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Volumn 4, Issue 2, 2008, Pages 146-156

Dietary toxins, endoplasmic reticulum (ER) stress and diabetes

Author keywords

Bafilomycin; Cytokines; Diabetes; Endoplasmic reticulum stress; Islet beta cell; Plecomacrolide

Indexed keywords

BAFILOMYCIN; CONCANAMYCIN A; CYTOKINE; GAMMA INTERFERON; GELDANAMYCIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INSULIN; INTERLEUKIN 1BETA; MACROLIDE; MITOGEN ACTIVATED PROTEIN KINASE; NIGERICIN; NITRIC OXIDE; PROINSULIN; PROTEIN BCL 2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; THAPSIGARGIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN;

EID: 48749118120     PISSN: 15733998     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339908784220697     Document Type: Review
Times cited : (10)

References (132)
  • 1
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • Atkinson MA, Leiter EH. The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 1999; 5: 601-604.
    • (1999) Nat Med , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 3
    • 10244260369 scopus 로고    scopus 로고
    • Immune cells, pancreas development, regeneration and type 1 diabetes
    • Homo-Delarche F, Drexhage HA. Immune cells, pancreas development, regeneration and type 1 diabetes. Trends Immunol 2004; 25: 222-9.
    • (2004) Trends Immunol , vol.25 , pp. 222-229
    • Homo-Delarche, F.1    Drexhage, H.A.2
  • 4
    • 0028607474 scopus 로고
    • Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. The Childhood Diabetes in Finland Study Group
    • Roder ME, Knip M, Hartling SG, Karjalainen J, Akerblom HK, Binder C. Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. The Childhood Diabetes in Finland Study Group. J Clin Endocrinol Metab 1994; 79: 1570-1575.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1570-1575
    • Roder, M.E.1    Knip, M.2    Hartling, S.G.3    Karjalainen, J.4    Akerblom, H.K.5    Binder, C.6
  • 5
    • 0038222568 scopus 로고    scopus 로고
    • Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes- indication of a increased environmental pressure?
    • Hermann R, Knip M, Veijola R, et al. Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes- indication of a increased environmental pressure? Diabetologia 2003; 46: 420-425.
    • (2003) Diabetologia , vol.46 , pp. 420-425
    • Hermann, R.1    Knip, M.2    Veijola, R.3
  • 6
    • 0026616008 scopus 로고
    • Comparison of the incidence of insulin-dependent diabetes mellitus, in childhood among five Baltic populations during 1983-1988
    • Tuomilehto J, Podar T, Brigis G, et al. Comparison of the incidence of insulin-dependent diabetes mellitus, in childhood among five Baltic populations during 1983-1988. Int J Epidemiol 1992; 21: 518-27.
    • (1992) Int J Epidemiol , vol.21 , pp. 518-527
    • Tuomilehto, J.1    Podar, T.2    Brigis, G.3
  • 7
    • 0028972954 scopus 로고
    • Increase in incidence of insulin-dependent diabetes mellitus among children in Finland
    • Tuomilehto J, Virtala E, Karvonen M, et al. Increase in incidence of insulin-dependent diabetes mellitus among children in Finland. Int J Epidemiol 1995; 24: 984-992.
    • (1995) Int J Epidemiol , vol.24 , pp. 984-992
    • Tuomilehto, J.1    Virtala, E.2    Karvonen, M.3
  • 8
    • 0036897063 scopus 로고    scopus 로고
    • Rise of childhood type 1 diabetes in the 20th century
    • Gale EA. Rise of childhood type 1 diabetes in the 20th century. Diabetes 2002; 51: 3353-3361.
    • (2002) Diabetes , vol.51 , pp. 3353-3361
    • Gale, E.A.1
  • 10
    • 0026560497 scopus 로고
    • Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population
    • Bodansky HJ, Staines A, Stephenson C, Haigh D, Cartwright R. Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population. Br Med J 1992; 304: 1020-22.
    • (1992) Br Med J , vol.304 , pp. 1020-1022
    • Bodansky, H.J.1    Staines, A.2    Stephenson, C.3    Haigh, D.4    Cartwright, R.5
  • 11
    • 0034747957 scopus 로고    scopus 로고
    • Raymond NT, Jones JR, Swift et al. Comparative incidence of Type 1 diabetes in children aged under 15 years from South Asian and White or Other ethnic backgrounds in Leicestershire, UK, 1989 to 1998. Diabetologia 2001; 44: B32-6.
    • Raymond NT, Jones JR, Swift PG, et al. Comparative incidence of Type 1 diabetes in children aged under 15 years from South Asian and White or Other ethnic backgrounds in Leicestershire, UK, 1989 to 1998. Diabetologia 2001; 44: B32-6.
  • 12
    • 0035802695 scopus 로고    scopus 로고
    • Intake of vitamin D and risk of type 1 diabetes: A birth-cohort, study
    • Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort, study. Lancet 2001; 358: 1500-3.
    • (2001) Lancet , vol.358 , pp. 1500-1503
    • Hypponen, E.1    Laara, E.2    Reunanen, A.3    Jarvelin, M.R.4    Virtanen, S.M.5
  • 13
    • 0033811930 scopus 로고    scopus 로고
    • Use of cod liver oil during pregnancy associated with lower risk of Type 1 diabetes in the offspring
    • Stene LC, Ulriksen J, Magnus P, Joner G. Use of cod liver oil during pregnancy associated with lower risk of Type 1 diabetes in the offspring. Diabetologia 2000; 43: 1093-8.
    • (2000) Diabetologia , vol.43 , pp. 1093-1098
    • Stene, L.C.1    Ulriksen, J.2    Magnus, P.3    Joner, G.4
  • 14
    • 0043063940 scopus 로고    scopus 로고
    • Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus
    • Zella JB, McCary LC, DeLuca HF. Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus. Arch Biochem Biophys 2003; 417: 77-80.
    • (2003) Arch Biochem Biophys , vol.417 , pp. 77-80
    • Zella, J.B.1    McCary, L.C.2    DeLuca, H.F.3
  • 15
    • 0037304073 scopus 로고    scopus 로고
    • Vitamin D and autoimmune diabetes
    • Zella JB, DeLuca HF. Vitamin D and autoimmune diabetes. J Cell Biochem 2003; 88: 216-222.
    • (2003) J Cell Biochem , vol.88 , pp. 216-222
    • Zella, J.B.1    DeLuca, H.F.2
  • 16
    • 0345707497 scopus 로고    scopus 로고
    • In utero dietary exposures and risk of islet autoimmunity in children
    • Fronczak CM, Baron AE, Chase HP, et al. In utero dietary exposures and risk of islet autoimmunity in children. Diabetes Care 2003; 26: 3237-42.
    • (2003) Diabetes Care , vol.26 , pp. 3237-3242
    • Fronczak, C.M.1    Baron, A.E.2    Chase, H.P.3
  • 17
    • 2142812574 scopus 로고    scopus 로고
    • Transplacental exposure to bafiloimycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice
    • Hettiarachchi KD, Zimmet PZ, Myers MA. Transplacental exposure to bafiloimycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice. J Autoimmun 2004; 22: 287-296.
    • (2004) J Autoimmun , vol.22 , pp. 287-296
    • Hettiarachchi, K.D.1    Zimmet, P.Z.2    Myers, M.A.3
  • 19
    • 0034840293 scopus 로고    scopus 로고
    • Dietary microbial toxins and type 1 diabetes-a new meaning for seed and soil
    • Myers MA, Mackay IR, Rowley MJ, Zimmet PZ. Dietary microbial toxins and type 1 diabetes-a new meaning for seed and soil. Diabetologia 2001; 44: 1199-200.
    • (2001) Diabetologia , vol.44 , pp. 1199-1200
    • Myers, M.A.1    Mackay, I.R.2    Rowley, M.J.3    Zimmet, P.Z.4
  • 20
    • 0242609973 scopus 로고    scopus 로고
    • Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus
    • Araki E, Oyadomari S, Mori M. Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Exp Biol Med 2003; 228: 1213-1217.
    • (2003) Exp Biol Med , vol.228 , pp. 1213-1217
    • Araki, E.1    Oyadomari, S.2    Mori, M.3
  • 21
    • 0037288692 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and diabetes mellitus
    • Araki E, Oyadomari S, Mori M. Endoplasmic reticulum stress and diabetes mellitus. Intern Med 2003; 42: 7-14.
    • (2003) Intern Med , vol.42 , pp. 7-14
    • Araki, E.1    Oyadomari, S.2    Mori, M.3
  • 22
    • 33644858343 scopus 로고    scopus 로고
    • The unfolded protein response: A stress signaling pathway critical for health and disease
    • Zhang K, Kaufman RJ. The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 2006; 66: S102-9.
    • (2006) Neurology , vol.66
    • Zhang, K.1    Kaufman, R.J.2
  • 23
    • 33645142635 scopus 로고    scopus 로고
    • Viruses, ER stress, and interferon responses
    • He B. Viruses, ER stress, and interferon responses. Cell Death Differ 2006; 13: 393-403.
    • (2006) Cell Death Differ , vol.13 , pp. 393-403
    • He, B.1
  • 24
    • 0141459477 scopus 로고    scopus 로고
    • Induction of apoptosis of RAW 264.7 cells by the cytostatic macrolide apicularen A
    • Hong J, Yamaki K, Ishihara K, Ahn JW, Zee O, Ohuchi K. Induction of apoptosis of RAW 264.7 cells by the cytostatic macrolide apicularen A. J Pharm Pharmacol 2003; 55: 1299-309.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 1299-1309
    • Hong, J.1    Yamaki, K.2    Ishihara, K.3    Ahn, J.W.4    Zee, O.5    Ohuchi, K.6
  • 25
    • 0037023726 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by ER stress pathway involving ATF6 and CHOP
    • Gotoh T, Oyadomari S, Mori K, Mori M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by ER stress pathway involving ATF6 and CHOP. J Biol Chem 2002; 277: 12343-50.
    • (2002) J Biol Chem , vol.277 , pp. 12343-12350
    • Gotoh, T.1    Oyadomari, S.2    Mori, K.3    Mori, M.4
  • 26
    • 0034141706 scopus 로고    scopus 로고
    • Down-regulation of the encloplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol)
    • Yang GH, Li S, Pestka JJ. Down-regulation of the encloplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). Toxicol Appl Pharmacol 2000; 162: 207-17.
    • (2000) Toxicol Appl Pharmacol , vol.162 , pp. 207-217
    • Yang, G.H.1    Li, S.2    Pestka, J.J.3
  • 27
    • 18844419215 scopus 로고    scopus 로고
    • Human cytomegalovirus infection activates and regulates the unfolded protein response
    • Isler JA, Skalet AH, Alwine JC. Human cytomegalovirus infection activates and regulates the unfolded protein response. J Virol 2005; 79: 6890-9.
    • (2005) J Virol , vol.79 , pp. 6890-6899
    • Isler, J.A.1    Skalet, A.H.2    Alwine, J.C.3
  • 28
    • 16244405250 scopus 로고    scopus 로고
    • Hepatilis C virus, ER stress, and oxidative stress
    • Tardif KD, Waris G, Siddiqui A. Hepatilis C virus, ER stress, and oxidative stress. Trends Microbiol 2005; 13: 159-63.
    • (2005) Trends Microbiol , vol.13 , pp. 159-163
    • Tardif, K.D.1    Waris, G.2    Siddiqui, A.3
  • 29
    • 23744461982 scopus 로고    scopus 로고
    • Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion
    • Benali-Furet NL, Chami M, Houel L, et al. Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene 2005; 24: 4921-33.
    • (2005) Oncogene , vol.24 , pp. 4921-4933
    • Benali-Furet, N.L.1    Chami, M.2    Houel, L.3
  • 30
    • 33645154135 scopus 로고    scopus 로고
    • Cellular response to endoplasmic reticulum stress: A matter of life or death
    • Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 2006; 13: 363-73.
    • (2006) Cell Death Differ , vol.13 , pp. 363-373
    • Boyce, M.1    Yuan, J.2
  • 31
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein responce
    • Schroder M, Kaufman RJ. ER stress and the unfolded protein responce. Mutat Res 2005; 569: 29-63.
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 32
    • 33646183455 scopus 로고    scopus 로고
    • Control of ER-initiated apoptosis by Bel-2 proteins
    • Oakes SA, Lin SS, Bassik MC. Control of ER-initiated apoptosis by Bel-2 proteins. Curr Mol Med 2006; 6: 99-109.
    • (2006) Curr Mol Med , vol.6 , pp. 99-109
    • Oakes, S.A.1    Lin, S.S.2    Bassik, M.C.3
  • 33
    • 0043028611 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulunt stress to cell death program in isolated human pancreatic islets: Effects of gene transfer of Bel-2
    • Contreras JL, Smyth CA, Bilbao G, et al. Coupling endoplasmic reticulunt stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bel-2. Transpl Int 2003; 16: 537-542.
    • (2003) Transpl Int , vol.16 , pp. 537-542
    • Contreras, J.L.1    Smyth, C.A.2    Bilbao, G.3
  • 34
    • 0036022403 scopus 로고    scopus 로고
    • ER stress-mediated apoptosis in beta cells
    • Oyadomari S, Araki E, Mori M. ER stress-mediated apoptosis in beta cells. Apoptosis 2002; 7: 335-345.
    • (2002) Apoptosis , vol.7 , pp. 335-345
    • Oyadomari, S.1    Araki, E.2    Mori, M.3
  • 36
    • 4444232905 scopus 로고    scopus 로고
    • The unfolded protein response - a stress signaling pathway of the endoplasmic reticulum
    • Sheu X, Zhang K, Kaufman RJ. The unfolded protein response - a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat 2004; 28: 79-92.
    • (2004) J Chem Neuroanat , vol.28 , pp. 79-92
    • Sheu, X.1    Zhang, K.2    Kaufman, R.J.3
  • 37
    • 0036175128 scopus 로고    scopus 로고
    • Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
    • Oyadomari S, Koizumi A, Takeda K, et al. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 2002; 109: 525-532.
    • (2002) J Clin Invest , vol.109 , pp. 525-532
    • Oyadomari, S.1    Koizumi, A.2    Takeda, K.3
  • 38
    • 0035800471 scopus 로고    scopus 로고
    • Protein synthesis. The perks of balancing glucose
    • Sonenberg N, Newgard CB. Protein synthesis. The perks of balancing glucose. Science 2001; 293: 818-819.
    • (2001) Science , vol.293 , pp. 818-819
    • Sonenberg, N.1    Newgard, C.B.2
  • 39
    • 0033634641 scopus 로고    scopus 로고
    • Perk is essential for translational regulation and cell survival during the unfolded protein response
    • Harding H, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5: 897-904.
    • (2000) Mol Cell , vol.5 , pp. 897-904
    • Harding, H.1    Zhang, Y.2    Bertolotti, A.3    Zeng, H.4    Ron, D.5
  • 40
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306: 457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 41
    • 33747849846 scopus 로고    scopus 로고
    • Regulation of insulin biosynthesis in pancreatic beta cells by an ER-resident protein kinase IRE1
    • Lipson KL, Fonseca SG, Ishigaki S, et al. Regulation of insulin biosynthesis in pancreatic beta cells by an ER-resident protein kinase IRE1. Cell Metab 2006; 4: 245-254.
    • (2006) Cell Metab , vol.4 , pp. 245-254
    • Lipson, K.L.1    Fonseca, S.G.2    Ishigaki, S.3
  • 42
    • 0034425698 scopus 로고    scopus 로고
    • EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
    • Delopine M, Nicolino M, Barrett T, Grolamaully M, Lathrop GM, Julier C. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet 2000; 25: 406-409.
    • (2000) Nat Genet , vol.25 , pp. 406-409
    • Delopine, M.1    Nicolino, M.2    Barrett, T.3    Grolamaully, M.4    Lathrop, G.M.5    Julier, C.6
  • 43
    • 0030826078 scopus 로고    scopus 로고
    • Wolfram (DIDMOAD) syndrome
    • Barrett TG, Bundey SE. Wolfram (DIDMOAD) syndrome. J Med Genet 1997; 34: 838-41.
    • (1997) J Med Genet , vol.34 , pp. 838-841
    • Barrett, T.G.1    Bundey, S.E.2
  • 44
    • 0026755751 scopus 로고
    • Wolfram syndrome: Evidence of a diffuse neurodegenerative disease by magnetic resonance imaging
    • Rando TA, Horton JC, Layzer RB. Wolfram syndrome: evidence of a diffuse neurodegenerative disease by magnetic resonance imaging. Neurology 1992; 42: 1220-4.
    • (1992) Neurology , vol.42 , pp. 1220-1224
    • Rando, T.A.1    Horton, J.C.2    Layzer, R.B.3
  • 45
    • 0024599929 scopus 로고
    • Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome
    • Karasik A, O'Hara C, Srikanta S, et al. Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome. Diabetes Care 1989; 12: 135-8.
    • (1989) Diabetes Care , vol.12 , pp. 135-138
    • Karasik, A.1    O'Hara, C.2    Srikanta, S.3
  • 46
    • 17344362695 scopus 로고    scopus 로고
    • A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
    • Inoue H, Tanizawa Y, Wasson J, et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 1998; 20: 143-8.
    • (1998) Nat Genet , vol.20 , pp. 143-148
    • Inoue, H.1    Tanizawa, Y.2    Wasson, J.3
  • 47
    • 0031761895 scopus 로고    scopus 로고
    • Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein
    • Strom TM, Hortnagel K, Hofmann S, et al. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Hum Mol Genet 1998; 7: 2021-8.
    • (1998) Hum Mol Genet , vol.7 , pp. 2021-2028
    • Strom, T.M.1    Hortnagel, K.2    Hofmann, S.3
  • 48
    • 28244435870 scopus 로고    scopus 로고
    • WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
    • Fonseca SG, Fukuma M, Lipson KL, et al. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem 2005; 280: 39609-15.
    • (2005) J Biol Chem , vol.280 , pp. 39609-39615
    • Fonseca, S.G.1    Fukuma, M.2    Lipson, K.L.3
  • 49
    • 2942731683 scopus 로고    scopus 로고
    • Disruption of the WIFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion
    • Ishihara H, Takeda S, Tamura A, et al. Disruption of the WIFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Hum Mol Genet 2004; 13: 1159-70.
    • (2004) Hum Mol Genet , vol.13 , pp. 1159-1170
    • Ishihara, H.1    Takeda, S.2    Tamura, A.3
  • 50
    • 27744523525 scopus 로고    scopus 로고
    • Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
    • Riggs A, Bernal-Mizrachi E, Ohsugi M, et al. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia 2005; 48: 2313-21.
    • (2005) Diabetologia , vol.48 , pp. 2313-2321
    • Riggs, A.1    Bernal-Mizrachi, E.2    Ohsugi, M.3
  • 52
    • 7944235945 scopus 로고    scopus 로고
    • Abnormal proinsulin congeners as autoantigens that initiate the pathogenesis of Type 1 diabetes
    • Csorba TR, Lyon AW. Abnormal proinsulin congeners as autoantigens that initiate the pathogenesis of Type 1 diabetes. Med Hypotheses 2005; 64: 186-191.
    • (2005) Med Hypotheses , vol.64 , pp. 186-191
    • Csorba, T.R.1    Lyon, A.W.2
  • 53
    • 0038826958 scopus 로고    scopus 로고
    • Proinsulin-a pathogenic autoantigen in type 1 diabetes
    • Narendran P, Mannering SI, Harrison LC. Proinsulin-a pathogenic autoantigen in type 1 diabetes. Autoimmun Rev 2003; 2: 204-210.
    • (2003) Autoimmun Rev , vol.2 , pp. 204-210
    • Narendran, P.1    Mannering, S.I.2    Harrison, L.C.3
  • 54
    • 0029360443 scopus 로고
    • Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes
    • Rudy G, Stone N, Harrison LC, et al. Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med 1995; 1: 625-633.
    • (1995) Mol Med , vol.1 , pp. 625-633
    • Rudy, G.1    Stone, N.2    Harrison, L.C.3
  • 55
    • 0035500757 scopus 로고    scopus 로고
    • Evidence that a peptide spanning B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of Type 1 diabetes
    • Chen W, Bergerot I, Elliott JF. Evidence that a peptide spanning B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of Type 1 diabetes. J Immunol 2001; 167: 4923-4935.
    • (2001) J Immunol , vol.167 , pp. 4923-4935
    • Chen, W.1    Bergerot, I.2    Elliott, J.F.3
  • 56
    • 0030069688 scopus 로고    scopus 로고
    • Protection of non obese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Daniel D, Wegmann DR. Protection of non obese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 1996; 93: 956-960.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 57
    • 0028861576 scopus 로고
    • Insulin immunization of non-obese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription
    • Muir A. Insulin immunization of non-obese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest 1995; 95: 628-634.
    • (1995) J Clin Invest , vol.95 , pp. 628-634
    • Muir, A.1
  • 58
    • 0031777665 scopus 로고    scopus 로고
    • Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration
    • Hutchings P, Cooke A. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration. J Autoimmun 1998; 11: 127-130.
    • (1998) J Autoimmun , vol.11 , pp. 127-130
    • Hutchings, P.1    Cooke, A.2
  • 59
    • 0031025574 scopus 로고    scopus 로고
    • Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
    • French MB, Allison J, Cram D, et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1997; 46: 34-39.
    • (1997) Diabetes , vol.46 , pp. 34-39
    • French, M.B.1    Allison, J.2    Cram, D.3
  • 60
    • 0028914351 scopus 로고
    • Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
    • Daniel D, Gill RG, Schlott N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995; 25: 1056-62.
    • (1995) Eur J Immunol , vol.25 , pp. 1056-1062
    • Daniel, D.1    Gill, R.G.2    Schlott, N.3    Wegmann, D.4
  • 61
    • 0032823399 scopus 로고    scopus 로고
    • Identification of an MHC-class I restricted autoantigen in type 1 diabetes by screening an organ specific cDNA library
    • Wong FS. Identification of an MHC-class I restricted autoantigen in type 1 diabetes by screening an organ specific cDNA library. Nat Med 1999; 5: 1026-31.
    • (1999) Nat Med , vol.5 , pp. 1026-1031
    • Wong, F.S.1
  • 62
    • 85047689216 scopus 로고    scopus 로고
    • Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient mice
    • Thebault-Baumont K, Dubois-Laforgue D, Krief P, et al. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient mice. J Clin Invest 2003; 111: 851-857.
    • (2003) J Clin Invest , vol.111 , pp. 851-857
    • Thebault-Baumont, K.1    Dubois-Laforgue, D.2    Krief, P.3
  • 63
    • 0036894358 scopus 로고    scopus 로고
    • Proinsulin 2 knockout NOD mice: A model for genetic variation of insulin gene expression in type 1 diabetes
    • Dubois-Lafforgue D, Mogenet L, Thebault K, Jami J, Krief P, Boitard C. Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes. Diabetes 2002; 51: 489-493.
    • (2002) Diabetes , vol.51 , pp. 489-493
    • Dubois-Lafforgue, D.1    Mogenet, L.2    Thebault, K.3    Jami, J.4    Krief, P.5    Boitard, C.6
  • 64
    • 17144365015 scopus 로고    scopus 로고
    • Proinsulin disulfide maturation and misfolding in the ER
    • Liu M, Li Y, Cavener D, Arvan P. Proinsulin disulfide maturation and misfolding in the ER. J Biol Chem 2005; 208: 13209-13212.
    • (2005) J Biol Chem , vol.208 , pp. 13209-13212
    • Liu, M.1    Li, Y.2    Cavener, D.3    Arvan, P.4
  • 65
    • 0036175125 scopus 로고    scopus 로고
    • Ron D. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J Clin Invest 2002; 109: 443-445.
    • Ron D. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J Clin Invest 2002; 109: 443-445.
  • 66
    • 0032524013 scopus 로고    scopus 로고
    • Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period
    • Kayo T, Koizumi A. Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period. J Clin Invest 1998; 101: 2112-2118.
    • (1998) J Clin Invest , vol.101 , pp. 2112-2118
    • Kayo, T.1    Koizumi, A.2
  • 67
    • 0023932360 scopus 로고
    • Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients
    • Heaton DA, Millward BA, Gray IP, et al. Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia 1988; 31: 182-184.
    • (1988) Diabetologia , vol.31 , pp. 182-184
    • Heaton, D.A.1    Millward, B.A.2    Gray, I.P.3
  • 69
    • 0026585133 scopus 로고
    • Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients
    • Spinas GA, Snorgaard O, Hartling SG, Oberholzer M, Berger W. Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients. Diabetes Care 1992; 15: 632-637.
    • (1992) Diabetes Care , vol.15 , pp. 632-637
    • Spinas, G.A.1    Snorgaard, O.2    Hartling, S.G.3    Oberholzer, M.4    Berger, W.5
  • 70
    • 0024435846 scopus 로고
    • Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
    • Hartling SG, Lindgren F, Dahlqvist G, Persson B, Binder C. Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 1989; 138: 1271-1274.
    • (1989) Diabetes , vol.138 , pp. 1271-1274
    • Hartling, S.G.1    Lindgren, F.2    Dahlqvist, G.3    Persson, B.4    Binder, C.5
  • 71
    • 0025850463 scopus 로고
    • Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients
    • Lindgren FA, Hattling SG, Dahlquist GG, Binder C, Efendic S, Persson BE. Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients. Diabet Med 1991; 8: 638-643.
    • (1991) Diabet Med , vol.8 , pp. 638-643
    • Lindgren, F.A.1    Hattling, S.G.2    Dahlquist, G.G.3    Binder, C.4    Efendic, S.5    Persson, B.E.6
  • 72
    • 0030040425 scopus 로고    scopus 로고
    • Hyperproinsulinemia is associated with increased beta cell demand after hernipancreatectomy in humans
    • Seaquist ER, Kahn SE, Clark PM, Hales CN, Porte DJ, Robertson RP. Hyperproinsulinemia is associated with increased beta cell demand after hernipancreatectomy in humans. J Clin Invest 1996; 97: 455-460.
    • (1996) J Clin Invest , vol.97 , pp. 455-460
    • Seaquist, E.R.1    Kahn, S.E.2    Clark, P.M.3    Hales, C.N.4    Porte, D.J.5    Robertson, R.P.6
  • 73
    • 0037343364 scopus 로고    scopus 로고
    • Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway
    • Halban PA, Irminger JC. Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway. Mol Biol Cell 2003; 14: 1195-1203.
    • (2003) Mol Biol Cell , vol.14 , pp. 1195-1203
    • Halban, P.A.1    Irminger, J.C.2
  • 74
    • 0032740992 scopus 로고    scopus 로고
    • Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release
    • Hostens K, Pavlovic D, Zambre Y, et al. Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. J Clin Invest 1999; 104: 67-72.
    • (1999) J Clin Invest , vol.104 , pp. 67-72
    • Hostens, K.1    Pavlovic, D.2    Zambre, Y.3
  • 75
    • 21044453408 scopus 로고    scopus 로고
    • Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type 1 diabetes
    • Jaeschke A, Rincon M, Doran B, et al. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type 1 diabetes. Proc Natl Acad Sci USA 2005; 102: 6931-5.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6931-6935
    • Jaeschke, A.1    Rincon, M.2    Doran, B.3
  • 76
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-6.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 77
    • 4043073652 scopus 로고    scopus 로고
    • An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
    • Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev 2004; 18: 1976-80.
    • (2004) Genes Dev , vol.18 , pp. 1976-1980
    • Jaeschke, A.1    Czech, M.P.2    Davis, R.J.3
  • 79
    • 19944432792 scopus 로고    scopus 로고
    • 2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
    • 2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005; 54: 452-461.
    • (2005) Diabetes , vol.54 , pp. 452-461
    • Cardozo, A.K.1    Ortis, F.2    Storling, J.3
  • 80
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta cell death in Type 1 and Type 2 diabetes. Many differences, Few similarities
    • Cnop M, Welsh N, Jonas J, Jorns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic beta cell death in Type 1 and Type 2 diabetes. Many differences, Few similarities. Diabetes 2005; 54: S97-S107.
    • (2005) Diabetes , vol.54
    • Cnop, M.1    Welsh, N.2    Jonas, J.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 81
    • 0035845568 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
    • Oyadomari S, Takeda K, Takiguchi M, et al. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci USA 2002; 98: 10845-50.
    • (2002) Proc Natl Acad Sci USA , vol.98 , pp. 10845-10850
    • Oyadomari, S.1    Takeda, K.2    Takiguchi, M.3
  • 82
    • 33646533330 scopus 로고    scopus 로고
    • Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms
    • Pirot P, Eizirik DL, Cardozo AK. Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms. Diabetologia 2006; 49: 1229-36.
    • (2006) Diabetologia , vol.49 , pp. 1229-1236
    • Pirot, P.1    Eizirik, D.L.2    Cardozo, A.K.3
  • 83
    • 33745962325 scopus 로고    scopus 로고
    • Nitric oxide and endoplasmic reticulum stress
    • Gotoh T, Mori M. Nitric oxide and endoplasmic reticulum stress. Arterioscler Thromb Vasc Biol 2006; 26: 1439-1446.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1439-1446
    • Gotoh, T.1    Mori, M.2
  • 84
    • 0032745552 scopus 로고    scopus 로고
    • Pharmaceutically active secondary metabolites of microorganisms
    • Demain AL. Pharmaceutically active secondary metabolites of microorganisms. Appl Microbiol Biotechnol 1999; 52: 455-63.
    • (1999) Appl Microbiol Biotechnol , vol.52 , pp. 455-463
    • Demain, A.L.1
  • 85
    • 0040117958 scopus 로고    scopus 로고
    • Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases
    • Drose S, Altendorf K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol 1997; 200: 1-8.
    • (1997) J Exp Biol , vol.200 , pp. 1-8
    • Drose, S.1    Altendorf, K.2
  • 86
    • 0033967198 scopus 로고    scopus 로고
    • Structure, mechanism and regulation of the clathrin-coated vesicle and yeast vacuolar H(+)-ATPases
    • Forgac M. Structure, mechanism and regulation of the clathrin-coated vesicle and yeast vacuolar H(+)-ATPases. J Fxp Biol 2000; 203: 71-80.
    • (2000) J Fxp Biol , vol.203 , pp. 71-80
    • Forgac, M.1
  • 88
    • 0037040244 scopus 로고    scopus 로고
    • Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site
    • Bowman BJ, Bowman EJ. Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. J Biol Chem 2002; 277: 3965-72.
    • (2002) J Biol Chem , vol.277 , pp. 3965-3972
    • Bowman, B.J.1    Bowman, E.J.2
  • 89
    • 0026948004 scopus 로고
    • The role of the V-ATPase in renal epithelial H+ transport
    • Gluck S, Nelson R. The role of the V-ATPase in renal epithelial H+ transport. J Exp Biol 1992; 172: 205-18.
    • (1992) J Exp Biol , vol.172 , pp. 205-218
    • Gluck, S.1    Nelson, R.2
  • 90
    • 0032943534 scopus 로고    scopus 로고
    • +-ATPase cause renal tubular acidosis with sensorineural deafness
    • +-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet 1999; 21: 84-90.
    • (1999) Nat Genet , vol.21 , pp. 84-90
    • Karet, F.E.1    Finberg, K.E.2    Nelson, R.3
  • 92
    • 18344407785 scopus 로고    scopus 로고
    • The gene encoding the mouse homologue of the human osteoclast-specific 111-kDa V-ATPase subunit bears a deletion in Osteosclerotic (oc/oc) mutants
    • Scimeca JC, Franchi A, Trojani. C, et al. The gene encoding the mouse homologue of the human osteoclast-specific 111-kDa V-ATPase subunit bears a deletion in Osteosclerotic (oc/oc) mutants. Bone 2000; 26: 207-213.
    • (2000) Bone , vol.26 , pp. 207-213
    • Scimeca, J.C.1    Franchi, A.2    Trojani, C.3
  • 93
    • 0032748995 scopus 로고    scopus 로고
    • Atp6I deficient mice exhibit severe Osteopetrosis due to loss of osteoclast-mediated extracellular acidification
    • Li Y, Chen W, Liang Y, Li E, Stashenko P. Atp6I deficient mice exhibit severe Osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet 1999; 23: 447-451.
    • (1999) Nat Genet , vol.23 , pp. 447-451
    • Li, Y.1    Chen, W.2    Liang, Y.3    Li, E.4    Stashenko, P.5
  • 94
    • 14444282582 scopus 로고    scopus 로고
    • 5-(5,6-Dichloro-2- indolyl)-2-methoxy-2,4-pentadienamides: Novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity
    • Gagliardi S, Nadler G, Consolandi E, et al. 5-(5,6-Dichloro-2- indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem 1998; 41: 1568-73.
    • (1998) J Med Chem , vol.41 , pp. 1568-1573
    • Gagliardi, S.1    Nadler, G.2    Consolandi, E.3
  • 95
    • 33745091487 scopus 로고    scopus 로고
    • Vacuolar ATPase as a drug discovery target
    • Niikura K. Vacuolar ATPase as a drug discovery target. Drugs News Perspect 2006; 19: 139-143.
    • (2006) Drugs News Perspect , vol.19 , pp. 139-143
    • Niikura, K.1
  • 96
    • 0032407699 scopus 로고    scopus 로고
    • Structure, function and regulation of the vacuolar (H+)- ATPases
    • Forgac M. Structure, function and regulation of the vacuolar (H+)- ATPases. FEBS Lett 1998; 440: 258-263.
    • (1998) FEBS Lett , vol.440 , pp. 258-263
    • Forgac, M.1
  • 97
    • 1842424890 scopus 로고    scopus 로고
    • Effect of inhibiting vacuolar acidification on insulin signaling in hepatocytes
    • Balbis A, Baquiran G, Dumas V, Posner BI. Effect of inhibiting vacuolar acidification on insulin signaling in hepatocytes. J Biol Chem 2004; 279: 12777-85.
    • (2004) J Biol Chem , vol.279 , pp. 12777-12785
    • Balbis, A.1    Baquiran, G.2    Dumas, V.3    Posner, B.I.4
  • 99
    • 33749549372 scopus 로고    scopus 로고
    • The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas
    • Hettiarachchi KD, Zimmet PZ, Myers MA. The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas. Food Chem Toxicol 2006; 44: 1966-1977.
    • (2006) Food Chem Toxicol , vol.44 , pp. 1966-1977
    • Hettiarachchi, K.D.1    Zimmet, P.Z.2    Myers, M.A.3
  • 100
    • 33646497230 scopus 로고    scopus 로고
    • The plecomacrolide vacuolar-ATPase inhibitor, Bafilomycin, alters insulin signaling in MIN6 β-cells
    • Hettiarachchi KD, Zimmet PZ, Myers MA. The plecomacrolide vacuolar-ATPase inhibitor, Bafilomycin, alters insulin signaling in MIN6 β-cells. Cell Biol Toxicol 2006; 22: 169-181.
    • (2006) Cell Biol Toxicol , vol.22 , pp. 169-181
    • Hettiarachchi, K.D.1    Zimmet, P.Z.2    Myers, M.A.3
  • 101
  • 102
    • 5244224827 scopus 로고    scopus 로고
    • X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
    • Muchmore SW, Sattler M, Liang H, et al. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 1996; 381: 335-41.
    • (1996) Nature , vol.381 , pp. 335-341
    • Muchmore, S.W.1    Sattler, M.2    Liang, H.3
  • 103
    • 1842332735 scopus 로고    scopus 로고
    • Bel-x(L) forms an ion channel in synthetic lipid membranes
    • Minn AJ, Velez P, Schendel SL, et al. Bel-x(L) forms an ion channel in synthetic lipid membranes. Nature 1997; 385: 353-7.
    • (1997) Nature , vol.385 , pp. 353-357
    • Minn, A.J.1    Velez, P.2    Schendel, S.L.3
  • 104
    • 33745958168 scopus 로고    scopus 로고
    • 2+ homeostasis in the endoplasmic reticulum
    • 2+ homeostasis in the endoplasmic reticulum. Cell Death Differ 2006; 13: 1409-18.
    • (2006) Cell Death Differ , vol.13 , pp. 1409-1418
    • Pinton, P.1    Rizzuto, R.2
  • 105
    • 33751176506 scopus 로고    scopus 로고
    • Nitric oxide production by v-ATPase inhibitors bafilomycin Al and concanamycin A and its role in apoptosis in RAW 264.7 cells
    • Hong J, Nakano Y, Yokomakura A, et al. Nitric oxide production by v-ATPase inhibitors bafilomycin Al and concanamycin A and its role in apoptosis in RAW 264.7 cells. J Pharmacol Exp Ther 2006; 319: 672-81.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 672-681
    • Hong, J.1    Nakano, Y.2    Yokomakura, A.3
  • 106
    • 24044446158 scopus 로고    scopus 로고
    • Archazolid and apicularen: Novel specific V-ATPase inhibitors
    • Huss M, Sasse F, Kunze B, et al. Archazolid and apicularen: novel specific V-ATPase inhibitors. BMC Biochem 2005; 6: 13.
    • (2005) BMC Biochem , vol.6 , pp. 13
    • Huss, M.1    Sasse, F.2    Kunze, B.3
  • 107
    • 14344258133 scopus 로고    scopus 로고
    • Induction of nitric oxide production by the cytostatic macrolide apicularen A and possible role of nitric oxide in apicularen A-induced apoptosis in RAW 264.7 cells
    • Hong J, Yokomakura A, Nakano Y, et al. Induction of nitric oxide production by the cytostatic macrolide apicularen A and possible role of nitric oxide in apicularen A-induced apoptosis in RAW 264.7 cells. J Pharmacol Exp Ther 2005; 312: 968-77.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 968-977
    • Hong, J.1    Yokomakura, A.2    Nakano, Y.3
  • 108
    • 33646485923 scopus 로고    scopus 로고
    • Inhibition of v-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells
    • Hong J, Yokomakura A, Nakano Y, et al. Inhibition of v-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Lett 2006; 580: 2723-30.
    • (2006) FEBS Lett , vol.580 , pp. 2723-2730
    • Hong, J.1    Yokomakura, A.2    Nakano, Y.3
  • 109
    • 18744382408 scopus 로고    scopus 로고
    • Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha
    • Marcu MG, Doyle M, Bertolotti A, Ron D, Hendershot L, Neckers L. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol Cell Biol 2002;22: 8506-13.
    • (2002) Mol Cell Biol , vol.22 , pp. 8506-8513
    • Marcu, M.G.1    Doyle, M.2    Bertolotti, A.3    Ron, D.4    Hendershot, L.5    Neckers, L.6
  • 110
    • 15544385359 scopus 로고    scopus 로고
    • Miyata Y. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des 2005; 11: 1131-8.
    • Miyata Y. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des 2005; 11: 1131-8.
  • 111
    • 33749352630 scopus 로고    scopus 로고
    • Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90. inhibition by geldanamycin and proteasome inhibition by velcade
    • Mimnaugh EG, Xu W, Vos M, Yuan X, Neckers L. Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90. inhibition by geldanamycin and proteasome inhibition by velcade. Mol Cancer Res 2006; 4: 667-81.
    • (2006) Mol Cancer Res , vol.4 , pp. 667-681
    • Mimnaugh, E.G.1    Xu, W.2    Vos, M.3    Yuan, X.4    Neckers, L.5
  • 112
    • 0031891726 scopus 로고    scopus 로고
    • Geldanamycin, an hsp90/ GRP94-binding drug, induces increased transcriptign of ER chaperones via the ER stress pathway
    • Lawson B, Brewer JW, Hendershot, LM. Geldanamycin, an hsp90/ GRP94-binding drug, induces increased transcriptign of ER chaperones via the ER stress pathway. J Cell Physiol 1998; 174: 170-8.
    • (1998) J Cell Physiol , vol.174 , pp. 170-178
    • Lawson, B.1    Brewer, J.W.2    Hendershot, L.M.3
  • 113
    • 77951504667 scopus 로고
    • Correlation of pbytotoxin production with pathogenicity of streptomyces-scabies isolates from scab infected potato tubers
    • King RR, Lawrence CH, Clark MC. Correlation of pbytotoxin production with pathogenicity of streptomyces-scabies isolates from scab infected potato tubers. Am Potato J 1991; 68: 675-680.
    • (1991) Am Potato J , vol.68 , pp. 675-680
    • King, R.R.1    Lawrence, C.H.2    Clark, M.C.3
  • 114
  • 115
    • 84950387374 scopus 로고
    • The cause of deep pitted scab of potatoes
    • Archuleta JG, Easton GD. The cause of deep pitted scab of potatoes. Am Potato J 1981; 58: 385-392.
    • (1981) Am Potato J , vol.58 , pp. 385-392
    • Archuleta, J.G.1    Easton, G.D.2
  • 116
    • 0026446051 scopus 로고
    • Diversity among Streptomyces strains causing potato scab
    • Doering-Saad C, Kampfer P, Manulis S, et al. Diversity among Streptomyces strains causing potato scab. Appl Environ Microbiol 1992; 58: 3932-40.
    • (1992) Appl Environ Microbiol , vol.58 , pp. 3932-3940
    • Doering-Saad, C.1    Kampfer, P.2    Manulis, S.3
  • 117
    • 0043154339 scopus 로고    scopus 로고
    • Production of phytotoxins, concanamycins A and B by Streptomyces spp. causing potato scab
    • Natsume M, Ryu R, Abe H. Production of phytotoxins, concanamycins A and B by Streptomyces spp. causing potato scab. Ann Phytopathol Soc Jpn 1996; 62: 411-413.
    • (1996) Ann Phytopathol Soc Jpn , vol.62 , pp. 411-413
    • Natsume, M.1    Ryu, R.2    Abe, H.3
  • 118
    • 0043167086 scopus 로고    scopus 로고
    • Differential production of phytotoxins and concanamycins A and B by potato common scab-causing Streptomyces
    • Natsume M, Yamada A, Tashiro N, Abe H. Differential production of phytotoxins and concanamycins A and B by potato common scab-causing Streptomyces. Ann Phytol Soc Jpn 1998; 64: 202-204.
    • (1998) Ann Phytol Soc Jpn , vol.64 , pp. 202-204
    • Natsume, M.1    Yamada, A.2    Tashiro, N.3    Abe, H.4
  • 119
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase in incidence. of Type 1 diabetes-the analysis of the data on published incidence trends
    • Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide increase in incidence. of Type 1 diabetes-the analysis of the data on published incidence trends. Diabetologia 1999; 42: 1395-1403.
    • (1999) Diabetologia , vol.42 , pp. 1395-1403
    • Onkamo, P.1    Vaananen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 121
    • 28444488345 scopus 로고    scopus 로고
    • Spring harvest? Reflections on the rise of type 1 diabetes
    • Gale EA. Spring harvest? Reflections on the rise of type 1 diabetes. Diabetologia 2005; 48: 2445-50.
    • (2005) Diabetologia , vol.48 , pp. 2445-2450
    • Gale, E.A.1
  • 122
    • 0034763697 scopus 로고    scopus 로고
    • Is childhood-onset type 1 diabetes a wealth-related disease? An ecological analysis of European incidence rates
    • Patterson CC, Dahlquist G, Soltesz G, Green A. Is childhood-onset type 1 diabetes a wealth-related disease? An ecological analysis of European incidence rates. Diabetologia 2001; 44: B9-B16.
    • (2001) Diabetologia , vol.44
    • Patterson, C.C.1    Dahlquist, G.2    Soltesz, G.3    Green, A.4
  • 124
    • 0034751499 scopus 로고    scopus 로고
    • Bayesian analysis of geographical variation in the incidence of Type 1 diabetes in Finland
    • Rytkonen M, Ranta J, Tuomilehto J, Karvonen M. Bayesian analysis of geographical variation in the incidence of Type 1 diabetes in Finland. Diabetologia 2001; 44: B37-44.
    • (2001) Diabetologia , vol.44
    • Rytkonen, M.1    Ranta, J.2    Tuomilehto, J.3    Karvonen, M.4
  • 125
    • 3042755394 scopus 로고    scopus 로고
    • Type 1 diabetes among sardinian children is increasing: The Sardinian diabetes register for children aged 0-14 years (1989-1999)
    • Casu A, Pascutto C, Bernardinelli L, Songini M. Type 1 diabetes among sardinian children is increasing: the Sardinian diabetes register for children aged 0-14 years (1989-1999). Diabetes Care 2004; 27: 1623-1629.
    • (2004) Diabetes Care , vol.27 , pp. 1623-1629
    • Casu, A.1    Pascutto, C.2    Bernardinelli, L.3    Songini, M.4
  • 126
    • 33744948470 scopus 로고    scopus 로고
    • Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes
    • Virtanen SM, Kenward MG, Erkkola M, et al. Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetologia 2006; 49: 1512-1521.
    • (2006) Diabetologia , vol.49 , pp. 1512-1521
    • Virtanen, S.M.1    Kenward, M.G.2    Erkkola, M.3
  • 130
    • 0031688082 scopus 로고    scopus 로고
    • Descriptive epidemiology of IDDM in Hokkaido, Japan: The Childhood IDDM Hokkaido Registry
    • Matsuura N, Fukuda K, Okuno A, et al. Descriptive epidemiology of IDDM in Hokkaido, Japan: the Childhood IDDM Hokkaido Registry Diabetes Care 1998; 21: 1632-1636.
    • (1998) Diabetes Care , vol.21 , pp. 1632-1636
    • Matsuura, N.1    Fukuda, K.2    Okuno, A.3
  • 132
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of Type 2 Diabetes
    • Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of Type 2 Diabetes. Science 2006; 313: 1137-1140.
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3


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