Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt

Virology

Volumn 286, Issue 1, 2001, Pages 23-30

  Rangarajan, Annapoorni ^a   Syal, Ruchi ^a   Selvarajah, Suganya ^a   Chakrabarti, Oishee ^a   Sarin, Apurva ^a   Krishna, Sudhir ^a  

^a UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH1 RECEPTOR; ONCOPROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL IMMORTALIZATION; CELL TRANSFORMATION; GENE ACTIVATION; GENE MUTATION; HUMAN; NONHUMAN; ONCOGENE; PAPILLOMA VIRUS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UTERINE CERVIX TUMOR;

PAPILLOMAVIRUS;

EID: 0035919676     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.0867     Document Type: Article

References (24)

1. Notch signaling: Cell fate control and signal integration in development
2. TAN-1, the human homolog of the Drosophila Notch gene is broken by chromosomal translocations in T lymphoblastic neoplasms
3. Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands
4. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis
5. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma
6. Oncogenic forms of Notch1 lacking either the primary binding site for RBP-Jk or nuclear localization sequences retain the ability to associate with RBP-Jk and activate transcription
7. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
8. Neoplastic transformation by truncated alleles of human Notch1/TAN1 and Notch2
9. Alterations in Notch signaling in neoplastic lesions of the human cervix
10. The link between integration and expression of HPV-16 genomes and cellular changes in the evolution of CIN lesions
11. Halting angiogenesis suppresses carcinoma cell invasion
12. The hallmarks of cancer
13. Papillomavirus infections - A major cause of human cancers
14. Pleiotropic effects of HPV-16 E6 oncogene expression in human epithelial cell lines
15. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
16. Disruption of epithelial cell-matrix interactions induces apoptosis
17. Collateral expression of proangiogenic and tumorigenic properties in intestinal epithelial cell variants selected for resistance to anoikis
18. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
19. Notch and the immune system
20. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
21. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
22. Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds
23. Ras pathway signals are required for notch-mediated oncogenesis
24. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice