PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells

Biochemical and Biophysical Research Communications

Volumn 340, Issue 1, 2006, Pages 286-290

  Hyoda, Kanae ^a   Hosoi, Toru ^a,b   Horie, Naohiro ^a   Okuma, Yasunobu ^a,c   Ozawa, Koichiro ^b   Nomura, Yasuyuki ^a,d  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c CHIBA INSTITUTE OF SCIENCE   (Japan)

^d DAIICHI UNIVERSITY OF PHARMACY   (Japan)

Author keywords

CHOP; Endoplasmic reticulum stress; LY294002; PD98059; PI3K Akt pathway; Wortmannin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CCAAT ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; THAPSIGARGIN; TUNICAMYCIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; STRESS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; ENDOPLASMIC RETICULUM; FIBROBLASTS; GENE EXPRESSION REGULATION; MICE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTOR CHOP;

ANIMALIA;

EID: 29244438467     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.007     Document Type: Article

References (26)

1. T. Katayama, K. Imaizumi, N. Sato, K. Miyoshi, T. Kudo, J. Hitomi, T. Morihara, T. Yoneda, F. Gomi, Y. Mori, Y. Nakano, J. Takeda, T. Tsuda, Y. Itoyama, O. Murayama, A. Takashima, P. St. George-Hyslop, M. Takeda, and M. Tohyama Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response Nat. Cell Biol. 1 1999 479 485
2. Y. Imai, M. Soda, H. Inoue, N. Hattori, Y. Mizuno, and R. Takahashi An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Cell 105 2001 891 902
3. K. Mori Tripartite management of unfolded proteins in the endoplasmic reticulum Cell 101 2000 451 454
4. H. Zinszner, M. Kuroda, X. Wang, N. Batchvarova, R.T. Lightfoot, H. Remotti, J.L. Stevens, and D. Ron CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes Dev. 12 1998 982 995
5. X.Z. Wang, B. Lawson, J.W. Brewer, H. Zinszner, A. Sanjay, L.J. Mi, R. Boorstein, G. Kreibich, L.M. Hendershot, and D. Ron Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153) Mol. Cell. Biol. 16 1996 4273 4280
6. Y. Ma, J.W. Brewer, J.A. Diehl, and L.M. Hendershot Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response J. Mol. Biol. 318 2002 1351 1365
7. T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, and J. Yuan Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β Nature 403 2000 98 103
8. T. Nakagawa, and J. Yuan Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis J. Cell Biol. 150 2000 887 894
9. F. Urano, X. Wang, A. Bertolotti, Y. Zhang, P. Chung, and H.P. Harding Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 Science 287 2000 664 666
10. H.L. Pahl, and P.A. Baeuerle A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-κB EMBO J. 14 1995 2580 2588
11. R.J. Kaufman Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls Genes Dev. 13 1999 1211 1233
12. B.M. Burgering, and P.J. Coffer Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction Nature 376 1995 599 602
13. H. Dudek, S.R. Datta, T.F. Franke, M.J. Birnbaum, R. Yao, G.M. Cooper, R.A. Segal, D.R. Kaplan, and M.E. Greenberg Regulation of neuronal survival by the serine-threonine protein kinase Akt Science 275 1997 661 665
14. D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex Science 307 2005 1098 1101
15. D.R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B.A. Hemmings Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15 1996 6541 6551
16. D.R. Alessi, S.R. James, C.P. Downes, A.B. Holmes, P.R. Gaffney, C.B. Reese, and P. Cohen Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr. Biol. 7 1997 261 269
17. X. Wang The expanding role of mitochondria in apoptosis Genes Dev. 15 2001 2922 2933
18. L. del Peso, M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt Science 278 1997 687 689
19. M.H. Cardone, N. Roy, H.R. Stennicke, G.S. Salvesen, T.F. Franke, E. Stanbridge, S. Frisch, and J.C. Reed Regulation of cell death protease caspase-9 by phosphorylation Science 282 1998 1318 1321
20. S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M.E. Greenberg Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 1997 231 241
21. S. Srinivasan, M. Ohsugi, Z. Liu, S. Fatrai, E. Bernal-Mizrachi, and M.A. Permutt Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells Diabetes 54 2005 968 975
22. T. Hosoi, T. Kawagishi, Y. Okuma, J. Tanaka, and Y. Nomura Brain stem is a direct target for leptin's action in the central nervous system Endocrinology 143 2002 3498 3504
23. T. Hosoi, S. Suzuki, J. Nomura, A. Ono, Y. Okuma, S. Akira, and Y. Nomura Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells Mol. Brain Res. 124 2004 159 164
24. K. Mori Frame switch splicing and regulated intramembrane proteolysis: key words to understand the unfolded protein response Traffic 4 2003 519 528
25. A.J. King, H. Sun, B. Diaz, D. Barnard, W. Miao, S. Bagrodia, and M.S. Marshall The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 Nature 396 1998 180 183
26. S. Wennstrom, and J. Downward Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor Mol. Cell. Biol. 19 1999 4279 4288