FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice

Journal of Clinical Investigation

Volumn 112, Issue 8, 2003, Pages 1202-1210

  Yoshimura, Shinichi ^a   Teramoto, Tetsuyuki ^a   Whalen, Michael J ^a   Irizarry, Michael C ^a   Takagi, Yasushi ^a   Qiu, Jianhua ^a   Harada, Jun ^a   Waeber, Christian ^a   Breakefield, Xandra O ^b   Moskowitz, Michael A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CELL NUCLEUS ANTIGEN; FIBROBLAST GROWTH FACTOR 2;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN CORTEX; BRAIN INJURY; CELL DEGENERATION; CELL DIVISION; CELL LABELING; CELL LOSS; CELL PROTECTION; CELL SPECIFICITY; CONTROLLED STUDY; DENTATE GYRUS; GENE OVEREXPRESSION; GENE TRANSFER; GRANULE CELL; HERPES SIMPLEX VIRUS 1; HIPPOCAMPUS; IMMUNOMODULATION; MOUSE; NERVE CELL; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL;

EID: 9144274986     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16618     Document Type: Article

References (52)

1. Altman, J., and Das, G.D. 1965. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124:319-335.
2. Eriksson, P.S., et al. 1998. Neurogenesis in the adult human hippocampus. Nat. Med. 4:1313-1317.
3. Gage, F.H. 2000. Mammalian neural stem cells. Science. 287:1433-1438.
4. Gould, E., Tanapat, P., McEwen, B.S., Flugge, G., and Fuchs, E. 1998. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. U. S. A. 95:3168-3171.
5. Kempermann, G., Kuhn, H.G., and Gage, F.H. 1997. More hippocampal neurons in adult mice living in an enriched environment. Nature. 386:493-495.
6. Kempermann, G., Kuhn, H.G., and Gage, F.H. 1997. Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc. Natl. Acad. Sci. U. S. A. 94:10409-10414.
7. Kornack, D.R., and Rakic, P.C. 1999. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc. Natl. Acad. Sci. U. S. A. 96:5768-5773.
8. Covolan, L., Ribeiro, L.T., Longo, B.M., and Mello, L.E. 2000. Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus. Hippocampus. 10:169-180.
9. Dash, P.K., Mach, S.A., and Moore, A.N. 2001. Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury. J. Neurosci. Res. 63:313-319.
10. Gould, E., and Tanapat, P. 1997. Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat. Neuroscience. 80:427-436.
11. Gray, W.P., and Sundstrom, L.E. 1998. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res. 790:52-59.
12. Jin, K., et al. 2001. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl. Acad. Sci. U. S. A. 98:4710-4715.
13. Liu, J., Solway, K., Messing, R.O., and Sharp, F.R. 1998. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 18:7768-7778.
14. Takagi, Y., et al. 1999. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Res. 831:283-287.
15. Yoshimura, S., et al. 2001. FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc. Natl. Acad. Sci. U. S. A. 98:5874-5879.
16. Cameron, H.A., Hazel, T.G., and McKay, R.D. 1998. Regulation of neurogenesis by growth factors and neurotransmitters. J. Neurobiol. 36:287-306.
17. Ghosh, A., and Greenberg, M.E. 1995. Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron. 15:89-103.
18. Kuhn, H.G., Winkler, J., Kempermann, G., Thal, L.J., and Gage, F.H. 1997. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J. Neurosci. 17:5820-5829.
19. Temple, S., and Qian, X. 1995. bFGF, neurotrophins, and the control or cortical neurogenesis. Neuron. 15:249-252.
20. Vicario-Abejon, C., Johe, K.K., Hazel, T.G., Collazo, D., and McKay, R.D. 1995. Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons. Neuron. 15:105-114.
21. Vaccarino, F.M., et al. 1999. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat. Neurosci. 2:246-253.
22. Ray, J., Peterson, D.A., Schinstine, M., and Gage, F.H. 1993. Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 90:3602-3606.
23. Pettmann, B., Labourdette, G., Weibel, M., and Sensenbrenner, M. 1986. The brain fibroblast growth factor (FGF) is localized in neurons Neurosci. Lett. 68:175-180.
24. Walicke, P.A., Feige, J.J., and Baird, A. 1989. Characterization of the neuronal receptor for basic fibroblast growth factor and comparison to receptors on mesenchymal cells. J. Biol. Chem. 264:4120-4126.
25. Wanaka, A., Johnson, E.M., Jr., and Milbrandt, J. 1990. Localization of FGF receptor mRNA in the adult rat central nervous system. Neuron. 5:267-281.
26. Ku, P.T., and D'Amore, P.A. 1995. Regulation of basic fibroblast growth factor (bFGF) gene and protein expression following its release from sublethally injured endothelial cells. J. Cell Biochem. 58:328-343.
27. Cuevas, P. 1997. Therapeutic prospects for fibroblast growth factor treatment of brain ischemia. Neurol. Res. 19:355-356.
28. Dietrich, W.D., Alonso, O., Busto, R., and Finklestein, S.P. 1996. Posttreatment with intravenous basic fibroblast growth factor reduces histopathological damage following fluid-percussion brain injury in rats. J. Neurotrauma. 13:309-316.
29. Mocchetti, I., and Wrathall, J.R. 1995. Neurotrophic factors in central nervous system trauma. J. Neurotrauma. 12:853-870.
30. Tretter, Y.P., et al. 2000. Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo. Nat. Med. 6:812-815.
31. Nakatomi, H., et al. 2002. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 110:429-441.
32. Colicos, M.A., and Dash, P.K. 1996. Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits. Brain Res. 739:120-131.
33. Dietrich, W.D., Alonso, O., and Halley, M. 1994. Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J. Neurotrauma. 11:289-301.
34. Scheff, S.W., Baldwin, S.A., Brown, R.W., and Kraemer, P.J. 1997. Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact. J. Neurotrauma. 14:615-627.
35. Smith, D.H., et al. 1995. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J. Neurotrauma. 12:169-178.
36. Zhou, M., et al. 1998. Fibroblast growth factor 2 control of vascular tone. Nat. Med. 4:201-207.
37. Steward, O., et al. 1999. Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Exp. Neurol. 157:19-42.
38. Whalen, M.J., et al. 1999. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. J. Cereb. Blood Flow Metab. 19:835-842.
39. Ikeda, K., Saeki, Y., Gonzalez-Agosti, C., Ramesh, V., and Chiocca, E.A. 1999. inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer. J. Neurosurg. 91:85-92.
40. Fraefel, C., et al. 1996. Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J. Virol. 70:7190-7197.
41. Cavalieri, B. 1966. Geometria degli indivisibli. Unione Tipografico-Editrice. Torino, Italy. 872 pp.
42. Nakamura, M., et al. 1999. Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice. J. Comp. Neurol. 412:681-692.
43. Takeuchi, A., et al. 2000. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am. J. Pathol. 157:331-339.
44. West, M.J., Slomianka, L., and Gundersen, H.J. 1991. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231:482-497.
45. West, M.J. 1993. New stereologic methods for counting neurons. Neurobiol. Aging. 14:275-285.
46. Rink, A., et al. 1995. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. Am. J. Pathol. 147:1575-1583.
47. Friesel, R.E., and Maciag, T. 1995. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 9:919-925.
48. Saksela, O., and Rifkin, D.B. 1990. Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J. Cell Biol. 110:767-775.
49. Penc, S.F., et al. 1998. Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function. J. Biol. Chem. 273:28116-28121.
50. Dietzmann, K., et al. 2000. Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests: an immunohistochemical study. Pathol. Res. Pract. 196:15-21.
51. Reilly, J.F., and Kumari, V.G. 1996. Alterations in fibroblast growth factor receptor expression following brain injury. Exp. Neurol. 140:139-150.
52. Kato, M., et al. 1998. Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat. Med. 4:691-697.