Update on herpesvirus amplicon vectors

Molecular Therapy

Volumn 10, Issue 4, 2004, Pages 630-643

  Oehmig, Angelika ^a   Fraefel, Cornel ^b   Breakefield, Xandra O ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Institute of Virology   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED DNA; ETOPOSIDE; GLYCOPROTEIN GP 120; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERPESVIRUS VECTOR; RETROVIRUS VECTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADENO ASSOCIATED VIRUS; AMPLICON; ANTIGEN PRESENTING CELL; BIOLUMINESCENCE; CANCER IMMUNOTHERAPY; CELL TYPE; CLINICAL PROTOCOL; CYTOTOXIC T LYMPHOCYTE; DNA MODIFICATION; DNA PACKAGING; DRUG SAFETY; DRUG TARGETING; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENE SEQUENCE; GENE THERAPY; GENE VECTOR; GENETIC ENGINEERING; GENETIC REGULATION; GENETIC SCREENING; GENETIC STABILITY; GLIOMA; GROWTH INHIBITION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 1; HERPES VIRUS; HOST CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HYBRID; IMMUNE RESPONSE; MOUSE; NERVE CELL; NERVOUS SYSTEM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PROTEIN FUNCTION; RAT; REVIEW; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; TRANSGENE; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VIRION; VIRUS GENOME; VIRUS IDENTIFICATION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; GENE THERAPY; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HUMANS; NEURONS; TISSUE DISTRIBUTION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; INSERTION SEQUENCES;

EID: 4644362951     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.06.641     Document Type: Review

References (152)

1. C. Fraefel D.R. Jacoby X.O. Breakefield Herpes simplex virus type 1-based amplicon vector system Adv. Virus Res. 55 2000 425-452
2. M. Sena-Esteves Y. Saeki C. Fraefel X.O. Breakefield HSV-1 amplicon vectors-simplicity and versatility Mol. Ther. 2 2000 9-15
3. M. Simonato R. Manservigi P. Marconi J.C. Glorioso Gene transfer into neurons for the molecular analysis of behaviour: focus on herpes simplex vectors Trends Neurosci. 23 2000 183-190
4. E.A. Burton D.J. Fink J.C. Glorioso Gene delivery using herpes simplex virus vectors DNA Cell Biol. 21 2002 915-936
5. W.F. Goins et al. Delivery using herpes simplex virus: an overview Methods Cell. Biol. 246 2004 257-299
6. C. Herz B. Roizman The alpha promoter regulator-ovalbumin chimeric gene resident in human cells is regulated like the authentic alpha 4 gene after infection with herpes simplex virus 1 mutants in alpha 4 gene Cell 33 1983 145-151
7. E.A. Burton Q. Bai W.F. Goins J.C. Glorioso Replication-defective genomic herpes simplex vectors: design and production Curr. Opin. Biotechnol. 13 2002 424-428
8. E.A. Chiocca M. Aghi G. Fulci Viral therapy for glioblastoma Cancer J. 9 2003 167-179
9. L. Zerboni M. Sommer C.F. Ware A.M. Arvin Varicella-zoster virus infection of a human CD4-positive T-cell line Virology 270 2000 278-285
10. G. Gerna E. Percivalle A. Sarasini F. Baldanti G. Campanini M.G. Revello Rescue of human cytomegalovirus strain AD169 tropism for both leukocytes and human endothelial cells J. Gen. Virol. 84 2003 1431-1436
11. D.H. Dockrell Human herpesvirus 6: molecular biology and clinical features J. Med. Microbiol. 52 2003 5-18
12. C.M. Borza L.M. Hutt-Fletcher Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus Nat. Med. 8 2002 594-599
13. S.M. Akula F.Z. Wang J. Vieira B. Chandran Human herpesvirus 8 interactions with target cells involves heparan sulfate Virology 282 2001 245-255
14. L.P. Deiss J. Chou N. Frenkel Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus J. Virol. 59 1986 605-618
15. J.V. Spencer B.L. Trus F.P. Booy A.C. Steven W.W. Newcomb J.C. Brown Structure of the herpes simplex virus capsid: peptide A862-H880 of the major capsid protein is displayed on the rim of the capsomer protrusions Virology 228 1997 229-235
16. P. Desai S. Person Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid J. Virol. 72 1998 7563-7568
17. C. Potel K. Kaelin I. Gautier P. Lebon J. Coppey F. Rozenberg Incorporation of green fluorescent protein into the essential envelope glycoprotein B of herpes simplex virus type 1 J. Virol. Methods 105 2002 13-23
18. J. Knez P.T. Bilan J.P. Capone A single amino acid substitution in herpes simplex virus type 1 VP16 inhibits binding to the virion host shutoff protein and is incompatible with virus growth J. Virol. 77 2003 2892-2902
19. J.L.C. McKnight M. Doerr Y. Zhang An 85-kilodalton herpes simplex virus type 1 alpha trans-induction factor (VP16)-VP13/14 fusion protein retains the transactivation and structural properties of the wild-type molecule during virus infection J. Virol. 68 1994 1750-1757
20. E.L. Bearer X.O. Breakefield D. Schuback T.S. Reese J.H. LaVail Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument Proc. Natl. Acad. Sci. USA 97 2000 8146-8150
21. G. Elliott P. O'Hare Intercellular trafficking and protein delivery by a herpesvirus structural protein Cell 88 1997 223-233
22. C.S. Liu B. Kong H.H. Xia K.A. Ellem M.Q. Wei VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death J. Gene Med. 3 2001 145-152
23. K.N. Wills et al. Intratumoral spread and increased efficacy of a p53-VP22 fusion protein expressed by a recombinant adenovirus J. Virol. 75 2001 8733-8741
24. W.A. Wybranietz et al. Enhanced suicide gene effect by adenovirus transduction of a VP22-cytosine deaminase (CD) fusion gene Gene Ther. 8 2001 1654-1664
25. M.T. Sciortino B. Taddeo A.P. Poon A. Mastino B. Roizman Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) mRNA to uninfected cells for expression prior to viral infection Proc. Natl. Acad. Sci. USA 99 2002 8318-8323
26. B.D. Zelus R.S. Stewart J. Ross The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro J. Virol. 70 1996 2411-2419
27. B.M. Karr G.S. Read The virion host shutoff function of herpes simplex virus degrades the 5′ end of a target mRNA before the 3′ end Virology 264 1999 195-204
28. M.T. Sciortino M. Suzuki B. Taddeo B. Roizman RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions J. Virol. 75 2001 8105-8116
29. R. Spaete N. Frenkel The herpes virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector Cell 30 1982 295-304
30. R.R. Spaete N. Frenkel The herpes simplex virus amplicon: analyses of cis-acting replication functions Proc. Natl. Acad. Sci. USA 82 1985 694-698
31. A.D. Kwong N. Frenkel Biology of herpes simplex virus (HSV) defective viruses and development of the amplicon system in: M.G. Kaplitt A.D. Loewy eds. Viral Vectors 1995 Academic Press New York 25-42
32. E.R. Detrait et al. Reporter gene transfer induces apoptosis in primary cortical neurons Mol. Ther. 5 2002 723-730
33. D.M. Krisky et al. Deletion of multiple immediate early genes from herpes simplex virus reduces cytotoxicity and improves gene transfer to neurons in culture Gene Ther. 5 1998 1593 1603
34. J.A. Olschowka G.A. Bishop S.D. Hurley M.A. Mastrangelo H.J. Federoff Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS Mol. Ther. 7 2003 218-227
35. C. Logvinoff A.L. Epstein Genetic engineering of herpes simplex virus and vector genomes carrying loxP sites in cells expressing Cre recombinase Virology 267 2000 102-110
36. C. Logvinoff A.L. Epstein Intracellular Cre-mediated deletion of the unique packaging signal carried by a herpes simplex virus type 1 recombinant and its relationship to the cleavage-packaging process J. Virol. 2000 74
37. C. Logvinoff A.L. Epstein A novel approach for herpes simplex virus type 1 amplicon vector production, using the Cre-loxP recombination system to remove helper virus Hum. Gene Ther. 12 2001 161-167
38. C. Zaupa V. Revol-Guyot A.L. Epstein Improved packaging system for generation of high-level noncytotoxic HSV-1 amplicon vectors using Cre-loxP site-specific recombination to delete the packaging signals of defective helper genomes Hum. Gene Ther. 14 2003 1049-1063
39. C. Cunningham A.J. Davison A cosmid-based system for constructing mutants of herpes simplex virus type 1 Virology 197 1993 116-124
40. C. Fraefel et al. Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells J. Virol. 70 1996 7190-7197
41. T.A. Stavropoulos C.A. Strathdee An enhanced packaging system for helper-dependent herpes simplex virus vectors J. Virol. 72 1998 7137-7143
42. Y. Saeki et al. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors Hum. Gene Ther. 9 1998 2787-2794
43. B.C. Horsburgh M.M. Hubinette D. Qiang M.L. MacDonald F. Tufaro Allele replacement: an application that permits rapid manipulation of herpes simplex virus type 1 genomes Gene Ther. 6 1999 922-930
44. H. Shizuya Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector Proc. Natl. Acad. Sci. USA 89 1992 8794-8797
45. Y. Saeki C. Fraefel T. Ichikawa X.O. Breakefield E.A. Chiocca Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome Mol. Ther. 3 2001 591-601
46. M. Sun G.R. Zhang T. Yang L. Yu A.I. Geller Improved titers for helper virus-free simplex virus type 1 plasmid vectors by optimization of the packaging protocol and addition of noninfectious herpes simplex virus-related particles (previral DNA replication enveloped particles) to the packaging procedure Hum. Gene Ther. 10 1999 2005-2011
47. M. Sun J. Lee L. Yu A.I. Geller Modest increases in the titers of helper virus-free herpes simplex virus 1 (HSV-1) vectors by packaging in a cell line with inducible expression of HSV-1 VP16 or by treatment with N-N′-hexamethylene-bis-acetamide Acta Virol. 44 2000 365-369
48. W.J. Bowers D.F. Howard A.I. Brooks M.W. Halterman H.J. Federoff Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers Gene Ther. 8 2001 111-120
49. T. Yang G.R. Zhang W. Zhang M. Sun X. Wang A.I. Geller Enhanced reporter gene expression in the rat brain from helper virus-free HSV-1 vectors packaged in the presence of specific mutated HSV-1 proteins that affect the virion Brain Res. Mol. Brain Res. 90 2001 1-16
50. P.A. Johnson A. Miyanohara F. Levine T. Cahill T. Friedman Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1 J. Virol. 66 1992 2952-2965
51. P.A. Johnson M.J. Wang T. Friedmann Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function J. Virol. 68 1994 6347-6362
52. M.J. Wood A.P. Byrnes D.W. Pfaff S.D. Rabkin H.M. Charlton Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors Gene Ther. 1 1994 283-291
53. B.K. Jin et al. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector Hum. Gene Ther. 7 1996 2015-2024
54. M.G. Kaplitt A.D. Kwong S.P. Kleopoulos C.V. Mobbs S.D. Rabkin W.D. Pfaff Preproenkephalin promoter yields region-specific and long-term expression in adult brain after in vivo gene transfer via a defective herpes simplex viral vector Proc. Natl. Acad. Sci. USA 91 1994 8979-8983
55. U. Herrlinger et al. HSV-1 infected-cell proteins influence tetracycline-regulated transgene expression J. Gene Med. 2 2000 379-389
56. + progenitor cells by human cytomegalovirus, evidence for inhibition of hematopoiesis and viral replication Blood 88 1996 1277-1283
57. J.P. Maciejewski S.C. St. Jeor Human cytomegalovirus infection of human hematopoietic progenitor cells Leuk. Lymphoma 33 1999 1-13
58. M. Messerle I. Crnkovic W. Hammerschmidt H. Ziegler U.H. Koszinowski Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome Proc. Natl. Acad. Sci. USA 94 1997 14759-14763
59. E.M. Borst G. Hahn U.H. Koszinowski M. Messerle Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: A new approach for construction of HCMV mutants J. Virol. 73 1999 8320-8329
60. E.M. Borst M. Messerle Construction of a cytomegalovirus-based amplicon: a vector with a unique transfer capacity Hum. Gene Ther. 14 2003 959-970
61. W. Hammerschmidt B. Sugden Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus Cell 55 1988 427-433
62. W. Hammerschmidt B. Sugden Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes Nature 340 1989 393-397
63. H.J. Delecluse D. Pich T. Hilsendegen C. Baum W. Hammerschmidt A first-generation packaging cell line for Epstein-Barr virus-derived vectors Proc. Natl. Acad. Sci. USA 96 1999 5188-5193
64. R.E. White R. Wade-Martins M.R. James Infectious delivery of 120-kilobase genomic DNA by an Epstein-Barr virus amplicon vector Mol. Ther. 5 2002 427-435
65. R. Borenstein O. Singer A. Moseri N. Frenkel Use of amplicon-6 vectors derived from human herpesvirus 6 for efficient expression of membrane-associated and -secreted proteins in T cells J. Virol. 78 2004 4730-4743
66. H. Romi O. Singer D. Rapaport N. Frenkel Tamplicon-7, a novel T-lymphotropic vector derived from human herpesvirus 7 J. Virol. 73 1999 7001-7007
67. J. Prieto J. Solera E. Tabares Development of new expression vector based on pseudorabies virus amplicons: application to human insulin expression Virus Res. 89 2002 123-129
68. L.W. Enquist Exploiting circuit-specific spread of pseudorabies virus in the central nervous system: Insights to pathogenesis and circuit tracers J. Infect. Dis. 186 Suppl. 2 2002 S209-S214
69. A.J Stevenson et al. A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy Cancer Gene Ther. 7 2000 1077-1085
70. P.G. Spear Entry of alphaherpesviruses into cells Semin. Virol. 4 1993 167-180
71. D. WuDunn P.G. Spear Initial interaction of herpes simplex virus with cells is binding to heparan sulfate J. Virol. 63 1989 52-58
72. B.C. Herold D. WuDunn N. Soltys P.G. Spear Glycoprotein C of herpes simplex virus type 1 plays a principal role in the absorption of virus to cells and in infectivity J. Virol. 65 1991 1090-1098
73. R.I. Montgomery M.S. Warner B.J. Lum P.G. Spear Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family Cell 87 1996 427-436
74. R.J. Geraghty C. Krummenacher G.H. Cohen R.J. Eisenberg P.G. Spear Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor Science 280 1988 1618-1620
75. M.S. Warner et al. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus Virology 246 1998 179-189
76. K. Satoh-Horikawa et al. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities J. Biol. Chem. 275 2000 10291-10299
77. D. Shukla et al. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry Cell 99 1999 13-22
78. A. Turner B. Bruun T. Minson H. Browne Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system J. Virol. 72 1998 873-875
79. B. Sodeik M.W. Ebersold A. Helenius Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus J. Cell Biol. 136 1997 1007-1021
80. S. Laquerre D.B. Anderson D.B. Stolz J.C. Glorioso Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells J. Virol. 72 1998 9683-9697
81. M. Butcher K. Raviprakash H.P. Ghosh Acid pH-induced fusion of cells by herpes simplex virus glycoproteins gB and gD J. Biol. Chem. 265 1990 5862-5868
82. G. Campadelli-Fiume E. Avitabile S. Fini D. Stirpe M. Arsenakis B. Roizman Herpes simplex virus glycoprotein D is sufficient to induce spontaneous pH-independent fusion in a cell line that constitutively expresses the glycoprotein Virology 166 1988 598-602
83. D.B. Anderson et al. Pseudotyping of glycoprotein D-deficient herpes simplex virus type 1 with vesicular stomatitis virus glycoprotein G enables mutant virus attachment and entry J. Virol. 74 2000 2481-2487
84. M.A. Spear et al. HSV-1 amplicon peptide display vector J. Virol. Methods 107 2003 71-79
85. P. Grandi et al. HSV-1 virions engineered for specific binding to cell surface receptor Mol. Ther. 9 2004 419-427
86. D.R. Marsh G.A. Dekaban W. Tan C.A. Strathdee L.C. Weaver Herpes simplex viral and amplicon vector-mediated gene transfer into glia and neurons in organotypic spinal cord and dorsal root ganglion cultures Mol. Ther. 1 2000 464-478
87. M. Agudo et al. Highly efficient and specific gene transfer to Purkinje cells in vivo using a herpes simplex virus I amplicon Hum. Gene Ther. 13 2002 665-674
88. L.C. Costantini D.R. Jacoby S. Wang C. Fraefel X.O. Breakefield O. Isacson Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors Hum. Gene Ther. 10 1999 2481 -2494
89. S. Yoshimura et al. FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice J. Clin. Invest. 112 2003 1202-1210
90. Arvanian V.L. et al. Inducing NMDA-2D subunit expression prevents loss of plasticity in maturing motor neurons. J. Neurophys. 23: 8706-8712
91. K. Aboody-Guterman et al. Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo NeuroReport 8 1997 3801-3808
92. V. Sandler S. Wang K. Angelo H. Lo X.O. Breakefield D.E. Clapham Modified herpes simplex virus delivery of enhanced GFP into the central nervous system J. Neurosci. Methods 121 2002 211-219
93. B. Lu H.J. Federoff Y. Wang L.A. Goldsmith G. Scott Topical application of viral vectors for epidermal gene transfer J. Invest. Dermatol. 108 1997 803-808
94. R.A. Willis et al. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice Hum. Gene Ther. 12 2001 1867-1879
95. W.J. Bowers X. Chen H. Guo D.R. Frisina H.J. Federoff R.D. Frisina Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea Mol. Ther. 6 2002 12-18
96. M.L. Derby M. Sena-Esteves X.O. Breakefield D.P. Corey Gene transfer into the mammalian inner ears using HSV-1 and vaccinia virus vectors Hear. Res. 134 1999 1-8
97. K. Shah et al. In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas Cancer Res. 64 2004 273-278
98. C. Fraefel et al. Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors Mol. Med. 3 1997 813-825
99. Y. Wang S. Mukherjee C. Fraefel X.O. Breakefield P.D. Allen Herpes simplex virus type 1 amplicon vector-mediated gene transfer to muscle Hum. Gene Ther. 13 2002 261-273
100. R.M. Kotin R.M. Linden K.I. Berns Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination 11 1992 5071-5078
101. K.M. Johnston et al. HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells Hum. Gene Ther. 8 1997 359-370
102. T. Heister I. Heid M. Ackermann C. Fraefel Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19 J. Virol. 76 2002 7163-7173
103. Wang Y. et al. Herpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by sitespecific integration. J. Virol. 76, 7150-7162
104. G. Rizzuto et al. Development of animal models for adeno-associated virus site-specific integration J. Virol. 73 1999 2517-2526
105. S.M.J. Young D.M. McCarty N. Degtyareva R.J. Samulski Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination J. Virol. 74 2000 3953-3966
106. J.C. Bakowska M.V. DiMaria S.M. Camp Y. Wang P.D. Allen X.O. Breakefield Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep(+) hybrid amplicon vector Gene Ther. 10 2003 1691-1702
107. J.L. Yates N. Warren B. Sugden Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells Nature 313 1985 812-815
108. S. Wang J.-M. Vos A hybrid herpes virus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo J. Virol. 70 1996 8422-8430
109. R. Wade-Martins E.R. Smith E. Tyminski E.A. Chiocca Y. Saeki An infectious transfer and expression system for genomic DNA loci in human and mouse cells Nat. Biotechnol. 19 2001 1067-1070
110. R. Wade-Martins Y. Saeki E.A. Chiocca Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells Mol. Ther. 7 2003 604-612
111. M. Sena-Esteves Y. Saeki S. Camp E.A. Chiocca X.O. Breakefield Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein Barr virus hybrid amplicons J. Virol. 73 1999 10426-10439
112. M. Sena-Esteves J.A. Hampl S.M. Camp X.O. Breakefield Generation of stable retrovirus packaging cell lines after transduction with herpes simplex virus hybrid amplicon vectors J. Gene Med. 4 2002 229-239
113. J.A. Hampl et al. Potentiated gene delivery to tumor using herpes simplex virus/Epstein Barr/RV tribrid amplicon vectors Hum. Gene Ther. 14 2003 611-626
114. M.W. Halteman C.C. Miller H.J. Federoff Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53 J. Neurosci. 19 1999 6818-6824
115. B. Lu H.J. Federoff Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression Hum. Gene Ther. 6 1995 419-428
116. R. Pollock M. Giel K. Linher T. Clackson Regulation of endogenous gene expression with a small-molecule dimerizer Nat. Biotechnol. 20 2002 729-733
117. R. Pollock T. Clackson Dimerizer-regulated gene expression Curr. Opin. Biotechnol. 13 2002 459-467
118. S. Wang J. Petravicz X.O. Breakefield Single HSV-amplicon vector mediates drug-induced gene expression via dimerizer system Mol. Ther. 7 2003 790-800
119. S. Freundlieb C. Schirra-Muller H. Bujard A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells J. Gene Med. 1 1999 4-12
120. D.C. Bragg D.J. Slater X.O. Breakefield TorsinA and early onset torsion dystonia S. Fahn M. Hallet M.R. DeLong eds. In Dystonia 4: Advances in Neurology 2004 Lippincott Williams, Wilkins, Philadelphia 87-93
121. D.C. Bragg et al. Perinuclear biogenesis of mutant torsinA inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors Neuroscience 125 2004 651-661
122. C.Y. Huang C.R. Brandt Rapid in vivo isolation of gene expression elements using an HSV amplicon system J. Virol. Methods 113 2003 1-12
123. J.E. Conway S. Zolotukhin N. Muzyczka G.S. Hayward B.J. Byrne Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing rep and cap J. Virol. 71 1997 8780-8789
124. X. Zhang et al. High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H Hum. Gene Ther. 10 1999 2527-2537
125. E. Feudner M. de Alwis A.J. Thrasher R.R. Ali S. Fauser Optimization of recombinant adeno-associated virus production using a herpes simplex virus amplicon system J. Virol. Methods 96 2001 97-105
126. S. Kubo Y. Saeki E.A. Chiocca K. Matani An HSV amplicon-based helper system for helper-dependent adenoviral vectors Biochem. Biophys. Res. Commun. 307 2003 826-830
127. A. Moore J.P. Basilion E.A. Chiocca R. Weissleder Measuring transferrin receptor gene expression by NMR imaging Biochem. Biophys. Acta 1402 1998 239-249
128. J.L. Casey et al. Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation Science 240 1988 924-928
129. J.P. Basilion M.C. Kennedy H. Beinert C.M. Massinople R.D. Klausner T.A. Rouault Overexpression of iron-responsive element-binding protein and its analytical characterization as the RNA-binding form, devoid of an iron-sulfur cluster Arch. Biochem. Biophys. 311 1994 517-522
130. R. Weissleder et al. In vivo magnetic resonance imaging of transgene expression Nat. Med. 6 2000 351-355
131. T. Ichikawa et al. MRI of transgene expression: correlation of therapeutic gene expression Neoplasia 4 2002 523-530
132. J. Rieger U. Naumann T. Glaser A. Ashkenazi M. Weller APO2 ligand: a novel lethal weapon against malignant glioma? FEBS Lett. 427 1998 124-128
133. E.B. Brown et al. In vivo measurement of gene expression, angiogenesis and physiological function in using multiphoton laser scanning microscopy Nat. Med. 7 2001 864-868
134. S.M. Messerli et al. A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe Neoplasia 6 2004 95-105
135. L. Corey P.G. Spear Infections with herpes simplex viruses N. Engl. J. Med. 314 1986 749-757
136. G.A. Bishop S.D. Marlin S.A. Schwartz J.C. Glorioso Human natural killer cell recognition of herpes simplex virus type 1 glycoproteins: specificity analysis with the use of monoclonal antibodies and antigenic variants J. Immunol. 133 1984 2206-2214
137. U. Herrlinger et al. Pre-existing herpes simplex virus-1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector Gene Ther. 5 1998 809-819
138. A. Chahlavi S. Rabkin T. Todo P. Sundaresan R. Martuza Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice Gene Ther. 6 1999 1751-1758
139. A.B. Hill B.C. Barnett A.J. McMichael D.J. McGeoch HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2 J. Immunol. 152 1994 2736-2741
140. + T lymphocytes Cell 77 1994 525-535
141. R. Tomazin et al. Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP 15 1996 3256-3266
142. H.W. Favoreel H.J. Nauwynck M.B. Pensaert A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G J. Virol. 63 1989 4479-4488
143. I. Frank H.M. Friedman A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G J. Virol. 63 1989 4479-4488
144. W.J. Bowers J.A. Olschowka H.J. Federoff Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy Gene Ther. 10 2003 941-945
145. M. Toda R.L. Martuza S.D. Rabkin Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor Mol. Ther. 2 2000 324-329
146. A.A. Cardoso J.L. Schultze V.A. Boussiotis G.J. Freeman M.J. Seamon Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen Blood 88 1996 41-48
147. K.A. Tolba et al. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia Blood 98 2001 287-295
148. K.A. Tolba et al. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia Mol. Ther. 6 2002 455-463
149. K.A. Tolba et al. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity Cancer Res. 62 2002 6545-6551
150. P.K. Hocknell et al. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses J. Virol. 76 2002 5565-5580
151. X. Wang R.D. Wiley T.G. Evans W.J. Bowers H.J. Federoff S. Dewhurst Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming Vaccine 21 2003 2288-2297
152. K. Shah Y. Tang X. Breakefield R. Weissleder Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo Oncogene 22 2003 6865-6872