The orphan nuclear receptor estrogen-related receptor or α is a transcriptional regulator of the human medium-cha n Acyl coenzyme A dehydrogenase gene

Molecular and Cellular Biology

Volumn 17, Issue 9, 1997, Pages 5400-5409

  Sladek, Robert ^a,b   Bader, Jo Ann ^a   Giguère, Vincent ^a,c  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; ESTROGEN RECEPTOR; MEDIUM CHAIN FATTY ACID; OXIDOREDUCTASE;

ANIMAL CELL; ARTICLE; BINDING SITE; BROWN ADIPOSE TISSUE; EMBRYO; GENE EXPRESSION; IN SITU HYBRIDIZATION; INTESTINE MUCOSA; LIPID OXIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0030787844     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.9.5400     Document Type: Article

References (41)

1. Blackwell, T. K., L. Kretzner, E. M. Blackwood, R. N. Eisenman, and H. Weintraub. 1990. Sequence-specific DNA-binding by the c-myc protein. Science 250:1149-1151.
2. Bremer, J., and H. Osmundsen. 1984. Fatty acid oxidation and its regulation, p. 113-154. In S. Numa (ed.). Fatty acid metabolism and its regulation. Elsevier Science. Amsterdam, The Netherlands.
3. Brown, J. R., I. O. Daar, J. R. Krug, and L. E. Maquat. 1985. Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol. Cell. Biol. 5:1694-1706.
4. Carroll, J. E., B. S. McGuire, V. F. Chancey, and K. B. Harrison. 1989. Acyl-CoA dehydrogenase enzymes during early postnatal development in the rat. Biol. Neonate 55:185-190.
5. Carter, M. E., T. Gulick, D. D. Moore, and D. P. Kelly. 1994. A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs. Mol. Cell. Biol. 14:4360-4372.
6. Carter, M. E., T. Gulick, B. D. Raisher, T. Caira, J. A. A. Ladias, D. D. Moore, and D. P. Kelly. 1993. Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. J. Biol. Chem. 268:13805-13810.
7. Disch, D. L., T. A. Rader, S. Cresci, T. C. Leone, P. M. Barger, R. Vega, P. A. Wood, and D. P. Kelly. 1996. Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression. Mol. Cell. Biol. 16:4043-4051.
8. Duran, M., M. Hofkamp, W. J. Rhead, J. M. Sandubray, and S. K. Wadman. 1986. Sudden child death and 'healthy' affected family members with medium-chain acyl-coenzyme A dehydrogenase deficiency. Pediatrics 78:1052-1057.
9. Fukasawa, K. M., and S. S. Li. 1987. Complete nucleotide sequence of the mouse lactate dehydrogenase-A functional gene: comparison of the exonintron organization of dehydrogenase genes. Genetics 116:99-105.
10. Giallongo, A., S. Venturella, D. Oliva, G. Barbieri, P. Rubino, and S. Feo. 1993. Structural features of the human gene for muscle-specific enolase. Differential splicing in the 5′-untranslated sequence generates two forms of mRNA. Eur. J. Biochem. 214:367-374. (Erratum 218:1095.)
11. Giguère, V., M. Tini, G. Flock, E. S. Ong, R. M. Evans, and G. Utulakowski. 1994. Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan nuclear receptors. Genes Dev. 8:538-553.
12. Giguère, V., N. Yang, P. Segui, and R. M. Evans. 1988. Identification of a new class of steroid hormone receptors. Nature 331:91-94.
13. Green, H., and M. Meuth. 1974. An established pre-adipose cell line and its differentiation in culture. Cell 3:127-133.
14. Gulick, T., S. Cresci, T. Caira, D. D. Moore, and D. P. Kelly. 1994. The peroxisome proliferator activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. USA 91:11012-11016.
15. Hainline, B. E., D. J. Kahlenbeck, J. Grant, and A. W. Strauss. 1993. Tissue specific and developmental expression of rat long-and medium-chain acyl-CoA dehydrogenases. Biochim. Biophys. Acta 1216:460-168.
16. Johnston, S. D., X. Liu, F. Zuo, T. L. Eisenbraun, S. R. Wiley, R. J. Kraus, and J. E. Mertz. 1997. Estrogen-related receptor α 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol. Endocrinol. 11:342-352.
17. Kelly, D. P., J. L. Gordon, and A. W. Strauss. 1989. The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins: medium-chain acyl CoA dehydrogenase and mitochondrial malate dehydrogenase. J. Biol. Chem. 264:18921-18925.
18. Lala, D. S., D. A. Rice, and K. L. Parker. 1992. Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol. Endocrinol. 6:1249-1258.
19. Leone, T. C., S. Cresci, M. E. Carter, Z. F. Zhang, D. S. Lala, A. W. Strauss, and D. P. Kelly. 1995. The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites. J. Biol. Chem. 270:16308-16314.
20. Lydon, J. P., R. F. Power, and O. M. Conneely. 1992. Differential modes of activation define orphan subclasses within the steroid/thyroid receptor superfamily. Gene Expr. 2:273-283.
21. Mathupala, S. P., A. Rempel, and P. L. Pedersen. 1995. Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. J. Biol. Chem. 270:16918-16925.
22. McBroom, L. D. B., G. Flock, and V. Giguère. 1995. The nonconserved hinge region and distinct amino-terminal domains of the RORα orphan nuclear receptor isoforms are required tor proper DNA bending and RORα-DNA interactions. Mol. Cell. Biol. 15:796-808.
23. Nagao, M., B. Parimoo, and K. Tanaka. 1993. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat. J. Biol. Chem. 268:24114-24124.
24. Raisher, B. D., T. Gulick, Z. Zhang, A. W. Strauss, D. D. Moore, and D. P. Kelly. 1992. Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J. Biol. Chem. 267:20264-20269.
25. Richard, S., and H. H. Zingg. 1990. The human oxytocin gene promoter is regulated by estrogens. J. Biol. Chem. 265:6098-6103.
26. Roe, C. R., and P. M. Coates. 1995. Mitochondrial fatty acid oxidation disorders. McGraw-Hill, New York, N.Y.
27. Ross, S. R., L. Choy, R. A. Graves, N. Fox, V. Solevjeva, S. Klaus, D. Ricquier, and B. M. Spiegelman. 1992. Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene. Proc. Natl. Acad. Sci. USA 89:7561-7565.
28. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
29. Schulz, H. 1991. Beta oxidation of fatty acids. Biochim. Biophys. Acta 1081: 109-120.
30. Somasekhar, M. B., and J. Gorski. 1988. An estrogen-responsive element from the 5′-flanking region of the rat prolactin gene functions in MCF-7 but not in HeLa cells. Gene 69:23-28.
31. Stanley, C. A., D. E. Hale, P. M. Coates, C. L. Hall, B. E. Corkey, W. Yang, R. I. Kelley, E. L. Gonzales, J. R. Williamson, and L. Baker. 1983. Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels. Pediatric Res. 17:877-884.
32. Takeno, T., and S. S. Li. 1989. Structure of the human lactate dehydrogenase B gene. Biochem. J. 257:921-924.
33. Tini, M., G. Otulakowski, M. L. Breitman, L.-T. Tsui, and V. Giguère. 1993. An everted repeat mediates retinoic acid induction of the γF-crystallin gene: evidence of a direct role for retinoids in lens development. Genes Dev. 7:295-307.
34. Umesono, K., and R. M. Evans. 1989. Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146.
35. Wiley, S. R., R. J. Kraus, F. Zuo, E. E. Murray, K. Loritz, and J. E. Mertz. 1993. SV40 early-to-late switch involves titration of cellular transcriptional repressors. Genes Dev. 7:2206-2219.
36. Wilkinson, D. G. 1992. In situ hybridization: a practical approach. IRL Press, Oxford, United Kingdom.
37. Wilson, T. E., T. J. Fahrner, and J. Milbrandt. 1993. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol. Cell. Biol. 13:5794-5804.
38. Xue, J.-C., E. J. Schwarz, A. Chawla, and M. A. Lazar. 1996. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARγ. Mol. Cell. Biol. 16:1567-1575.
39. Yang, N. Y., H. Shigeta, H. P. Shi, and C. T. Teng. 1996. Estrogen-related receptor, hErr1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J. Biol. Chem. 271:5795-5804.
40. Zhang, B., S. L. Marcus, F. G. Sajjadi, K. Alvares, J. K. Reddy, S. Subramani, R. A. Rachubinski, and J. P. Capone. 1992. Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc. Natl. Acad. Sci. USA 89:7541-7545.
41. Zuo, F. R., and J. E. Mertz. 1995. Simian virus 40 late gene expression is regulated by members of the steroid thyroid hormone receptor superfamily. Proc. Natl. Acad. Sci. USA 92:8586-8590.