Direct infection of CD34+ progenitor cells by human cytomegalovirus: Evidence for inhibition of hematopoiesis and viral replication

Blood

Volumn 88, Issue 4, 1996, Pages 1277-1283

  Movassagh, Mojgan ^b   Gozlan, Joël ^b   Senechal, Brigitte ^b   Baillou, Claude ^b   Petit, Jean Claude ^b   Lemoine, François M ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; METHYLCELLULOSE; VIRUS DNA;

ANTIGEN EXPRESSION; ARTICLE; BONE MARROW SUPPRESSION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; EMBRYO; FLUORESCENCE ACTIVATED CELL SORTER; HEMATOPOIESIS; HUMAN; HUMAN CELL; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS REPLICATION;

EID: 0029848813     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.4.1277.bloodjournal8841277     Document Type: Article

References (31)

1. Alford CA, Britt WJ: Cytomegalovirus, in Field BN, Knipe DN (eds): Virology (ed 2). New York, NY, Raven, 1990, p 1981
2. Wingard JR, Yen-Hung Chen D, Burns WH, Fuller DJ, Braine HG, Yeager AM, Kaiser H, Burke PJ, Graham ML, Santos GW, Saral R: Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogenic bone marrow transplantation. Blood 71:1432. 1988
3. Verdonck LF, De Gast GC, Van Heugten HG, Nieuwenhuis HK, Dekker AW: Cytomegalovirus infection causes delayed platelet recovery after bone marrow transplantation. Blood 78:844, 1991
4. Boppana SB, Pass RF, Britt WJ, Stagno S, Alford CA: Symptomatic congenital Cytomegalovirus infection: Neonatal morbidity and mortality. Pediatr Infect Dis J 11:97, 1992
5. MacKintosh FR, Adlish J, Hall SW. St Jeor S, Smith E, Tavassoli M, Zanjani ED: Suppression of normal human hematopoiesis by Cytomegalovirus in vitro. Exp Hematol 21:243, 1993
6. Apperley JF, Dowding C, Hibbin J, Buiter J, Matutes E, Sissons PJ, Gordon M, Goldman JM: The effect of cytomegalovirus on hemopoiesis: In vitro evidence for selective infection of marrow stromal cells. Exp Hematol 1:38, 1989
7. Simmons P, Kaushansky K, Torok-storb B: Mechanisms of cytomegalovirus-mediated myelosuppression: Perturbation of stromal cell function versus direct infection of myeloid cells. Proc Natl Acad Sci USA 87:1386, 1990
8. Sing GK, Ruscetti FW: Preferential suppression of myelopoiesis in normal human bone marrow cells after in vitro challenge with human cytomegalovirus. Blood 75:1965, 1990
9. Maciejewski JP, Bruening EE, Donahue RE, Mocarski ES, Young NS, St Jeor SC. Infection of hematopoietic progenitor cells by human cytomegalovirus. Blood 80:170, 1992
10. Torok-Storb B, Fries B, Myerson D: Cytomegalovirus mediated cytopenia, in Guigon M (ed): The Negative Regulation of Hematopoiesis. London, UK, Colloque INSERM/John Libbey Eurotext Ltd, 1993, p 383
11. Lagneaux L, Delforge A, Snoeck R, Stryckmans P. Bron D: Decreased production of cytokines after cytomegalovirus infection of marrow-derived stromal cells. Exp Hematol 22:26, 1994
12. Alpert G, Mazeron MC, Colimon R, Plotkin S: Rapid detection of human cytomegalovirus in the urine of humans. J Infect Dis 15:2, 1985
13. + cells via p55 TNFα receptors. Blood 84:2506. 1994
14. Pontvert-Delucq S, Breton-Gorius J. Schmitt C, Baillou C, Guichard J, Najman A, Lemoine FM: Characterization and functional analysis of adult human bone marrow cell subsets in relation to B-lymphoid development. Blood 82:417, 1993
15. + subpopulations in response to growth factors. Blood 82:3307, 1993
16. Chee M, Rudolph S-A, Plachter B, Barrell B, Jahn G: Identification of the major capsid protein gene of human cytomegalovirus. J Virol 63:1345, 1989
17. Stenberg RM, Thomsen DR, Stinski MF: Structural analysis of the major immediate early gene of human cytomegalovirus. J Viral 49:190, 1984
18. Gozlan J, Caburet F, Tancrede C, Petit J-C: A reverse polymerase chain reaction method for detection of human cytomegalovirus late transcripts in cells infected in vitro. J Virol Methods 40:1. 1992
19. Kwoks S, Higuchi R: Avoiding false positives with PCR. Nature 339:237, 1989
20. Revello MG, Percivalle E, Di Matteo A, Morini F, Gerna G: Nuclear expression of the lower matrix protein of human cytomegalovirus in peripheral blood leukocytes of immunocompromised viraemic patients. J Gen Virol 73:437, 1992
21. Rakusan TA, Juneja HS, Fleischmann WR: Inhibition of hemopoietic colony formation by human cytomegalovirus in vitro. J Infect Dis 159:127, 1989
22. Minton EJ, Tysoe C, Sinclair JH, Sissons JG: Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow. J Virol 68:4017, 1994
23. Moses AV, Garnett HM: The effect of human cytomegalovirus on the production and biologic action of Interleukin-1. J Infect Dis 162:381, 1990
24. Sindre H, Rollag H, Tjonnfjord G, Ranneberg-Nilsen T, Veiby OP, Beck S, Degré M, Hestdal K: Human cytomegalovirus suppression of and latency in early pluripotent hematopoietic stem cells. The Fifth International Cytomegalovirus Conference, Stockholm, Sweden, May 21-24, 1995, p 197, 158 (abstr)
25. Nelson JA, Gnann JW, Ghazal P: Regulation and tissue-specific expression of human cytomegalovirus. Curr Top Microbiol Immunol 154:75, 1990
26. Wainsheker BG, Wilton S, Rice GPA: Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in monocyuc cell line. J Immunol 140:1625, 1988
27. Sinclair JH, Baillie LA, Bryant JA, Taylor-Wiedeman J, Sissons JGP: Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line. J Gen Virol 73:433, 1992
28. Ibanez CE, Schrier R, Ghazal P, Wiley C, Nelson JA. Human cytomegalovirus productively infects primary differentiated macrophages. J Virol 65:6581, 1991
29. Lathey JL, Spector SA: Unrestricted replication of human cytomegalovirus in hydrocortisone treated macrophages. J Virol 65:6371, 1991
30. Roberts WD, Weinberg KI, Kohn DB, Sender L, Parkman R, Lenarsky C: Granulocyte recovery in pediatric marrow transplant recipients treated with ganciclovir for cytomegalovirus infection. Am J Pediatr Hematol Oncol 15:320, 1993
31. Bilgrami S, Almeida GD, Quinn JJ, Tuck D, Bergstrom S, Dainiak N, Poliquin C, Ascensao JL: Pancytopenia in allogeneic marrow transplant recipients: Role of cytomegalovirus. Br J Haematol 87:357, 1994