Herpes simplex virus type 1-based amplicon vector systems

Advances in Virus Research

Volumn 55, Issue , 2000, Pages 425-451

  Fraefell, Cornel ^a   Jacoby, David R ^b   Breakefield, Xandra O ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM; DEFECTIVE VIRUS; GENE THERAPY; GENE VECTOR; GENETICS; HELPER VIRUS; HERPES SIMPLEX VIRUS 1; METHODOLOGY; PHYSIOLOGY; PLASMID; REVIEW;

BACTERIA; DEFECTIVE VIRUSES; GENE THERAPY; GENETIC VECTORS; HELPER VIRUSES; HERPESVIRUS 1, HUMAN; PLASMIDS;

EID: 0034571749     PISSN: 00653527     EISSN: 15578399     Source Type: Book Series    
DOI: 10.1016/s0065-3527(00)55011-8     Document Type: Review

References (122)

1. G Campadelli-Fiume D Stirpe A Boscaro E Avitabile L Foa-Tomasi D Barker B Roizman Glycoprotein C dependent attachment of herpes simplex virus to susceptible cells leading to productive infection Virology 178 1990 213 222
2. B.C Herold D WuDunn N Soltys P.G Spear Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity J. Virol. 65 1991 1090 1098
3. E Lycke M Johansson B Svennerholm U Lindahl Binding of herpes simplex virus to cellular heparan sulfate, an initial step in the adsorption process J. Gen. Virol. 72 1991 1131 1137
4. M.-T Shieh D WuDunn R.I Montgomery J.D Esko P.G Spear Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans J. Cell Biol. 116 1992 1273 1281
5. S Laquerre R Argnani D.B Anderson S Zucchini R Manservigi J.C Glorioso Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread J. Virol. 72 1998 6119 6130
6. W Cai B Gu S Person Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion J. Virol. 62 1988 2596 2604
7. P.G Desai P.A Schaffer A.C Minson Excretion of non-infectious virus particles lacking glycoprotein H by a temperature-sensitive mutant of herpes simplex virus type 1: Evidence that gH is essential for virion infectivity J. Gen. Virol. 69 1988 1147 1156
8. M.W Ligas D.C Johnson A herpes simplex virus mutant in which glycoprotein D sequences are replaced by β-galactosidase sequences binds to but is unable to penetrate into cells J. Viral. 62 1988 1486 1494
9. R.I Montgomery M.S Warner B.J Lum P.G Spear Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family Cell 87 1996 427 436
10. T Terry-Allison R.I Montgomery C Whitbeck R Xu G.H Cohen R.J Eisenberg P.G Spear HveA (Herpesvirus Entry Mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion J. Viral. 72 1998 5802 5810
11. R.J Geraghty C Krummenacher G.H Cohen R.J Eisenberg P.G Spear Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor Science 280 1998 1618 1620
12. B Sodeik M.W Ebersold A Helenius Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus J. Cell Biol. 136 1997 1007 1021
13. N.D Stow Localization of an origin of DNA replication in the TRs/IRs repeated region of the herpes simplex virus type 1 genome EMBO J. 1 1982 863 867
14. D Lockshon D.A Galloway Cloning and characterization of OriL2, a large palindromic replication origin of herpes simplex virus type 2 J. Viral. 58 1986 513 521
15. C.J Lukonis J Burkham S.K Weller Herpes simplex virus type 1 prereplicative sites are a heterologous population: Only a subset are likely to be precursors to replication compartments J. Virol. 71 1997 4771 4781
16. D.W Martin P.C Weber The a sequence is dispensable for isomerization of the herpes simplex virus type 1 genome J. Virol. 70 1996 8801 8812
17. D Bataille A.L Epstein Equimolar generation of the four possible arrangements of adjacent L components in herpes simplex virus type 1 replicative intermediates J. Virol. 71 1997 7736 7743
18. W Gilbert D Dressler DNA replication: the rolling-circle model 3rd edition Cold Spring Harbor Symp. Quant. Biol. 33 1968 473 484
19. A Severini D.G Scraba D.L Tyrrell Branched structures in the intracellular DNA of herpes simplex virus type 1 J. Virol. 70 1996 3169 3175
20. X Zhang S Efstathiou A Simmons Identification of novel herpes simplex virus replicative intermediates by field inversion gel electrophoresis: Implications for viral DNA amplification strategies Virology 202 1994 530 539
21. B Roizman A.E Sears Herpes simplex viruses and their replication B.N Fields D.M Knipe P.M Howley 3rd edition Fields Virology Vol. 2 1996 Lippincott-Raven Philadelphia 2231 2295
22. R.J Jacob B Roizman Anatomy of herpes simplex virus DNA. VIII. Properties of the replicating DNA J. Virol. 23 1977 394 411
23. D.A Vlazny A Kwong N Frenkel Site specific cleavage-packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 79 1982 1423 1427
24. L.P Deiss J Chou N Frenkel Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus J. Virol. 59 1986 605 618
25. A.C Steven P.G Spear Herpesvirus capsid assembly and envelopment W Chiu R Burnett R Garcea Structural Biology of Viruses 1997 Oxford University Press New York 312 351
26. J.G Stevens Latent herpes simplex virus and the nervous system Curr. Top. Microbiol. Immunol. 70 1975 31 50
27. D.L Rock A.B Nesburn H Ghiasi J Ong T.L Llewis J.R Lokensgard S.L Wechsler Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1 J. Virol. 62 1987 3820 3826
28. P von Magnus Incomplete forms of influenza virus Adv. Virus Res. 2 1954 59 78
29. N Frenkel H Locker B Batterson G.S Hayward B Roizman Anatomy of herpes simplex virus. VI. Defective DNA originates from the S component J. Virol. 20 1976 527 531
30. H Locker N Frenkel Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin) J. Virol. 29 1979 1065 1077
31. H Locker N Frenkel I Halliburton Structure and expression of class II defective herpes simplex virus genomes encoding infected cell polypeptide number 8 J. Virol. 43 1982 574 593
32. R.R Spaete N Frenkel The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector Cell 30 1982 295 304
33. A.D Kwong N Frenkel Efficient expression of chimeric chicken ovalbumin gene amplified within defective virus genomes Virology 142 1985 421 425
34. C Preston Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild type or the temperature sensitive mutant tsK J. Virol. 29 1979 257 284
35. A.I Geller X.O Breakefield Defective HSV 1 vector expresses Escherichia coli β-galactosidase in cultured peripheral neurons Science 241 1988 1667 1669
36. A.I Geller K Keyomarski J Bryan A.B Pardee An efficient deletion mutant packaging system for defective HSV 1 vectors: Potential applications to neuronal physiology and human gene therapy 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 87 1990 8950 8954
37. F Lim D Hartley P Starr P Lang S Song L Yu Y Wang A.I Geller Generation of high-titer defective HSV1 vectors using an IE2 deletion mutant and quantitative study of expression in cultured cortical cells Biotechniques 20 1996 458 469
38. T Paterson R.D Everett A prominent serine-rich region on Vmw175, the major regulatory protein of herpes simplex virus type 1 is not essential for virus growth in tissue culture J. Gen. Virol. 71 1990 1775 1783
39. I Davidson N.D Stow Expression of an immediate early polypeptide and activation of a viral origin of DNA replication in cells containing a fragment of herpes simplex virus DNA Virology 141 1985 77 88
40. P.A Johnson A Miyanohara F Levine T Cahill T Friedman Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1 J. Virol. 66 1992 2952 2965
41. A.M McCarthy L McMahan P.A Schaffer Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient J. Virol. 63 1989 18 27
42. I.L Smith M.A Hardwicke R.M Sandri-Goldin Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression Virology 186 1992 74 86
43. P.A Pechan M Fotaki R.L Thompson R.J Dunn M Chase E.A Chiocca X.O Breakefield A novel “piggyback” packaging system for herpes simplex virus amplicon vectors Hum. Gene Ther. 7 1996 2003 2013
44. H Berthomme S Fournel A.L Epstein Increased transcomplementation properties of plasmids carrying HSV 1 origin of replication and packaging signals Virology 216 1996 437 443
45. C Cunningham A.J Davison A cosmid-based system for constructing mutants of herpes simplex virus type 1 Virology 197 1993 116 124
46. C Fraefel S Song F Lim P Lang L Yu Y Wang P Wild A.I Geller Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells J. Virol. 70 1996 7190 7197
47. C Fraefel X.O Breakefield D Jacoby HSV 1 amplicon E.A Chiocca X.O Breakefield Gene Therapy for Neurological Disorders and Brain tumors 1998 Humana Press Ottawa 63 82
48. C Fraefel D.R Jacoby C Lage H Hilderbrand J.Y Chou F.W Alt X.O Breakefield J.A Majzoub Efficient gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors Mol. Med. 3 1997 813 825
49. K.M Johnston D Jacoby P Pechan C Fraefel P Borghesani D Schuback R.J Dunn F.L Smith X.O Breakefield HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells Hum. Gene Ther 8 1997 359 370
50. K.S Aboody-Guterman P.A Pechan N.G Rainov M Sena-Esteves A Jacobs E.Y Snyder P Wild E Schraner K Tobler X.O Breakefield C Fraefel Green fluorescent protein as a reporter for retrovirus and helper virus-free HSV-1 amplicon vector-mediated gene transfer into neural cells in culture and in vivo Neuroreport 8 1997 3801 3808
51. H Shizuya B Birren U.-J Kim V Mancino T Slepak Y Tachiiri S Melvin Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 89 1992 8794 8797
52. V.A Luckow S.C Lee G.F Barry P.O Olins Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli J. Virol. 67 1993 4566 4579
53. M Messerle I Crnkovic W Hammerschmidt H Ziegler U.H Koszinowski Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 94 1997 14759 14763
54. Y Saeki T Ichikawa A Saeki E.A Chiocca K Tobler M Ackermann X.O Breakefield C Fraefel HSV-1 DNA amplified as bacterial artificial chromosome in E. coli : Rescue of replication-competent virus progeny and packaging of amplicon vectors Hum. Gene Ther. 10 1998 2787 2794
55. T.A Stavropoulos C.A Strathdee An enhanced packaging system for helper-dependent herpes simplex virus vectors J. Virol. 72 1998 7137 7143
56. S McKnight R Tjian Transcriptional selectivity of viral genes in mammalian cells Cell 46 1986 795 805
57. B Lu H.J Federoff Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression Hum. Gene Ther. 6 1995 419 428
58. T.J Meier D.Y Ho R.M Sapolsky Increased expression of calbindin D28k via herpes simplex virus amplicon vector decreases calcium ion mobilization and enhances neuronal survival after hypoglycemic challenge J. Neurochem.. 69 1997 1039 1047
59. Y Liu A Rabinovitch W Suarez-Pinzon B Muhkerjee M Brownlee D Edelstein H.J Federoff Expression of the bcl-2 gene from a defective HSV 1 amplicon vector protects pancreatic beta-cells from apoptosis Hum. Gene Ther. 7 1996 1719 1726
60. S.L Fink L.K Chang D.Y Ho R.M Sapolsky Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock J. Neurochem. 68 1997 961 969
61. H.J Federoff M.D Geschwind A.I Geller J.A Kessler Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 89 1992 1636 1640
62. X.O Breakefield C.M Kramm E.A Chiocca P.A Pechan Herpes simplex virus vectors for tumor therapy R.E Sobol K.J Scanlon The Internet Book of Gene Therapy: Cancer Gene Therapeutics 1995 Appleton and Lange Stamford, CT 41 56
63. G Davar M.F Kramer D Garber A.L Roca J.K Anderson W Bebrin D.M Coen M Kosz-Vnenchak D.M Knipe X.O Breakefield O Isacson Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors J. Comp. Neurol. 339 1994 3 11
64. U Blömer L Naldini T Kafri D Trono I.M Verma F.H Gage Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector J. Virol. 71 1997 6641 6649
65. M.J During J.R Naegele K.L O'Malley A.I Geller Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase Science 266 1994 1399 1403
66. M.G Kaplitt A.D Kwong S.P Kleopoulos C.V Mobbs S.D Rabkin D.W Pfaff Preproenkephalin promoter yield region-specific and long-term expression in adult brain after in vivo gene transfer via a defective herpes simplex viral vector 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 91 1994 8979 8983
67. B.K Jin M Belloni B Conti H.J Federoff R Starr J.H Son H Baker T.H Joh Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector Hum. Gene Ther. 7 1996 2015 2024
68. D.Y Ho T.C Saydam S.L Fink M.S Lawrence R.M Sapolsky Defective herpes virus vectors expressing the rat brain glucose transporter protect cultured neurons from necrotic insults J. Neurochem. 65 1995 842 850
69. M.E Fotaki J.R Pink J Mous Tetracycline-responsive gene expression in mouse brain after amplicon-mediated gene transfer Gene Ther. 4 1997 901 908
70. D.Y Ho J.R McLaughlin R.M Sapolsky Inducible gene expression from defective herpes simplex virus vectors using the tetracycline responsive promoter system Brain Res. Mol. Brain Res. 41 1996 200 209
71. A.L Brooks B Muhkerjee N Panahian D Cory-Slechta H.J Federoff Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase Nat. Biotechnol. 15 1997 57 62
72. R.M Kotin R.M Linden K.I Berns Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination EMBO J. 1992 5071 5078 11
73. R.M Linden P Ward C Giraud E Winocour K.I Berns Site-specific integration by adeno-associated virus 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 93 1996 11288 11294
74. C Balague M Kalla W.-W Zhang Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome J. Virol. 71 1997 3299 3306
75. R.T Surosky M Urabe S.G Godwin S.A McQuiston G.J Kurtzman K Ozawa G Natsoulis Adeno-associated virus rep proteins target DNA sequences to a unique locus in the human genome J. Virol. 71 1997 7951 7959
76. M Nonoyama J.S Pagano Separation of Epstein-Barr virus DNA from large chromosomal DNA in non-virus producing cells Nature New Biol. 238 1972 169 171
77. T Lindahl A Adams G Bjursell G.W Bornkamm C Kaschka-Dierich U Jehn Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line J. Mol. Biol. 102 1976 511 530
78. D.A Wysokenski J.L Yates Multiple EBNA1-binding sites are required to form an EBNAl-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus J. Virol. 63 1989 2657 2666
79. T.A Gahn C.L Schildkraut The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication Cell 58 1989 527 535
80. J Yates N Warren D Reisman B Sugden A cis -acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 81 1984 3806 3810
81. T Middleton B Sugden Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1 J. Virol. 68 1994 4067 4071
82. F Langle-Rouault V Patzel A Benavente M Taillez N Silvestre A Bompard G Sczakiel E Jacobs K Rittner Up to 100-fold increase of apparent gene expression in the presence of Epstein-Barr virus oriP sequences and EBNAl: Implications of the nuclear import of plasmids J. Virol. 72 1998 6181 6185
83. T.-Q Sun E Livanos J.-M Vos Engineering a mini-herpesvirus as a general strategy to transduce up to 180 kb of functional self-replicating human mini-chromosomes Gene Ther. 3 1996 1081 1088
84. J.G Wohlgemuth S.H Kang G.H Bulboaca K.A Nawotka M.P Calos Long-term gene expression from autonomously replicating vectors in mammalian cells Gene Ther. 3 1996 503 512
85. S Wang J.-M Vos A hybrid herpes virus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo J. Virol. 70 1996 8422 8430
86. J.B Wilson J.L Bell A.J Levine Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice EMBO J. 15 1996 3117 3126
87. S Wang S Di W.-B Young C Jacobson C.J Link Jr. A novel herpesvirus amplicon system for in vivo gene delivery Gene Ther. 4 1997 1132 1141
88. P Balan N Davis-Poynter S Bell H Atkinson H Browne T Minson An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gl or the putative gJ J. Gen. Virol. 75 1994 1245 1258
89. K.S Dingwell L.C Doering D.C Johnson Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus J. Virol. 69 1995 7087 7098
90. A.H Rux W.T Moore J.D Lambris W.R Abrams C Peng H.M Friedman G.H Cohen R.J Eisenberg Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus J. Virol. 70 1996 5455 5465
91. R Tal-Singer C Peng M Ponce de Leon W.R Abrams B.W Banfield F Tufaro G.H Cohen R.J Eisenberg Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules J. Virol. 69 1995 4471 4483
92. S Laquerre D.B Anderson D.B Stolz J.C Glorioso Recombinant herpes simplex virus type 1 engineered for targeted binding to the erythropoietin receptor bearing cells J. Virol. 72 1998 9683 9697
93. D.Y Ho S.L Fink M.S Lawrence T.J Meier T.C Saydam R Dash R.M Sapolsky Herpes simplex virus vector system: Analysis of its in vivo and in vitro cytopathic effects J. Neurosci. Methods 57 1995 205 215
94. L.A Samaniego L Neiderhiser N.A DeLuca Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins J. Virol. 72 1998 3307 3320
95. A.D Kwong N Frenkel The herpes simplex virus virion host shut off function J. Virol. 63 1989 4834 4839
96. A.A Oroskar G.S Read Control of mRNA stability by the virion host shutoff function of herpes simplex virus J. Virol. 63 1989 1897 1906
97. S Stern M Tanaka W Herr The Oct-1 homeo domain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16 Nature 341 1989 624 630
98. S.P Weinheimer B.A Boyd S.K Durham J.L Resnik D.R O'Boyle Deletion of the VP16 open reading frame of herpes sinplex virus type 1 J. Virol. 66 1992 258 269
99. C.I Ace T.A McKee J.M Ryan J.M Cameron C.M Preston Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression J. Virol. 63 1989 2260 2269
100. P.A Johnson M.J Wang T Friedmann Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function J. Virol. 68 1994 6347 6362
101. W Batterson D Furlong B Roizman Molecular genetics of herpes simplex virus. VIII. Further characterization of a temperature-sensitive mutant defective in release of viral DNA and in other stages of the viral reproductive cycle. J. Virol. 45 1983 397 407
102. C.A MacLean A Dolan F.E Jamieson D.J McGeoch The myristylated virion proteins of herpes simplex virus type 1: Investigation of their role in the virus life cycle J. Gen. Virol. 73 1992 539 547
103. J.D Bains B Roizman The UL11 gene of herpes simplex virus 1 encodes a function that facilitates nucleocapsid envelopment and egress from cells J. Virol. 66 1992 5168 5174
104. C Addison F.J Rixon J.W Palfreyman M O'Hara V.G Preston Characterisation of a herpes simplex virus type 1 mutant which has a temperature-sensitive defect in penetration of cells and assemply of capsids Virology 138 1984 246 259
105. N Savard F.-L Cosset A.L Epstein Defective herpes simplex virus type 1 vectors harboring gag, pol, and env genes can be used to rescue defective retrovirus vectors J. Virol. 71 1997 4111 4117
106. J.E Conway S Zolothukin N Muzycka G.S Hayward B.J Byrne Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap J. Virol. 71 1997 8780 8789
107. J Meyer S Nick T Stamminger F Grummt G Jahn H.J Lipps Inhibition of HIV -1 replication by a high-copy-number vector expressing antisense RNA for reverse transcriptase Gene 129 1993 263 268
108. J.G McArthur L.K Beitel J.W Chamberlain C.P Stanners Elements which stimulate gene amplification in mammalian cells: Role of recombinogenic sequences/structures and transcriptional activation Nucleic Acids Res. 19 1991 2477 2484
109. M.J Cooper M Lippa J.M Payne G Hatzivassiliou E Reifenberg B Fayaz J.C Perales L.J Morrison D Templeton R.L Piekaarz J Tan Safety-modified episomal vectors for human gene therapy 3rd Ed. Proc. Natl. Acad. Sci. U.S.A. 94 1997 6450 6455
110. M.S Caddle M.P Calos Analysis of the autonomous replication behavior in human cells of the dihydrofolate reductase putative chromosomal origin of replication Nucleic Acids Res. 20 1992 5971 5978
111. D.C Mah P.A Dijkwel A Todd V Klein G.B Price M Zannis-Hadjopoulos ors 12, a mammalian autonomously replicating DNA sequence associates with the nuclear matrix in a cell cycle-dependent manner J. Cell Sci. 105 1993 807 818
112. C McWhinney M Leffak Autonomous replication of a DNA fragment containing the chromosomal replication origin of the human c-myc gene Nucleic Acids Res. 18 1990 1233 1242
113. L Zhang U Sankar D.J Lampe H.M Robertson F.L Graham The himar 1 mariner transposase cloned in a recombinant adenovirus vector is functional in mammalian cells Nucleic Acids Res. 26 1998 3687 3693
114. Z Ivics P.B Hackett R.H Plasterk Z Izsvak Molecular reconstruction of sleeping beauty, a Tel-like transposon from fish, and its transposition in human cells Cell 91 1997 501 510
115. D.W Russell R.K Hirata Human gene targeting by viral vectors Nat. Genet. 18 1998 325 330
116. Q Wang M.W Taylor Correction of a deletion mutant by gene targeting with an adenovirus vector Mol. Cell. Biol. 13 1993 918 927
117. K Mitani M Wakamiya P Hasty F.L Graham A Bradley C.T Caskey Gene targeting in mouse embryonic stem cells with an adenoviral vector Somat. Cell Mol. Genet. 21 1995 221 231
118. s stimulate origin function J. Virol. 65 1991 2601 2611
119. K Umene Herpes simplex virus type 1 variant a sequence generated by recombination and breakage of the a sequence in defined regions, including the one involved in recombination J. Viral. 67 1993 5685 5691
120. S Miyatake R.L Martuza S.D Rabkin Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma Cancer Gene Ther 4 1997 222 228
121. P Pechan U Herrlinger M Aghi A Jacobs X.O Breakefield Combined HSV 1 recombinant and amplicon piggyback vectors: Replication-competent and defective forms, and terapeutic efficacy for experimental gliomas Journal of Gene Medicine 1 1999 176 185
122. L.C Costantini D.R Jacoby S Wang C Fraefel X.O Breakefield O Isacson Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors Human Gene Therapy 10 1999 2481 2494