O'Malley BW, DeMayo FJ 2006 The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism. Mol Endocrinol 20:1138-1152
63. Picard F, Géhin M, Annicotte J-S, Rocchi S, Champy M-F, O'Malley BW, Chambon P, Auwerx J 2002 SRC-1 and TIF2 control energy balance between white and brown adipose tissue. Cell 111: 931-941
64. Louet JF, Coste A, Amazit L, Tannour-Louet M, Wu RC, Tsai SY, Tsai MJ, Auwerx J, O'Malley BW 2006 Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci USA 103:17868-17873
65. Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy JK, Evans RM, Rosenfeld MG, Hunter T 2006 Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab 3:111-122
66. Christian M, White R, Parker MG 2006 Metabolic regulation by the nuclear receptor corepressor RIP140. Trends Endocrinol Metab 17: 243-250
67. Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG 2004 Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci USA 101:8437-8442
68. Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R, Parker M 2007 The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle. Cell Metab 6:236-245
69. Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP 2006 Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest 116:125-136
70. Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM 1999 Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. Mol Endocrinol 13:2151-2162
71. Huss JM, Kopp RP, Kelly DP 2002 Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ. Identification of novel leucine-rich interaction motif within PGC-1α. J Biol Chem 277:40265-40274
72. Laganière J, Tremblay GB, Dufour CR, Giroux S, Rousseau F, Giguère V 2004 A polymorphic autoregulatory hormone response element in the human estrogen related receptor α (ERRα) promoter dictates PGC-1α control of ERRα expression. J Biol Chem 279: 18504-18510
73. Schreiber SN, Knutti D, Brogli K, Uhlmann T, Kralli A 2003 The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor ERRα. J Biol Chem 278:9013-9018
74. Gaillard S, Dwyer MA, McDonnell DP 2007 Definition of the molecular basis for estrogen receptor-related receptor-α-cofactor interactions. Mol Endocrinol 21:62-76
75. Kamei Y, Ohizumi H, Fujitani Y, Nemoto T, Tanaka T, Takahashi N, Kawada T, Miyoshi M, Ezaki O, Kakizuka A 2003 PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci USA 100:12378-12383
76. Greschik H, Althage M, Flaig R, Sato Y, Peluso-Iltis C, Chavant V, Choulier L, Cronet P, Rochel N, Schule R, Stromstedt PE, Moras D 2008 Communication between the ERRα homodimer interface and the PGC-1α binding surface via the helix 8-9 loop. J Biol Chem 283:20220-20230
77. Horard B, Castet A, Bardet PL, Laudet V, Cavailles V, Vanacker JM 2004 Dimerization is required for transactivation by estrogen-receptor-related (ERR) orphan receptors: evidence from amphioxus ERR. J Mol Endocrinol 33:493-509
78. Barry JB, Giguère V 2005 Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor α. Cancer Res 65:6120-6129
79. Augereau P, Badia E, Carascossa S, Castet A, Fritsch S, Harmand PO, Jalaguier S, Cavailles V 2006 The nuclear receptor transcriptional coregulator RIP140. Nucl Recept Signal 4:e024
80. Castet A, Herledan A, Bonnet S, Jalaguier S, Vanacker JM, Cavailles V 2006 Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol Endocrinol 20:1035-1047
81. Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker MG, White R 2007 Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor α. Mol Endocrinol 21:1581-1592
82. Sanyal S, Matthews J, Bouton D, Kim HJ, Choi HS, Treuter E, Gustafsson JA 2004 Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor γ. Mol Endocrinol 18:312-325
83. Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2006 Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126:789-799
84. Ichida M, Nemoto S, Finkel T 2002 Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-α). J Biol Chem 277:50991-50995
85. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2005 A nuclear receptor atlas: 3T3-L1 adipogenesis. Mol Endocrinol 19:2437-2450
86. Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM 2005 A nuclear receptor atlas: macrophage activation. Mol Endocrinol 19:2466-2477
87. Gofflot F, Chartoire N, Vasseur L, Heikkinen S, Dembele D, Le Merrer J, Auwerx J 2007 Systematic gene expression mapping clusters nuclear receptors according to their function in the brain. Cell 131:405-418
88. Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM 2006 Nuclear receptor expression links the circadian clock to metabolism. Cell 126:801-810
89. Cartoni R, Leger B, Hock MB, Praz M, Crettenand A, Pich S, Ziltener JL, Luthi F, Deriaz O, Zorzano A, Gobelet C, Kralli A, Russell AP 2005 Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise. J Physiol 567: 349-358
90. Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM 2004 ERRα and GABPAα/β specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 101:6570-6575
91. Liu D, Zhang Z, Teng CT 2005 Estrogen-related receptor-γ and peroxisome proliferator-activated receptor-γ coactivator-1α regulate estrogen-related receptor-α gene expression via a conserved multi-hormone response element. J Mol Endocrinol 34:473-487
92. Schulz H 1991 β-Oxidation of fatty acids. Biochim Biophys Acta 1081:109-120
93. Nagao M, Parimoo B, Tanaka K 1993 Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat. J Biol Chem 268:24114-24124
94. Hainline BE, Kahlenbeck DJ, Grant J, Strauss AW 1993 Tissue specific and developmental expression of rat long- and medium-chain acyl-CoA dehydrogenases. Biophysica et Biochemica Acta 1216:460-468
95. Leone TC, Cresci S, Carter ME, Zhang ZF, Lala DS, Strauss AW, Kelly DP 1995 The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites. J Biol Chem 270: 16308-16314
96. Carter ME, Gulick T, Moore DD, Kelly DP 1994 A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs. Mol Cell Biol 14:4360-4372
97. Carter ME, Gulick T, Raisher BD, Caira T, Ladias JAA, Moore DD, Kelly DP 1993 Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. J Biol Chem 268:13805-13810
98. Disch DL, Rader TA, Cresci S, Leone TC, Barger PM, Vega R, Wood PA, Kelly DP 1996 Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression. Mol Cell Biol 16:4043-4051
99. Raisher BD, Gulick T, Zhang Z, Strauss AW, Moore DD, Kelly DP 1992 Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J Biol Chem 267:20264-20269
100. Gulick T, Cresci S, Caira T, Moore DD, Kelly DP 1994 The peroxisome proliferator activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci USA 91:11012-11016
101. Vega RB, Kelly DP 1997 A role for estrogen-related receptor α in the control of mitochondrial fatty acid β-oxidation during brown adipocyte differentiation. J Biol Chem 272:31693-31699
102. Kim MS, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C 2005 Suppression of estrogen-related receptor α and medium-chain acyl-coenzyme A dehydrogenase in the acute-phase response. J Lipid Res 46:2282-2288
103. Huss JM, Torra IP, Staels B, Giguère V, Kelly DP 2004 Estrogen-related receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol 24:9079-9091
104. Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, Oakeley EJ, Kralli A 2004 The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 101:6472-6477
105. Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M 2003 Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115:629-640
106. Gaillard S, Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, Mc-Donnell DP 2006 Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Mol Cell 24:797-803
107. Rangwala SM, Li X, Lindsley L, Wang X, Shaughnessy S, Daniels TG, Szustakowski J, Nirmala NR, Wu Z, Stevenson SC 2007 Estrogen-related receptor α is essential for the expression of antioxidant protection genes and mitochondrial function. Biochem Biophys Res Commun 357:231-236
108. Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguère V, Evans RM 2007 ERRγ directs and maintains the transition to oxidative metabolism in the post-natal heart. Cell Metab 6:13-24
109. Soriano FX, Liesa M, Bach D, Chan DC, Palacin M, Zorzano A 2006 Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-γ coactivator-1 α, estrogen-related receptor-α, and mitofusin 2. Diabetes 55:1783-1791
110. Luo J, Sladek R, Carrier J, Bader J-A, Richard D, Giguère V 2003 Reduced fat mass in mice lacking orphan nuclear receptor estrogenrelated receptor α. Mol Cell Biol 23:7947-7956
111. Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP 2005 PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 25:10684-10694
112. Araki M, Motojima K 2006 Identification of ERRα as a specific partner of PGC-1α for the activation of PDK4 gene expression in muscle. FEBS J 273:1669-1680
113. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA 2006 Estrogenrelated receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem 281:39897-39906
114. Herzog B, Cardenas J, Hall RK, Villena JA, Budge PJ, Giguère V, Granner DK, Kralli A 2006 Estrogen-related receptor α is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 281:99-106
115. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM 2001 Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138
116. Boustead JN, Stadelmaier BT, Eeds AM, Wiebe PO, Svitek CA, Oeser JK, O'Brien RM 2003 Hepatocyte nuclear factor-4 α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1 α (PGC-1 α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells. Biochem J 369:17-22
117. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM 2003 Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature 423:550-555
118. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM 2003 Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1α): requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc Natl Acad Sci USA 100: 4012-4017
119. Laflamme N, Giroux S, Loredo-Osti JC, Elfassihi L, Dodin S, Blanchet C, Morgan K, Giguère V, Rousseau F 2005 A frequent regulatory variant of the estrogen-related receptor α gene associated with BMD in French-Canadian premenopausal women. J Bone Miner Res 20:938-944
120. Zhang J, Lazar MA 2000 The mechanism of action of thyroid hormones. Annu Rev Physiol 62:439-466
121. Sjogren M, Alkemade A, Mittag J, Nordstrom K, Katz A, Rozell B, Westerblad H, Arner A, Vennstrom B 2007 Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1. EMBO J 26:4535-4545
122. Quignodon L, Vincent S, Winter H, Samarut J, Flamant F 2007 A point mutation in the activation function 2 domain of thyroid hormone receptor α1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism. Mol Endocrinol 21:2350-2360
123. Gloss B, Trost S, Bluhm W, Swanson E, Clark R, Winkfein R, Janzen K, Giles W, Chassande O, Samarut J, Dillmann W 2001 Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor α or β. Endocrinology 142:544-550
124. Wikstrom L, Johansson C, Salto C, Barlow C, Campos Barros A, Baas F, Forrest D, Thoren P, Vennstrom B 1998 Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α 1. EMBO J 17:455-461
125. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA 2001 Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. J Clin Invest 108:97-105
126. Marrif H, Schifman A, Stepanyan Z, Gillis MA, Calderone A, Weiss RE, Samarut J, Silva JE 2005 Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-α gene products. Endocrinology 146:2872-2884
127. Vanacker JM, Bonnelye E, Delmarre C, Laudet V 1998 Activation of the thyroid receptor α gene promoter by the orphan nuclear receptor ERRα. Oncogene 17:2429-2435
128. Lefebvre P, Chinetti G, Fruchart JC, Staels B 2006 Sorting out the roles of PPAR α in energy metabolism and vascular homeostasis. J Clin Invest 116:571-580
129. Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H 2007 RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov 6:793-810
130. Villarroya F, Iglesias R, Giralt M 2004 Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes. Curr Med Chem 11:795-805
131. Shulman AI, Mangelsdorf DJ 2005 Retinoid X receptor heterodimers in the metabolic syndrome. N Engl J Med 353:604-615
132. Bavner A, Sanyal S, Gustafsson JA, Treuter E 2005 Transcriptional corepression by SHP: molecular mechanisms and physiological consequences. Trends Endocrinol Metab 16:478-488
133. Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, Choi HS 2002 Differential regulation of the orphan nuclear receptor SHP gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem 277:1739-1748
134. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD 2005 The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes. Cell Metab 2:227-238
135. Akter MH, Yamaguchi T, Hirose F, Osumi T 2008 Perilipin, a critical regulator of fat storage and breakdown, is a target gene of estrogen receptor-related receptor α. Biochem Biophys Res Commun 368:563-568
136. Ma K, Saha PK, Chan L, Moore DD 2006 Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 116:1102-1109
137. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD 2006 Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol 20:2671-2681
138. Trottier J, Milkiewicz P, Kaeding J, Verreault M, Barbier O 2006 Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors. Mol Pharm 3:212-222
139. Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker MG 2005 RIP140-targeted repression of gene expression in adipocytes. Mol Cell Biol 25:9383-9391
140. Nichol D, Christian M, Steel JH, White R, Parker MG 2006 RIP140 expression is stimulated by estrogen-related receptor α during adipogenesis. J Biol Chem 281:32140-32147
141. Scarpulla RC 2008 Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88:611-638
142. Vogelstein B, Lane D, Levine AJ 2000 Surfing the p53 network. Nature 408:307-310
143. Vousden KH, Lane DP 2007 p53 in health and disease. Nat Rev Mol Cell Biol 8:275-283
144. Bensaad K, Vousden KH 2007 p53: new roles in metabolism. Trends Cell Biol 17:286-291
145. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM 2006 p53 regulates mitochondrial respiration. Science 312:1650-1653
146. Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y 2006 A global map of p53 transcription-factor binding sites in the human genome. Cell 124:207-219
147. Cawley S, Bekiranov S, Ng HH, Kapranov P, Sekinger EA, Kampa D, Piccolboni A, Sementchenko V, Cheng J, Williams AJ, Wheeler R, Wong B, Drenkow J, Yamanaka M, Patel S, Brubaker S, Tammana H, Helt G, Struhl K, Gingeras TR 2004 Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116:499-509
148. Chen J, Nathans J 2007 Estrogen-related receptor β/NR3B2
149. Luo J, Sladek R, Bader J-A, Rossant J, Giguère V 1997 Placental abnormalities in mouse embryos lacking orphan nuclear receptor ERRβ. Nature 388:778-782
150. Cannon B, Nedergaard J 2004 Brown adipose tissue: function and physiological significance. Physiol Rev 84:277-359
151. Villena JA, Hock MB, Giguère V, Kralli A 2007 Orphan nuclear receptor ERRα is essential for adaptive thermogenesis. Proc Natl Acad Sci USA 104:1418-1423
152. Murase T, Aoki M, Wakisaka T, Hase T, Tokimitsu I 2002 Antiobesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism. J Lipid Res 43:1312-1319
153. Carrier JC, Deblois G, Champigny C, Levy E, Giguère V 2004 Estrogen related-receptor α (ERRα) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine. J Biol Chem 279:52052-52058
154. Huss JM, Kelly DP 2005 Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest 115:547-555
155. Lehman JJ, Kelly DP 2002 Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol 29:339-345
156. Taegtmeyer H, Golfman L, Sharma S, Razeghi P, van Arsdall M 2004 Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann NY Acad Sci 1015:202-213
157. Neubauer S 2007 The failing heart-an engine out of fuel. N Engl J Med 356:1140-1151
158. Huss JM, Imahashi K-I, Dufour C, Weinheimer CJ, Courtois M, Kovacs A, Giguère V, Murphy E, Kelly DP 2007 The nuclear receptor ERRα is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab 6:25-37
159. Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, Onoe K, Day NK, Good RA, Ohno H 2002 Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 99:9392-9397
160. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D 2000 Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26:435-439
161. Rousset S, Emre Y, Join-Lambert O, Hurtaud C, Ricquier D, Cassard-Doulcier AM 2006 The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine 35:135-142
162. Kamei Y, Lwin H, Saito K, Yokoyama T, Yoshiike N, Ezaki O, Tanaka H 2005 The 2.3 genotype of ESRRA23 of the ERR α gene is associated with a higher BMI than the 2.2 genotype. Obes Res 13:1843-1844
163. Larsen LH, Rose CS, Sparso T, Overgaard J, Torekov SS, Grarup N, Jensen DP, Albrechtsen A, Andersen G, Ek J, Glumer C, Borch-Johnsen K, Jorgensen T, Hansen T, Pedersen O 2007 Genetic analysis of the estrogen-related receptor α and studies of association with obesity and type 2 diabetes. Int J Obes 31:365-370
164. Lowell BB, Shulman GI 2005 Mitochondrial dysfunction and type 2 diabetes. Science 307:384-387
165. Warburg O 1956 On respiratory impairment in cancer cells. Science 124:269-270
166. Bui T, Thompson CB 2006 Cancer's sweet tooth. Cancer Cell 9:419-420
167. Chen EI, Hewel J, Krueger JS, Tiraby C, Weber MR, Kralli A, Becker K, Yates III JR, Felding-Habermann B 2007 Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res 67:1472-1486
168. Ao A, Wang H, Kamarajugadda S, Lu J 2008 Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors. Proc Natl Acad Sci USA 105:7821-7826
169. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM 2001 Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1. Mol Cell 8:971-982
170. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J 2006 Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127:1109-1122