Use of Amplicon-6 Vectors Derived from Human Herpesvirus 6 for Efficient Expression of Membrane-Associated and -Secreted Proteins in T Cells

Journal of Virology

Volumn 78, Issue 9, 2004, Pages 4730-4743

  Borenstein, Ronen ^a   Singer, Oded ^a   Moseri, Adi ^a   Frenkel, Niza ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN D; GREEN FLUORESCENT PROTEIN;

AMPLICON; AMPLICON 6 VECTOR; ARTICLE; CLONING VECTOR; DNA REPLICATION ORIGIN; ELECTROPORATION; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; GENE REPLICATION; GENOMIC FRAGMENT; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPERINFECTION; T LYMPHOCYTE; TRANSGENE; VIRUS CULTURE; VIRUS GENOME;

GENE DELETION; GENE EXPRESSION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HELPER VIRUSES; HERPESVIRUS 6, HUMAN; HUMANS; JURKAT CELLS; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; PROTEINS; T-LYMPHOCYTES; TRANSGENES; VIRAL ENVELOPE PROTEINS;

EID: 4644300204     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.9.4730-4743.2004     Document Type: Article

References (91)

1. Ablashi, D., A. H. Z. Berneman, et al. 1993. Human herpesvirus-6 strain groups: a nomenclature. Arch. Virol. 129:363-366.
2. Ablashi, D. V., H. B. Eastman, C. B. Owen, M. M. Roman, J. Friedman, J. B. Zabriskie, D. L. Peterson, G. R. Pearson, and J. E. Whitman. 2000. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. J. Clin. Virol. 16:179-191.
3. Akhyani, N., R. Berti, M. B. Brennan, S. S. Soldan, J. M. Eaton, H. F. McFarland, and S. Jacobson. 2000. Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis. J. Infect. Dis. 182:1321-1325.
4. Alvarez-Lafuente, R., C. Martin-Estefania, V. de Las Heras, C. Castrillo, J. J. Picazo, E. Varela de Seijas, and R. A. Gonzalez. 2002. Active human herpesvirus 6 infection in patients with multiple sclerosis. Arch. Neurol. 59:929-933.
5. Asada, H., V. Klaus-Kovtun, H. Golding, S. I. Katz, and A. Blauvelt. 1999. Human herpesvirus 6 infects dendritic cells and suppresses human immunodeficiency virus type 1 replication in coinfected cultures. J. Virol. 73:4019-4028.
6. Beck, R., H. Wiendl, G. Jahn, A. Melms, and F. Neipel. 2003. Human herpesvirus 6 in serum and spinal fluid of patients with multiple sclerosis? Arch. Neurol. 60:639-640.
7. Bernstein, D. I., and L. R. Stanberry. 1999. Herpes simplex virus vaccines. Vaccine 17:1681-1689.
8. Bordignon, C., C. Bonini, S. Verzeletti, N. Nobili, D. Maggioni, C. Traversari, R. Giavazzi, P. Servida, E. Zappone, E. Benazzi, et al. 1995. Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogencic bone marrow transplantation. Hum. Gene Ther. 6:813-819.
9. Bourne, N., G. N. Milligan, M. R. Schleiss, D. I. Bernstein, and L. R. Stanberry. 1996. DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2. Vaccine 14:1230-1234.
10. Briggs, M., J. Fox, and R. S. Tedder. 1988. Age prevalence of antibody to human herpesvirus 6. Lancet i:1058-1059.
11. Buttgereit, P., and I. G. Schmidt-Wolf. 2002. Gene therapy of lymphoma. J. Hematother. Stem Cell Res. 11:457-467.
12. Buttgereit, P., S. Weineck, G. Ropke, A. Marten, K. Brand, T. Heinicke, W. H. Caselmann, D. Huhn, and I. G. Schmidt-Wolf. 2000. Efficient gene transfer into lymphoma cells using adenoviral vectors combined with lipofection. Cancer Gene Ther. 7:1145-1155.
13. Calvario, A., A. Bozzi, M. Scarasciulli, C. Ventola, R. Seccia, D. Stomati, and B. Brancasi. 2002. Herpes Consensus PCR test: a useful diagnostic approach to the screening of viral diseases of the central nervous system. J. Clin. Virol. 25(Suppl. 1):S71-S78.
14. Campadelli-Fiume, G. 2000. Virus receptor arrays, CD46 and human herpesvirus 6. Trends Microbiol. 8:436-438.
15. Campadelli-Fiume, G., F. Cocchi, L. Menotti, and M. Lopez. 2000. The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells. Rev. Med. Virol. 10:305-319.
16. Carrigan, D. R., W. R. Drobyski, S. K. Russler, M. A. Tapper, K. K. Knox, and R. C. Ash. 1991. Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation. Lancet 338:147-149.
17. Chia, J. K., and A. Chia. 2003. Diverse etiologies for chronic fatigue syndrome. Clin. Infect. Dis. 36:671-673.
18. Cone, R. W., M. L. Huang, R. Ashley, and L. Corey. 1993. Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J. Clin. Microbiol. 31:1262-1267.
19. Cone, R. W., M. L. Huang, L. Corey, J. Zeh, R. Ashley, and R. Bowden. 1999. Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations. J. Infect. Dis. 179:311-318.
20. Deiss, L. P., J. Chou, and N. Frenkel. 1986. Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA. J. Virol. 59:605-618.
21. Deiss, L. P., and N. Frenkel. 1986. Herpes simplex virus amplicon: cleavage of concatemeric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence. J. Virol. 57:933-941.
22. Deng, H., and S. Dewhurst. 1998. Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. J. Virol. 72:320-329.
23. Di Luca, D., M. Zorzenon, P. Mirandola, R. Colle, G. A. Botta, and E. Cassai. 1995. Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome. J. Clin. Microbiol. 33:1660-1661.
24. Dominguez, G., T. R. Dambaugh, F. R. Stamey, S. Dewhurst, N. Inoue, and P. E. Pellett. 1999. Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J. Virol. 73:8040-8052.
25. Drobyski, W. R., W. M. Dunne, E. M. Burd, K. K. Knox, R. C. Ash, M. M. Horowitz, N. Flomenberg, and D. R. Carrigan. 1993. Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: evidence of a marrow-suppressive role for HHV-6 in vivo. J. Infect. Dis. 167:735-739.
26. Engels, B. C., D. B. Kohn, and G. M. Podsakoff. 2003. Update on gene therapy of inherited immune deficiencies. Curr. Opin. Mol. Ther. 5:503-507.
27. Engels, B., H. Cam, T. Schuler, S. Indraccolo, M. Gladow, C. Baum, T. Blankenstein, and W. Uckert. 2003. Retroviral vectors for high-level transgene expression in T lymphocytes. Hum. Gene Ther. 14:1155-1168.
28. Fox, J. D., M. Briggs, P. A. Ward, and R. S. Tedder. 1990. Human herpesvirus 6 in salivary glands. Lancet 336:590-593.
29. Frenkel, N., and Sarid, R. 1996. Herpes simplex virus-1 amplicons, p. 143-148. In P. R. Lovenstein and L. W. Enquist (ed.), Protocols for gene transfer in neuroscience: towards gene therapy of neurological disorders. John Wiley & Sons, Inc., New York, N.Y.
30. Frenkel, N., G. C. Katsafanas, L. S. Wyatt, T. Yoshikawa, and Y. Asano. 1994. Bone marrow transplant recipients harbor the B variant of human herpesvirus 6. Bone Marrow Transplant 14:839-843.
31. Frenkel, N., E. C. Schirmer, G. Katsafanas, and C. H. June. 1990. T-cell activation is required for efficient replication of human herpesvirus 6. J. Virol. 64:4598-4602.
32. Frenkel, N., O. Singer, and A. D. Kwong. 1994. Minireview: the herpes simplex virus amplicon: a versatile defective virus vector. Gene Ther. 1(Suppl. 1):S40-S46.
33. Frenkel, N., and E. Roffman. 1995. Human herpesvirus 7, p. 2609-2622. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
34. Gompels, U. A., J. Nicholas, G. Lawrence, et al. 1995. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209:29-51.
35. Higgins, T. J., K. M. Herold, R. L. Arnold, S. P. McElhiney, K. E. Shroff, and C. J. Pachuk. 2000, Plasmid DNA-expressed secreted and nonsecreted forms of herpes simplex virus glycoprotein D2 induce different types of immune responses. J. Infect. Dis. 182:1311-1320.
36. Holmes, G. P., J. E. Kaplan, J. A. Stewart, B. Hunt, P. F. Pinsky, and L. B. Schonberger. 1987. A cluster of patients with a chronic mononucleosis-like syndrome: is Epstein-Barr virus the cause? JAMA 257:2297-2302.
37. Huang, L. M., C. Y. Lee, J. Y. Chen, C. S. Yang, J. D. Wang, M. H. Chang, C. Y. Hsu, and P. F. Kuo. 1992. Primary human herpesvirus 6 infections in children: a prospective serologic study. J. Infect. Dis. 165:1163-1164.
38. Isegawa, Y., T. Mukai, K. Nakano, M. Kagawa, J. Chen, Y. Mori, T. Sunagawa, K. Kawanishi, J. Sashihara, A. Hata, P. Zou, H. Kosuge, and K. Yamanishi. 1999. Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J. Virol. 73:8053-8063.
39. Jarrett, R. F., D. A. Clark, S. F. Josephs, and D. E. Onions. 1990. Detection of human herpesvirus-6 DNA in peripheral blood and saliva. J. Med. Virol. 32:73-76.
40. Kaiser, J. 2003. Gene therapy: seeking the cause of induced leukemias in X-SCID trial. Science 299:495.
41. Kakimoto, M., A. Hasegawa, S. Fujita, and M. Yasukawa. 2002. Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection. J. Virol. 76:10338-10345.
42. Kim, J. S., K. S. Lee, J. H. Park, M. Y. Kim, and W. S. Shin. 2000. Detection of human herpesvirus 6 variant A in peripheral blood mononuclear cells from multiple sclerosis patients. Eur. Neurol. 43:170-173.
43. Koelle, D. M., S. Barcy, M. L. Huang, R. L. Ashley, L. Corey, J. Zeh, S. Ashton, and D. Buchwald. 2002. Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome. Clin. Infect. Dis. 35:518-525.
44. Kondo, K., T. Kondo, T. Okuno, M. Takahashi, and K. Yamanishi. 1991. Latent human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 72:1401-1408.
45. Kwong, A. D., and N. Frenkel. 1984. Herpes simplex virus amplicon: effect of size on replication of constructed defective genomes containing eucaryotic DNA sequences. J. Virol. 51:595-603.
46. Langenberg, A. G., R. L. Burke, S. F. Adair, R. Sekulovich, M. Tigges, C. L. Dekker, and L. Corey. 1995. A recombinant glycoprotein vaccine for herpes simplex virus type 2: safety and immunogenicity. Ann. Intern. Med. 122:889-898.
47. Levine, P. H., N. Jahan, P. Murari, M. Manak, and E. S. Jaffe. 1992. Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J. Infect. Dis. 166:291-295.
48. Locker, H., and N. Frenkel. 1979. Structure and origin of defective genomes contained in serially passaged herpes simplex virus type 1 (Justin). J. Virol. 29:1065-1077.
49. Locker, H., N. Frenkel, and I. Halliburton. 1982. Structure and expression of class II defective herpes simplex virus genomes encoding infected cell polypeptide number 8. J. Virol. 43:574-593.
50. Luppi, M., P. Barozzi, A. Maiorana, R. Marasca, R. Trovato, R. Fano, L. Ceccherini-Nelli, and G. Torelli. 1995. Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors. J. Med. Virol. 47:105-111.
51. Marshall, E. 2002. Clinical research: gene therapy suspect in leukemia-like disease. Science 298:34-35.
52. Martin, M. E., B. J. Thomson, R. W. Honess, M. A. Craxton, U. A. Gompels, M. Y. Liu, E. Littler, J. R. Arrand, I. Teo, and M. D. Jones. 1991. The genome of human herpesvirus 6: maps of unit-length and concatemeric genomes for nine restriction endonucleases. J. Gen. Virol. 72:157-168.
53. McClements, W. L., M. E. Armstrong, R. D. Keys, and M. A. Liu. 1996. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proc. Natl. Acad. Sci. USA 93:11414-11420.
54. Meeker, T. C., L. T. Lay, J. M. Wroblewski, F. Turturro, Z. Li, and P. Seth. 1997. Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease. Clin. Cancer Res. 3:357-364.
55. Megaw, A. G., D. Rapaport, B. Avidor, N. Frenkel, and A. J. Davison. 1998. The DNA sequence of the RK strain of human herpesvirus 7. Virology 244:119-132.
56. Mirandola, P., A. Stefan, E. Brambilla, G. Campadelli-Fiume, and L. M. Grimaldi. 1999. Absence of human herpesvirus 6 and 7 from spinal fluid and serum of multiple sclerosis patients. Neurology 53:1367-1368.
57. Montgomery, R. I., M. S. Warner, B. J. Lum, and P. G. Spear. 1996. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87:427-436.
58. Okuno, T., K. Higashi, K. Shiraki, K. Yamanishi, M. Takahashi, Y. Kokado, M. Ishibashi, S. Takahara, T. Sonoda, K. Tanaka, et al. 1990. Human herpesvirus 6 infection in renal transplantation. Transplantation 49:519-522.
59. Okuno, T., K. Takahashi, K. Balachandra, K. Shiraki, K. Yamanishi, M. Takahashi, and K. Baba. 1989. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J. Clin. Microbiol. 27:651-653.
60. Ongradi, J., C. Rajda, C. L. Marodi, A. Csiszar, and L. Vecsei. 1999. A pilot study on the antibodies to HHV-6 variants and HHV-7 in CSF of MS patients. J. Neurovirol. 5:529-532.
61. Pellett, D. A. 2002. Human herpesviruses 6A, 6B, and 7 and their replication, p. 2769-2784. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott-Raven Publishers, Philadelphia, Pa.
62. Rapaport, D., D. Engelhard, G. Tagger, R. Or, and N. Frenkel. 2002. Antiviral prophylaxis may prevent human herpesvirus-6 reactivation in bone marrow transplant recipients. Transplant. Infect. Dis. 4:10-16.
63. Rieux, C., A. Gautheret-Dejean, D. Challine-Lehmann, C. Kirch, H. Agut, and J. P. Vernant. 1998. Human herpesvirus-6 meningoencephalitis in a recipient of an unrelated allogeneic bone marrow transplantation. Transplantation 65:1408-1411.
64. Romi, H., O. Singer, D. Rapaport, and N. Frenkel. 1999. Tamplicon-7, a novel T-lymphotropic vector derived from human herpesvirus 7. J. Virol. 73:7001-7007.
65. Sairenji, T., K. Yamanishi, Y. Tachibana, G. Bertoni, and T. Kurata. 1995. Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human herpesvirus 7 in patients with chronic fatigue syndrome. Intervirology 38:269-273.
66. Sambrook, J. F., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
67. Santoro, F., P. E. Kennedy, G. Locatelli, M. S. Malnati, E. A. Berger, and P. Lusso. 1999. CD46 is a cellular receptor for human herpesvirus 6. Cell 99:817-827.
68. Schirmer, E. C., L. S. Wyatt, K. Yamanishi, W. J. Rodriguez, and N. Frenkel. 1991. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc. Natl. Acad. Sci. USA 88:5922-5926.
69. Singer, O., and N. Frenkel. 1997. Human herpesvirus 7 (HHV-7) DNA: analyses of clones spanning the entire genome. Arch. Virol. 142:287-303.
70. Soto, N. E., and S. E. Straus. 2000. Chronic fatigue syndrome and herpesviruses: the fading evidence. Herpes 7:46-50.
71. Spaete, R. R., and N. Frenkel. 1982. The herpes simplex virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector. Cell 30:295-304.
72. Stanberry, L. R. 1998. Herpes: vaccines for HSV. Dermatol. Clin. 16:811-816.
73. Strasser, J. E., R. L. Arnold, C. Pachuk, T. J. Higgins, and D. I. Bernstein. 2000. Herpes simplex virus DNA vaccine efficacy: effect of glycoprotein D plasmid constructs. J. Infect. Dis. 182:1304-1310.
74. Straus, S. E., A. Wald, R. G. Kost, R. McKenzie, A. G. Langenberg, P. Hohman, J. Lekstrom, E. Cox, M. Nakamura, R. Sekulovich, A. Izu, C. Dekker, and L. Corey. 1997. Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial. J. Infect. Dis. 176:1129-1134.
75. Tedder, R. S., M. Briggs, C. H. Cameron, R. Honess, D. Robertson, and H. Whittle. 1987. A novel lymphotropic herpesvirus. Lancet ii:390-392.
76. Thomson, B. J., S. Dewhurst, and D. Gray. 1994. Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini. J. Virol. 68:3007-3014.
77. Turner, S., D. DiLuca, and U. Gompels. 2002. Characterisation of a human herpesvirus 6 variant A "amplicon" and replication modulation by U94-Rep "latency gene." J. Virol. Methods 105:331-341.
78. 5 integrin in SUDHL-1 cells derived from anaplastic large-cell lymphoma. Clin. Cancer Res. 6:185-192.
79. Tyler, K. L. 2003. Human herpesvirus 6 and multiple sclerosis: the continuing conundrum. J. Infect. Dis. 187:1360-1364.
80. Ueda, K., K. Kusuhara, M. Hirose, K. Okada, C. Miyazaki, K. Tokugawa, M. Nakayama, and K. Yamanishi. 1989. Exanthem subitum and antibody to human herpesvirus-6. J. Infect. Dis. 159:750-752.
81. Vlazny, D. A., and N. Frenkel. 1981. Replication of herpes simplex virus DNA: localization of replication recognition signals within defective virus genomes. Proc. Natl. Acad. Sci. USA 78:742-746.
82. Vlazny, D. A., A. Kwong, and N. Frenkel. 1982. Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleo-capsids containing full-length viral DNA. Proc. Natl. Acad. Sci. USA 79:1423-1427.
83. Wallace, H. L., II, B. Natelson, W. Gause, and J. Hay. 1999. Human herpesviruses in chronic fatigue syndrome. Clin. Diagn. Lab. Immunol. 6:216-223.
84. Weijtens, M. E., R. A. Willemsen, E. H. Hart, and R. L. Bolhuis. 1998. A retroviral vector system "STITCH" in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes. Gene Ther. 5:1195-1203.
85. Whitley, R. J., and B. Roizman. 2002. Herpes simplex viruses: is a vaccine tenable? J. Clin. Investig. 110:145-151.
86. Wyatt, L. S., N. Balachandran, and N. Frenkel. 1990. Variations in the replication and antigenic properties of human herpesvirus 6 strains. J. Infect. Dis. 162:852-857.
87. Wyatt, L. S., W. J. Rodriguez, N. Balachandran, and N. Frenkel. 1991. Human herpesvirus 7: antigenic properties and prevalence in children and adults. J. Virol. 65:6260-6265.
88. Yamanishi, K. 1992. Human herpesvirus 6. Microbiol. Immunol. 36:551-561.
89. Yamanishi, K. 2002. Human herpesvirus 6 and human herpesvirus 7, p. 2785-2801. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott-Raven Publishers, Philadelphia, Pa.
90. Yamanishi, K., T. Okuno, K. Shiraki, M. Takahashi, T. Kondo, Y. Asano, and T. Kurata. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i:1065-1067.
91. Yoshikawa, T., S. Suga, Y. Asano, T. Nakashima, T. Yazaki, R. Sobue, M. Hirano, M. Fukuda, S. Kojima, and T. Matsuyama. 1991. Human herpesvirus-6 infection in bone marrow transplantation. Blood 78:1381-1384.