In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

Nature Medicine

Volumn 7, Issue 7, 2001, Pages 864-868

  Brown, Edward B ^a   Campbell, Robert B ^a   Tsuzuki, Yoshikazu ^a   Xu, Lei ^a   Carmeliet, Peter ^b   Fukumura, Dai ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL POPULATION; GENE EXPRESSION; HEMODYNAMICS; LASER MICROSCOPY; LEUKOCYTE ADHERENCE; MEASUREMENT; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING;

CELL ADHESION; GENE EXPRESSION; HEMODYNAMIC PROCESSES; LASERS; LEUKOCYTES; MICROSCOPY; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; PHOTONS;

EID: 0034918106     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/89997     Document Type: Article

References (20)

1. Transparent window models and intravital microscopy: Imaging gene expression, physiological function and drug delivery in tumors
2. Angiogenesis in cancer and other diseases
3. Two-photon laser scanning fluorescence microscopy
4. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex
5. Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability
6. Tumor induction of VEGF promoter activity in stromal cells
7. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
8. Heterogeneous vascular dependence of tumor cell populations
9. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
10. Tissue perfusion inhomogeneity during early tumor growth in rats
11. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adeno-carcinoma LS174T in SCID mice
12. Leukocyte-endothelial adhesion and angiogenesis in tumors
13. Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions
14. High-speed, two-photon scanning microscope
15. Perfusion of single tumor microvessels: Application to vascular permeability measurement
16. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
17. Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery
18. Direct in vivo measurement of targeted binding in a human tumor xenograft
19. Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis
20. Apoptosis: An early event in metastatic inefficiency