Abnormal proinsulin congeners as autoantigens that initiate the pathogenesis of Type 1 diabetes

Medical Hypotheses

Volumn 64, Issue 1, 2005, Pages 186-191

  Csorba, Thomas R ^a   Lyon, Andrew W ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b CALGARY LABORATORY SERVICES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CHLORINE; DIMER; DISULFIDE; IMMUNOGLOBULIN; INSULIN; IODINE; PROINSULIN;

AUTOIMMUNITY; B LYMPHOCYTE; CELL DESTRUCTION; CELL MEMBRANE; CELL SURFACE; CROSS LINKING; CYTOTOXIC T LYMPHOCYTE; DIMERIZATION; ELECTROPHORESIS; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HORMONE METABOLISM; HUMAN; HYPERGLYCEMIA; IMMUNE SYSTEM; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; REVIEW; T LYMPHOCYTE;

EID: 7944235945     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.04.021     Document Type: Article

References (25)

1. Gepts W., Lecompte P. The pancreatic islet in diabetes. Am. J. Med. 70:1981;105-115
2. Harrison L.C. Islet cell antigens in insulin-dependent diabetes. Immunol. Today. 13:1992;348-352
3. Narendran P., Mannering S.I., Harrison L.C. Proinsulin - a pathogenic autoantigen in type I diabetes. Autoimmun. Revs. 2:2003;204-210
4. Kuglin B., Gries F.A., Kolb H. Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment. Diabetes. 37:1988;130-132
5. Bohmer K., Keilacker H., Kuglin B., Hubinger A., Bertrams J., Gries F.A., et al. Proinsulin autoantibodies are more closely associated with type 1 (insulin-dependent) diabetes mellitus than insulin autoantibodies. Diabetologia. 34:1991;830-834
6. Robbins D.C., Cooper S.M., Fineberg S.E., Mead P.M. Antibodies to covalent aggregates of insulin in blood of insulin-using diabetic patients. Diabetes. 36:1987;838-841
7. Palmer J.P. Insulin autoantibodies: their role in the pathogenesis of IDDM. Diabetes - Metab. Rev. 3:1987;1005-1015
8. Csorba T.R. Higher molecular weight insulin precursors as autoantigens in type I diabetes. Med. Hypotheses. 33:1990;113-116
9. Csorba T.R., Gattner H.G. Cross-linking of insulin induced by iodination. Horm. Metab. Res. 2:1970;304-306
10. Csorba T.R., Ungar M., Gattner H.G. Partial dimerization of insulin [Abstract]. Clin. Biochem. 6:1973;332-333
11. Pekar A.H., Frank B.H. Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH. Biochem. 11:1972;4013-4016
12. Csorba T.R., Cannon M.M., Ungar M., Track N.S. Incubation of insulin in hyperglycemic blood generates insulin dimers. Brandenburg D., Wollmer A. Insulin: chemistry, structure and function of insulin and related hormones. 1980;539-547 Walter de Gruyter & Co., Berlin-New York
13. Knaus K.J., Morillas M., Swietnicki W., Malone M., Surewicz W.K., Yee V.C. Crystal structure of the human prior protein reveals a mechanism for oligomerization. Nature Struct. Biol. 8:2001;770-774
14. Hutton J.C. Secretory granules. Experientia. 40:1984;1091-1098
15. Orci L. The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited. Diabetologia. 28:1985;528-546
16. Hartling S.G., Lindgren F., Dahlqvist G., Persson B., Binder C. Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes. 38:1989;1271-1274
17. Spinas G.A., Snorgaard O., Hartling S.G., Oberholzer M., Berger W. Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients. Diabet. Care. 15:1992;632-637
18. Ludvigsson J., Heding L. Abnormal proinsulin/C-peptide ratio in juvenile diabetes. Acta Diabet. Lat. 19:1982;351-358
19. Rudy G., Stone N., Harrison L.C., Colman P.G., McNair P., Brusic V., et al. Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol. Med. 1:1995;625-633
20. Eisenbarth G.S., Kotzin B.L. Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction. J. Clin. Invest. 111:2003;179-184
21. Tian J., Gregori S., Adorini L., Kaufman D.L. The frequency of high avidity T cells determine the hierarchy of determinant spreading. J. Immunol. 166:2001;7144-7157
22. Chen W., Bergerot I., Elliott J.F., et al. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of Type 1 diabetes. J. Immunol. 167:2001;4923-4935
23. Tait B.D., Harrison L.C., Drummond B.P., Stewart V., Varney M.D., Honeyman M.C. HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum. Immunol. 42:1995;116-122
24. Harrison L.C., Campbell I.L., Colman P.G., Joseph J.L., Chu S., Kielchynski W.E. Type 1 diabetes: immunopathology and immunotherapy. Mazzaferri E.L., Bar R.S., Kreisberg R.A. Advances in endocrinology and metabolism. vol. 1:1990;36-94 Mosby Year Book Inc.
25. Ramstrom O., Lehn J.M. In situ generation and screening of a dynamic combinatorial carbohydrate library against concanavalin A. Chembiochem. 1:2000;41-48