Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ

Journal of Medicinal Chemistry

Volumn 48, Issue 9, 2005, Pages 3107-3109

  Zuercher, William J ^a   Gaillard, Stéphanie ^b   Orband Miller, Lisa A ^a   Chao, Esther Y H ^a   Shearer, Barry G ^a   Jones, David G ^a   Miller, Aaron B ^a   Collins, Jon L ^a   McDonnell, Donald P ^b   Willson, Timothy M ^a  

^a GLAXOSMITHKLINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; CELL NUCLEUS RECEPTOR; DIETHYLSTILBESTROL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR GAMMA; ESTROGEN RELATED ORPHAN NUCLEAR RECEPTOR BETA; ESTROGEN RELATED ORPHAN NUCLEAR RECEPTOR GAMMA; GSK 4716; GSK 9089; HYDRAZONE DERIVATIVE; PHENOL DERIVATIVE; RECEPTOR INTERACTING PROTEIN 140; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LIGAND BINDING; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; ESTROGEN RECEPTOR BETA; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENES, REPORTER; HEAT-SHOCK PROTEINS; HELA CELLS; HUMANS; HYDRAZINES; LIGANDS; MOLECULAR MIMICRY; PHENOLS; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 20944432239     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050161j     Document Type: Article

References (16)

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