Infectious delivery of 120-kilobase genomic DNA by an Epstein-Barr virus amplicon vector

Molecular Therapy

Volumn 5, Issue 4, 2002, Pages 427-435

  White, Robert E ^a   Wade Martins, Richard ^a   James, Michael R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

BAC; Episome; Epstein Barr virus; Functional genomics; Gene therapy; Genomic DNA

Indexed keywords

GENOMIC DNA; VIRUS VECTOR;

AMPLICON; ARTICLE; B LYMPHOCYTE; CELL IMMORTALIZATION; CONTROLLED STUDY; DNA PACKAGING; EPISOME; EPSTEIN BARR VIRUS; GENE CONSTRUCT; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENETIC TRANSFECTION; GENOME SIZE; HUMAN; HUMAN CELL; LATENT PERIOD; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE CULTURE; MOLECULAR CLONING; NONHUMAN; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CONCENTRATION; VIRUS INFECTIVITY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 4; INSERTION SEQUENCES;

EID: 0036230136     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0557     Document Type: Article

References (38)

1. Stable correction of a genetic deficiency in human cells by a 115 kb episomal genomic transgene
2. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
3. Epstein-Barr virus/human vector provides high-level long-term expression of α1-antitrypsin in mice
4. An element in intron 1 of the CFTR gene augments intestinal expression in vivo
5. Locus control regions-coming of age at a decade plus
6. Going the distance: A current view of enhancer action
7. A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells
8. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells
9. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
10. Replication of latent Epstein-Barr virus genomes in Raji cells
11. The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication
12. Isolation of human sequences that replicate autonomously in human cells
13. EBNA-1: A protein pivotal to latent infection by Epstein-Barr virus
14. Stable episomal maintenance of yeast artificial chromosomes in human cells
15. A system for shuttling 200-kb BAC/PAC clones into human cells: Stable extrachromosomal persistence and long-term ecotopic gene expression
16. Long-term stability of large insert genomic DNA episomal shuttle vectors in human cells
17. Epstein-Barr virus-based vectors that replicate in rodent cells
18. Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus
19. Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes
20. Structure and role of the terminal repeats of Epstein-Barr virus in processing and packaging of virion DNA
21. Therapeutic gene delivery in human B-lymphoblastoid cells by engineered non-transforming infectious Epstein-Barr virus
22. Engineering 100-300-kb DNA as persisting extrachromosomal elements in human cells using human artificial episomal chromosomes system
23. Properties of I-Ppo I: A rare cutting intron-encoded endonuclease
24. New Epstein-Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
25. Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells
26. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis
27. Development of a competitive PCR method for physical titration of recombinant EBV vector in a helper-dependent packaging system
28. Optimal lengths for DNAs encapsidated by Epstein-Barr virus
29. Packaging of 200 kb engineered DNA as infectious Epstein-Barr virus
30. Gene therapy strategies for treating Epstein-Barr virus-associated lymphomas: Comparison of two different Epstein-Barr virus-based vectors
31. Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA class I expression in Type I diabetic cells
32. Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells
33. A first generation packaging cell line for Epstein-Barr virus-derived vectors
34. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor based vector
35. Sequences adjacent to oriP improve the persistence of Epstein-Barr virus-based episomes in B cells
36. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments
37. Lipid-mediated enhancement of transfection by a nonviral integrin targeting vector