Estrogen-related receptor α is essential for the expression of antioxidant protection genes and mitochondrial function

Biochemical and Biophysical Research Communications

Volumn 357, Issue 1, 2007, Pages 231-236

  Rangwala, Shamina M ^a   Li, Xiaoyan ^a   Lindsley, Loren ^a   Wang, Xiaomei ^a   Shaughnessy, Stacey ^a   Daniels, Thomas G ^a   Szustakowski, Joseph ^a   Nirmala, N R ^a   Wu, Zhidan ^a   Stevenson, Susan C ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Estrogen related receptor; Mitochondrial gene expression; Nuclear respiratory factor 2; Oxidative metabolism; Peroxisome proliferator activated receptor coactivator 1 ; Type 2 diabetes

Indexed keywords

CITRATE SYNTHASE; ESTROGEN RELATED RECEPTOR ALPHA; GA BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

AEROBIC METABOLISM; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; GENE OVEREXPRESSION; MITOCHONDRION; MOUSE; NONHUMAN; NULL ALLELE; OXIDATIVE STRESS; PRIORITY JOURNAL; STIMULATION; TRANSCRIPTION INITIATION;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION; HEAT-SHOCK PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MUS;

EID: 34147096849     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.03.126     Document Type: Article

References (33)

1. Hong H., Yang L., and Stallcup M.R. Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. Journal of Biological Chemistry 274 (1999) 22618-22626
2. Heard D.J., Norby P.L., Holloway J., and Vissing H. Human ERR gamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: Tissue-specific isoforms are expressed during development and in the adult. Molecular Endocrinology 14 (2000) 382-392
3. Schreiber S.N., Knutti D., Brogli K., Uhlmann T., and Kralli A. The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha). Journal of Biological Chemistry 278 (2003) 9013-9018
4. Schreiber S.N., Emter R., Hock M.B., Knutti D., Cardenas J., Podvinec M., Oakeley E.J., and Kralli A. The estrogen-related receptor alpha (ERR alpha) functions in PPAR gamma coactivator 1 alpha (PGC-1 alpha)-induced mitochondrial biogenesis. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 6472-6477
5. Mootha V.K., Handschin C., Arlow D., Xie X., St P.J., Sihag S., Yang W., Altshuler D., Puigserver P., Patterson N., Willy P.J., Schulman I.G., Heyman R.A., Lander E.S., and Spiegelman B.M. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 6570-6575
6. Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., DiPietro L., Cline G.W., and Shulman G.I. Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 300 (2003) 1140-1142
7. Petersen K.F., Dufour S., Befroy D., Garcia R., and Shulman G.I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes New England. Journal of Medicine 350 (2004) 664-671
8. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., and Groop L.C. PGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics 34 (2003) 267-273
9. Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., Landaker E.J., Goldfine A.B., Mun E., DeFronzo R., Finlayson J., Kahn C.R., and Mandarino L.J. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proceedings of the National Academy of Sciences of the United States of America 100 (2003) 8466-8471
10. Villena J.A., Hock M.B., Chang W.Y., Barcas J.E., Giguere V., and Kralli A. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proceedings of the National Academy of Sciences of the United States of America 104 (2007) 1418-1423
11. Luo J.M., Sladek R., Carrier J., Bader J.A., Richard D., and Giguere V. Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Molecular and Cellular Biology 23 (2003) 7947-7956
12. Irizarry R.A., Hobbs B., Collin F., Beazer-Barclay Y.D., Antonellis K.J., Scherf U., and Speed T.P. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4 (2003) 249-264
13. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., and Groop L.C. PGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics 34 (2003) 267-273
14. Szustakowski J.D., Lee J.H., Marrese C.A., Kosinski P.A., Ninnala N.R., and Kemp D.M. Identification of novel pathway regulation during myogenic differentiation. Genomics 87 (2006) 129-138
15. Smyth G.K. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology 3 1 (2004) Article 3
16. Storey J.D. A direct approach to false discovery rates. Journal of the Royal Statistical Society Series B-Statistical Methodology 64 (2002) 479-498
17. Storey J.D., and Tibshirani R. Statistical significance for genomewide studies. Proceedings of the National Academy of Sciences of the United States of America 100 (2003) 9440-9445
18. Moyes C.D., MathieuCostello O.A., Tsuchiya N., Filburn C., and Hansford R.G. Mitochondrial biogenesis during cellular differentiation. American Journal of Physiology. Cell Physiology 41 (1997) C1345-C1351
19. Wu Z.D., Puigserver P., Andersson U., Zhang C.Y., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., and Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
20. Castet A., Herledan A., Bonnet S., Jalaguier S., Vanacker J.M., and Cavailles V. Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Molecular Endocrinology 20 (2006) 1035-1047
21. Augereau P., Badia E., Balaguer P., Carascossa S., Castet A., Jalaguier S., and Cavailles V. Negative regulation of hormone signaling by RIP140. The Journal of Steroid Biochemistry and Molecular Biology 102 (2006) 51-59
22. Xu D., and Finkel T. A role for mitochondria as potential regulators of cellular life span. Biochemical and Biophysical Research Communications 294 (2002) 245-248
23. Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., Giardino I., and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 (2000) 787-790
24. Houstis N., Rosen E.D., and Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440 (2006) 944-948
25. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jager S., Handschin C., Zheng K.N., Lin J.D., Yang W.L., Simon D.K., Bachoo R., and Spiegelman B.M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127 (2006) 397-408
26. Valle I., varez-Barrientos A., Arza E., Lamas S., and Monsalve M. PGC-1 alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovascular Research 66 (2005) 562-573
27. Horard B., and Vanacker J.M. Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. Journal of Molecular Endocrinology 31 (2003) 349-357
28. Huss J.M., Torra I.P., Staels B., Giguere V., and Kelly D.P. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor at signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Molecular and Cellular Biology 24 (2004) 9079-9091
29. Zhang Z., and Teng C. Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression. Molecular and Cellular Endocrinology 264 (2007) 128-141
30. Mortensen O.H., Frandsen L., Schjerling P., Nishimura E., and Grunnet N. PGC-1 alpha and PGC-1 beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype. American Journal of Physiology. Endocrinology and Metabolism 291 (2006) E807-E816
31. Leone T.C., Lehman J.J., Finck B.N., Schaeffer P.J., Wende A.R., Boudina S., Courtois M., Wozniak D.F., Sambandam N., Bernal-Mizrachi C., Chen Z.J., Holloszy J.O., Medeiros D.M., Schmidt R.E., Saffitz J.E., Abel E.D., Semenkovich C.F., and Kelly D.P. PGC-1 alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biology 3 (2005) 672-687
32. Koves T.R., Li P., An J., Akimoto T., Slentz D., Ilkayeva O., Dohm G.L., Yan Z., Newgard C.B., and Muoio D.M. Peroxisome proliferator-activated receptor-gamma co-activator 1 alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. Journal of Biological Chemistry 280 (2005) 33588-33598
33. Petersen K.F., and Shulman G.I. Etiology of insulin resistance. American Journal of Medicine 119 (2006) 10S-16S