Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6545-6551

  Tolba, Khaled A ^a   Bowers, William J ^a   Muller, Jacquelyn ^a   Housekneckt, Vickie ^a   Giuliano, Rita E ^a   Federoff, Howard J ^a   Rosenblatt, Joseph D ^b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; PERFORIN;

ADENOCARCINOMA; AMPLICON; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; B CELL LYMPHOMA; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG MECHANISM; EFFECTOR CELL; GENE EXPRESSION; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; IMMUNE RESPONSE; INJECTION; LYMPH NODE; LYMPHOID TISSUE; MEMORY CELL; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TH1 CELL; VIRAL GENE DELIVERY SYSTEM;

ADENOCARCINOMA; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CHEMOKINES, CC; DENDRITIC CELLS; GENE THERAPY; GENETIC VECTORS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; LYMPHOMA, B-CELL; MICE; MICE, INBRED BALB C; RNA, MESSENGER; SIMPLEXVIRUS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0037112502     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Goodnow, C. C. Chance encounters and organized rendezvous. Immunol. Rev., 156: 5-10, 1997
2. Steinman, R. M., Pack, M., and Inaba, K. Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev., 156: 25-37, 1997
3. Moser, B., and Loetscher, P. Lymphocyte traffic control by chemokines. Nat. Immunol., 2: 123-128, 2001
4. Sallusto, F., Mackay, C. R., and Lanzavecchia, A. The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol., 18: 593-620, 2000
5. Mellman, I., and Steinman, R. M. Dendritic cells: Specialized and regulated antigen processing machines. Cell, 106: 255-258, 2001
6. Saeki, H., Moore, A., Brown, M., and Hwang, S. Cutting edge: Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol., 162: 2472-2475, 1999
7. Baekkevold, E. S., Yamanaka, T., Palframan, R. T., Carlsen, H. S., Reinholt, F. P., von Andrian, U. H., Brandtzaeg, P., and Haraldsen, G. The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med., 193: 1105-1112, 2001
8. Chan, V. W., Kothakota, S., Rohan, M. C., Panganiban-Lustan, L., Gardner, J. P., Wachowicz, M. S., Winter, J. A., and Williams, L. T. Secondary lymphoid-tissue chemokine (SLC) is chemotactic for mature dendritic cells. Blood, 93: 3610-3616, 1999
9. Hirao, M., Onai, N., Hiroishi, K., Watkins, S. C., Matsushima, K., Robbins, P. D., Lotze, M. T., and Tahara, H. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes. Cancer Res., 60: 2209-2217, 2000
10. Kellermann, S. A., Hudak, S., Oldham, E. R., Liu, Y. J., and McEvoy, L. M. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 β are potent chemoattractants for in vitro- and in vivo-derived dendritic cells. J. Immunol., 162: 3859-3864, 1999
11. Sallusto, F., Lenig, D., Forster, R., Lipp, M., and Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (Lond.), 401: 708-712, 1999
12. Gunn, M., Kyuwa, S., Tam, C., Kakiuchi, T., Matsuzawa, A., Williams, L., and Nakano, H. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med., 189: 451-460, 1999
13. Forster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Muller, I., Wolf, E., and Lipp, M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell, 99: 23-33, 1999
14. Grewal, I., and Flavell, R. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol., 16: 111-135. 1998
15. Kutubuddin, M., Federoff, H., Challita-Eid, P., Halterman, M., Day, B., Atkinson, M., Planelles, V., and Rosenblatt, J. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 93: 643-654, 1999
16. Toda, M., Martuza, R. L., Kojima, H., and Rabkin, S. D. In situ cancer vaccination: An IL-12 defective vector/replication-competent herpes simplex virus combination induces local and systemic antitumor activity. J. Immunol., 160: 4457-4464, 1998
17. Geller, A., Keyomarsi, K., Bryan, J., and Pardee, A. An efficient deletion mutant packaging system for defective herpes simplex virus vectors: Potential applications to human gene therapy and neuronal physiology. Proc. Natl. Acad. Sci. USA, 87: 8950-8954, 1990
18. Geller, A., and Freese, A. Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli β-galactosidase. Proc. Natl. Acad. Sci. USA, 87: 1149-1153, 1990
19. Geschwind, M., Kessler, J., Geller, A., and Federoff, H. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Brain Res. Mol. Brain Res., 24: 327-335, 1994
20. Banchereau, J., and Steinman, R. M. Dendritic cells and the control of immunity. Nature (Lond.), 392: 245-252, 1998
21. Sallusto, F., and Lanzavecchia, A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev., 177: 134-140, 2000
22. Allavena, P., Sica, A., Vecchi, A., Locati, M., Sozzani, S., and Mantovani, A. The chemokine receptor switch paradigm and dendritic cell migration: Its significance in tumor tissues. Immunol. Rev., 177: 141-149, 2000
23. Sozzani, S., Allavena, P., D’Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., and Mantovani, A. Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties. J. Immunol., 161: 1083-1086, 1998
24. Sozzani, S., Allavena, P., Vecchi, A., and Mantovani, A. The role of chemokines in the regulation of dendritic cell trafficking. J. Leukoc. Biol., 66: 1-9, 1999
25. Sharma, S., Stolina, M., Luo, J., Strieter, R., Burdick, M., Zhu, L., Batra, R., and Dubinett, S. Secondary lymphoid tissue chemokine mediates T cell-dependent anti-tumor responses in vivo. J. Immunol., 164: 4558-4563, 2000
26. Vicari, A., Ait-Yahia, S., Chemin, K., Mueller, A., Zlotnik, A., and Caux, C. Antitumor effects of the mouse chemokine 6Ckine/SLC through angiostatic and immunological mechanisms. J. Immunol., 165: 1992-2000, 2000
27. Kirk, C., Hartigan-O’Connor, D., Nickoloff, B., Chamberlain, J., Giedlin, M., Aukerman, L., and Mule, J. T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: Augmentation of dendritic cell-based immunotherapy. Cancer Res., 61: 2062-2070, 2001
28. Albert, M. L., Sauter, B., and Bhardwaj, N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature (Lond.), 392: 86-89, 1998
29. Macatonia, S., Hosken, N., Litton, M., Vieira, P., Hsieh, C., Culpepper, J., Wysocka, M., Trinchieri, G., Murphy, K., and O’Garra, A. Dendritic cells produce IL-12 and direct the development of ThI cells from naive CD4+ T cells. J. Immunol., 154: 5071-5079, 1995
30. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., and Alber, G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med., 184: 747-752, 1996
31. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N., and Schuler, G. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med., 184: 741-746, 1996
32. Krisky, D., Wolfe, D., Goins, W., Marconi, P., Ramakrishnan, R., Mata, M., Rouse, R., Fink, D., and Glorioso, J. Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. Gene Ther., 5: 1593-1603, 1998
33. Groves, R., Allen, M., Ross, E., Barker, J., and MacDonald, D. Tumour necrosis factor a is pro-inflammatory in normal human skin and modulates cutaneous adhesion molecule expression. Br. J. Dermatol., 132: 345-352, 1995
34. Groves, R., Ross, E., Barker, J., Ross, J., Camp, R., and MacDonald, D. Effect of in vivo interleukinon adhesion molecule expression in normal human skin. J. Investig. Dermatol., 98: 384-387, 1992
35. Haraldsen, G., Kvale, D., Lien, B., Farstad, I., and Brandtzaeg, P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J. Immunol., 156: 2558-2565, 1996
36. Sallusto, F., Palermo, B., Lenig, D., Miettinen, M., Matikainen, S., Julkunen, I., Forster, R., Burgstahler, R., Lipp, M., and Lanzavecchia, A. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur. J. Immunol., 29: 1617-1625, 1999