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Volumn 97, Issue 2, 1996, Pages 455-460

Hyperproinsulinemia is associated with increased β cell demand after hemipancreatectomy in humans

Author keywords

diabetes; hemipancreatectomy; insulin; pancreas transplantation; proinsulin

Indexed keywords

GLUCOSE; INSULIN; PROINSULIN;

EID: 0030040425     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118435     Document Type: Article
Times cited : (95)

References (34)
  • 1
    • 0025989824 scopus 로고
    • Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance
    • Shiraishi, I., Y. Iwamoto, T. Kuzuya, A Matsuda, and S Kumakura. 1991. Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance. Diabetologia. 34:737-741.
    • (1991) Diabetologia. , vol.34 , pp. 737-741
    • Shiraishi, I.1    Iwamoto, Y.2    Kuzuya, T.3    Matsuda, A.4    Kumakura, S.5
  • 2
    • 0025268864 scopus 로고
    • Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus
    • Saad, M. F., S. E. Kahn, and R. G Nelson. 1990. Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus J. Clin Endocrinol & Metab 70:1247-1253.
    • (1990) J. Clin Endocrinol & Metab , vol.70 , pp. 1247-1253
    • Saad, M.F.1    Kahn, S.E.2    Nelson, R.G.3
  • 3
    • 0026327857 scopus 로고
    • Follow-up of women with previous GDM. Insulin, C-peptide, and proinsulin responses to oral glucose load
    • Persson, B., U Hanson, S G. Hartling, and C. Binder. 1991. Follow-up of women with previous GDM. Insulin, C-peptide, and proinsulin responses to oral glucose load. Diabetes. 40(Suppl 2):136-141.
    • (1991) Diabetes. , vol.40 , Issue.2 SUPPL. , pp. 136-141
    • Persson, B.1    Hanson, U.2    Hartling, S.G.3    Binder, C.4
  • 4
    • 0023932360 scopus 로고
    • Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients
    • Heaton, D A., B. A Millward, I. P. Gray, Y Tun, C. N Hales, D A. Pyke, and R. D. Leslie 1988 Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia. 31:182-184.
    • (1988) Diabetologia , vol.31 , pp. 182-184
    • Heaton, D.A.1    Millward, B.A.2    Gray, I.P.3    Tun, Y.4    Hales, C.N.5    Pyke, D.A.6    Leslie, R.D.7
  • 5
    • 0024435846 scopus 로고
    • Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
    • Hartling, S. G F. Lindgren, G Dahlqvist, and B. Persson. 1989 Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity Diabetes 38:1271-1274
    • (1989) Diabetes , vol.38 , pp. 1271-1274
    • Hartling, S.G.1    Lindgren, F.2    Dahlqvist, G.3    Persson, B.4
  • 6
    • 0025850463 scopus 로고
    • Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients
    • Lindgren, F A , S. G. Hartling, G. G. Dahlquist, C. Binder, S Efendic, and B. E Persson. 1991. Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients Diabetic Med. 8.638-643.
    • (1991) Diabetic Med. , vol.8 , pp. 638-643
    • Lindgren, F.A.1    Hartling, S.G.2    Dahlquist, G.G.3    Binder, C.4    Efendic, S.5    Persson, B.E.6
  • 7
    • 0026585133 scopus 로고
    • Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients
    • Spinas, G A., O. Snorgaard S G. Hartling, M. Oberholzer, and W. Berger. 1992. Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients Diabetes Care 15:632-637.
    • (1992) Diabetes Care , vol.15 , pp. 632-637
    • Spinas, G.A.1    Snorgaard, O.2    Hartling, S.G.3    Oberholzer, M.4    Berger, W.5
  • 9
    • 0024463227 scopus 로고
    • Hyperproinsulinemia and amyloid in NIDDM Clues to etiology of islet β-cell dysfunction?
    • Porte, D Jr., and S. E. Kahn. 1989. Hyperproinsulinemia and amyloid in NIDDM Clues to etiology of islet β-cell dysfunction? Diabetes. 38:1333-1336.
    • (1989) Diabetes , vol.38 , pp. 1333-1336
    • Porte Jr., D.1    Kahn, S.E.2
  • 10
    • 0025736943 scopus 로고
    • Relative hypersecretion of proinsulin in rat model of NIDDM
    • Leahy, J. L , P A Halban, and G. C. Weir 1991. Relative hypersecretion of proinsulin in rat model of NIDDM. Diabetes 40:885-889
    • (1991) Diabetes , vol.40 , pp. 885-889
    • Leahy, J.L.1    Halban, P.A.2    Weir, G.C.3
  • 11
    • 0026652507 scopus 로고
    • Effects of hemipancreatectomy on pancreatic α and β cell function in healthy human donors
    • Seaquist, E R , and R. P. Robertson. 1992. Effects of hemipancreatectomy on pancreatic α and β cell function in healthy human donors. J. Clin. Invest. 89:1761-1766.
    • (1992) J. Clin. Invest. , vol.89 , pp. 1761-1766
    • Seaquist, E.R.1    Robertson, R.P.2
  • 12
    • 0023616646 scopus 로고
    • Pancreas transplantation
    • Sutherland, D E 1987. Pancreas transplantation. Diabetes Metab. Rev 3.1061-1090.
    • (1987) Diabetes Metab. Rev , vol.3 , pp. 1061-1090
    • Sutherland, D.E.1
  • 13
  • 14
    • 0028043148 scopus 로고
    • Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors
    • Seaquist, E R., K. Pyzdrowski, A Moran, A. U Teuscher, and R. P Robertson. 1994. Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors. Diabetologia. 37.1036-1043.
    • (1994) Diabetologia , vol.37 , pp. 1036-1043
    • Seaquist, E.R.1    Pyzdrowski, K.2    Moran, A.3    Teuscher, A.U.4    Robertson, R.P.5
  • 15
    • 0018773208 scopus 로고
    • Potentiation of insulin secretory responses by plasma glucose levels in man: Evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation
    • Halter, J. B , R J. Graf, and D. Porte, Jr. 1979. Potentiation of insulin secretory responses by plasma glucose levels in man: evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation. J. Clin. Endocrinol. & Melab. 48:946-954.
    • (1979) J. Clin. Endocrinol. & Melab. , vol.48 , pp. 946-954
    • Halter, J.B.1    Graf, R.J.2    Porte Jr., D.3
  • 16
    • 0021751981 scopus 로고
    • Diminished B cell secretory capacity in patients with non-insulin-dependent diabetes mellitus
    • Ward, W. K , D. C Bolgiano, B. McKnight, J. B. Halter, and D. Porte, Jr. 1984. Diminished B cell secretory capacity in patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 74.1318-1328.
    • (1984) J. Clin. Invest. , vol.74 , pp. 1318-1328
    • Ward, W.K.1    Bolgiano, D.C.2    McKnight, B.3    Halter, J.B.4    Porte Jr., D.5
  • 17
    • 0000476083 scopus 로고
    • Immunoassay of insulin, two antibody system. Plasma insulin levels of normal, subdiabetic and diabetic rats
    • Morgan, C. R., and A Lazarow. 1963. Immunoassay of insulin, two antibody system. Plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes. 12.115-126.
    • (1963) Diabetes , vol.12 , pp. 115-126
    • Morgan, C.R.1    Lazarow, A.2
  • 18
    • 0022910962 scopus 로고
    • A sensitive radioimmunoassay for human proinsulin. with sequential use of antisera to C-peptide and insulin
    • Ward, W K., T. L. Paquette, B. H. Frank, and D. Porte, Jr. 1986. A sensitive radioimmunoassay for human proinsulin. with sequential use of antisera to C-peptide and insulin. Clin Chem. 32.728-733.
    • (1986) Clin Chem. , vol.32 , pp. 728-733
    • Ward, W.K.1    Paquette, T.L.2    Frank, B.H.3    Porte Jr., D.4
  • 19
    • 0028230040 scopus 로고
    • What β-cell defect could lead to hyperproinsulinemia in NIDDM?
    • Rhodes, C J., and C. Alarcón. 1994. What β-cell defect could lead to hyperproinsulinemia in NIDDM? Diabetes. 43:511-517.
    • (1994) Diabetes , vol.43 , pp. 511-517
    • Rhodes, C.J.1    Alarcón, C.2
  • 21
    • 0019240371 scopus 로고
    • Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus
    • Neufeld, M., N. K. Maclaren, W. J. Riley, D. Lezottes, J. V. McLaughlin, J. Silverstein, and A. L. Rosenbloom. 1980. Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus. Diabetes. 29.589-592.
    • (1980) Diabetes , vol.29 , pp. 589-592
    • Neufeld, M.1    Maclaren, N.K.2    Riley, W.J.3    Lezottes, D.4    McLaughlin, J.V.5    Silverstein, J.6    Rosenbloom, A.L.7
  • 22
    • 0015416775 scopus 로고
    • Direct measurement of plasma proinsulin in normal and diabetic subjects
    • Duckworth, W. C., A. E. Kitabchi, and M. Heinemann. 1972. Direct measurement of plasma proinsulin in normal and diabetic subjects. Am. J. Med. 53:418-427.
    • (1972) Am. J. Med. , vol.53 , pp. 418-427
    • Duckworth, W.C.1    Kitabchi, A.E.2    Heinemann, M.3
  • 23
    • 0016209121 scopus 로고
    • Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states
    • Gorden, P., C. M. Hendricks, and J. Roth. 1974. Circulating proinsulin-like component in man: increased proportion in hypoinsulinemic states. Diabetologia. 10:469-474.
    • (1974) Diabetologia , vol.10 , pp. 469-474
    • Gorden, P.1    Hendricks, C.M.2    Roth, J.3
  • 24
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
    • Ward, W. K., E. C LaCava, T. L Paquette, J. C. Beard. B. J. Wallum, and D. Porte. Jr 1987. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 30:698-702.
    • (1987) Diabetologia , vol.30 , pp. 698-702
    • Ward, W.K.1    LaCava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte Jr., D.6
  • 25
    • 0028912883 scopus 로고
    • Increased secretory demand iather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus J
    • Alarcón, C., J. L. Leahy, G. T. Schuppin, and C. J. Rhodes. 1995. Increased secretory demand iather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus J. Clin. Invest. 95.1032-1039.
    • (1995) Clin. Invest. , vol.95 , pp. 1032-1039
    • Alarcón, C.1    Leahy, J.L.2    Schuppin, G.T.3    Rhodes, C.J.4
  • 26
    • 0028062156 scopus 로고
    • Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia
    • Birkeland, K. I , P. A Torjesen, and J. Eriksson. 1994. Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia. Diabetes Care. 17:1307-1310.
    • (1994) Diabetes Care , vol.17 , pp. 1307-1310
    • Birkeland, K.I.1    Torjesen, P.A.2    Eriksson, J.3
  • 27
    • 0027217510 scopus 로고
    • Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans
    • Kahn, S E , F F. Horber, R. L. Prigeon, and M. W Haymond. 1993. Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans Diabetes. 42:1082-1085.
    • (1993) Diabetes , vol.42 , pp. 1082-1085
    • Kahn, S.E.1    Horber, F.F.2    Prigeon, R.L.3    Haymond, M.W.4
  • 28
    • 0024538602 scopus 로고
    • Increased β-cell secretory-capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance
    • Kahn, S. E., J. C. Beard, M. W. Schwartz, W. K. Ward, H. L. Ding, R N. Bergman, G. J. Taborsky, Jr., and D. Porte, Jr. 1989. Increased β-cell secretory-capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes. 38:562-568.
    • (1989) Diabetes , vol.38 , pp. 562-568
    • Kahn, S.E.1    Beard, J.C.2    Schwartz, M.W.3    Ward, W.K.4    Ding, H.L.5    Bergman, R.N.6    Taborsky Jr., G.J.7    Porte Jr., D.8
  • 29
    • 0026110135 scopus 로고
    • β-cells in type II diabetes mellitus
    • Porte, D , Jr. 1991. β-cells in type II diabetes mellitus. Diabetes. 40:166-180.
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 30
    • 0017752575 scopus 로고
    • The histocompatibility system in juvenile, insulin-dependent diabetic multiplex kindreds
    • Barbosa, J., R King, and H. Noreen. 1977. The histocompatibility system in juvenile, insulin-dependent diabetic multiplex kindreds. J Clin. Invest. 60:989-998.
    • (1977) J Clin. Invest. , vol.60 , pp. 989-998
    • Barbosa, J.1    King, R.2    Noreen, H.3
  • 31
    • 0025435316 scopus 로고
    • Plasma proinsulin in first-degree relatives of type 2 diabetic subjects
    • Beer, S. F , S. O'Rahilly, R. S Spivey, C. N. Hales, and R. C. Turner 1990. Plasma proinsulin in first-degree relatives of type 2 diabetic subjects. Diabetes Res. 14:51-54.
    • (1990) Diabetes Res. , vol.14 , pp. 51-54
    • Beer, S.F.1    O'Rahilly, S.2    Spivey, R.S.3    Hales, C.N.4    Turner, R.C.5
  • 34
    • 0024271685 scopus 로고
    • Reduction of glycemic potentiation. Sensitive indicator of β-cell loss in partially pancreatectomized dogs
    • Ward, W. K , B. J Wallum, J. C. Beard, G. J. Taborsky, Jr., and D. Porte, Jr 1988 Reduction of glycemic potentiation. Sensitive indicator of β-cell loss in partially pancreatectomized dogs Diabetes. 37:723-729.
    • (1988) Diabetes , vol.37 , pp. 723-729
    • Ward, W.K.1    Wallum, B.J.2    Beard, J.C.3    Taborsky Jr., G.J.4    Porte Jr., D.5


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