Human herpesvirus 6: Molecular biology and clinical features

Journal of Medical Microbiology

Volumn 52, Issue 1, 2003, Pages 5-18

  Dockrell, D H ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; FOSCARNET; GANCICLOVIR;

APOPTOSIS; CLINICAL FEATURE; DISEASE ASSOCIATION; DOWN REGULATION; EXANTHEMA SUBITUM; GENOME; HERPES VIRUS INFECTION; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MOLECULAR BIOLOGY; PEDIATRICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 6, HUMAN; HUMANS; IMMUNOCOMPROMISED HOST; ROSEOLOVIRUS INFECTIONS;

EID: 0037238229     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.05074-0     Document Type: Review

References (179)

1. Ablashi, D., Agut, H., Berneman, Z. & 29 other authors (1993). Human herpesvirus-6 strain groups: a nomenclature. Arch Virol 129, 363-366.
2. Akashi, K., Eizuru, Y., Sumiyoshi, Y., Minematsu, T., Hara, S., Harada, M., Kikuchi, M., Niho, Y. & Minamishima, Y. (1993). Brief report: severe infectious mononucleosis-like syndrome and primary human herpesvirus 6 infection in an adult. N Engl J Med 329, 168-171.
3. Akhyani, N., Berti, R., Brennan, M. B., Soldan, S. S., Eaton, J. M., McFarland, H. F. & Jacobson, S. (2000). Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis. J Infect Dis 182, 1321-1325.
4. Anderson, R. A., Liu, D. X. & Gompels, U. A. (1996). Definition of a human herpesvirus-6 betaherpesvirus-specific domain in glycoprotein gH that governs interaction with glycoprotein gL: substitution of human cytomegalovirus glycoproteins permits group-specific complex formation. Virology 217, 517-526.
5. Ansari, A. & Emery, V. C. (1999). The U69 gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses. J Virol 73, 3284-3291.
6. Asada, H., Klaus-Kovtun, V., Golding, H., Katz, S. I. & Blauvelt, A. (1999). Human herpesvirus 6 infects dendritic cells and suppresses human immunodeficiency virus type 1 replication in coinfected cultures. J Virol 73, 4019-4028.
7. Ashshi, A. M., Cooper, R. J., Klapper, P. E., Al-Jiffri, O. & Moore, L. (2000). Detection of human herpes virus 6 DNA in fetal hydrops. Lancet 355, 1519-1520.
8. Bandobashi, K., Daibata, M., Kamioka, M., Tanaka, Y., Kubonishi, I., Taguchi, H., Ohtsuki, Y. & Miyoshi, I. (1997). Human herpesvirus 6 (HHV-6)-positive Burkitt's lymphoma: establishment of a novel cell line infected with HHV-6. Blood 90, 1200-1207.
9. Berneman, Z. N., Ablashi, D. V., Li, G., Eger-Fletcher, M., Reitz, M. S., Jr, Hung, C. L., Brus, I., Komaroff, A. L. & Gallo, R. C. (1992). Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc Natl Acad Sci U S A 89, 10552-10556.
10. Brown, N. A., Sumaya, C. V., Liu, C.-R., Ench, Y., Kovacs, A., Coronesi, M. & Kaplan, M. H. (1988). Fall in human herpesvirus 6 seropositivity with age. Lancet ii, 396.
11. Burd, E. M. & Carrigan, D. R. (1993). Human herpesvirus 6 (HHV-6)-associated dysfunction of blood monocytes. Virus Res 29, 79-90.
12. Burd, E. M., Knox, K. K. & Carrigan, D. R. (1993). Human herpesvirus-6-associated suppression of growth factor-induced macrophage maturation in human bone marrow cultures. Blood 81, 1645-1650.
13. Cardinali, G., Gentile, M., Cirone, M., Zompetta, C., Frati, L., Faggioni, A. & Torrisi, M. R. (1998). Viral glycoproteins accumulate in newly formed annulate lamellae following infection of lymphoid cells by human herpesvirus 6. J Virol 72, 9738-9746.
14. Carrigan, D. R. (1995). Human herpesvirus-6 and bone marrow transplantation. Blood 85, 294-295.
15. Carrigan, D. R. & Knox, K. K. (1994). Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6-associated bone marrow suppression in bone marrow transplant patients. Blood 84, 3307-3310.
16. Carrigan, D. R., Knox, K. K. & Tapper, M. A. (1990). Suppression of human immunodeficiency virus type 1 replication by human herpesvirus-6. J Infect Dis 162, 844-851.
17. Carrigan, D. R., Drobyski, W. R., Russler, S. K., Tapper, M. A., Knox, K. K. & Ash, R. C. (1991). Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation. Lancet 338, 147-149.
18. Caserta, M. T., Mock, D. J. & Dewhurst, S. (2001). Human herpesvirus 6. Clin Infect Dis 33, 829-833.
19. Challoner, P. B., Smith, K. T., Parker, J. D. & 12 other authors (1995). Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A 92, 7440-7444.
20. Chang, F. Y., Singh, N., Gayowski, T., Wagener, M. M. & Marino, I. R. (1998). Fever in liver transplant recipients: changing spectrum of etiologic agents. Clin Infect Dis 26, 59-65.
21. Chiu, S. S., Cheung, C. Y., Tse, C. Y. C. & Peiris, M. (1998). Early diagnosis of primary human herpesvirus 6 infection in childhood: serology, polymerase chain reaction, and virus load. J Infect Dis 178, 1250-1256.
22. Chou, S. & Marousek, G. I. (1992). Homology of the envelope glycoprotein B of human herpesvirus-6 and cytomegalovirus. Virology 191, 523-528.
23. Chou, S. W. & Scott, K. M. (1990). Rises in antibody to human herpesvirus 6 detected by enzyme immunoassay in transplant recipients with primary cytomegalovirus infection. J Clin Microbiol 28, 851-854.
24. Chua, K. B., Lam S. K., AbuBakar, S., Lim, S. T., Paranjothy, M., Koh, M. T. & Lee, W. S. (2000). The predictive value of uvulo-palatoglossal junctional ulcers as an early clinical sign of exanthem subitum due to human herpesvirus 6. J Clin Virol 17, 83-90.
25. Clark, D. A. (2000). Human herpesvirus 6. Rev Med Virol 10, 155-173.
26. Clark, D. A., Kidd, I. M., Collingham, K. E., Tarlow, M., Ayeni, T., Riordan, A., Griffiths, P. D., Emery, V. C. & Pillay, D. (1997). Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction. Arch Dis Child 77, 42-45.
27. Coates, A. R. & Bell, J. (1998). HHV-6 and multiple sclerosis. Nat Med 4, 537-538.
28. Cone, R. W., Hackman, R. C., Huang, M. L., Bowden, R. A., Meyers, J. D., Metcalf, M., Zeh, J., Ashley, R. & Corey, L. (1993). Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. N Engl J Med 329, 156-161.
29. Cone, R. W., Huang, M. W. & Hackman, R. C. (1994). Human herpesvirus 6 and pneumonia. Leuk Lymphoma 15, 235-241.
30. Cone, R. W., Huang, M. L., Hackman, R. C. & Corey, L. (1996). Coinfection with human herpesvirus 6 variants A and B in lung tissue. J Clin Microbiol 34, 877-881.
31. Corbellino, M., Lusso, P., Gallo, R. C., Parravicini, C., Galli, M. & Moroni, M. (1993). Disseminated human herpesvirus 6 infection in AIDS. Lancet 342, 1242.
32. Dahl, H., Fjaertoft, G., Norsted, T., Wang, F. Z., Mousavi-Jazi, M. & Linde, A. (1999). Reactivation of human herpesvirus 6 during pregnancy. J Infect Dis 180, 2035-2038.
33. Daibata, M., Taguchi, T., Nemoto, Y., Taguchi, H. & Miyoshi, I. (1999). Inheritance of chromosomally integrated human herpesvirus 6 DNA. Blood 94, 1545-1549.
34. Deng, H. & Dewhurst, S. (1998). Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. J Virol 72, 320-329.
35. DesJardin, J. A., Gibbons, L., Cho, E., Supran, S. E., Falagas, M. E., Werner, B. G. & Snydman, D. R. (1998). Human herpesvirus 6 reactivation is associated with cytomegalovirus infection and syndromes in kidney transplant recipients at risk for primary cytomegalovirus infection. J Infect Dis 178, 1783-1786.
36. DesJardin, J. A., Cho, E., Supran, S., Gibbons, L., Werner, B. G. & Snydman, D. R. (2001). Association of human herpesvirus 6 reactivation with severe cytomegalovirus-associated disease in orthotopic liver transplant recipients. Clin Infect Dis 33, 1358-1362.
37. Dockrell, D. H. & Paya, C. V. (2001). Human herpesvirus-6 and -7 in transplantation. Rev Med Virol 11, 23-36.
38. Dockrell, D. H., Prada, J., Jones, M. F. & 8 other authors (1997). Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease. J Infect Dis 176, 1135-1140.
39. Dockrell, D. H., Smith, T. F. & Paya, C. V. (1999a). Human herpesvirus 6. Mayo Clin Proc 74, 163-170.
40. Dockrell, D. H., Mendez, J. C., Jones, M., Harmsen, W. S., Ilstrup, D. M., Smith, T. F., Wiesner, R. H., Krom, R. A. & Paya, C. V. (1999b). Human herpesvirus 6 seronegativity before transplantation predicts the occurrence of fungal infection in liver transplant recipients. Transplantation 67, 399-403.
41. Dominguez, G., Dambaugh, T. R., Stamey, F. R., Dewhurst, S., Inoue, N. & Pellett, P. E. (1999). Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73, 8040-8052.
42. Drobyski, W. R., Dunne, W. M., Burd, E. M., Knox K. K., Ash, R. C., Horowitz, M. M., Flomenberg, N. & Carrigan, D. R. (1993). Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: evidence of a marrow-suppressive role of HHV-6 in vivo. J Infect Dis 167, 735-739.
43. Emery, V. C. (2001). Human herpesviruses 6 and 7 in solid organ transplant recipients. Clin Infect Dis 32, 1357-1360.
44. Emery, V. C., Atkins, M. C., Bowen, E. F. & 7 other authors (1999). Interactions between β-herpesviruses and human immunodeficiency virus in vivo: evidence for increased human immunodeficiency viral load in the presence of human herpesvirus 6. J Med Virol 57, 278-282.
45. Fairfax, M. R., Schacker, T., Cone, R. W., Collier, A. C. & Corey, L. (1994). Human herpesvirus 6 DNA in blood cells of human immunodeficiency virus-infected men: correlation of high levels with high CD4 cell counts. J Infect Dis 169, 1342-1345.
46. Flamand, L., Gosselin, J., D'Addario, M., Hiscott, J., Ablashi, D. V., Gallo, R. C. & Menezes, J. (1991). Human herpesvirus 6 induces interleukin1β and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures. J Virol 65, 5105-5110.
47. Flamand, L., Stefanescu, I., Ablashi, D. V. & Menezes, J. (1993). Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6. J Virol 67, 6768-6777.
48. Flamand, L., Gosselin, J., Stefanescu, I., Ablashi, D. & Menezes, J. (1995). Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation. Blood 85, 1263-1271.
49. Flamand, L., Stefanescu, I. & Menezes, J. (1996). Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. ] Clin Invest 97, 1373-1381.
50. Flamand, L., Romerio, F., Reitz, M. S. & Gallo, R. C. (1998). CD4 promoter transactivation by human herpesvirus 6. J Virol 72, 8797-8805.
51. Flebbe-Rehwaldt, L. M., Wood, C. & Chandran, B. (2000). Characterization of transcripts expressed from human herpesvirus 6A strain GS immediate-early region B U16-U17 open reading frames. J Virol 74, 11040-11054.
52. French, C., Menegazzi, P., Nicholson, L., Macaulay, H., DiLuca, D. & Gompels, U. A. (1999). Novel, nonconsensus cellular splicing regulates expression of a gene encoding a chemokine-like protein that shows high variation and is specific for human herpesvirus 6. Virology 262, 139-151.
53. Gautheret-Dejean, A., Manichanh, C., Thien-Ah-Koon, F., Fillet, A. M., Mangeney, N., Vidaud, M., Dhedin, N., Vernant, J. P. & Agut, H. (2002). Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients. J Virol Methods 100, 27-35.
54. Gobbi, A., Stoddart, C. A., Malnati, M. S. & 9 other authors (1999). Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. J Exp Med 189, 1953-1960.
55. Gobbi, A., Stoddart, C. A., Locatelli, G. & 9 other authors (2000). Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1. J Virol 74, 8726-8731.
56. Gompels, U. A., Nicholas, J., Lawrence, G., Jones, M., Thomson, B. J., Martin, M. E., Efstathiou, S., Craxton, M. & Macaulay, H. A. (1995). The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209, 29-51.
57. Gosselin, J., Tomolu, A., Gallo, R. C. & Flamand, L. (1999). Interleukin-15 as an activator of natural killer cell-mediated antiviral response. Blood 94, 4210-4219.
58. Gravel, A., Gosselin, J. & Flamand, L. (2002). Human herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies. J Biol Chem 277, 19679-19687.
59. Griffiths, P. D., Ait-Khaled, M., Bearcroft, C. R. & 11 other authors (1999). Human herpesviruses 6 and 7 as potential pathogens after liver transplant: prospective comparison with the effect of cytomegalovirus. J Med Virol 59, 496-501.
60. Griffiths, P. D., Clark, D. A. & Emery, V. C. (2000). Betaherpesviruses in transplant recipients. J Antimicrob Chemother 45 (Suppl. T3), 29-34.
61. Grivel, J.-C., Ito, Y., Faga, G., Santoro, F., Shaheen, F., Malnati, M. S., Fitzgerald, W., Lusso, P. & Margolis, L. (2001). Suppression of CCR5-but not CXCR4-tropic HIV-1 in lymphoid tissue by human herpesvirus 6. Nat Med 7, 1232-1235.
62. Hall, C. B. (1997). Human herpesviruses at sixes, sevens, and more. Ann Intern Med 127, 481-483.
63. Hall, C. B., Long, C. E., Schnabel, K. C. & 7 other authors (1994). Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 331, 432-438.
64. Hall, C. B., Caserta, M. T., Schnabel, K. C., Long, C., Epstein, L. G., Insel, R. A., Dewhurst, S. (1998). Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clin Infect Dis 26, 132-137.
65. Hasegawa, A., Yasukawa, M., Sakai, I. & Fujita, S. (2001). Transcriptional down-regulation of CXC chemokine receptor 4 induced by impaired association of transcription regulator YY1 with c-Myc in human herpesvirus 6-infected cells. J Immunol 166, 1125-1131.
66. He, J., McCarthy, M., Zhou, Y., Chandran, B. & Wood, C. (1996). Infection of primary human fetal astrocytes by human herpesvirus 6. J Virol 70, 1296-1300.
67. Herbein, G., Strasswimmer, J., Altieri, M., Woehl-Jaegle, M. L., Wolf, P. & Obert, G. (1996). Longitudinal study of human herpesvirus 6 infection in organ transplant recipients. Clin Infect Dis 22, 171-173.
68. Humar, A., Malkan, G., Moussa, G., Greig, P., Levy, G. & Mazzulli, T. (2000). Human herpesvirus-6 is associated with cytomegalovirus reactivation in liver transplant recipients. J Infect Dis 181, 1450-1453.
69. Humar, A., Kumar, D., Caliendo, A. M., Moussa, G., Ashi-Sulaiman, A., Levy, G. & Mazzulli, T. (2002). Clinical impact of human herpesvirus 6 infection after liver transplantation. Transplantation 73, 599-604.
70. Ichimi, R., Jin-no, T. & Ito, M. (1999). Induction of apoptosis in cord blood lymphocytes by HHV-6. J Med Virol 58, 63-68.
71. Imbert-Marcille, B. M., Tang, X. W., Lepelletier, D., Besse, B., Moreau, P., Billaudel, S. & Milpied, N. (2000). Human herpesvirus 6 infection after autologous or allogeneic stem cell transplantation: a single-center prospective longitudinal study of 92 patients. Clin Infect Dis 31, 881-886.
72. Inagi, R., Guntapong, R., Nakao, M., Ishino, Y., Kawanishi, K., Isegawa, Y. & Yamanishi, K. (1996). Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2. J Med Virol 49, 34-40.
73. Inoue, Y., Yasukawa, M. & Fujita, S. (1997). Induction of T-cell apoptosis by human herpesvirus 6. J Virol 71, 3751-3759.
74. Irving, W. L. & Cunningham, A. L. (1990). Serological diagnosis of infection with human herpesvirus type 6. BMJ 300, 156-159.
75. Irving, W. L., Ratnamohan, V. M., Hueston, L. C., Chapman, J. R. & Cunningham, A. L. (1990). Dual antibody rises to cytomegalovirus and human herpesvirus type 6: frequency of occurrence in CMV infections and evidence for genuine reactivity to both viruses. J Infect Dis 161, 910-916.
76. Isegawa, Y., Ping, Z., Nakano, K., Sugimoto, N. & Yamanishi, K. (1998). Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. J Virol 72, 6104-6112.
77. Isegawa, Y., Mukai, T., Nakano, K. & 10 other authors (1999). Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J Virol 73, 8053-8063.
78. Isomura, H., Yamada, M., Yoshida, M., Tanaka, H., Kitamura, T., Oda, M., Nii, S. & Seino, Y. (1997). Suppressive effects of human herpesvirus 6 on in vitro colony formation of hematopoietic progenitor cells. J Med Virol 52, 406-412.
79. Jacobs, U., Ferber, J. & Klehr, H. U. (1994). Severe allograft dysfunction after OKT3-induced human herpes virus-6 reactivation. Transplant Proc 26, 3121.
80. Kashanchi, F., Araujo, J., Doniger, J. & 10 other authors (1997). Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene 14, 359-367.
81. Kasolo, F. C., Mpabalwani, E. & Gompels, U. A. (1997). Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. J Gen Virol 78, 847-856.
82. Katsafanas, G. C., Schirmer, E. C., Wyatt, L. S. & Frenkel, N. (1996). In vitro activation of human herpesviruses 6 and 7 from latency. Proc Natl Acad Sci U S A 93, 9788-9792.
83. + cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Proc Natl Acad Sci U S A 94, 7600-7605.
84. Kidd, I. M., Clark, D. A., Bremner, J. A. G., Pillay, D., Griffiths, P. D. & Emery, V. C. (1998). A multiplex PCR assay for the simultaneous detection of human herpesvirus 6 and human herpesvirus 7, with typing of HHV-6 by enzyme cleavage of PCR products. J Virol Methods 70, 29-36.
85. Kidd, I. M., Clark, D. A., Sabin, C. A., Andrew, D., Hassan-Walker, A. F., Sweny, P., Griffiths, P. D. & Emery, V. C. (2000). Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection. Transplantation 69, 2400-2404.
86. Kirn, E., Krueger, E., Boehmer, S., Klussmann, J. P. & Krueger, G. R. (1997). In vitro cytobiological effects of human herpesviruses 6 and 7: immunohistological monitoring of apoptosis, differentiation and cell proliferation. Anticancer Res 17, 4623-4632.
87. Knowles, W. A. & Gardner, S. D. (1988). High prevalence of antibody to human herpesvirus-6 and seroconversion associated with rash in two infants. Lancet ii, 912-913.
88. Knox, K. K. & Carrigan, D. R. (1992). In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection. J Infect Dis 165, 925-929.
89. Knox, K. K., Brewer, J. H., Henry, J. M., Harrington, D. J. & Carrigan, D. R. (2000). Human herpesvirus 6 and multiple sclerosis: systemic active infections in patients with early disease. Clin Infect Dis 31, 894-903.
90. Kondo, K., Shimada, K., Sashihara, J., Tanaka-Taya, K. & Yamanashi, K. (2002). Identification of human herpesvirus 6 latency-associated transcripts. J Virol 76, 4145-4151.
91. Kositanont, U., Wasi, C., Wanprapar, N. & 9 other authors (1999). Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1. J Infect Dis 180, 50-55.
92. Kosuge, H., Tanaka-Taya, K., Miyoshi, H., Amo, K., Harada, R., Ebihara, T., Kawahara, Y., Yamanishi, K. & Nishikawa, T. (2000). Epidemiological study of human herpesvirus-6 and human herpesvirus-7 in pityriasis rosea. Br J Dermatol 143, 795-798.
93. Krueger, G. R., Koch, B., Leyssens, N. & 11 other authors (1998). Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries. Vox Sang 75, 193-197.
94. Lanphear, B. P., Hall, C. B., Black, J. & Auinger, P. (1998). Risk factors for the early acquisition of human herpesvirus 6 and human herpesvirus 7 infections in children. Pediatr Infect Dis J 17, 792-795.
95. Lau, Y. L., Peiris, M., Chan, G. C., Chan, A. C., Chiu, D. & Ha, S. Y. (1998). Primary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusion. Bone Marrow Transplant 21, 1063-1066.
96. Lautenschlager, I., Hockerstedt, K., Linnavuori, K. & Taskinen, E. (1998). Human herpesvirus-6 infection after liver transplantation. Clin Infect Dis 26, 702-707.
97. Lautenschlager, I., Hockerstedt, K., Linnavuori, K. & Taskinen, E. (1999). Human herpesvirus 6 infection increases adhesion molecule expression in liver allografts. Transplant Proc 31, 479-480.
98. Lautenschlager, I., Linnavuori, K. & Hockerstedt, K. (2000). Human herpesvirus-6 antigenemia after liver transplantation. Transplantation 69, 2561-2566.
99. Levy, J. A. (1997). Three new human herpesviruses (HHV6, 7, and 8). Lancet 349, 558-563.
100. Levy, J. A., Ferro, F., Greenspan, D. & Lennette, E. T. (1990a). Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet 335, 1047-1050.
101. Levy, J. A., Landay, A. & Lennette, E. T. (1990b). Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture. J Clin Microbiol 28, 2362-2364.
102. Lin, K. & Ricciardi, R. P. (1998). The 41-kDa protein of human herpesvirus 6 specifically binds to viral DNA polymerase and greatly increases DNA synthesis. Virology 250, 210-219.
103. Lin, W. C., Moore, J. O., Mann, K. P., Traweek, S. T. & Smith, C. (1999). Post transplant CD8+ γδ T-cell lymphoma associated with human herpes virus-6 infection. Leuk Lymphoma 33, 377-384.
104. Liu, D. X., Gompels, U. A., Foa-Tomasi, L. & Campadelli-Fiume, G. (1993). Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies. Virology 197, 12-22.
105. Ljungman, P., Wang, F.-Z., Clark, D. A., Emery, V. C., Remberger, M., Ringden, O. & Linde, A. (2000). High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients. Br J Haematol 111, 774-781.
106. Locatelli, G., Santoro, F., Veglia, F., Gobbi, A., Lusso, P. & Malnati, M. S. (2000). Real-time quantitative PCR for human herpesvirus 6 DNA. J Clin Microbiol 38, 4042-4048.
107. Luppi, M., Barozzi, P., Morris, C. & 7 other authors (1999). Human herpesvirus 6 latently infects early bone marrow progenitors in vivo. J Virol 73, 754-759.
108. Lusso, P. & Gallo, R. C. (1995). Human herpesvirus 6 in AIDS. Immunol Today 16, 67-71.
109. Lusso, P., Markham, P. D., Tschachler, E., di Marzo Veronese, F., Salahuddin, S. Z., Ablashi, D. V., Pahwa, S., Krohn, K. & Gallo, R. C. (1988). In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J Exp Med 167, 1659-1670.
110. + T lymphocytes by HIV-1 and HHV-6. Nature 337, 370-373.
111. + mature human T cell populations and clones by human herpesvirus 6. Transcriptional down-regulation of CD3. J Immunol 147, 685-691.
112. Lusso, P., Malnati, M. S., Garzino-Demo, A., Crowley, R. W., Long, E. O. & Gallo, R. C. (1993). Infection of natural killer cells by human herpesvirus 6. Nature 362, 458-462.
113. Lusso, P., Garzino-Demo, A., Crowley, R. W. & Malnati, M. S. (1995). Infection of γ/δ T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. J Exp Med 181, 1303-1310.
114. Manichanh, C., Olivier-Aubron, C., Lagarde, J.-P., Aubin, J.-T., Bossi, P., Gautheret-Dejean, A., Huraux, J.-M. & Agut, H. (2001). Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo. J Gen Virol 82, 2767-2776.
115. Martin, M. E., Nicholas, J., Thomson, B. J., Newman, C. & Honess, R. W. (1991). Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6. J Virol 65, 5381-5390.
116. Mattes, F. M., McLaughlin, J. E., Emery, V. C., Clark, D. A. & Griffiths, P. D. (2000). Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7. J Clin Pathol 53, 612-614.
117. Mayne, M., Cheadle, C., Soldan, S. S. & 7 other authors (2001). Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms. J Virol 75, 11641-11650.
118. Mendez, J. C., Dockrell, D. H., Espy, M. J., Smith, T. F., Wilson, J. A., Harmsen, W. S., Ilstrup, D. & Paya, C. V. (2001). Human β-herpesvirus interactions in solid organ transplant recipients. J Infect Dis 183, 179-184.
119. Menotti, L., Mirandola, P., Locati, M. & Campadelli-Fiume, G. (1999). Trafficking to the plasma membrane of the seven-transmembrane protein encoded by human herpesvirus 6 U51 gene involves a cell-specific function present in T lymphocytes. J Virol 73, 325-333.
120. Milne, R. S. B., Mattick, C., Nicholson, L., Devaraj, P., Alcami, A. & Gompels, U. A. (2000). RANTES binding and down-regulation by a novel human herpesvirus-6 β chemokine receptor. J Immunol 164, 2396-2404.
121. Mirandola, P., Menegazzi, P., Merighi, S., Ravaioli, T., Cassai, E. & Di Luca, D. (1998). Temporal mapping of transcripts in herpesvirus 6 variants. J Virol 72, 3837-3844.
122. Mori, Y., Yagi, H., Shimamoto, T., Isegawa, Y., Sunagawa, T., Inagi, R., Kondo, K., Tano, Y. & Yamanishi, K. (1998). Analysis of human herpesvirus 6 U3 gene, which is a positional homolog of human cytomegalovirus UL 24 gene. Virology 249, 129-139.
123. Mori, Y., Dhepakson, P., Shimamoto, T., Ueda, K., Gomi, Y., Tani, H., Matsuura, Y. & Yamanishi, K. (2000). Expression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo. J Virol 74, 6096-6104.
124. Mori, Y., Seya, T., Huang, H. L, Akkapaiboon, P., Dhepakson, P. & Yamanishi, K. (2002). Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J Virol 76, 6750-6761.
125. Niederman, J. C., Lui, C.-R., Kaplan, M. H. & Brown, N. A. (1988). Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet ii, 817-819.
126. Nitsche, A., Muller, C. W., Radonic, A., Landt, O., Ellerbrok, H., Pauli, G. & Siegert, W. (2001). Human herpesvirus 6A DNA is detected frequently in plasma but rarely in peripheral blood leukocytes of patients after bone marrow transplantation. J Infect Dis 183, 130-133.
127. Okuno, T., Takahashi, K., Balachandra, K., Shiraki, K., Yamanishi, K., Takahashi, M. & Baba, K. (1989). Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol 27, 651-653.
128. Osman, H. K., Peiris, J. S., Taylor, C. E., Warwicker, P., Jarrett, R. F. & Madeley, C. R. (1996). "Cytomegalovirus disease" in renal allograft recipients: is human herpesvirus 7 a co-factor for disease progression? J Med Virol 48, 295-301.
129. Pellett, P. E., Black, J. B. & Yamamoto, M. (1992). Human herpesvirus 6: the virus and the search for its role as a human pathogen. Adv Virus Res 41, 1-52.
130. Pfeiffer, B., Berneman, Z. N., Neipel, F., Chang, C. K., Tirwatnapong, S. & Chandran, B. (1993). Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies. J Virol 67, 4611-4620.
131. Pitkaranta, A., Piiparinen, H., Mannonen, L., Vesaluoma, M. & Vaheri, A. (2000). Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR. J Clin Microbiol 38, 2753-2755.
132. Pruksananonda, P., Hall, C. B., Insel, R. A. & 8 other authors (1992). Primary human herpesvirus 6 infection in young children. N Engl J Med 326, 1445-1450.
133. Razonable, R. R., Fanning, C., Brown, R. A., Espy, M. J., Rivero, A., Wilson, J., Kremers, W., Smith, T. F. & Paya, C. V. (2002). Selective reactivation of human herpesvirus 6 variant A occurs in critically ill immunocompetent hosts. J Infect Dis 185, 110-113.
134. Reeves, W. C., Stamey, F. R., Black, J. B., Mawle, A. C., Stewart, J. A. & Pellett, P. E. (2000). Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study. Clin Infect Dis 31, 48-52.
135. Robert, C., Aubin, J. T., Visse, B., Fillet, A. M., Huraux, J. M. & Agut, H. (1996). Difference in permissiveness of human fibroblast cells to variants A and B of human herpesvirus-6. Res Virol 147, 219-225.
136. Robinson, W. S. (1994). Human herpesvirus 6. Curr Clin Top Infect Dis 14, 159-169.
137. Rogers, J., Rohal, S., Carrigan, D. R., Kusne, S., Knox, K. K., Gayowski, T., Wagener, M. M., Fung, J. J. & Singh, N. (2000). Human herpesvirus-6 in liver transplant recipients: role in pathogenesis of fungal infections, neurologic complications, and outcome. Transplantation 69, 2566-2573.
138. Rosenfeld, C. S., Rybka, W. B., Weinbaum, D., Carrigan, D. R., Knox, K. K., Andrews, D. F. & Shadduck, R. K. (1995). Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6. Exp Hematol 23, 626-629.
139. Rotola, A., Ravaioli, T., Gonelli, A., Dewhurst, S., Cassai, E. & Di Luca, D. (1998). U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture. Proc Natl Acad Sci U S A 95, 13911-13916.
140. Salahuddin, S. Z., Ablashi, D. V., Markham, P. D. & 8 other authors (1986). Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234, 596-601.
141. Santoro, F., Kennedy, P. E., Locatelli, G., Malnati, M. S., Berger, E. A. & Lusso, P. (1999). CD46 is a cellular receptor for human herpesvirus 6. Cell 99, 817-827.
142. Saxinger, C., Polesky, H., Eby, N., Grufferman, S., Murphy, R., Tegtmeir, G., Parekh, V., Memon, S. & Hung, C. (1988). Antibody reactivity with HBLV (HHV-6) in US populations. J Virol Methods 21, 199-208.
143. Schiewe, U., Neipel, F., Schreiner, D. & Fleckenstein, B. (1994). Structure and transcription of an immediate-early region in the human herpesvirus 6 genome. J Virol 68, 2978-2985.
144. Schirmer, E. C., Wyatt, L. S., Yamanashi, K., Rodriguez, W. J. & Frenkel, N. (1991). Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci U S A 88, 5922-5926.
145. Secchiero, P., Carrigan, D. R., Asano, Y., Benedetti, L., Crowley, R. W., Komaroff, A. L., Gallo, R. C. & Lusso, P. (1995a). Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 171, 273-280.
146. Secchiero, P., Zella, D., Crowley, R. W., Gallo, R. C. & Lusso, P. (1995b). Quantitative PCR for human herpesviruses 6 and 7. J Clin Microbiol 33, 2124-2130.
147. Sieczkowski, L., Chandran, B. & Wood, C. (1995). The human immunodeficiency virus tat gene enhances replication of human herpesvirus-6. Virology 211, 544-553.
148. Simmons, A., Demmrich, Y., La Vista, A. & Smith, K. (1992). Replication of human herpesvirus 6 in epithelial cells in vitro. J Infect Dis 166, 202-205.
149. Singh, N. (2000). Human herpesviruses-6, -7 and -8 in organ transplant recipients. Clin Microbiol Infect 6, 453-459.
150. Singh, N. & Carrigan D. R. (1996). Human herpesvirus-6 in transplantation: an emerging pathogen. Ann Intern Med 124, 1065-1071.
151. Singh, N. & Paterson, D. L. (2000). Encephalitis caused by human herpesvirus-6 in transplant recipients: relevance of a novel neurotropic virus. Transplantation 69, 2474-2479.
152. Singh, N., Carrigan, D. R., Gayowski, T. & Marino, I. R. (1997). Human herpesvirus-6 infection in liver transplant recipients: documentation of pathogenicity. Transplantation 64, 674-678.
153. Singh, N., Husain, S., Carrigan, D. R., Knox, K. K., Weck, K. E., Wagener, M. M. & Gayowski, T. (2002). Impact of human herpesvirus-6 on the frequency and severity of recurrent hepatitis C virus hepatitis in liver transplant recipients. Clin Transplant 16, 92-96.
154. Soldan, S. S., Berti, R., Salem, N. & 9 other authors (1997). Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 3, 1394-1397.
155. Soldan, S. S., Fogdell-Hahn, A., Brennan, M. B., Mittleman, B. B., Ballerini, C., Massacesi, L., Seya, T., McFarland, H. F. & Jacobson, S. (2001). Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis. Ann Neurol 50, 486-493.
156. Sugaya, N., Yoshikawa, T., Miura, M., Ishizuka, T., Kawakami, C. & Asano, Y. (2002). Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7. Clin Infect Dis 34, 461-466.
157. Suzuki, Y., Inagi, R., Aono, T., Yamanishi, K. & Shiohara, T. (1998). Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 134, 1108-1112.
158. Takagi, M., Unno, A., Maruyama, T., Kaneko, K. & Obinata, K. (1996). Human herpesvirus-6 (HHV-6)-associated hemophagocytic syndrome. Pediatr Hematol Oncol 13, 451-456.
159. Takahashi, K., Sonoda, S., Higashi, K., Kondo, T., Takahashi, H., Takahashi, M. & Yamanishi, K. (1989). Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J Virol 63, 3161-3163.
160. Takemoto, M., Shimamoto, T., Isegawa, Y. & Yamanashi, K. (2001). The R3 region, one of three major repetitive regions of human herpesvirus 6, is a strong enhancer of immediate-early gene U95. J Virol 75, 10149-10160.
161. Thomson, B. J., Efstathiou, S. & Honess, R. W. (1991). Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. Nature 351, 78-80.
162. Tigue, N. J. & Kay, J. (1998). Autoprocessing and peptide substrates for human herpesvirus 6 proteinase. J Biol Chem 273, 26441-26446.
163. Tong, C. Y., Bakran, A., Williams, H., Cheung, C. Y. & Peiris, J. S. (2000). Association of human herpesvirus 7 with cytomegalovirus disease in renal transplant recipients. Transplantation 70, 213-216.
164. Torrisi, M. R., Gentile, M., Cardinali, G., Cirone, M., Zompetta, C., Lotti, L. V., Frati, L. & Faggioni, A. (1999). Intracellular transport and maturation pathway of human herpesvirus 6. Virology 257, 460-471.
165. van den Bosch, G., Locatelli, G., Geerts, L. & 7 other authors (2001). Development of reverse transcriptase PCR assays for detection of active human herpesvirus 6 infection. J Clin Microbiol 39, 2308-2310.
166. van Loon, N. M., Gummuluru, S., Sherwood, D. J., Marentes, R., Hall, C. B. & Dewhurst, S. (1995). Direct sequence analysis of human herpesvirus 6 (HHV-6) sequences from infants and comparison of HHV-6 sequences from mother/infant pairs. Clin Infect Dis 21, 1017-1019.
167. Wang, F. Z., Dahl, H., Linde, A., Brytting, M., Ehrnst, A. & Ljungman, P. (1996). Lymphotropic herpesviruses in allogeneic bone marrow transplantation. Blood 88, 3615-3620.
168. Wang, F. Z., Linde, A., Hagglund, H., Testa, M., Locasciulli, A. & Ljungman, P. (1999). Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? Clin Infect Dis 28, 562-568.
169. Ward, K. N., Gray, J. J. & Efstathiou, S. (1989). Brief report: primary human herpesvirus 6 infection in a patient following liver transplantation from a seropositive donor. J Med Virol 28, 69-72.
170. Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y. & Kurata, T. (1988). Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i, 1065-1067.
171. Yasukawa, M., Yakushijin, Y., Furukawa, M. & Fujita, S. (1993). Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus. J Virol 67, 6259-6264.
172. + T lymphocytes in human herpesvirus-6 infection. J Gen Virol 79, 143-147.
173. Yasukawa, M., Hasegawa, A., Sakai, I. & 8 other authors (1999). Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7. J Immunol 162, 5417-5422.
174. Yoshida, M., Yamada, M., Tsukazaki, T., Chatterjee, S., Lakeman, F. D., Nii, S. & Whitley, R. J. (1998). Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral Res 40, 73-84.
175. Yoshikawa, T., Asano, Y., Ihira, M. & 9 other authors (2002). Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. J Infect Dis 185, 847-853.
176. Zerr, D. M., Gooley, T. A., Yeung, L., Huang, M. L., Carpenter, P., Wade, J. C., Corey, L. & Anasetti, C. (2001). Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients. Clin Infect Dis 33, 763-771.
177. Zerr, D. M., Gupta, D., Huang, M.-L., Carter, R. & Corey, L. (2002). Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clin Infect Dis 34, 309-317.
178. Zhou, Y., Chandran, B. & Wood, C. (1997). Transcriptional patterns of the pCD41 (U27) locus of human herpesvirus 6. J Virol 71, 3420-3430.
179. Zou, P., Isegawa, Y., Nakano, K., Haque, M., Horiguchi, Y. & Yamanishi, K. (1999). Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. J Virol 73, 5926-5933.