Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

Genes and Development

Volumn 16, Issue 17, 2002, Pages 2252-2263

  Talora, Claudio ^a   Sgroi, Dennis C ^a   Crum, Christopher P ^b   Paolo Dotto, G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

c Fos; Fra 1; Keratinocyte transformation; Notch; p21WAF1 Cip1

Indexed keywords

CELL SURFACE RECEPTOR; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PROTEIN C FOS; PROTEIN P21; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FRA 1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARCINOGENESIS; CARCINOMA CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; MALIGNANT TRANSFORMATION; MICROSCOPY; PRIORITY JOURNAL; RNA ANALYSIS; TRANSCRIPTION REGULATION; UTERINE CERVIX CARCINOMA; WART VIRUS;

CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; DOWN-REGULATION; FEMALE; GENES, VIRAL; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MEMBRANE PROTEINS; NUCLEAR PROTEINS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RECEPTORS, CELL SURFACE; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR VIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS;

HUMAN PAPILLOMAVIRUS TYPES; MAMMALIA;

EID: 0036713311     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.988902     Document Type: Article

References (44)

1. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
2. Notch signaling: Cell fate control and signal integration in development
3. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2
4. Fra-1: A serum-inducible, cellular immediate-early gene that encodes a fos-related antigen
5. The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions
6. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
7. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
8. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
9. Laser capture microdissection
10. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
11. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
12. Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
13. Rapid induction of senescence in human cervical carcinoma cells
14. Human ligands of the Notch receptor
15. Notch signaling as a target in multimodality cancer therapy
16. Signalling downstream of activated mammalian Notch
17. Deletion and translocation of chromosome 11q13 sequences in cervical carcinoma cell lines
18. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2
19. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
20. Telomerase activation by the E6 gene product of human papillomavirus type 16
21. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
22. Stimulation of human epidermal differentiation by deltanotch signalling at the boundaries of stem-cell clusters
23. Biology of human papillomaviruses
24. Arbiter of differentiation and death: Notch signaling meets apoptosis
25. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
26. Notch signaling: From the outside in
27. Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein
28. Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt
29. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
30. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
31. Functions of human papillomavirus proteins
32. Notch signalling via RBP-J promotes myeloid differentiation
33. In vivo gene expression profile analysis of human breast cancer progression
34. Dynamics of notch expression during murine prostate development and tumorigenesis
35. Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex
36. Properties of a non-tumorigenic human cervical keratinocyte cell line
37. Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes
38. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
39. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways
40. Differential expression of the fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation
41. Fosrelated antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity
42. Antitumor promotion by phenolic antioxidants: Inhibition of AP-1 activity through induction of Fra expression
43. Alterations in Notch signaling in neoplastic lesions of the human cervix
44. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis