Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1782, Issue 9, 2008, Pages 489-497

  Talora, Claudio ^a   Campese, Antonio F ^a   Bellavia, Diana ^a   Felli, Maria Pia ^a   Vacca, Alessandra ^a   Gulino, Alberto ^a,b   Screpanti, Isabella ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

Author keywords

Autoimmunity; Lymphomagenesis; Notch signaling; Skin cancer

Indexed keywords

NOTCH RECEPTOR;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; CANCER INHIBITION; CARCINOGENESIS; CELL ACTIVATION; CELL DIFFERENTIATION; CELL TYPE; DROSOPHILA; EPIDERMIS; EPITHELIUM CELL; GENE DELETION; HUMAN; IMMUNE RESPONSE; KERATINOCYTE; LEUKEMOGENESIS; MAMMAL; MOLECULAR EVOLUTION; NONHUMAN; PANCREAS ISLET CELL TUMOR; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; SKIN; SKIN CANCER; T CELL LEUKEMIA; T LYMPHOCYTE; TUMOR GROWTH; UTERINE CERVIX CANCER;

ANIMALS; AUTOIMMUNITY; DISEASE; EVOLUTION; HUMANS; NEOPLASMS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 49349097988     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2008.06.008     Document Type: Review

References (113)

1. Blaumueller C.M., Qi H., Zagouras P., and Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90 (1997) 281-291
2. Logeat F., Bessia C., Brou C., LeBail O., Jarriault S., Seidah N.G., and Israel A. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 8108-8112
3. Artavanis-Tsakonas S., Rand M.D., and Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 284 (1999) 770-776
4. Rooke J., Pan D., Xu T., and Rubin G.M. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 273 (1996) 1227-1231
5. Pan D., and Rubin G.M. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90 (1997) 271-280
6. Sotillos S., Roch F., and Campuzano S. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 124 (1997) 4769-4779
7. Lieber T., Kidd S., and Young M.W. kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev. 16 (2002) 209-221
8. Zolkiewska A. ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol. Life Sci. 5 (2008) 2056-2068
9. Mumm J.S., Schroeter E.H., Saxena M.T., Griesemer A., Tian X., Pan D.J., Ray W.J., and Kopan R. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol. Cell 5 (2000) 197-206
10. Brou C., Logeat F., Gupta N., Bessia C., LeBail O., Doedens J.R., Cumano A., Roux P., Black R.A., and Israel A. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 5 (2000) 207-216
11. Peschon J.J., Slack J.L., Reddy P., Stocking K.L., Sunnarborg S.W., Lee D.C., Russell W.E., Castner B.J., Johnson R.S., Fitzner J.N., Boyce R.W., Nelson N., Kozlosky C.J., Wolfson M.F., Rauch C.T., Cerretti D.P., Paxton R.J., March C.J., and Black R.A. An essential role for ectodomain shedding in mammalian development. Science 282 (1998) 1281-1284
12. Hartmann D., de Strooper B., Serneels L., Craessaerts K., Herreman A., Annaert W., Umans L., Lubke T., Lena Illert A., von Figura K., and Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11 (2002) 2615-2624
13. Krebs L.T., Xue Y., Norton C.R., Shutter J.R., Maguire M., Sundberg J.P., Gallahan D., Closson V., Kitajewski J., Callahan R., Smith G.H., Stark K.L., and Gridley T. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 14 (2000) 1343-1352
14. Huppert S.S., Le A., Schroeter E.H., Mumm J.S., Saxena M.T., Milner L.A., and Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405 (2000) 966-970
15. Herreman A., Hartmann D., Annaert W., Saftig P., Craessaerts K., Serneels L., Umans L., Schrijvers V., Checler F., Vanderstichele H., Baekelandt V., Dressel R., Cupers P., Huylebroeck D., Zwijsen A., Van Leuven F., and De Strooper B. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 11872-11877
16. Francis R., McGrath G., Zhang J., Ruddy D.A., Sym M., Apfeld J., Nicoll M., Maxwell M., Hai B., Ellis M.C., Parks A.L., Xu W., Li J., Gurney M., Myers R.L., Himes C.S., Hiebsch R., Ruble C., Nye J.S., and Curtis D. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 (2002) 85-97
17. Kopan R., and Goate A. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron 33 (2002) 321-324
18. Tanigaki K., and Honjo T. Regulation of lymphocyte development by Notch signaling. Nat. Immunol. 8 (2007) 451-456
19. Fryer C.J., Lamar E., Turbachova I., Kintner C., and Jones K.A. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 16 (2002) 1397-1411
20. Bray S., Musisi H., and Bienz M. Bre1 is required for Notch signaling and histone modification. Dev. Cell 8 (2005) 279-286
21. Iso T., Kedes L., and Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell Physiol. 194 (2003) 237-255
22. Radtke F., Wilson A., and MacDonald H.R. Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila. Bioessays 27 (2005) 1117-1128
23. Sade H., Krishna S., and Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J. Biol. Chem. 279 (2004) 2937-2944
24. Dreesen O., and Brivanlou A.H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev. 3 (2007) 7-17
25. Gutierrez A., and Look A.T. NOTCH and PI3K-AKT pathways intertwined. Cancer Cell 12 (2007) 411-413
26. Hansson E.M., Lendahl U., and Chapman G. Notch signaling in development and disease. Semin. Cancer Biol. 14 (2004) 320-328
27. Martinez Arias A., Zecchini V., and Brennan K. CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?. Curr. Opin. Genet. Dev. 12 (2002) 524-533
28. Shawber C., Nofziger D., Hsieh J.J., Lindsell C., Bogler O., Hayward D., and Weinmaster G. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 122 (1996) 3765-3773
29. Bush G., diSibio G., Miyamoto A., Denault J.B., Leduc R., and Weinmaster G. Ligand-induced signaling in the absence of furin processing of Notch1. Dev. Biol. 229 (2001) 494-502
30. Ramain P., Khechumian K., Seugnet L., Arbogast N., Ackermann C., and Heitzler P. Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr. Biol. 11 (2001) 1729-1738
31. Le Gall M., De Mattei C., and Giniger E. Molecular separation of two signaling pathways for the receptor, Notch. Dev. Biol. 313 (2008) 556-567
32. Espinosa L., Ingles-Esteve J., Robert-Moreno A., and Bigas A. IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways. Mol. Biol. Cell 14 (2003) 491-502
33. Felli M.P., Vacca A., Calce A., Bellavia D., Campese A.F., Grillo R., Di Giovine M., Checquolo S., Talora C., Palermo R., Di Mario G., Frati L., Gulino A., and Screpanti I. PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene 24 (2005) 992-1000
34. Lubman O.Y., Ilagan M.X., Kopan R., and Barrick D. Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J. Mol. Biol. 365 (2007) 577-589
35. Vacca A., Felli M.P., Palermo R., Di Mario G., Calce A., Di Giovine M., Frati L., Gulino A., and Screpanti I. Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. Embo. J. 25 (2006) 1000-1008
36. Sakaguchi S., Ono M., Setoguchi R., Yagi H., Hori S., Fehervari Z., Shimizu J., Takahashi T., and Nomura T. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212 (2006) 8-27
37. Maillard I., Fang T., and Pear W.S. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 23 (2005) 945-974
38. Osborne B.A., and Minter L.M. Notch signalling during peripheral T-cell activation and differentiation. Nat. Rev. Immunol. 7 (2007) 64-75
39. Hoyne G.F., Le Roux I., Corsin-Jimenez M., Tan K., Dunne J., Forsyth L.M., Dallman M.J., Owen M.J., Ish-Horowicz D., and Lamb J.R. Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int. Immunol. 12 (2000) 177-185
40. Vigouroux S., Yvon E., Wagner H.J., Biagi E., Dotti G., Sili U., Lira C., Rooney C.M., and Brenner M.K. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J. Virol. 77 (2003) 10872-10880
41. Yvon E.S., Vigouroux S., Rousseau R.F., Biagi E., Amrolia P., Dotti G., Wagner H.J., and Brenner M.K. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood 102 (2003) 3815-3821
42. Maekawa Y., Tsukumo S., Chiba S., Hirai H., Hayashi Y., Okada H., Kishihara K., and Yasutomo K. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 19 (2003) 549-559
43. Amsen D., Blander J.M., Lee G.R., Tanigaki K., Honjo T., and Flavell R.A. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117 (2004) 515-526
44. Anastasi E., Campese A.F., Bellavia D., Bulotta A., Balestri A., Pascucci M., Checquolo S., Gradini R., Lendahl U., Frati L., Gulino A., Di Mario U., and Screpanti I. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J. Immunol. 171 (2003) 4504-4511
45. Kared H., Adle-Biassette H., Fois E., Masson A., Bach J.F., Chatenoud L., Schneider E., and Zavala F. Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through Notch signaling. Immunity 25 (2006) 823-834
46. Jurynczyk M., Jurewicz A., Raine C.S., and Selmaj K. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase Ctheta and attenuates experimental autoimmune encephalomyelitis. J. Immunol. 180 (2008) 2634-2640
47. Sospedra M., and Martin R. Antigen-specific therapies in multiple sclerosis. Int. Rev. Immunol. 24 (2005) 393-413
48. Hartung A.D., Bohnert A., Hackstein H., Ohly A., Schmidt K.L., and Bein G. Th2-mediated atopic disease protection in Th1-mediated rheumatoid arthritis. Clin. Exp. Rheumatol. 21 (2003) 481-484
49. Minter L.M., Turley D.M., Das P., Shin H.M., Joshi I., Lawlor R.G., Cho O.H., Palaga T., Gottipati S., Telfer J.C., Kostura L., Fauq A.H., Simpson K., Such K.A., Miele L., Golde T.E., Miller S.D., and Osborne B.A. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 6 (2005) 680-688
50. Elyaman W., Bradshaw E.M., Wang Y., Oukka M., Kivisakk P., Chiba S., Yagita H., and Khoury S.J. JAGGED1 and Delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179 (2007) 5990-5998
51. McGill M.A., and McGlade C.J. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J. Biol. Chem. 278 (2003) 23196-23203
52. Hustad C.M., Perry W.L., Siracusa L.D., Rasberry C., Cobb L., Cattanach B.M., Kovatch R., Copeland N.G., and Jenkins N.A. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140 (1995) 255-265
53. Matesic L.E., Haines D.C., Copeland N.G., and Jenkins N.A. Itch genetically interacts with Notch1 in a mouse autoimmune disease model. Hum. Mol. Genet. 15 (2006) 3485-3497
54. Ellisen L.W., Bird J., West D.C., Soreng A.L., Reynolds T.C., Smith S.D., and Sklar J. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66 (1991) 649-661
55. Ma S.K., Wan T.S., and Chan L.C. Cytogenetics and molecular genetics of childhood leukemia. Hematol. Oncol. 17 (1999) 91-105
56. Jundt F., Schwarzer R., and Dorken B. Notch signaling in leukemias and lymphomas. Curr. Mol. Med. 8 (2008) 51-59
57. Chiaramonte R., Calzavara E., Balordi F., Sabbadini M., Capello D., Gaidano G., Serra A., Comi P., and Sherbet G.V. Differential regulation of Notch signal transduction in leukaemia and lymphoma cells in culture. J. Cell Biochem. 88 (2003) 569-577
58. Aster J.C., Pear W.S., and Blacklow S.C. Notch signaling in leukemia. Annu. Rev. Pathol. (2008) 587-613
59. Bellavia D., Campese A.F., Checquolo S., Balestri A., Biondi A., Cazzaniga G., Lendahl U., Fehling H.J., Hayday A.C., Frati L., von Boehmer H., Gulino A., and Screpanti I. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 3788-3793
60. Allman D., Karnell F.G., Punt J.A., Bakkour S., Xu L., Myung P., Koretzky G.A., Pui J.C., Aster J.C., and Pear W.S. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med. 194 (2001) 99-106
61. Campese A.F., Garbe A.I., Zhang F., Grassi F., Screpanti I., and von Boehmer H. Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood 108 (2006) 305-310
62. Bellavia D., Campese A.F., Alesse E., Vacca A., Felli M.P., Balestri A., Stoppacciaro A., Tiveron C., Tatangelo L., Giovarelli M., Gaetano C., Ruco L., Hoffman E.S., Hayday A.C., Lendahl U., Frati L., Gulino A., and Screpanti I. Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. Embo. J. 19 (2000) 3337-3348
63. Weng A.P., Millholland J.M., Yashiro-Ohtani Y., Arcangeli M.L., Lau A., Wai C., Del Bianco C., Rodriguez C.G., Sai H., Tobias J., Li Y., Wolfe M.S., Shachaf C., Felsher D., Blacklow S.C., Pear W.S., and Aster J.C. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20 (2006) 2096-2109
64. Palomero T., Barnes K.C., Real P.J., Bender J.L., Sulis M.L., Murty V.V., Colovai A.I., Balbin M., and Ferrando A.A. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. Leukemia 20 (2006) 1279-1287
65. Ciofani M., Schmitt T.M., Ciofani A., Michie A.M., Cuburu N., Aublin A., Maryanski J.L., and Zuniga-Pflucker J.C. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172 (2004) 5230-5239
66. eMaillard I., Tu L., Sambandam A., Yashiro-Ohtani Y., Millholland J., Keeshan K., Shestova O., Xu L., Bhandoola A., and Pear W.S. The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J. Exp. Med. 203 (2006) 2239-2245
67. Garbe A.I., Krueger A., Gounari F., Zuniga-Pflucker J.C., and von Boehmer H. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J. Exp. Med. 203 (2006) 1579-1590
68. Garbe A.I., and von Boehmer H. TCR and Notch synergize in alphabeta versus gammadelta lineage choice. Trends Immunol. 28 (2007) 124-131
69. Talora C., Cialfi S., Oliviero C., Palermo R., Pascucci M., Frati L., Vacca A., Gulino A., and Screpanti I. Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis. Blood 107 (2006) 3313-3320
70. Bellavia D., Mecarozzi M., Campese A.F., Grazioli P., Talora C., Frati L., Gulino A., and Screpanti I. Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing. Embo. J. 26 (2007) 1670-1680
71. Vilimas T., Mascarenhas J., Palomero T., Mandal M., Buonamici S., Meng F., Thompson B., Spaulding C., Macaroun S., Alegre M.L., Kee B.L., Ferrando A., Miele L., and Aifantis I. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat. Med. 13 (2007) 70-77
72. Zweidler-McKay P.A., He Y., Xu L., Rodriguez C.G., Karnell F.G., Carpenter A.C., Aster J.C., Allman D., and Pear W.S. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood 106 (2005) 3898-3906
73. Hubmann R., Schwarzmeier J.D., Shehata M., Hilgarth M., Duechler M., Dettke M., and Berger R. Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia. Blood 99 (2002) 3742-3747
74. Leong K.G., and Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 107 (2006) 2223-2233
75. Rangarajan A., Syal R., Selvarajah S., Chakrabarti O., Sarin A., and Krishna S. Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology 286 (2001) 23-30
76. Allenspach E.J., Maillard I., Aster J.C., and Pear W.S. Notch signaling in cancer. Cancer Biol. Ther. 1 (2002) 466-476
77. Koch U., and Radtke F. Notch and cancer: a double-edged sword. Cell Mol. Life Sci. 64 (2007) 2746-2762
78. Qi R., An H., Yu Y., Zhang M., Liu S., Xu H., Guo Z., Cheng T., and Cao X. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res. 63 (2003) 8323-8329
79. Sriuranpong V., Borges M.W., Ravi R.K., Arnold D.R., Nelkin B.D., Baylin S.B., and Ball D.W. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res. 61 (2001) 3200-3205
80. Wang X.D., Leow C.C., Zha J., Tang Z., Modrusan Z., Radtke F., Aguet M., de Sauvage F.J., and Gao W.Q. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev. Biol. 290 (2006) 66-80
81. Nguyen B.C., Lefort K., Mandinova A., Antonini D., Devgan V., Della Gatta G., Koster M.I., Zhang Z., Wang J., Tommasi di Vignano A., Kitajewski J., Chiorino G., Roop D.R., Missero C., and Dotto G.P. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 20 (2006) 1028-1042
82. Croquelois A., Blindenbacher A., Terracciano L., Wang X., Langer I., Radtke F., and Heim M.H. Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology 41 (2005) 487-496
83. Dang T.P., Eichenberger S., Gonzalez A., Olson S., and Carbone D.P. Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice. Oncogene 22 (2003) 1988-1997
84. Doucas H., Mann C.D., Sutton C.D., Garcea G., Neal C.P., Berry D.P., and Manson M.M. Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt. J. Surg. Oncol. 97 (2008) 63-68
85. Rangarajan A., Talora C., Okuyama R., Nicolas M., Mammucari C., Oh H., Aster J.C., Krishna S., Metzger D., Chambon P., Miele L., Aguet M., Radtke F., and Dotto G.P. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. Embo. J. 20 (2001) 3427-3436
86. Vauclair S., Nicolas M., Barrandon Y., and Radtke F. Notch1 is essential for postnatal hair follicle development and homeostasis. Dev. Biol. 284 (2005) 184-193
87. Nicolas M., Wolfer A., Raj K., Kummer J.A., Mill P., van Noort M., Hui C.C., Clevers H., Dotto G.P., and Radtke F. Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 33 (2003) 416-421
88. de La Coste A., and Freitas A.A. Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation. Immunol. Lett. 102 (2006) 1-9
89. Lowell S., Jones P., Le Roux I., Dunne J., and Watt F.M. Stimulation of human epidermal differentiation by Delta-Notch signalling at the boundaries of stem-cell clusters. Curr. Biol. 10 (2000) 491-500
90. Estrach S., Cordes R., Hozumi K., Gossler A., and Watt F.M. Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J. Invest. Dermatol. 1 (2007) 1
91. Blanpain C., Lowry W.E., Pasolli H.A., and Fuchs E. Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 20 (2006) 3022-3035
92. Blanpain C., Horsley V., and Fuchs E. Epithelial stem cells: turning over new leaves. Cell 128 (2007) 445-458
93. Estrach S., Ambler C.A., Lo Celso C., Hozumi K., and Watt F.M. Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 133 (2006) 4427-4438
94. Brooker R., Hozumi K., and Lewis J. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 133 (2006) 1277-1286
95. Ong C.T., Cheng H.T., Chang L.W., Ohtsuka T., Kageyama R., Stormo G.D., and Kopan R. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J. Biol. Chem. 281 (2006) 5106-5119
96. Xia X., Qian S., Soriano S., Wu Y., Fletcher A.M., Wang X.J., Koo E.H., Wu X., and Zheng H. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 10863-10868
97. Proweller A., Tu L., Lepore J.J., Cheng L., Lu M.M., Seykora J., Millar S.E., Pear W.S., and Parmacek M.S. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res. 66 (2006) 7438-7444
98. Daniel B., Rangarajan A., Mukherjee G., Vallikad E., and Krishna S. The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions. J. Gen. Virol. 78 Pt 5 (1997) 1095-1101
99. Gray G.E., Mann R.S., Mitsiadis E., Henrique D., Carcangiu M.L., Banks A., Leiman J., Ward D., Ish-Horowitz D., and Artavanis-Tsakonas S. Human ligands of the Notch receptor. Am. J. Pathol. 154 (1999) 785-794
100. Zagouras P., Stifani S., Blaumueller C.M., Carcangiu M.L., and Artavanis-Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 6414-6418
101. Talora C., Sgroi D.C., Crum C.P., and Dotto G.P. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 16 (2002) 2252-2263
102. Wu L., Aster J.C., Blacklow S.C., Lake R., Artavanis-Tsakonas S., and Griffin J.D. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat. Genet. 26 (2000) 484-489
103. Yugawa T., Handa K., Narisawa-Saito M., Ohno S., Fujita M., and Kiyono T. Regulation of Notch1 gene expression by p53 in epithelial cells. Mol. Cell Biol. 27 (2007) 3732-3742
104. Talora C., Cialfi S., Segatto O., Morrone S., Kim Choi J., Frati L., Paolo Dotto G., Gulino A., and Screpanti I. Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. Exp. Cell Res. 305 (2005) 343-354
105. Cheng H.T., Kim M., Valerius M.T., Surendran K., Schuster-Gossler K., Gossler A., McMahon A.P., and Kopan R. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134 (2007) 801-811
106. Besseyrias V., Fiorini E., Strobl L.J., Zimber-Strobl U., Dumortier A., Koch U., Arcangeli M.L., Ezine S., Macdonald H.R., and Radtke F. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J. Exp. Med. 204 (2007) 331-343
107. Fleming R.J., Purcell K., and Artavanis-Tsakonas S. The NOTCH receptor and its ligands. Trends Cell Biol. 7 (1997) 437-441
108. Justice N.J., and Jan Y.N. Variations on the Notch pathway in neural development. Curr. Opin. Neurobiol. 12 (2002) 64-70
109. Panin V.M., Papayannopoulos V., Wilson R., and Irvine K.D. Fringe modulates Notch-ligand interactions. Nature 387 (1997) 908-912
110. Wang T., Baron M., and Trump D. An overview of Notch3 function in vascular smooth muscle cells. Prog. Biophys. Mol. Biol. 96 (2008) 499-509
111. Brennan K., and Gardner P. Notching up another pathway. Bioessays 24 (2002) 405-410
112. Endo Y., Osumi N., and Wakamatsu Y. Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development. Development 129 (2002) 863-873
113. Ng W.F., Duggan P.J., Ponchel F., Matarese G., Lombardi G., Edwards A.D., Isaacs J.D., and Lichler R.I. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 98 (2001) 2736-2744