VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death

Journal of Gene Medicine

Volumn 3, Issue 2, 2001, Pages 145-152

  Liu, ChunSheng ^a,b   Kong, BaiHua ^b   Xia, Helen HuiQin ^a   Ellem, Kay A O ^c   Wei, Ming Q ^a,d  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

GCV; Intercellular trafficking; Suicide gene therapy; TK; VP22

Indexed keywords

HERPES; HUMAN HERPESVIRUS 1;

ANTIVIRUS AGENT; GANCICLOVIR; HERPES SIMPLEX VIRUS TYPE 1 PROTEIN VP22; HYBRID PROTEIN; PRIMER DNA; THYMIDINE KINASE; VIRUS PROTEIN;

ANIMAL; ARTICLE; CELL DEATH; CELL LINE; CELL SURVIVAL; DRUG EFFECT; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HERPES SIMPLEX VIRUS 1; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TRANSPORT; WESTERN BLOTTING;

ANIMALS; ANTIVIRAL AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CELL DEATH; CELL LINE; CELL SURVIVAL; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GANCICLOVIR; HERPESVIRUS 1, HUMAN; HUMANS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; THYMIDINE KINASE; VIRAL STRUCTURAL PROTEINS;

EID: 0035287755     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.164     Document Type: Article

References (31)

1. Martin LA, Lemoine NR. Direct cell killing by suicide genes. Cancer Metastasis Rev 1996; 15: 301-316.
2. Hoganson DK, Batra RK, Olsen JC, Boucher RC. Comparison of the effect of three different toxin genes and their levels of expression on cell growth and bystander effects in lung adenocarcinoma. Cancer Res 1996; 56: 1315-1323.
3. Rogulski KR, Kim JH, Kim SH, Freyteg SO. Glioma cells transfected with an E. coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide. Hum Gene Ther 1997; 8: 73-85.
4. Hirschowitz E, Ohwada A, Pasca W, et al. In vivo adenovirus-mediated gene transfer of the E. coli cytosine deaminase gene to human colon carcinoma-derived tumours induces chemosensitivity to 5-fluorocytosine. Hum Gene Ther 1995; 6: 1055-1063.
5. Sorscher EJ, Peng S, Bebok Z, et al. Tumour cell bystander killing in colonic carcinoma utilising the E. coli DeoD gene to generate toxic purines. Gene Ther 1994; 1: 233-238.
6. Sacco MG, Benedetti S, Duflot-Dancer A, et al. Partial regression, yet incomplete eradication of mammary tumours in transgenic mice by retrovirally mediated TK transfer 'in vivo'. Gene Ther 1996; 3: 1151-1156.
7. Verma I, Somia N. Gene therapy problems, promises and prospects. Nature 1997; 389: 239-242.
8. Freeman SM, Abboud CN, Whartenby KA, et al. The "bystander effect": tumour regression when a fraction of the tumour mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
9. Ishii-Morita H, Agbaria R, Mullen CA, et al. Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment. Gene Ther 1997; 4: 244-251.
10. Dilber MS, Abedi MR, Christensson B, et al. Gap junction promotes the bystander effect of herpes simplex virus thymidine kinase in vivo. Cancer Res 1997; 57: 1523-1528.
11. LeMay DR, Kittaka M, Gordon EM, et al. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplx virus thymidine kinase gene therapy. Hum Gene Ther 1998; 9: 989-995.
12. Bonnekoh B, Greenhalgh DA, Bundman DS, et al. Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo. J Invest Dermatol 1995; 104: 313-317.
13. Engelmann C, Panis Y, Bolard J, et al. Liposomal encapsulation of gaciclovir enhances the efficiency of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats. Hum Gene Ther 1999; 10: 1545-1551.
14. Ram Z, Walbridge S, Heiss JD, et al. In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumours. J Neurosurg 1994; 80: 535-540.
15. Chen SH, Kosai K, Xu B, et al. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival. Cancer Res 1996; 56: 3758-3762.
16. O'Malley BW, Cope KA, Chen D, et al. Combination gene therapy for oral cancer in a murine model. Cancer Res 1996; 56: 1737-1741.
17. O'Malley BW, Sewell Jr DA, Li D, et al. The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer. Mol Endocrinol 1997; 11: 667-673.
18. Benedetti S, Dimeco F, Pollo B, et al. Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspective for the combined transfection of the interleukin-4 gene. Hum Gene Ther 1997; 8: 1345-1353.
19. Danthinne X, Aoki K, Kurachi AL, et al. Combination gene delivery of the cell cycle inhibitor p27 with thymidine kinase enhances prodrug cytotoxicity. J Virol 1998; 72: 9201-9207.
20. Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997; 88: 223-233.
21. Elliott G, Meredith DM. The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49. J Gen Virol 1992; 73: 723-726.
22. Elliott G, O'Reilly D, O'Hare P. Phosphorylation of the herpes simplex virus type 1 tegument protein VP22. Virology 1996; 226: 140-145.
23. Leslie J, Rixon FJ, McLauchlan J. Overexpression of the herpes simplex virus type 1 tegument protein VP22 increases its incorporation into virus particles. Virology 1996; 226: 60-68.
24. Phelan A, Elliott G, O'Hare P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nature Biotechnol 1998; 16: 440-443.
25. Fang B, Xu B, Kock P, Roth JA. Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther 1998; 5: 1420-1424.
26. Wei MQ, Ramesh N, Sappen J, et al. Sustained gene expression in transplanted skin in rats. Gene Ther 1999; 6: 840-844.
27. Ramesh N, Kim ST, Wei MQ, et al. High-titre bicistronic retroviral vectors employing foot-and-mouth diseases virus internal ribosome entry site. Nucleic Acids Res 1996; 24: 2697-2700.
28. Elliott G, O'Hare P. Intercellular trafficking of VP22-GFP fusion proteins. Gene Ther 1999; 6: 149-151.
29. Dilber MS, Phelan A, Aints A, et al. Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein VP22. Gene Ther 1999; 6: 12-21.
30. Bonnekoh B, Greenhalgh DA, Chen SH, et al. Adenoviral-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model. J Invest Dermatol 1998; 111: 867-871.
31. Wang XQ, Ellem KA. Heterogeneity in the HeLa cell cycle response to UVC analyzed by the BrdUrd two-parameter method. Exp Cell Res 1994; 212: 176-189.