PGC-1, a versatile coactivator

Trends in Endocrinology and Metabolism

Volumn 12, Issue 8, 2001, Pages 360-365

  Knutti, Darko ^a   Kralli, Anastasia ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; DNA BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSCRIPTION FACTOR;

ANIMAL; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; PHYSIOLOGY; REVIEW; RNA SPLICING; THERMOGENESIS;

ANIMALS; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA SPLICING; THERMOGENESIS; TRANSCRIPTION FACTORS;

EID: 0035488897     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(01)00457-X     Document Type: Review

References (56)

1. Weintraub, H. (1993) The MyoD family and myogenesis: redundancy, networks, and thresholds, Cell 75, 1241-1244
2. Rosen, E.D. et al. (2000) Transcriptional regulation of adipogenesis. Genes Dev. 14, 1293-1307
3. Callaerts, P. et al. (1997) PAX-6 in development and evolution. Annu. Rev. Neurosci. 20, 483-532
4. Puigserver, P. et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839
5. Wu, Z. et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124
6. Lehman, J.J. et al. (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106, 847-856
7. Glass, C.K. and Rosenfeld, M.G. (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14, 121-141
8. Robyr, D. et al. (2000) Nuclear hormone receptor coregulators in action: diversity for shared tasks. Mol. Endocrinol. 14, 329-347
9. Lowell, B.B. (1998) Adaptive thermogenesis: turning on the heat. Curr. Biol. 8, R517-R520
10. Butow, R.A. and Bahassi, E.M. (1999) Adaptive thermogenesis: orchestrating mitochondrial biogenesis. Curr. Biol. 9, R767-R769
11. Lowell, B.B. and Spiegelman, B.M. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660
12. Esterbauer, H. et al. (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62, 98-102
13. Knutti, D. et al. (2000) A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20, 2411-2422
14. Goto, M. et al. (2000) cDNA cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem. Biophys. Res. Commun. 274, 350-354
15. Vega, R.B. et al. (2000) The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20, 1868-1876
16. Nedergaard, J. et al. (2001) UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim. Biophys. Acta 1504, 82-106
17. Michael, L.F. et al. (2001) Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc. Natl. Acad. Sci. U. S. A. 98, 3820-3825
18. Tcherepanova, I. et al. (2000) Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J. Biol. Chem. 275, 16302-16308
19. Kersten, S. et al. (2000) Roles of PPARs in health and disease. Nature 405, 421-424
20. Soboll, S. (1993) Thyroid hormone action on mitochondrial energy transfer. Biochim. Biophys. Acta 1144, 1-16
21. Silva, J.E. (1995) Thyroid hormone control of thermogenesis and energy balance. Thyroid 5, 481-492
22. Garesse, R. and Vallejo, C.G. (2001) Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes. Gene 263, 1-16
23. 3 Ezaki, O. (1997) Regulatory elements in the insulin-responsive glucose transporter (GLUT4) gene. Biochem. Biophys. Res. Commun. 241, 1-6
24. Shore, P and Sharrocks, A.D. (1995) The MADS-box family of transcription factors. Eur. J. Biochem. 229, 1-13
25. Vidal-Puig, A. et al. (1996) Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J. Clin. Invest. 97, 2553-2561
26. Branco, M. et al. (1999) 3,5,3′-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. Am. J. Physiol. 276, E179-E187
27. Himms-Hagen, J. (1990) Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 4, 2890-2898
28. Leone, T.C. et al. (1999) A critical role for the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the cellular fasting response: the PPAR alpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U. S. A. 96, 7473-7478
29. Kersten, S. et al. (1999) Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489-1498
30. Sapolsky, R.M. et al. (2000) How do glucocorticolds influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21, 55-89
31. Lemberger, T. et al. (1994) Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J. Biol. Chem. 269, 24527-24530
32. Moriscot, A. et al. (1993) Corticosteroneinhibits uncoupling protein gene expression in brown adipose tissue. Am. J. Physiol. 265, E81-E87
33. Strack, A.M. et al. (1995) Corticosterone decreases nonshivering thermogenesis and increases lipid storage in brown adipose tissue. Am. J. Physiol. 268, R183-R191
34. Soumano, K. et al. (2000) Glucocorticoids inhibit the transcriptional response of the uncoupling protein-1 gene to adrenergic stimulation in a brown adipose cell line. Mol. Cell. Endocrinol. 165, 7-15
35. Fukuhara, K. et al. (1996) Interrelations between sympathoadrenal system and hypothalamo-pituitary-adrenocortical/thyroid systems in rats exposed to cold stress. J. Neuroendocrinol. 8, 533-541
36. Knutti, D. et al. (2001) Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. U. S. A. 98, 9713-9718
37. Puigserver, P. et al. (1999) Activation of PPAR gamma coactivator-1 through transcription factor docking. Science 286, 1368-1371
38. Monsalve, M. et al. (2000) Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol. Cell 6, 307-316
39. Lefstin, J.A. and Yamamoto, K.R. (1998) Allosteric effects of DNA on transcriptional regulators. Nature 392, 885-888
40. Graveley, B.R. (2000) Sorting out the complexity of SR protein functions. RNA 6, 1197-1211
41. Blencowe, B.J. et al. (1999) SR-related proteins and the processing of messenger RNA precursors. Biochem. Cell. Biol. 77, 277-291
42. Huang, Y. and Steitz, J.A. (2001) Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. Mol. Cell 7, 899-905
43. Proudfoot, N. (2000) Connecting transcription to messenger RNA processing. Trends Biochem. Sci. 25, 290-293
44. Hirose, Y. and Manley, J.L. (2000) RNA polymerase II and the integration of nuclear events. Genes Dev. 14, 1415-1429
45. Dahmus, M.E. (1996) Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271, 19009-19012
46. Cramer, P. et al. (1997) Functional association between promoter structure and transcript alternative splicing. Proc. Natl. Acad. Sci. U. S. A. 94, 11456-11460
47. Cramer, P. et al. (1999) Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Mol. Cell 1, 251-258
48. Roberts, G.C. et al. (1998) Co-transcriptional commitment to alternative splice site selection. Nucleic Acids Res. 26, 5568-5572
49. Hallier, M. et al. (1998) The transcription factor Spi- 1/PU.1 interacts with the potential splicing factor TLS. J. Biol. Chem. 273, 4838-4842
50. Yang, L. et al. (1998) OncoproteinTLS interacts with serine-arginine proteins involved in RNA splicing. J. Biol. Chem. 273, 27761-27764
51. Powers, C.A. et al. (1998) TLS (translocated-inliposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors. Mol. Endocrinol. 12, 4-18
52. Uranishi, H. et al. (2001) Involvement of the prooncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator. J. Biol. Chem. 276, 13395-13401
53. Ge, H. et al. (1998) A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol. Cell 2, 751-759
54. Bruhn, L. et al. (1997) ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev. 11, 640-653
55. Zhou, Z. et al. (2000) The protein Aly links premessenger-RNA splicing to nuclear export in metazoans. Nature 407, 401-405
56. Chen, S.L. et al. (2000) The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C- dependent gene expression and skeletal muscle differentiation. Genes Dev. 14, 1209-1228